Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domain. by Pranav Danthi, Caroline M Coffey, John S L Parker, Ty W Abel, Terence S Dermody

“…To evaluate the contribution of the mu1 phi domain to the induction of apoptosis following reovirus infection, phi mutant viruses were generated by reverse genetics and analyzed for the capacity to penetrate cell membranes and elicit apoptosis. …”
Get full text

The Flavonoid Glabridin Induces OCT4 to Enhance Osteogenetic Potential in Mesenchymal Stem Cells by June Seok Heo, Seung Gwan Lee, Hyun Ok Kim

“…Assessments of cell viability, cell proliferation, β-galactosidase activity, differentiation, and gene expression by reverse transcription PCR were subsequently performed in the absence or presence of glabridin. …”
Get full text

Coordination of Supply Chain under Blockchain System-Based Product Lifecycle Information Sharing Effort by Saidjahon Hayrutdinov, Mahmoud S. R. Saeed, Azamat Rajapov

“…The study used the game theory reverse induction method to compare the Nash equilibrium solutions under different decision-making scenarios and discussed the chain member’s constraint condition of Blockchain system investment. …”
Get full text

Impact of zinc oxide nanoparticles on biosynthesis of thymoquinone in cell cultures of Nigella sativa by Ambreen, Mubarak Ali Khan, Afzal Raza, Reema Yousaf, Huma Ali, Hadeer Darwish

“…Hypocotyl explants were cultured on Murashige and Skoog (MS) media with varying levels of ZnO-NPs, resulted in callus induction and biomass formation. Optimal response in callus growth parameters were observed when explants were grown on MS media supplemented with 60 mg/L ZnO-NPs, resulting in 71.2 % callus induction frequency, 28.2 g/L fresh biomass, 9.7 g/L dry biomass, and 63 % water content. …”
Get full text

Haematophysiological Effects of Carica Papaya (Pawpaw) Leaves Extracts on Albino Wistar Rats Previously Treated with Phenyldrazine by Eze, I.R. , Achukwu U.P. , Omorodion, N.T. * , Belonwu, N.J.K.

“…Heamoglobin concentration of group l increased significantly to (14.980±2.620) while that of the experimental groups (group l and ll) did not increase significantly increased order to reverse to pre-induction. Recticulocytosis significantly decreased (p<0.05) in the three groups (group l, ll, ll), whereas platelet count was significantly increased only in the experimental groups (group ll, lll) with values of (1248±71.052) and (982.833±177.42). …”
Get full text

Dysregulation of lncRNA TFAP2A‐AS1 is involved in the pathogenesis of pulpitis by the regulation of microRNA‐32‐5p by Mingming Liu, Weijing Jia, Lin Bai, Qiaolin Lin

“…The expression of TFAP2A‐AS1 decreased upon the osteogenic differentiation of hDPSCs, and increased upon the LPS induction. TFAP2A‐AS1 can reverse the osteogenic differentiation of hDPSCs, as evidenced by decreased levels of dentine sialophosphoprotein, dentin matrix protein−1, and ALP activity. …”
Get full text

Controlling salt deposition patterns using engineered substrates and thermal gradients by Zhao Xia, Qi Liu, J. Carlos Santamarina

“…Salt spreading on a vertical substrate can be halted by imposing a downward thermal gradient to reverse the Marangoni flow direction within the capillary menisci or by engineering the surface roughness to reduce wettability. …”
Get full text

Duplication of the Rabies Virus Glycoprotein Enhances the Virus Propagation Rate and Immunogenicity by Ashkan Alamdary, Alireza Gholami, Mohammad Azizi, Zahra Noormohammadi

“…This study assessed the effects of integrating an extra copy of the glycoprotein gene into the rabies virus genome using reverse genetics on the immunogenicity and titer of the recombinant virus. …”
Get full text

Steatosis is involved in the progression of kidney disease in a high-fat-diet-induced non-alcoholic steatohepatitis mouse model. by Shintaro Hamada, Tomoaki Takata, Kentaro Yamada, Marie Yamamoto, Yukari Mae, Takuji Iyama, Suguru Ikeda, Tsutomu Kanda, Takaaki Sugihara, Hajime Isomoto

“…We observed the early changes of CKD and speculate that the underlying mechanisms that link CKD and NASH are the induction of ER stress and apoptosis. Further, we observed the activation of Nfe2l2 in the steatosis-induced CKD mouse model. …”
Get full text

Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells by Yanyan Zhu, Qinghong Ji, Min Hong

“…Upon cellular internalization, the antisense PNA component selectively hybridized with human telomerase reverse transcriptase (hTERT) mRNA through sequence-specific recognition, inducing structural detachment from the GO surface. …”
Get full text

Experimental study on the effect of lncRNA-Scarna10 on resveratrol-induced M2 polarization of macrophages by LUO Jianming, JING Jie, LIANG Yaodan, ZHANG Taicheng, CHENG Dongyu, JIANG Haixing, QIN Shanyu

“…Conclusion The expression of Scarna10 is upregulated in M1 macrophages following RSV intervention, and silencing Scarna10 can reverse the RSV-induced promotion of M1-to-M2 macrophage polarization.…”
Get full text

Cu²⁺ and Zn²⁺ Ions Affecting Biochemical Paths and DNA Methylation of Rye (<i>Secale cereale</i> L.) Anther Culture Influencing Plant Regeneration Efficiency by Wioletta Monika Dynkowska, Renata Orłowska, Piotr Waligórski, Piotr Tomasz Bednarek

“…The Methylation-Sensitive Amplified Fragment Length Polymorphism approach was implemented to identify markers related to DNA methylation and sequence changes following the quantification of variation types, including symmetric and asymmetric sequence contexts. Reverse-Phase High-Pressure Liquid Chromatography (RP-HPLC) connected with mass spectrometry was utilized to determine SAM, GSH, and glutathione disulfide, as well as phytohormones, and RP-HPLC with a fluorescence detector to study polyamines changes originating in rye regenerants due to Cu²⁺ or Zn²⁺ presence in the induction medium. …”
Get full text

Small nuclear ribonucleoprotein polypeptide B2 regulated by SNHG4/miR-204-5p axis inhibits ferroptosis to aggravate the progression of hepatocellular carcinoma by Jiaxing Guo, Lingshu Li, Haiyan Wang, Zhenqin Gao, Chanjuan Shen, Bokang Yan

“…Abstract SNRPB2, a spliceosome component, is well known to participate in the pre-splicing of mRNA and enhance the apoptosis induction impact of ixazomib on multiple myeloma cells. …”
Get full text

An Evaluation of the Genotoxicity and Subchronic Oral Toxicity of Synthetic Curcumin by Sreenivasa Rao Damarla, Rajesh Komma, Upendra Bhatnagar, Navin Rajesh, Sadik Mohmad Abdulhamid Mulla

“…There was no evidence of mutagenicity in a bacterial reverse mutation test, whereas an in vitro mammalian chromosomal aberration test was positive for induction of chromosomal aberrations which is in line with results reported for natural curcumin. …”
Get full text

Nicotinic acid receptor GPR109A is down-regulated in human macrophage-derived foam cells. by Joshua T Chai, Janet E Digby, Neil Ruparelia, Andrew Jefferson, Ashok Handa, Robin P Choudhury

“…In conclusion, despite NA's anti-inflammatory effect on human macrophages, it has no effect on foam cells in reverse cholesterol transport; due to GPR109A down-regulation.…”
Get full text

Detection of Leukotriene Receptor CysLTR in Inflammatory Diseases by Molecular Imaging with Near-Infrared Fluorescence-Based Contrast Agents by Corinna Busch, Marta Passon, Matthias Wenzel, Ines Socher, Werner A. Kaiser, Ingrid Hilger

“…Expression of CysLT 1 R in HL-60 human promyelocytic leukemia cells in vitro could be proven by reverse transcriptase—polymerase chain reaction (PCR), real-time PCR, and flow cytometry. …”
Get full text

Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy by Daibang Nie, Jianying Zhang, Yiqin Zhou, Jiuyi Sun, Wang Wang, James H.-C. Wang

“…We then showed that rapamycin treatment was able to reverse the above senescent phenotypes and increase autophagy in the senescent PTSCs. …”
Get full text

Early Effects of P-15 on Human Bone Marrow Stem Cells by Francesco Carinci, Francesca Farinella, Annalisa Palmieri, Ambra Girardi, Vincenzo Sollazzo

“…To study the osteoinductive properties of peptide P-15, we analyzed the expression levels of bone related genes in human mesenchymal stem cells treated with this biomaterial.Material and methods: Using real time Reverse Transcription-Polymerase Chain Reaction the quantitative expression of specific genes, like transcriptional factors (RUNX2 and SP7), bone related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells marker (ENG) were examined.Results: P-15 causes a considerable induction of osteoblast transcriptional factor like osterix (SP7) and of the bone related genes osteopontin (SPP1) and osteocalcin (BGLAP). …”
Get full text

Gold complex QB1561 suppresses drug-resistant cancer cells by inhibiting TrxR and mitochondrial respiratory function by Hai-Ling Gao, Wenwen Ding, Zhi-Xin Shen, Qingbin Cui, Qingbin Cui

“…Novel agents that may reverse MDR and neutralize drug-resistant cancer cells are highly desirable for clinical practice. …”
Get full text

Current Management of Aneurysmal Subarachnoid Hemorrhage by Jay Max Findlay

“…The management of diagnosed symptomatic vasospasm is the prompt induction of hypertension with vasopressors, but if this fails to reverse deficits quickly after reaching a target systolic blood pressure of 200 mmHg, endovascular angioplasty is indicated, providing CT scanning rules out an established cerebral infarction. …”
Get full text