Circular RNA_0003489 reflects unfavorable treatment response and shortened survival in newly diagnosed multiple myeloma patients who receive bortezomib-based induction therapy by Senhua Song, Junjie Xie, Biao Xu, Qijie Ran

“…Circ_0003489 derived from BM plasma cells was detected by reverse transcription-quantitative polymerase chain reaction and cut by quartile and median for further analysis.Results Circ_0003489 expression was increased in NDMM patients versus donor controls (P < 0.001). …”
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Induction of Cytoplasmic dsDNA and cGAS-STING Immune Signaling After Exposure of Breast Cancer Cells to X-ray or High-Energetic Carbon Ions by Cristina Totis, MSc, Nicole B. Averbeck, PhD, Burkhard Jakob, PhD, Maik Schork, PhD, Gaia Volpi, MSc, Dennis F. Hintze, BSc, Marco Durante, PhD, Claudia Fournier, PhD, Alexander Helm, PhD

“…Purpose: Radiation therapy can trigger activation of the cyclic GMP-AMP synthase (cGAS)- Stimulator of interferon genes (STING) axis via cytoplasmic dsDNA fragment induction. The activation of cGAS-STING initiates innate immune signaling mediated by interferon type I that can contribute to eradicate the malignancy. …”
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The Destructive Action of IL-1α and IL-1β in IDDM is a Multistage Process: Evidence and Confirmation by Apoptotic Studies, Induction of Intermediates and Electron Microscopy by S. Vassiliadis, V. Dragiotis, E. Protopapadakis, I. Athanassakis, P. Mitlianga, K. Konidaris, G. K. Papadopoulos

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Inverse System Decoupling Control of Composite Cage Rotor Bearingless Induction Motor Based on Support Vector Machine Optimized by Improved Simulated Annealing-Genetic Algorithm by Chengling Lu, Junhui Cheng, Qifeng Ding, Gang Zhang, Jie Fang, Lei Zhang, Chengtao Du, Yanxue Zhang

“…To address the inherent nonlinearity and strong coupling among rotor displacement, speed, and flux linkage in the composite cage rotor bearingless induction motor (CCR-BIM), an inverse system decoupling control strategy based on a support vector machine (SVM) optimized by the improved simulated annealing-genetic algorithm (ISA-GA) is proposed. …”
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Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21. by Xinjian Peng, Wenping Li, Liang Yuan, Rajendra G Mehta, Levy Kopelovich, David L McCormick

“…The greater inhibitory activity of ATO in PC3 cells was associated with induction of autophagy in that cell line, as demonstrated by increased expression of LC3-II. miR-182 was consistently upregulated by ATO in PC3 cells, but not in LNCaP cells. …”
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Induction of apoptosis by Dae-Hwang-Mok-Dan-Tang in HCT-116 colon cancer cells through activation of caspases and inactivation of the phosphatidylinositol 3-kinase/Akt signaling by Cheol Park, Su Hyun Hong, Yung Hyun Choi

“…However, the pan-caspase inhibitor could reverse DHMDT-induced apoptosis. In addition, DHMDT suppressed the phosphoinositide 3-kinase (PI3K)/Akt pathway, and treatment with a potent inhibitor of PI3K further increased the apoptotic activity of DHMDT. …”
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Intentions and barriers to using long-acting reversible contraceptives among young women seeking safe abortion care in Addis Ababa, Ethiopia: a qualitative study by Betelhem Simeneh Kabeto, Endalew Gemechu Sendo, Workinesh Sineshaw Abebe

“…Abstract Background Long-acting reversible contraception (LARCs) including intrauterine devices and implants) are safe, highly effective, and recommended for adolescents, yet their use remains low. …”
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Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model by Jung Sook Choi, Jaechan Park, Kyoungho Suk, Cheil Moon, Yong-Ki Park, Hyung Soo Han

“…In this study, we demonstrated that hypothermic suppression of ICAM-1 induction is mediated by enhanced ERK1/2 activation and subsequent attenuation of STAT3 action.…”
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Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies by Luke S. Heuer, Nicolle Sweeney, Manuel Rojas, Weici Zhang, Andrew R. Mendelsohn, Manley Huang, Bo Yu, Paulina Ackerman, Qisheng Wei, Andrew B. Herr, James W. Larrick, William M. Ridgway

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EFFECT OF GRADEN CRESS (Lepidium sativum) ON CHROMOSOMAL ABERRATIONS AND ITS ANTI - EFFECT ON INDUCTION OF CHROMOSOMAL ABERRATIONS IN WHITE MICE BONE MARROW CELLS USING SHORT – TE... by Ilham A. Khalaf

“…Effect of garden cress Lepidium sativum (a cruciferous plant) on induction of chromosomal aberrations in bone marrow cells of white mice was studied , in addition to its effect to reverse the chromosomal aberrations induced by drug cyclophosphamide (Cp). …”
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Co-Induction of ULK-1 and AHSP mRNAs in Erythroid Precursor Cells Isolated From a Sirolimus-Treated β-Thalassemia Patient: A Case Report Study by Matteo Zurlo, Alessia Finotti, Alessia Finotti, Maria Rita Gamberini, Roberto Gambari, Roberto Gambari

“…Unc-51-like kinase 1 (Ulk-1)-mediated induction of autophagy and increased expression of the α-hemoglobin stabilizing protein (AHSP).Case PresentationThe studied case was a male transfusion dependent TM (Thalassemia Major) patient, aged 43 years, with a β039/β+IVSI-110 genotype (XmnI polymorphism: -/-), starting the first blood transfusion when he was 5 months old, and participating to the NCT03877809 (Sirthalaclin) clinical trial.MethodsExpression of AHSP and Ulk-genes in Erythroid precursor cells (ErPCs) was studied by Reverse transcription (RT)-qPCR and Western blotting ErPCs were isolated from the propositus after 90 and 180 days of treatment with sirolimus.Results and DiscussionThis study demonstrates for the first time that increase in the production of γ-globin2 mRNA and HbF in ErPCs from a patient with β-thalassemia treated with sirolimus might be associated with co-induction of Ulk-1 and AHSP genes.…”
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PHF19 before and post induction treatment possess favorable potency of reflecting treatment response to protease inhibitors, event-free survival, and overall survival in multiple m... by Hongyu An, Shiming Chen, Xin Zhang, Shandong Ke, Jinyong Ke, Yalan Lu

“…PHF19 in plasma cells from BM was quantified by reverse transcription-quantitative polymerase chain reaction.Results PHF19 at baseline and post induction treatment in MM patients were increased than in HCs. …”
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Clinical and physiological evaluation of free-ranging snow leopards immobilized with ketamine-xylazine in emergency situations by Animesh Talukdar, Anchal Bhasin, Dimpi Patel, Pankaj Raina, Prasad Tonde, Prateek Savita

“…Ketamine and xylazine were utilized in a drug mixture for rescue, rehabilitation, health assessment, and other capture purposes, with average doses of 6.535 ± 0.93 mgkg−1 and 1.937 ± 0.41 mgkg−1 of body weight, respectively. The average induction occurred at 3.85 ± 1.8 min. Respiratory rate, rectal temperature, and heart rate were monitored periodically post-induction, all remaining within clinically acceptable ranges. …”
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Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway by Hua Wu, Lihua Feng, Huang Wu, Lihong Wang, Hengyi Xu, Fen Fu

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Infusion of Sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate-Conjugated MOG35–55-Coupled Spleen Cells Effectively Prevents and Reverses Experimental Autoimmune Ence... by Lanfang Zhang, Yixian Guo, Chang-Qing Xia

“…In this study, we have evaluated our recently developed method for antigen-cell coupling using sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate (sulfo-SMCC) heterobifunctional crosslinker in prevention and reversal of experimental autoimmune encephalomyelitis (EAE). …”
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Spontaneous steatosis stimulation in geese induces liver fattening but impacts sexual maturation and muscle growth in a sex-dependent manner by C. Knudsen, S. Combes, L. Cauquil, M. Despeyroux, M-D. Bernadet, J-B. Laverze, X. Fernandez, S. Davail, C.M.D. Bonnefont, J. Arroyo, K. Ricaud

“…Our study aimed to i/ determine the feasibility of the induction of a spontaneous steatosis in female geese and ii/ evaluate its reversibility. …”
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Astragaloside IV regulates FOXM1 deubiquitination to ameliorate trophoblast damage caused by high glucose by Fan Li, Xiaofang Zhao

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M2 macrophage-derived exosomes reverse TGF-β1-induced epithelial mesenchymal transformation in BEAS-2B cells via the TGF-βRI/Smad2/3 signaling pathway by Chao Liu, Xiaolin Huang, Siqi Li, Wentao Ji, Tian Luo, Jianping Liang, Yanhua Lv

“…After exosome or SB431542 induction, TGF-β1-induced EMT was reversed. GW4869, an exosome release inhibitor, exhibited the ability to block the beneficial effects of exosomes. …”
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Neuromuscular blockade in anaesthesia for maxillofacial cancer surgery: specifics, advantages, challenges and solutions (literary review) by T. E. Selina, A. A. Afanasenkov, V. E. Gruzdev

“…Anatomical features of this category of patients affecting the permeability of the upper respiratory tract during standard induction of anesthesia are considered. Modern drugs for myoplegia and neuromuscular block reversal are presented. …”
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Comparative Study on Application of Hybrid SiC IGBT Device and Si IGBT Device in Rail Transit by Wei TIAN, Sunmeng XIE, Yanping CHEN, Rong ZHANG, Wu ZHU, Jie LIU, Yifan TAN

“…According to the characteristics of hybrid SiC IGBT devices, a converter module with low stray inductance in converter circuit was developed to meet the application requirements of hybrid SiC IGBT devices, and the influence of stray inductance of converter circuit on switching characteristics of hybrid SiC IGBT was studied. …”
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