Golgi condensation causes intestinal lipid accumulation through HIF-1α-mediated GM130 ubiquitination by NEDD4 by Hyunsoo Kim, Channy Park, Xiaofan Wei, Arun Chhetri, Laxman Manandhar, Gyuho Jang, Jaetaek Hwang, Batchingis Chinbold, Chagtsalmaa Chuluunbaatar, Hyug Moo Kwon, Raekil Park

“…Golgi condensation and lipid accumulation induced by GM130 depletion are reversed by exogenous GM130 induction in the intestinal epithelium. …”
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Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid‐Derived Suppressor Cell‐Secreted TGF‐β1 by Yahai Liang, Jinmei Li, Lihua Zhang, Jinling Zhou, Meilian Liu, Xiaoxia Peng, Weizhen Zheng, Zhennan Lai

“…Thereafter, we found that PVRL4 was packaged into exosomes in LUAD cells, and could be transferred into PBMCs to promote MDSC induction and the expression of MDSC‐secreted TGF‐β1. …”
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miR‐17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia‐Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation by Tianji Chen, Qiyuan Zhou, Haiyang Tang, Melike Bozkanat, Jason X.‐J. Yuan, J. Usha Raj, Guofei Zhou

“…PHD2 activator R59949 reverses vessel remodeling in existing hypertensive mice. …”
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Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway. by Haohui Guo, Dong Ding, Limei Wang, Jiangbo Yan, Long Ma, Qunhua Jin, Qunhua Jin

“…Met suppressed RANKL-induced activation of p-AMPK, NF-κB, phosphorylated extracellular regulated protein kinases (p-ERK) and up-regulation of genes involved in osteoclastogenesis. Met reversed decreases in BV/TV, Tb.Th, Tb.N, and CD, and an increase in Tb.Sp at 4 weeks postoperatively. …”
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Amyloid-related protein changes associated with dementia differ according to severity of hypoglycemia by Stephen L Atkin, Thozhukat Sathyapalan, Alexandra E Butler, Abu Saleh Md Moin, Ahmed Al-Qaissi, Hassan Kahal, Nitya Kumar

“…In T2D, there were no differential protein changes between the studies.Conclusions The differential changes in AD-related proteins were seen only in control subjects in response to iatrogenic induction of hypoglycemic insults of differing length and severity and may reflect a protective response that was absent in subjects with T2D. …”
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Roles of VWA1 and Rac2 in compensatory and decompensatory responses via FGF9/FGFR3 and p38 MAPK signaling pathways in condylar chondrocytes under distinct mechanical stress by Yuqi Liu, Fangwen Jia, Kangya Li, Chao Liang, Yanxi Li, Wei Geng

“…Conversely, decompensation markers prevailed in 1.5 mm iOVD and 18% CTS groups, showing Rac2 elevation and p38 MAPK pathway induction. Further validation revealed that Vwa1 silencing attenuated compensatory responses under 6% CTS, while exogenous FGF9 restored them. …”
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Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3... by Miao Xiong, Ziqiu He, Liping Wen, Aimin Zhao

“…Reversing this disorder sheds light on a novel mechanism in DSC regulation of trophoblasts, highlighting their significant role in URSA.…”
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SYMMETRY PRINCIPLE AS A BASIS FOR INTEGRATION IN SCIENCE AND ITS VALUE FOR EDUCATION by V. L. Gapontsev, V. A. Fedorov, M. G. Gapontseva

“…The ability of symmetry to combine the merits of the primary deductive concept and the general inductive concept reflects the tremendous work performed by mankind in the course of history to identify stable patterns, sets of invariants (the allocation of which is the basic condition for the development of intelligence) and the corresponding forms of symmetry. …”
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Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis by Zhen He, Zhen He, Jianxi Shi, Bing Zhu, Zhentao Tian, Zhihong Zhang, Changwen Zhang

“…The reversibility of both pathways by specific inhibitors establishes a causal mechanistic framework. …”
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TNF-Alpha Inhibitor Prevents Cigarette Smoke Extract-Induced Cell Death in Osteoarthritis-Derived Chondrocytes in Culture by Débora Levy, Alexandra Fernandes Calllera, Alyne Riani Moreira, Iolanda de Fátima Lopes Calvo Tibério, Pedro Nogueira Giglio, Marco Kawamura Demange, Sergio Paulo Bydlowski, Fernanda Degobbi Tenorio Quirino Dos Santos Lopes

“…All these effects promoted by CSE were reversed by TNF-alpha inhibitor. Collagen II, F-actin, and SOX9 were also analyzed, and CSE promoted alteration in the expression of these proteins. …”
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Controllable generation of interlayer Dzyaloshinskii-Moriya interactions in the L10-FePt/Pt/Fe multilayers for field-free magnetization switching by Xiao Deng, Yanzhe Zhao, Tao Zhu, Jingyan Zhang, He Huang, Pengwei Dou, Yuanbo Wang, Jialiang Li, He Bai, Xiaozhi Zhan, Sheng Cheng, Yaqin Guo, Jie Qi, Yunchi Zhao, Shouguo Wang

“…Meanwhile, the direction of the IL-DMI can be reversed in the L10-FePt/Pt/Fe multilayer, depending on the direction of the tilted magnetic field. …”
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Mesenchymal stem cells protect against sepsis-associated acute kidney injury by inducing Gal-9/Tim-3 to remodel immune homeostasis by Congjuan Luo, Feng Luo, Lin Che, Hui Zhang, Long Zhao, Wei Zhang, Xiaofei Man, Quandong Bu, Hong Luan, Bin Zhou, Haiyan Zhou, Yan Xu

“…Treatment with MSCs plus soluble Tim-3 blunted the therapeutic effect of MSCs, inhibited the induction of Tregs, and suppressed the inhibition of differentiation into Th17 cells.Conclusion Treatment with MSCs significantly reversed the Th1/Th2 balance. …”
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Antinociceptive and anti-ulcerogenic effect of hydroethanolic stem bark extract of Ricinodendron heudelotii (Baill.) Pierre ex. Heckel (Euphorbiaceae): Involvement of the opioiderg... by Isaac Tabiri Henneh, Wisdom Ahlidja, Ernest Amponsah Asiamah, Denzel Opoku-Kwabi, Henry Mensah Korsah, Fynn Malcom, Stephen Mensah Arhin, Michael Buenor Adinortey, Francis Ackah Armah

“…The opioid receptor antagonist, naloxone, reversed the analgesic effect, indicating that the extract may be acting via the opioidergic pathway. …”
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Pharmacological Modulation of the Unfolded Protein Response as a Therapeutic Approach in Cutaneous T-Cell Lymphoma by Nadia St. Thomas, Benjamin N. Christopher, Leticia Reyes, Reeder M. Robinson, Lena Golick, Xiaoyi Zhu, Eli Chapman, Nathan G. Dolloff

“…This immunosuppression could be reversed by JG-023, other HSP70 inhibitors, Btz, and combinations of these UPR-targeted drugs. …”
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Carnitine palmitoyltransferase 1C promotes EMT-associated cisplatin resistance in non-small cell lung cancer cells by Renjie Chen, Jiahui Wang, Shuoyu Huang, Xuefeng Hu, Xinran He, Tiange Zhang, Yunhan Hu, Huijun Wei, Sihui Nian, Yushu Huang, Zhihao Wu

“…Ectopic expression of Snail reversed the increase in cisplatin sensitivity triggered by CPT1C knockdown. …”
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Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats by Wafa A. AL-Megrin, Manal F. El-Khadragy, Manal H. Hussein, Shahenda Mahgoub, Doaa M. Abdel-Mohsen, Heba Taha, Ashraf A. A. Bakkar, Ahmed E. Abdel Moneim, Hatem K. Amin

“…Oxidative damage, inflammatory cytokines, and apoptotic cell death play a major role in the induction and progression of male testicular damage. …”
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Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27kip1 pathway by Shu-Chun Chuang, Ya-Shuan Chou, Yi-Shan Lin, Je-Ken Chang, Chung-Hwan Chen, Mei-Ling Ho

“…Previous reports have indicated that COX-2 is constitutively expressed in osteogenic cells instead of being expressed only after pathogenic induction, and that it facilitates osteoblast proliferation via PTEN/Akt/p27kip1 signalling. …”
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Bone marrow mesenchymal stem cells overexpressing stromal cell- derived factor 1 aid in bone formation in osteoporotic mice by Yanghao Wang, Ya Xiao, XinYu Yang, Fei He, Jun Hu, Guang Yang, Weizhou Wang

“…Promoting bone regeneration and reversing its loss by infusion of exogenous bone marrow mesenchymal stem cells (BMSCs) is a potentially effective treatment for osteoporosis. …”
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Gut-Brain Axis-Based Polygala Tenuifolia and Magnolia Officinalis Improve D-gal-Induced Cognitive Impairment in Mice Through cAMP and NF-κB Signaling Pathways by Yang D, Li W, Chen Q, Liu S, Peng C, Deng F, Meng Y, Yang Y, Yan P, Ao H, Huang L

“…A mouse model was established by D-gal induction, and the effects of PT, MO, and PM on CI were evaluated through behavioral tests, pathological staining, and Enzyme-Linked Immunosorbent Assay (ELISA). …”
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First ATG101-recruiting small molecule degrader for selective CDK9 degradation via autophagy–lysosome pathway by Ye Zhong, Jing Xu, Huiying Cao, Jie Gao, Shaoyue Ding, Zhaohui Ren, Huali Yang, Yili Sun, Maosheng Cheng, Jia Li, Yang Liu

“…Selective CDK9 degraders possess potent clinical advantages over reversible CDK9 inhibitors. Herein, we report the first ATG101-recruiting selective CDK9 degrader, AZ-9, based on the hydrophobic tag kinesin degradation technology. …”
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