Assessing the potential for in vivo modulation of FTH1 gene expression with small peptides to restore and enhance androgen receptor pathway inhibition in prostate cancer by Crawford Currie, Christian Bjerknes, McKayla Nicol, Sateesh Kumar, Bomi Framroze

“…The FT-002a-enzalutamide combination was more effective than FT-005 in reducing tumor mass and volume and modulating FTH1 and TFRC expression. The reversal by the peptides of this oncogenic expression pattern points to a reduction in the tumor free iron via increased iron storage in ferritin and a reduction in iron influx via the transferrin receptor. …”
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Multi-Physical Field Coupling Analysis of Electro-Controlled Permanent Magnet Blank Holder Processes Considering Thermal Magnetic Losses by Zhanshan Wang, Linyuan Meng, Gaochao Yu, Xiaoyu Ji

“…The results indicated that an increase in temperature leads to a reduction in magnetic force, with a maximum reduction of 18.57% observed after thermal equilibrium. …”
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Long-term left atrial adaptations to reduced training load in former elite athletes: a long-term follow-up longitudinal observational study by Ahmad Sajadieh, Robin Christensen, Jens Jakob Thune, Mikkel Aaroee, Susanne Glasius Tischer, Christian Have Dall, Hanne Rasmusen

“…LA contraction strain was increased (change from baseline: 1.4%, 95% CI: 0.4% to 2.5%), while LV filling pressure increased (E/e’ change from baseline: 0.4, 95% CI: 0.1 to 0.7).Conclusions 7 years of reduced training does not reverse exercise-induced LA enlargement in former elite endurance athletes. …”
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Lipodystrophy induced by combination antiretroviral therapy in HIV/AIDS patients: A Belgrade cohort study by Dragović Gordana, Danilović Dragana, Dimić Aleksandra, Jevtović Đorđe

“…Highly active antiretroviral therapy (HAART) has led to dramatic reductions in mortality and morbidity of HIV/AIDS-patients. …”
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Role of MiR‐542‐3p/Integrin‐Linked Kinase/Myocardin Signaling Axis in Hypoxic Pulmonary Hypertension by Linqing Li, Weining Zhou, Qingrong Ji, Xianzhao Zhang, Ni Yang, Kaiyou Song, Shunpeng Hu, Cunfei Liu, Zhihong Ou, Fengwei Zhang, Yuda Wei, Jiantong Hou

“…MiR‐542‐3p antagomir reversed hypoxia‐induced pulmonary vascular remodeling and also reversed hypoxia‐induced reduction in ILK, Myocardin expression, and phenotype transition in rat pulmonary arteries. …”
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Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in Pseudomonas aeruginosa isolates in a tertiary hospital by Alessandra Imeneo, Laura Campogiani, Laura Campogiani, Pietro Vitale, Andrea Di Lorenzo, Andrea Di Lorenzo, Grazia Alessio, Davide Natale Abate, Maria Grazia Celeste, Anna Altieri, Cartesio D’Agostini, Cartesio D’Agostini, Vincenzo Malagnino, Vincenzo Malagnino, Massimo Andreoni, Massimo Andreoni, Marco Iannetta, Marco Iannetta, Loredana Sarmati, Loredana Sarmati

“…A subsequent increase after a first reduction in C/T resistance rate was observed, probably due to persistence of resistant isolates and antibiotic selective pressure. …”
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Renal Protective Effect of DPP-4 Inhibitors in Type 2 Diabetes Mellitus Patients: A Cohort Study by Young-Gun Kim, JungHyun Byun, Dukyong Yoon, Ja Young Jeon, Seung Jin Han, Dae Jung Kim, Kwan-Woo Lee, Rae Woong Park, Hae Jin Kim

“…Although eGFR was not changed 1 year after DPP-4i treatment, reductions in eGFR were slowed in patients with microalbuminuria and reversed in the macroalbuminuria or normoalbuminuria groups, 4 years after treatment. …”
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Modulation of microglial phagocytosis via the GAS6-MERTK pathway regulates pathological angiogenesis in the mouse oxygen-induced retinopathy model by Canelif Yilmaz, Irina Korovina, Anke Witt, Farid Abdallah, Bianca Müller, Carmen Hentsche, Anika Fleischhauer, Stephan Speier, Andreas Deussen, Anne Klotzsche - von Ameln

“…In myeloid SOCS3-deficient mice, we observed a reduction of pathological NV in OIR. This reduction could be reversed by neutralizing GAS6 via administration of recombinant MERTK protein, the receptor for GAS6 expressed on myeloid cells. …”
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Inhaled corticosteroids in asthma and chronic obstructive pulmonary disease combined phenotype: when to use and what to expect? by Srishankar Bairy, Tarun Tiwari, Himanshu Mittal, Neeraj Gupta, Meghana M

“…Additionally, there was a notable reduction in the FeNO level, along with decreases in the TEC, serum IgE levels, and sputum eosinophils. …”
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Electroacupuncture reduces neuroinflammation and neuronal pyroptosis via downregulating Neat1 in rats after stroke by Bin Chen, Xiaoyong Zhong, Wanqing Lin, Zhaolian Cai, Xiaofang You, Renyu Yu

“…Moreover, the positive impacts of EA on neurobehavioural recovery, suppression of brain damage and reduction in MAP2 degradation were reversed by Neat1 overexpression. …”
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Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions by Wenhua Liu, Na Li, Dongsheng Tang, Lang Qin, Zhiqiang Zhu

“…Structural alterations: 7.2% mean gray matter reduction in prefrontal cortex (Cohen’s d = 0.81). …”
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N1-Methylnicotinamide Improves Hepatic Insulin Sensitivity via Activation of SIRT1 and Inhibition of FOXO1 Acetylation by Jingfan Zhang, Yu Chen, Cong Liu, Ling Li, Ping Li

“…As Sirt1 expression was inhibited, the reduction of hepatocyte gluconeogenesis and the regulation of the insulin signaling pathway by MNAM were reversed. …”
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Relieving Effect of <i>Artemisia ordosica Krasch</i> Extract on DSS-Induced Colitis by Regulating Immunity, Antioxidant Function, Gut Microbiota, and Bile Acid Metabolism in Mice by Min Jiang, Xuekai Zhang, Xiao Jin, Binlin Shi, Yuanqing Xu, Zheqi Wang

“…The results showed that the iron reduction capacity of AOE was positively correlated with its concentration. …”
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Evaluation of a user‐friendly CSDS cage apparatus for studying depressive‐like behaviors in rodents by Hao Zhang, Dongmei Gao, Minghu Hu, Wanqing Zhou, Muxuan Han, Ya Sun, Yang Zhang, Jieqiong Wang, Mingzhou Gao

“…Significant reductions in sucrose preference and urine sniffing time were observed, while the OFT revealed decreased central zone total distance, residence time, and frequency of entry. …”
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Techno-economic analysis and process simulation of alkoxylated surfactant production in a circular carbon economy framework by Oliver J. Fisher, Jhuma Sadhukhan, Thorin Daniel, Jin Xuan

“…It evaluates a thermo-catalytic pathway involving Fischer-Tropsch (FT) synthesis with syngas generated by the reverse-water gas-shift reaction, where CO2 reacts with H2. …”
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Unraveling the causal pathway between phosphatidylinositol, metabolites, and metabolic syndrome: a Mendelian randomization study by YueGuang Yang, YanLing Ma, Ming Li, YuBo Han, Li Liu

“…Nevertheless, the causal association between PI and MetS remains unclear due to the presence of confounding factors and the potential for reverse causation in observational settings. This study seeks to clarify the causal link between PI and MetS while investigating the role of mediating metabolites. …”
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RITUXIMAB THERAPY MONITORING IN PATIENTS WITH RHEUMATOID ARTHRITIS HROUGH PERIPHERAL BLOOD GENE EXPRESSION ANALYSIS by E. V. Chetina, A. V. Pivanova, K. Kh. Kuzikyants, A. Yu. Devyataikina, G. V. Lukina, E. Yu. Samarkina, A. P. Aleksankin, E. N. Aleksandrova

“…RTM therapy resulted in reductions in DAS28, ESR, CRP levels, and CD10+ B lymphocyte depletion (p &lt; 0.05). …”
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Understanding the active site in chameleon-like bifunctional catalyst for practical rechargeable zinc-air batteries by Xiongwei Zhong, Xiao Xiao, Qizhen Li, Mengtian Zhang, Zhitong Li, Leyi Gao, Biao Chen, Zhiyang Zheng, Qingjin Fu, Xingzhu Wang, Guangmin Zhou, Baomin Xu

“…The adaptive oxidation of RuSA-NiFe LDH to oxyhydroxide species (RuSA-NiFeOOH) during charging exposes active sites for the oxygen evolution reaction, while reversible reduction to NiFe LDH during discharge exposes active sites for the oxygen reduction reaction. …”
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Molten air—A new class of high capacity batteries by Stuart Licht

“…The cells use air and a molten electrolyte, are quasi-reversible (rechargeable) and have the capacity for multiple electrons stored per molecule, have high intrinsic electric energy storage capacities. …”
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The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer by Valentina Cutano, Ming Li Chia, Eleanor M. Wigmore, Lorna Hopcroft, Stuart C. Williamson, Amanda L. Christie, Brandon Willis, James Kerr, Jenny Ashforth, Rhys Fox, Sophie D’Arcy, Lauren Bradshaw, Catherine Blaker, Cath Eberlein, Lambert Montava-Garriga, Elza C. de Bruin, Susan E. Critchlow, Kevin M. Brindle, Simon T. Barry, Susana Ros

“…Downregulating FOXM1 expression reversed resistance to capivasertib, while FOXM1 overexpression reduced capivasertib efficacy. …”
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