Five-year comparison of clinical and echocardiographic outcomes of pure aortic stenosis with pure aortic regurgitation or mixed aortic valve disease in the COMMENCE trialCentral Me... by Vinod H. Thourani, MD, John D. Puskas, MD, Bartley Griffith, MD, Lars G. Svensson, MD, PhD, Philippe Pibarot, DVM, PhD, Michael A. Borger, MD, PhD, David Heimansohn, MD, Thomas Beaver, MD, MPH, Eugene H. Blackstone, MD, Anna Liza M. Antonio, DrPH, Joseph E. Bavaria, MD, MPH

“…There was a significant difference in LV reverse remodeling in the Pure AR + MAVD group compared to the Pure AS group at 5 years. …”
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MiR- 223 alleviates the heat-stress-induced inhibition of cell proliferation by targeting PRDM1 by Siqi Xia, Huimei Fan, Jianghai Xiao, Ci Shen, Yongping Yan, Meigui Wang, Tao Tang, Wenqiang Sun, Jie Wang, Xianbo Jia, Songjia Lai

“…Importantly, after heat stress, the miR- 223 mimic or the knockdown of PRDM1 in MAC-T was proven to partially reverse the inhibition of proliferation. Conclusion Consequently, the miR- 223 targeting PRDM1 might be important in alleviating heat-stress-induced inhibition of cell proliferation. …”
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Elevated IL-6 Expression in Autologous Adipose-Derived Stem Cells Regulates RANKL Mediated Inflammation in Osteoarthritis by Hyun-Joo Lee, Dae-Yong Kim, Hyeon jeong Noh, Song Yi Lee, Ji Ae Yoo, Samuel Jaeyoon Won, Yoon Sang Jeon, Ji Hoon Baek, Dong Jin Ryu

“…Moreover, the group of ASCs with high IL-6 expression showed a marked reduction in RANKL expression, suggesting enhanced potential to control osteoclast activity and subsequent cartilage defect in OA. …”
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Persistence of Ebola virus in semen among Ebola virus disease survivors in Sierra Leone: A cohort study of frequency, duration, and risk factors. by A E Thorson, G F Deen, K T Bernstein, W J Liu, F Yamba, N Habib, F R Sesay, P Gaillard, T A Massaquoi, S L R McDonald, Y Zhang, K N Durski, S Singaravelu, E Ervin, H Liu, A Coursier, J E Marrinan, A Ariyarajah, M Carino, P Formenty, U Ströher, M Lamunu, G Wu, F Sahr, W Xu, B Knust, N Broutet, Sierra Leone Ebola Virus Persistence Study Group

“…The men provided semen for testing, analyzed by quantitative reverse transcription PCR (qRT-PCR) for the presence of EBOV RNA. …”
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Nicotinamide Phosphoribosyltransferase Acetylation Mediating Muscle Dysfunction Contributes to Sleep Apnoea in Obesity by Liu Zhang, Ya Ru Yan, Shi Qi Li, Ying Ni Lin, Yi Wang, Yu Qing Wang, Ning Li, Fang Ying Lu, Xian Wen Sun, Li Yue Zhang, Jian Ping Zhou, Yong Jie Ding, Qing Yun Li

“…Conclusions These findings highlight the crucial role of SIRT1‐mediated NAMPT deacetylation on obesity‐induced muscle dysfunction, suggesting targeting NAMPT has the potential to reverse the obesity induced muscle dysfunction and provide effective treatment options for OSA.…”
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Photosynthetic response of Solidago gigantea Aition and Calamagrostis epigejos L. (Roth) to complex environmental stress on heavy metal contaminated sites by Wojciech Bąba, Agnieszka Kompała-Bąba, Edyta Sierka, Wojciech Bierza

“…The increase in the I–P part of the induction curve typically attributed to the reduction of electron transporters (ferredoxin, intermediary acceptors, and NADP) of the PSI acceptor side was observed in both SgC and SgLZ but not in CeLZ populations. …”
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Analysis of molecular mechanisms of the development of experimental diabetes in Wistar rats under conditions of intermittent hypoxia by T. V. Ivanenko

“…Such interventions can potentially lead to improvements in insulin resistance, a reduction in glycemia, and an overall enhancement of cardiorespiratory function. …”
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Visnagin treatment attenuates DSS-induced colitis by regulating inflammation, oxidative, stress, and mucosal damage by Vemula Sravathi, Madhuri Doppalapudi, Ravi Kumar Yadala, Anilkumar Banothu, Vijaya Kumar Anumolu, Hanuman Donga Durga Veera, Bhaskar Debbarma

“…This protective effect was further supported by a significant reduction in oxidative and nitrosative stress which was evident from decreased levels of nitrite and Malondialdehyde (MDA) in VIS treated groups 4 and 5. …”
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TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…This study confirmed TRAP1’s critical role in the pathogenesis of DR.Results: Our findings elucidate a significant reduction in TRAP1 expression in diabetic rat retinas, particularly in the pigment epithelium. …”
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Global burden of prostate cancer: age-period-cohort analysis from 1990 to 2021 and projections until 2040 by Feifan Chu, Lumin Chen, Qing Guan, Zujie Chen, Qiwei Ji, Yuning Ma, Jinzhong Ji, Mingxin Sun, Tingyang Huang, Haihan Song, Hao Zhou, Xiuquan Lin, Yichun Zheng

“…By 2040, it is projected that the global ASIR of prostate cancer will reverse its current trend and increase, while the age-standardized mortality rate and DALY rate will continue to decline, and the counts of incidence, mortality, and DALYs will keep rising. …”
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Strain promoted azide alkyne cycloaddition, an efficient surface functionalization strategy for microRNA magnetic separation by Djamila Kechkeche, Sirine El Mousli, Claire Poujouly, Emilie Secret, Vincent Dupuis, Isabelle Le Potier, Marie-Emmanuelle Goriot, Julien Siracusa, Sébastien Banzet, Jean Gamby, Jean-Michel Siaugue

“…In an emergency context, the detection of microRNA (miRNA), which are potential biomarkers of cardiovascular and muscular pathologies is hampered by the time required for the various steps involved: treatment of the patient sample, reverse transcription (RT), and finally polymerase chain reaction (PCR). …”
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Impact of Wheat Harvest on Levels and Sources of PM2.5-associated PAHs in an Urban Area Located at the Center of Beijing-Tianjin-Hebei Region by Zhiyong Li, Zhenxin Li, Ziyuan Yue, Dingyuan Yang, Yutong Wang, Lan Chen, Songtao Guo, Jinsong Yao, Lei Wang, Xiao Lou, Xiaolin Xu, Jinye Wei, Baole Deng, Hong Wu

“…The strict emission reduction measures made the industry smallest contributor in BUA. …”
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Trump's second presidency begins: evaluating effects on the US health system by Scott L. Greer, Holly Jarman, Rachel Kulikoff, Miranda Yaver

“…Many of the particular actions, such as mass layoffs of specialist scientific and regulatory staff, will be difficult to reverse.…”
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Renewable energy-driven desalination for sustainable water production in the Middle East by Mohammad Alshawaf, Nawaf S. Alhajeri

“…The study also compared the production of energy and water, and emissions reductions of hypothetical 100 MW renewable energy plants in Kuwait, coupled with reverse osmosis (RO) desalination units. …”
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Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. by Hongtao Liu, Shujie Yu, Hua Zhang, Jian Xu

“…Pharmacological or genetic suppression of peroxynitrite (ONOO(-)) generation not only blocked the autophagy but also reversed the reduction of VEGFR2 and angiogenesis. …”
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Green and blue water response to drought modulated by background climate and vegetation by Jing Xiao, Fubao Sun, Tingting Wang, Wang Hong

“…Furthermore, drought reduces runoff more than evapotranspiration in humid regions, but the reverse pattern occurs in arid regions. Compared to other vegetation types, forests exhibit smaller drought-induced reductions in evapotranspiration but greater reductions in runoff. …”
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Comprehensive Analysis of Intermittent Fasting on Anthropometric Indices, Glycemic Control, and Serum Insulin Levels in Obese Patients with Type 2 Diabetes by Aparnna Unnikrishnan Nair, Naveenkumar Nallathambi, S Yogesh, Lakshmi Murugesan, Harini B. Narayanan, Rajiv Ranjan, Nithila Sivakumar, Lakshiya Ramamoorthy, K Arun

“…Results: After four weeks, significant reductions were observed in anthropometric indices and fasting blood sugar, but no change in serum insulin levels. …”
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AN INVESTIGATION INTO RUSSIA’S CURRENT LEVEL OF SELF-SUFFICIENCY IN GRAIN by Svetlana Viktorovna PANASENKO, Ibragim Agaevich RAMAZANOV, Oksana Sergeevna KARASHCHUK, Elena Aleksandrovna MAYOROVA, Alexander Fedorovich NIKISHIN

“…This paper attempts to determine the degree to which reductions in grain production in 2018 may affect Russia’s self-sufficiency in grain and grain prices. …”
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The value-added model of the supply chain of petrochemical industries with a sustainable development approach by ali amiri, seyed abbas heydari, vahidreza Mirabi

“…The proposed model leads to the improvement of the economic and commercial performance of companies due to optimization of processes, reduction of wastage, improvement of product quality, and reduction of costs. …”
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Non-Abelian spin Hall insulator by Ahmed Abouelkomsan, Liang Fu

“…We show that a non-Abelian spin Hall insulator, a state of two copies of the non-Abelian Moore-Read state, can be stabilized at half filling of time-reversal conjugate Chern bands. We elucidate that the existence of this phase relies on the reduction of opposite-spin interactions at short distances to overcome the Ising ferromagnetism. …”
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