Reduce Muscle Fibrosis through Exercise via NRG1/ErbB2 Modification in Diabetic Rats by Majid Amani, Masoud Rahmati, Mohammad Fathi, Hasan Ahmadvand

“…Since physical exercise has been indicated a protective strategy for improving glucose metabolism in skeletal muscle, we tested a hypothesis under which the endurance exercise training could reverse the produced skeletal muscle fibrosis by diabetes. …”
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p53 activation by knockdown technologies. by Mara E Robu, Jon D Larson, Aidas Nasevicius, Soraya Beiraghi, Charles Brenner, Steven A Farber, Stephen C Ekker

“…We show here that MO off-targeting results in induction of a p53-dependent cell death pathway. p53 activation has also recently been shown to be an unspecified off-target effect of siRNAs. …”
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Assembly Quality Control Technologies in Forced Clamping and Compensation Processes for Large and Integrated Aeronautical Composite Structures by Feiyan Guo, Qiangwei Bao, Jialiang Liu, Xiliang Sha

“…Finally, future research work is proposed, i.e., dynamic evolution behavior modeling and the equalization of the induction and control of physical assembly states.…”
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A review of biosimilars in psoriasis: impacts on efficacy, safety, access, and a first-hand look at biosimilar cost savings within the department of veterans affairs by Rebecca Reese, Shiva Ram Nanavath, Jennifer Martin, Jeffrey B. Travers, Craig A. Rohan

“…Background Psoriasis is a chronic immune-mediated systemic disease whose treatment has been revolutionized due to the induction of monoclonal antibody-based biologics. However, access to these drugs has been limited due to their high cost. …”
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Effect of Ultrasound-Guided Versus Conventional Recruitment Manoeuvres on Lung Aeration in Morbidly Obese Patients Undergoing Laparoscopic Bariatric Surgery: A Randomised Controlle... by Omar Mohamed Fathey Elkady, Sameh Abdelkhalik Ahmed, Mohamed Mohei Abu Yazed, Abdelraheem Moustafa Dowidar, Aliaa Mohamed Belal

“…Lung recruitment manoeuvres (RMs) are used to reverse atelectasis, and lung ultrasonography may offer a real-time, individualised approach to guide these interventions. …”
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PRDX1 knockdown promotes erastin-induced ferroptosis and impedes diffuse large B-cell lymphoma development by inhibiting the MAPK/ERK pathway by Chuanming Lin, Shuiling Xie, Menger Wang, Jianzhen Shen

“…PRDX1 knockdown reduced the phosphorylation levels of MEK and ERK both under conditions with or without erastin induction. The MAPK/ERK pathway agonist anisomycin, significantly reversed the inhibitory effects of PRDX1 knockdown on the malignant behaviors of DLBCL cells and the promotion of ferroptosis. …”
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Decreased Expression of Cav-1 Is Associated with Compromised Endometrial Angiogenesis during the Implantation Window in PCOS Rats: A Prospective Randomized Laboratory-Based Study by Huayun Xu, Guozeng Wang

“…The rats in the PCOS group mated after ovulation induction, while the rats in the control group mated during the estrus period. …”
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Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis by Eduardo Mendes, Evelyn Roxana Perez Umana, Daniel Di Pace Soares Penna, Fernando Augusto de Oliveira, Leandro Nascimento Lemos, Willian Rodrigues Ribeiro, Mateus Barbosa Casaro, Mariana Lazarini, Valéria Maia Oliveira, Caroline Marcantonio Ferreira

“…Recent studies have emphasized the impact of gut microbiota on skin health, but the reverse, how skin diseases affect gut homeostasis, has received less attention. …”
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Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X... by Amani Alsharidah, Zeyad Alehaideb, Sahar S. Alghamdi, Rasha S. Suliman, Saleh Althenayyan, Feras Almourfi, Bader Hazazi, Aljawharah Almogren, Abeer Al Tuwaijri, Mohamed Boudjelal, Afrah Alkhuriji, Sabine Matou-Nasri

“…CYP 2C9 gene and protein expression levels were evaluated using reverse transcription-quantitative polymerase chain reaction and Western blot. …”
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An in-depth appraisal of clinico-biochemical and radiological findings of COVID-19 patients during the COVID-19 pandemic in a dedicated COVID Care Hospital in Eastern India and its... by C. Mohan Rao, Amrut Kumar Mohapatra, Aswini Kumar Patnaik, Prem S. Panda, Prasanta Ranjan Behera

“…Vaccine-induced protection and the induction of herd immunity played a proactive role in the waning of the severity of clinical presentations.…”
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CD8+ T Cell-Mediated Immunity during Trypanosoma cruzi Infection: A Path for Vaccine Development? by Fernando dos Santos Virgilio, Camila Pontes, Mariana Ribeiro Dominguez, Jonatan Ersching, Mauricio Martins Rodrigues, José Ronnie Vasconcelos

“…Although they participate in parasite control and elimination, they are unable to clear the infection due to their low fitness, allowing the parasite to establish the chronic phase when these cells then play an active role in the induction of heart immunopathology. Vaccination with a number of subunit recombinant vaccines aimed at eliciting specific CD8+ T cells can reverse this path, thereby generating a productive immune response that will lead to the control of infection, reduction of symptoms, and reduction of disease transmission. …”
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Attenuation of Chikungunya Virus by a Single Amino Acid Substitution in the nsP1 Component of a Non-Structural Polyprotein by John Chamberlain, Stuart D. Dowall, Jack Smith, Geoff Pearson, Victoria Graham, John Raynes, Roger Hewson

“…The A533V-mutant CHIKV induced milder disease symptoms in the C57BL/6 mouse model than the wild-type virus, in terms of severity of inflammation, length of viraemic period, and histological changes. Furthermore, the induction of type I IFN occurred more rapidly in both CHIKV-infected cell cultures and the mouse model with the mutant CHIKV.…”
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Effect of experimental gestational diabetes and administration of glibenclamide on mRNA level of NLRP3-inflammasome and distribution of NLRP3+-cells in mesenteric lymph nodes in pr... by Т. М. Prozorova, V. A. Kamyshna, О. М. Kamyshnyi

“…A molecular-genetic study was carried out using polymerase chain reaction with real-time reverse transcription (RT–PCR) of mRNA expression level of the Nlrp3 gene. …”
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Activation of the β-adrenergic receptor exacerbates lipopolysaccharide-induced wasting of skeletal muscle cells by increasing interleukin-6 production. by Shino Matsukawa, Shinichi Kai, Hideya Seo, Kengo Suzuki, Kazuhiko Fukuda

“…Carvedilol, a nonselective β-adrenergic receptor antagonist, suppressed the facilitating effects of Epi on the Atrogin-1 mRNA induction by LPS, and abolished the effects of Epi on the MHC protein loss in the presence of LPS. …”
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Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders. by Anja Beierfuß, Hermann Dietrich, Christian Kremser, Monika Hunjadi, Andreas Ritsch, Thomas Rülicke, Claudius Thomé, Demissew Shenegelegn Mern

“…Experiments were performed using T1/T2-weighted magnetic resonance imaging, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, glucose-oxidase assay, enzyme-linked immunosorbent assay, quantitative reverse transcription PCR and western blot. APOE-knockout lumbar spines showed more advanced IVD degeneration, obstructed lumbar arteries and lower enhancement of contrast agent in IVDs. …”
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Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells by Vera Citro, Marta Clerici, Giovanna Della Porta, Nicola Maffulli, Aldo R. Boccaccini, Tina P. Dale, Nicholas R. Forsyth

“…The expression profiles of key tenogenic genes (Scleraxis [Scx], Tenomodulin [Tnmd], Thrombospondin-4 [Thromb-4] and Tenascin-C [Tnc-C]) were explored by quantitative reverse transcription PCR (RT-qPCR) following supplementation with individual GFs. …”
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Molecular characterisation of human peripheral blood stem cells by Ruzanna Ab Kadir, Shahrul Hisham Zainal Ariffin, Rohaya Megat Abdul Wahab, Sahidan Senafi

“…Stem cells in the isolated mononucleated cells were characterised using a multidisciplinary approach which was based on the expression of stem cell markers, morphology and the capacity to self-renew or proliferate and differentiate into specialised cells. Reverse transcription polymerase chain reaction was used to identify the expression of an HSC marker (signalling lymphocytic activation molecule family member 1, SLAMF1) and a MSC marker (CD105). …”
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Cytotoxic and apoptotic properties of silver chloride nanoparticles synthesized using Escherichia coli cell-free supernatant on human breast cancer MCF 7 cell line by Razieh Bigdeli, Masoumeh Shahnazari, Erfan Panahnejad, Reza Ahangari Cohan, Aziz Dashbolaghi, Vahid Asgary

“…Quantitative real-time reverse transcription-PCR and colourimetric assays were employed to investigate the mechanism of cell toxicity in several cell death pathways. …”
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EXPRESSION OF THE CYTOKINE GENES INDUCED BY HUMAN SERUM γ-GLOBULIN AND BY ITS METAL COMPLEXES WITH ZINC by S. B. Cheknev, M. V. Mezentseva, I. M. Shapoval, A. N. Narovlyansky

“…Synthesis of mRNAs for the key immunoactive cytokines was studied in mononuclear cells (MNC) from human peripheral blood, using reverse transcription and polymerase chain reaction, after incubation of isolated cells with human serum γ-globulin, zinc ions, or zinc-γ-globulin metal complexes. …”
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Octanoic Acid and Decanoic Acid Inhibit Tunicamycin-Induced ER Stress in Rat Aortic Smooth Muscle Cells by Wanida Sukketsiri, Varomyalin Tipmanee, Panlekha Rungruang, Mayo Higashihara, Tomoko Sumi, Tatsuya Moriyama, Nobuhiro Zaima

“…Given the link between ER stress and vascular cell pathological conditions, the primary goal of this research is to investigate the protective effects of OA and DA against ER stress induction in rat aortic smooth muscle cells (RASMCs). …”
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