Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis by Qianxue Lu, Jin Liu, Yufeng Xiong, Jun Jian, Jingsong Wang, Zhiyuan Chen, Shanshan Wan, Xiuheng Liu, Lei Wang

“…However, C3G pretreatment could reverse the reductive expression of NDRG2. Furthermore, we found that the combined treatment of C3G and si-NDRG2 could reverse the decreased EMT and ECM, which induced by C3G treatment only. …”
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Gut dysbiosis as a potential driver of Parkinson’s and Alzheimer’s disease pathogenesis by Jacob M. Pfaffinger, Kallie E. Hays, Jason Seeley, Priyadharshine Ramesh Babu, Rebecca Ryznar

“…Specifically, we examine reductions in short-chain fatty acid (SCFA)-producing bacteria and increases in lipopolysaccharide (LPS)-expressing bacteria that may drive neuroinflammation and contribute to protein misfolding. …”
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Diversity and function of soluble heterodisulfide reductases in methane-metabolizing archaea by Xingyu Lyu, Hang Yu, Yahai Lu

“…In anaerobic methane- and alkane-oxidizing archaea, the reverse reaction occurs. The cycling of heterodisulfide is vital to the energy conservation of these anaerobic microorganisms. …”
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Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD by Yongli Hou, Lili Zhang, Wenhao Wang, Keyan Cheng, Hui Wang, Yanfei Ji, Xiaoqiang Su, Min Hao

“…Conversely, these effects were reversed upon introduction of a miR-125b inhibitor. …”
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Pre-Pregnancy Provegetarian Food Pattern and the Risk of Developing Gestational Diabetes Mellitus: The Seguimiento Universidad de Navarra (SUN) Cohort Study by Vanessa Bullón-Vela, Ainara Martínez-Tabar, Maddi Etxezarreta-Uranga, Miguel Ángel Martínez-González, Francisco Javier Basterra-Gortari, Maira Bes-Rastrollo

“…Women in the highest quintile (Q5) of provegetarian food pattern before pregnancy exhibited a 42% relative reduction in the odds of GDM [adjusted OR (95% CI) Q5 vs. …”
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Persistent Infections in Tick Cell Lines: The Role of Viral-Derived DNA Forms in Hazara Virus Replication and Cellular Survival by Eva Dias, Filipe Tomaz, Silvia Fabi, Cristiano Salata, Ana Domingos, Gonçalo Seixas

“…The experiments characterized vDNAs production, viral titers, and subcellular localization, and they examined the effect of the reverse transcriptase inhibitor azidothymidine triphosphate (AZT). …”
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CRIM-negative infantile Pompe disease, long-term observation of the effect of enzyme replacement therapy: a clinical case by D. R. Sabirova, D. I. Sadykova, A. A. Kucheryavaya, A. A. Kashina, L. A. Sabirova

“…In case of early confirmation, the effectiveness of currently available ERT increases: the possibility to stop the disease progression, to reverse its individual clinical manifestations, and to improve the patient’s quality of life.…”
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The butyrate derived from probiotic Clostridium butyricum exhibits an inhibitory effect on multiple myeloma through cell death induction by Hiroaki Konishi, Takeshi Saito, Shuichiro Takahashi, Hiroki Tanaka, Katsuhiro Okuda, Hiroaki Akutsu, Tatsuya Dokoshi, Aki Sakatani, Keitaro Takahashi, Katsuyoshi Ando, Shin Kashima, Nobuhiro Ueno, Kentaro Moriichi, Naoki Ogawa, Mikihiro Fujiya

“…In this study, we screened the cell-free culture supernatants (CFCS) of 24 probiotic strains for antitumor effects against multiple myeloma (MM) cells and identified that the CFCS from Clostridium butyricum (C. butyricum) demonstrated the most significant reduction in MM cell viability. Further fractionation of this CFCS through reverse-phase and gel filtration chromatography revealed a high enrichment of butyrate in the antitumor fraction, as confirmed by gas chromatography-mass spectrometry. …”
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Proteomic profiling of cotton fiber developmental transition from cell elongation to secondary wall deposition by Zhou Xiaoyun, Hu Wenran, Li Bo, Yang Yang, Zhang Yong, Thow Kieran, Fan Ling, Qu Yanying

“…During the transition, upregulated proteins are mainly involved in carbohydrate/energy metabolism, oxidation–reduction, cytoskeleton, protein turnover, Ca²⁺ signaling, etc., whereas important downregulated proteins are mostly involved in phenylpropanoid and flavonoid secondary metabolism pathways. …”
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Tuning of nonlinear optical bistability tuned by fullerene concentration in polyaniline-fullerene (PANI-C60) hybrid organic films by Roshan Joseph Mathew, Syam Kishor K.S., Arun R. Chandran, Saji K.J., Sajeev U.S.

“…Switching of saturable absorption (SA) to reverse saturable absorption (RSA) behaviour (NLO bistability) was observed in these organic hybrid films by changing the concentration of C60 in the PANI matrix. …”
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Multifaceted investigation of esfenvalerate-induced toxicity on Allium cepa L. by Onur Sarsar, Oksal Macar, Tuğçe Kalefetoğlu Macar, Kültiğin Çavuşoğlu, Emine Yalçın, Ali Acar

“…The application of the highest dose of 0.98 mg/L esfenvalerate resulted in a significant decrease in physiological parameters, including a 51% reduction in rooting percentage, an 85.3% decrease in root elongation, and a 54.3% decrease in weight gain (p < 0.05). …”
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The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing <i>AP1S2</i> by B. Zhang, R. Liu, T. Ma, X. Li, Y. Zhao, H. Su, J. Li, Y. Li, H. Jiang, Q. Zhang

“…In B16-F10 cells, which overexpress miRNA-211 and goat skin, the opposite expression trends between <i>AP1S2</i> and miRNA-211 were analyzed by reverse transcription–quantitative PCR (RT-qPCR) and western blot. …”
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Extended Evaluation of Virological, Immunological and Pharmacokinetic Endpoints of CELADEN: A Randomized, Placebo-Controlled Trial of Celgosivir in Dengue Fever Patients. by Cynthia Sung, Yuan Wei, Satoru Watanabe, How Sung Lee, Yok Moi Khoo, Lu Fan, Abhay P S Rathore, Kitti Wing-Ki Chan, Milly M Choy, Uma S Kamaraj, October M Sessions, Pauline Aw, Paola F de Sessions, Bernett Lee, John E Connolly, Martin L Hibberd, Dhanasekaran Vijaykrishna, Limin Wijaya, Eng Eong Ooi, Jenny Guek-Hong Low, Subhash G Vasudevan

“…Replication competent virus was measured by plaque assay and compared to reverse transcription quantitative PCR (qPCR) of viral RNA. …”
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Hsa_circ_0059511 promote glioma cell proliferation and migration through hsa-miR-194-5p/HBEGF axis by Yajun Jing, Huang-cheng Shang-guan, Jiawei Cai, Jinye Su, Wei Huang, Qiu He, Xiaoyong Chen, Dezhi Kang, Zanyi Wu

“…Of note, we found that downregulation of hsa-miR-194-5p, a target microRNA of hsa_circ_0059511, could reverse the reduction in glioma cell proliferation and migration caused by silencing of hsa_circ_0059511. …”
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Application of novel oligomeric Co(II) complexes of 4,4′-bipyridine and 1,10-phenanthroline modified glassy carbon electrode for differential pulse voltammetric determination of ci... by Mezgebu Biresaw, Adane Kassa, Getinet Tamiru Tigineh, Atakilt Abebe

“…An oxidative peak at a lower potential with a six-fold increase in peak current was observed at the poly(C2)/GCE. The absence of a reductive peak in the reverse scan indicated the irreversibility of the electrochemical oxidation of CPF. …”
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Global partnerships in combating tropical diseases: assessing the impact of a U.S. withdrawal from the WHO by Ikponmwosa Jude Ogieuhi, Victor Oluwatomiwa Ajekiigbe, Stephen Olaide Aremu, Victory Okpujie, Peace Uchechi Bassey, Adetola Emmanuel Babalola, Pelumi Gbolagade-Jonathan, Chidera Stanley Anthony, Ifeoluwa Sandra Bakare

“…Failure to do so could reverse hard-won gains such as the 99% reduction in polio cases since 1988, the near-eradication of Guinea worm disease (from 3.5 million cases in 1986 to 14 in 2023), and declining NTD burdens, leading to resurgence and increased mortality among vulnerable populations worldwide, with devastating consequences for millions of people throughout the world. …”
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Metabolomics insights into the protective molecular mechanism of Vaccinium myrtillus against oxidative stress in intestinal cells by Sara Novi, Vicky Caponigro, Maria Rosaria Miranda, Giovanna Aquino, Matteo Delli Carri, Emanuela Salviati, Silvia Franceschelli, Carla Sardo, Manuela Giovanna Basilicata, Vincenzo Vestuto, Mario Felice Tecce, Federico Marini, Giacomo Pepe, Pietro Campiglia, Michele Manfra

“…In fact, BLUBE was able to partially reverse the downregulation of these pathways, effectively reducing oxidative stress and promoting cell survival. …”
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Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study. by Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards

“…<h4>Conclusions</h4>In this study, we found no evidence that genetically determined reduction in 25OHD levels conferred an increased risk of asthma, atopic dermatitis, or elevated total serum IgE, suggesting that efforts to increase vitamin D are unlikely to reduce risks of atopic disease.…”
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Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats by Xueru Xu, Shaoxiong Fu, Xiaomei Shi, Rongguo Liu

“…Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain reduction owing to this treatment are not clarified completely. …”
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Inhibition of caspase-1 by ginsenoside Rg1 ameliorates d-gal-induced renal aging and injury through suppression of oxidative stress and inflammation by Tingting Guo, Ting Xie, Xuejun Chen, Jingying Zhong, Zhenyu Bai, Huiyu Liang, Xiaoshan Zhao, Meixia Fang, Ya Xiao, Jun Zhang

“…The effect of Rg1 was assessed by hematoxylin and eosin and Masson staining, quantitative reverse transcription PCR, enzyme-linked immunosorbent assay, and Western blotting.Results Network pharmacology revealed that caspase-1 was one of the crucial targets. …”
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