A Mendelian randomization study: physical activities and chronic kidney disease by Rui Xiao, Li Dong, Bo Xie, Beizhong Liu

“…However, the causality is not clear; specifically, physical activity may protect against CKD, and CKD may lead to a reduction in physical activity. Our study examined the potential bidirectional relationship between physical activity and CKD by using a genetically informed method. …”
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A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population by Metha Yaikwawong, Pornpimon Ek-eudomsuk, Gunya Sittithumcharee, Vipavee Anupunpisit, Thavatchai Peerapatdit, Chaicharn Deerochanawong, Thep Himathongkam, Siwanon Jirawatnotai, Somlak Chuengsamarn

“…The expression of mRNA was measured by reverse transcription polymerase chain reaction. The rs926198 variant, but not the rs3807989 variant, was associated with T2DM. …”
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The reprogramming impact of SMAC-mimetic on glioblastoma stem cells and the immune tumor microenvironment evolution by Qiong Wu, Jianan Chen, Anders E. Berglund, Dongliang Du, Robert J. Macaulay, Arnold B. Etame

“…Results According to our observations, in vitro exposure to Xevinapant induced apoptosis along with significant viability reduction in a dose-dependent manner, in both human and mouse GSCs. …”
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A Systematic Preparation of Liposomes with Yerba Mate (<i>Ilex paraguariensis</i>) Extract by Yasmine Miguel Serafini Micheletto, Brenda Vieira de Jesus, Gisele Louro Peres, Vânia Zanella Pinto

“…This, combined with the reduction observed in DLS, suggests membrane reorganization, leading to the formation of unilamellar liposomes. …”
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Effect of foliar spray of Spermine and Spermidine on growth and some physiological characteristics of chickpea (Cicer arietinum L) under salt stress by Ali Ashori, Manoochehr Gholipoor, Mostafa Heidari

“…Nutrient and carbohydrate deficiency under saline stress is one of probable reasons for abscission of flowers and branch reduction leading to yield reduction which all can be reversed by exogenous polyamine application. …”
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Analyzing Insights of Super-Response in Cardiac Resynchronization Therapy with Fusion Pacing by Alexandra-Iulia Lazăr-Höcher, Simina Crișan, Cristina Văcărescu, Samuel Nistor, Adelina Andreea Faur-Grigori, Andreea Cozgarea, Petru Baneu, Liviu Cirin, Laurențiu Brăescu, Larissa Dăniluc, Dan Gaiță, Constantin-Tudor Luca, Dragoș Constantin Cozma

“…Super-responders (SRs) were those with substantial reverse remodeling, quantified by a ≥30% reduction in LVESV and a stable LVEF of ≥45% at follow-up. …”
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Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos by Zaheer Haider, Safeer Ullah, Tahir Muhammad, Chalani Dilshani Perera, Muhammad Tayyab Khan, Asif Jan, Seung-Eun Lee, Seo-Hyun Lee, Sung Woo Kim, Muhammad Idrees, Muhammad Idrees, Il-Keun Kong, Il-Keun Kong, Il-Keun Kong

“…A considerable drawback of SCNT-cloned embryos is the reduction in telomerase activity, which is crucial for DNA stability and genetic and epigenetic reprogramming. …”
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HGF decreases ANIT-induced liver damage through modulation of redox status. by Maricruz García-Barrera, Genaro J. Rosales-Muñoz, Alejandro Escobedo-Calvario, Roberto C. Lazzarini-Lechuga, Natalia Nuño-Lámbarri, Luis E. Gómez-Quiroz, Leticia Bucio-Ortiz

“…Results: The histological results suggest that HGF can reverse the cholestatic damage observed in time-independent H&E stains, which impacts the architecture of the liver parenchyma, through the decrease in inflammatory infiltrate corroborated with the reversal of the size of the sinusoid area. …”
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Social determinants of health in relation to firearm-related homicides in the United States: A nationwide multilevel cross-sectional study. by Daniel Kim

“…Upward social mobility was related to a 25% reduction in the gun homicide rate (IRR = 0.75, 95% CI 0.66-0.86, p < 0.001) and a 24% decrease in the number of homicide incidents (IRR = 0.76, 95% CI 0.67-0.87, p < 0.001). …”
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The impact of RAD51 protein on the sensitivity of ovarian cancer to neoadjuvant chemotherapy by LIU Hui, CHEN Yunqing, QI Huiyang, SUN Xin, LOU Yanhui

“…Methods Tumor biopsy tissue samples were collected before NACT from 47 patients with advanced high-grade serous ovarian cancer (HGSOC) who underwent NACT and intermediate tumor cell reduction surgery in Department of Gynecology, The Affiliated Hospital of Qingdao University, from June 2017 to June 2019. …”
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Impairment of Glucose Uptake Induced by Elevated Intracellular Ca²⁺ in Hippocampal Neurons of Malignant Hyperthermia-Susceptible Mice by Arkady Uryash, Alfredo Mijares, Jose A. Adams, Jose R. Lopez

“…Moreover, reducing the [Ca²⁺]_i within a specific range (100–130 nM) could reverse insulin resistance, a hallmark of type 2 diabetes mellitus (T2D).…”
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Work stress related lipid disorders and arterial hypertension in professional drivers: A cross-sectional study by Đinđić Nataša, Jovanović Jovica, Đinđić Boris, Jovanović Milan, Pešić Milica, Jovanović Jovana J.

“…Regular periodical examinations and workplace interventions aimed to decrease total OSI and underload are important aspects in primary prevention and additional reduction of cardiovascular risk. [Projekat Ministarstva nauke Republike Srbije, br. 43012 i br. 41018]…”
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The STING-activating nanofactory relieves T cell exhaustion in Mn-based tumor immunotherapy by regulating mitochondrial dysfunction by Nana Chen, Yushan Yang, Limin Fan, Yanni Cai, Weimin Yin, Zichen Yang, Yuge Zhao, Shiyu Chen, Hui Zhi, Liangyi Xue, Xiaoyou Zhang, Lulu An, Yongyong Li, Tianbin Ren

“…Beyond activating the STING pathway in dendritic cells, L@Mn@SPD alleviates TME hypoxia and effectively reverses CD8⁺ T cell exhaustion. In vivo, L@Mn@SPD achieved a 2.44-fold increase in tumor suppression compared to MnCl₂, along with a 47% rise in CD8⁺ T cell infiltration, a 62.1% reduction in PD-1 expression, and a 110% increase in IFN-γ secretion. …”
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Effect of p-InGaN Cap Layer on Low-Resistance Contact to p-GaN: Carrier Transport Mechanism and Barrier Height Characteristics by Mohit Kumar, Laurent Xu, Timothée Labau, Jérôme Biscarrat, Simona Torrengo, Matthew Charles, Christophe Lecouvey, Aurélien Olivier, Joelle Zgheib, René Escoffier, Julien Buckley

“…Current–voltage (I–V) characteristics indicated that the cap layer’s surface properties and strain-induced polarization effects influenced the Schottky barrier height and reverse current. The reduction in barrier height by approximately 0.42 eV in the p⁺⁺-InGaN layer enhanced hole tunneling, further lowering the contact resistivity. …”
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Nonlinear association of physical activity with early cardiovascular-kidney-metabolic syndrome risk: a comprehensive analysis of NHANES data from 2007 to 2018 by Haozhe Wang, Yike Zhang, Meimei Sun, Zhou Chen

“…Before the lowest point (6872 MET*min/week), any incremental increase in MVPA was associated with a reduction in early CKM risk, and moderate MVPA (600 − 12,600 MET*min/week) exerts a protective effect. …”
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LILRA5+ macrophages drive early oxidative stress surge in sepsis: a single-cell transcriptomic landscape with therapeutic implications by Peng Xu, Haoze Li, Zuo Tao, Zixuan Zhang, Xiaohuan Wang, Cheng Zhang

“…Real-time quantitative reverse transcription (qRT-PCR) and Western blotting validated expression of LILRA5 in both the cecal ligation and puncture (CLP) model and the lipopolysaccharide-induced sepsis model. …”
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Efficacy of probiotic administration in the complex treatment of chronic catarrhal gingivitis in children by O. I. Godovanets, D. G. Popesku, O. S. Godovanets, V. V. Bezruk, T. O. Bezruk

“…Clinical efficacy of the proposed method is evidenced by the local treatment periods reduction almost twice as large and approximately 2/3 decreased of the disease signs relapse as compared to the initial indices.…”
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The role of intestinal homeostasis in sevoflurane-induced myelin development and cognitive impairment in neonatal mice by Chang Liu, Jinjie Li, Ruizhu Liu, Guoqing Zhao, Guoqing Zhao

“…Timely supplementation with butyrate could effectively reverse these changes, indicating that gut homeostasis is crucial for brain neurodevelopment.ConclusionMultiple exposures to sevoflurane in neonatal mice disrupt gut homeostasis and affect oligodendrocyte differentiation and myelin development in the hippocampus and prefrontal cortex, inducing cognitive and memory impairments. …”
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Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway by Shanshan Yu, Xuecui Wei, Fangyuan Long, Heng Gu, Zhimin Hao

“…In this study, we aimed to establish how a reduction in Pggt1b expression in monocytes influences the onset and progression of psoriasis. …”
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Empirical Analysis of the Impact of Employment on the Elderly Mental Health in China by Wang H, Ge Q

“…The analytical approach involved fixed effects models for the core empirical analysis, propensity score matching (PSM) to address selection bias, and instrumental variable techniques to tackle reverse causality.Results: The study demonstrates that employment retains positive properties of status passage for Chinese older adults in multicultural contexts, with empirical evidence showing significant reduction in depressive symptoms (β = − 0.3945, p &lt; 0.01) and consequent improvement in mental health outcomes. …”
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