Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mech... by Laura Lagostena, Davide Rotondo, Davide Gualandris, Antonio Calisi, Candida Lorusso, Valeria Magnelli, Francesco Dondero

“…Both PFOS and PFOA caused a significant but reversible reduction in GABA receptor-mediated currents following one-minute pre-treatment. …”
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The landscape of renal protein S-acylation in mice with lipid-induced nephrotoxicity by Fangrui Xiu, Zhibo Gai, Peter Gehrig, Witold E. Wolski, Museer A. Lone, Michele Visentin

“…Because fatty acids can also be reversibly attached onto cysteine residues and modulate the function of several membrane-bound proteins, we studied the effect of high-fat diet (HFD) on the S-acylated proteome of mouse kidneys to uncover novel biochemical changes that might contribute to lipid-induced nephrotoxicity. …”
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Impact of resistance exercise variants on sarcopenia: a scoping review by Stuti Sharma, Mahak Sharma, Divya Tripathi, Gulshan Lal Khanna

“…Exercise intervention is important for the reversal or prevention of this muscle loss. Objective The study aimed to find out the influence of resistance exercise on Sarcopenia. …”
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Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol: a pilot study. by Miguel Debono, Rita Chadarevian, Richard Eastell, Richard J Ross, John Newell-Price

“…Cortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible. In a proof of concept study we examined the short-term effects of glucocorticoid receptor (GR) antagonism in patients with an adrenal incidentaloma to determine whether their insulin resistance was reversible.…”
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P47 | ASSESSMENT OF THE ANTI-INFLAMMATORY AND ANTIFIBROTIC EFFECTS OF HUMAN AMNIOTIC EPITHELIAL CELLS AFTER THEIR INTRATRACHEAL ADMINISTRATION IN A MOUSE MODEL OF BLEOMYCIN-INDUCE...

“…A single administration of 1 million hAECs into the trachea caused a significant reduction in inflammatory areas after 7 days. The degree of reduction of fibrous areas compared to daily treatment with Pirfenidone has also been assessed. …”
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Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress by Yumei Liao, Qinghua Zhang, Qiaoyun Shi, Peng Liu, Peiyun Zhong, Lingling Guo, Zijian Huang, Yinghui Peng, Wei Liu, Shiqing Zhang, István Adorján, Yumi Fukuzaki, Eri Kawashita, Xiao-Qi Zhang, Nan Ma, Xiaoshen Zhang, Zoltán Molnár, Lei Shi

“…Exogenous neuroserpin reversed the activation of multiple endoplasmic reticulum stress signaling molecules, the reduction in protein synthesis, and the upregulation of apoptotic transcription factors. …”
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Cardiac neuropathy development in patients with metabolic syndrome and carbohydrate metabolism disturbances (heart rate variability analysis) by E. V. Minakov, L. A. Kudaeva

“…In Group II, RMSSD and pNN50 values were significantly reduced during the 24 hours of the monitoring, while in Group I, these values were normal, with some reduction in the morning. Conclusion. HRV analysis identified early, completely reversible during the night, manifestations of cardiac neuropathy in patients with MS and IGT. …”
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Efficacy and safety of ab-externo radiofrequency sclerostomy in management of open-angle glaucoma by M. Abd El Latief Fathallah, R. M. Abdel-Hamid, S. H. Salah, A. F. El-Shiaty, O. M. El-Zawahry

“…Heat radiation to the cornea from radiofrequency waves was obvious in early cases — 5 (25%) in group (A), and 3 (15%) in group (B) that was reversible within the first 3 months postoperatively. …”
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Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. by Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W Doble, Lin Li, Corentin Cras-Méneur, Sara C Martinez, Cris M Welling, Morris F White, Ernesto Bernal-Mizrachi, James R Woodgett, M Alan Permutt

“…Despite treatment with agents that enhance beta-cell function and insulin action, reduction in beta-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. …”
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Corneal sensory nerve loss induced by repeated subconjunctival and topical bupivacaine disrupts tear secretion and enhances bacterial adhesion via neuropeptide modulation. by Ananya Datta, Grace Kelly Orallo, Nahomy Nelson

“…This approach led to a 2.3-fold (~56.6%) reduction in tear production without inducing epithelial damage (P < 0.0001). …”
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Targeting Latent HIV Reservoirs: Effectiveness of Combination Therapy with HDAC and PARP Inhibitors by Hasset Tibebe, Dacia Marquez, Aidan McGraw, Sophia Gagliardi, Cailyn Sullivan, Grace Hillmer, Kedhar Narayan, Coco Izumi, Adleigh Keating, Taisuke Izumi

“…Talazoparib-treated peripheral blood mononuclear cells co-cultured with K562 cells demonstrated enhanced NK-cell-mediated cytotoxicity, with a 10% reduction in K562 cell viability. These findings demonstrate that combining HDAC and PARP inhibitors augments latency reversal and reservoir reduction. …”
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Protective Effects of a Polyherbal Mixture on Intestinal Injury via the NF-κB Signaling Pathway and Gut Microbiota Modulation in Hyperuricemic Mice by Haoluan Wang, Yu Xi, Fengju Gu, Linlin Peng, Jian Li

“…Moreover, PHT suppressed serum LPS levels and inhibited the NF-κB pathway, leading to a reduction in TNF-α and IL-6 levels in the gut. Gut microbiota analysis revealed PHT reversed dysbiosis, enriching beneficial bacteria like <i>Duncaniella</i> sp. and <i>Heminiphilus faecis</i>. …”
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The evolution, characteristics, and driving forces of the rural-urban HCEs in China: based on the EIO-SDA model by Yang Yang, Meijian Yang, Jia Luo, Zhengzao Wang, Yuanying Chi, Yahui Chen

“…In 2015–2020, the driving force reversed, leading to a decline in urban per capita HCEs. …”
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Observation and Analysis of Deformation Control Performance of Hydraulic Servo Steel Support for a Soft Soil Pit—A Case Study of a Pit Project in Hangzhou by Chao Wang, Gang Lin, Hongliang Yao, Haibin Ding, Xiaolin Tang, Zhaorui Lin, Xuepeng Wang

“…In recent years, numerous foundation pit projects have incorporated Hydraulic Servo Steel Support (HSSS) to actively manage the axial forces of the internal supports, which has achieved significant reductions in the displacement of the retaining structures (<i>δ</i>_D). …”
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Anti-arthritic, immunomodulatory, and inflammatory regulation by the benzimidazole derivative BMZ-AD: Insights from an FCA-induced rat model by Ahmad Haseeb, Anjum Irfan, Usman Halima, Mobashar Aisha, Shabbir Arham, Bin Jardan Yousef A., Metouekel Amira, Dauelbait Musaab, Bourhia Mohammed

“…Blood profiles improved with significant reductions in white blood cells and platelets in treatment groups. …”
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Three‒Dimensional Numerical Simulation of the Breaching Process of Landslide Dams with Heterogeneous Structures by HU Xianrui, PENG Ming, FU Xiaoli, YANG Ge, ZHU Yan, SHI Zhenming, ZHANG Gongding

“…This delayed breach development resulted in longer times to peak (up to 120 s) and reduced peak discharge (2.1 L/s). Reverse vortices formed at the headcut bases enhanced local scouring but exerted limited influence on overall erosion rates. …”
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Reducing Caloric Intake Prevents Ischemic Injury and Myocardial Dysfunction and Affects Anesthetic Cardioprotection in Type 2 Diabetic Rats by Charissa E. van den Brom, Christa Boer, Rob F. P. van den Akker, Stephan A. Loer, R. Arthur Bouwman

“…Caloric intake was reduced by reversing WD-fed rats to CD. Myocardial function was determined with echocardiography. …”
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Nephroprotective Effects of Caffeine, Vanillin, and Their Combination against Experimental AlCl3-Induced Renal Toxicity in Adult Male Wistar Rats by Olakunle Bamikole Afolabi, Oluwaseun Ruth Olasehinde, Oyindamola Adeniyi Olaoye, Kikelomo Folake Jaiyesimi, Ilobekemen Lisa Ekakitie, Omotade Ibidun Oloyede

“…Furthermore, following the treatment, there was a significant (p < 0.05) increase in renal SOD, CAT, GPx, and GSH levels, along with a reduction in the MDA level. In addition, the treatment for 21 days caused a significant (p < 0.05) reversal to the altered histomorphological architecture. …”
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Liver Disease and Central Nervous System Dysfunction: Linking the Two - A Narrative Review by Maciej Tenderenda, Bartosz Buczkowski, Piotr Oleksy, Agnieszka Klecza, Aleksandra Broniak, Magdalena Reclik, Karol Zieliński, Aarushi Chourasia, Krzysztof Nowakowski, Martyna Chraścina

“…Conclusions: Addressing HE requires a multifaceted approach, including ammonia reduction, inflammation control, and neurotransmitter balance restoration. …”
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Detailed understanding of reduced geoeffectiveness of solar cycle 24 in association with geomagnetic storms by R. Selvakumaran, Sneha A. Gokani, Shirsh Lata Soni

“…Despite the reduced overall CME rate, the weaker interplanetary magnetic field (IMF) and solar wind pressure led to an 80% reduction in intense geomagnetic storms and a 40% reduction in moderate storms. …”
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