Hyperinflammatory repolarisation of ovarian cancer patient macrophages by anti-tumour IgE antibody, MOv18, restricts an immunosuppressive macrophage:Treg cell interaction by Gabriel Osborn, Jacobo López-Abente, Rebecca Adams, Roman Laddach, Melanie Grandits, Heather J. Bax, Jitesh Chauhan, Giulia Pellizzari, Mano Nakamura, Chara Stavraka, Alicia Chenoweth, Lais C. G. F. Palhares, Theodore Evan, Jessica Hui Cheah Lim, Amanda Gross, Lenny Moise, Shashi Jatiani, Mariangela Figini, Rodolfo Bianchini, Erika Jensen-Jarolim, Sharmistha Ghosh, Ana Montes, Ahmad Sayasneh, Rebecca Kristeleit, Sophia Tsoka, James Spicer, Debra H. Josephs, Sophia N. Karagiannis

“…IgE reverses macrophage-promoted Treg cell induction to increase CD8+ T cell expansion, a signature associated with improved patient prognosis. …”
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Icariin inhibits hypoxia/reoxygenation‐induced ferroptosis of cardiomyocytes via regulation of the Nrf2/HO‐1 signaling pathway by Xiu‐Juan Liu, Yan‐Fei Lv, Wen‐Zhu Cui, Yan Li, Yang Liu, Yi‐Tao Xue, Feng Dong

“…The expression of Nrf2 and HO‐1 in H/R‐induced H9C2 cells was reduced, whereas ICA treatment reversed this trend. Inhibition of the Nrf2/HO‐1 pathway reversed the protective effect of ICA on H/R‐induced ferroptosis. …”
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Recombinant human Neuritin protects cochlear ribbon synapses and hearing function via ERK1/2 activation post noise-induced injury by Haiyan Wang, Jinchi Hu, Shuangyan Liu, Fei Gui, Xiaopin Sun, Rong Chen, Guanwu Yin, Xiaoming Song, Yi Yang, Yu Hong

“…In addition, rhNeuritin reverses the decrease in phosphorylated extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) levels resulting from noise exposure. …”
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The Role of Mcl-1 in S. aureus-Induced Cytoprotection of Infected Macrophages by Joanna Koziel, Katarzyna Kmiecik, Daniela Chmiest, Katarzyna Maresz, Danuta Mizgalska, Agnieszka Maciag-Gudowska, Piotr Mydel, Jan Potempa

“…Consistent with this, we proved a crucial role of Mcl-1 in S. aureus-induced cytoprotection, since silencing of MCL1 by siRNA profoundly reversed the cytoprotection of infected cells leading to apoptosis. …”
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Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis by Jinhua Feng, Xi Huang, Yawen Peng, Wenyu Yang, Xinyi Yang, Ri Tang, Qiaoyi Xu, Yuan Gao, Zhengyu He, Shunpeng Xing, Shuya Mei

“…Treatment with shikonin effectively reversed these alterations, restoring the balance of mitochondrial dynamics, reversing EMT markers, and alleviating the severity of sepsis-associated PF. …”
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Anti-Inflammasome Effect of Impressic Acid on Diesel Exhaust Particulate Matter-Induced NLRP1 Inflammasome via the Keap1/p62/Nrf2-Signaling Pathway in Keratinocytes by Seung Yeon Lee, Gi Ho Lee, Jeonghwan Maeng, Su Yeon Kim, Hwi-Yeol Yun, Gil-Saeng Jeong, Hye Gwang Jeong

“…IPA attenuated the NLRP1 expression, caspase-1, IL-1β actuation, and NF-κB and IκB phosphorylation induction by DEP. IPA upregulated the Nrf2, HO-1, and NQO1 expression through CaMKKβ, AMPK, and GSK3β phosphorylation. …”
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Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a narrative review by Ingrid Pereira Marques, Carolina Rouanet Cavalcanti de Albuquerque, Natalia Vasconcellos de Oliveira Souza, João Brainer Clares de Andrade, Gisele Sampaio Silva, Pedro Kurtz

“…However, it is potentially reversible if appropriate treatment is promptly initiated. …”
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Sericin-coated MnO2@CeO2 nanocatalysts enable pH-responsive and synergistic vincristine delivery for lung cancer therapy by Kiana Bahrehmand, Sajad Moradi, Shokoufeh Rahmani, Elham Arkan, Faranak Aghaz

“…Reactive oxygen species (ROS) measurements indicated oxidative stress induction by MnO2@CeO2, while sericin mitigated excessive ROS production. …”
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Electroacupuncture Modulates Programmed Cell Death 1 Ligand 1 on Peripheral and Central Nervous Systems in a Mouse Fibromyalgia Pain Model by Huan-Chin Lin, Hsin-Cheng Hsu, Hsien-Yin Liao, Arbee L.P. Chen, Yi-Wen Lin

“…In contrast, levels of pain-related kinases increased after fibromyalgia induction, an effect which could be reversed by EA, PD-L1, or <i>Trpv1</i> deletion. …”
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Recovery from AMPA Receptor Potentiation by Ampakines by Daniel P. Radin, Rok Cerne, Jodi L. Smith, Jeffrey M. Witkin, Arnold Lippa

“…We further investigated the induction of the potentiated response by measuring glutamate-induced responses after transient applications of CX729 or CX729 plus glutamate. …”
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Effect of <i>Cnidoscolus aconitifolius</i> (Family Euphorbiaceae) Aqueous Leaf Extract on Some Antioxidant Enzymes and Haematological Parameters of High Fat Diet and Streptozotocin... by EA Obichi, CC Monago, DC Belonwu

“…Our findings suggest that CA exhibited reversal effects on these selected oxidative and haematologic markers in rats which were previously damaged by HFD and STZ.…”
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Morphed and moving: TNFα-driven motility promotes cell dissemination through MAP4K4-induced cytoskeleton remodeling by Min Ma, Martin Baumgartner

“…We discuss here the relevance of TNFα-MAP4K4 signaling for pathogen-driven cell dissemination and its potential impact on the induction of metastasis in human cancer.…”
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Integrated transcriptome profiling and in vitro analysis reveals MLN4924’s role in inducing ferroptosis in acute myeloid leukemia by Jinli Jian, Yuancheng Guo, Xiao Tang, Long Zhao, Bei Liu

“…Objectives: While ferroptosis induction emerges as a therapeutic strategy for solid tumors, its role in acute myeloid leukemia (AML) remains unexplored. …”
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Competition of Escherichia coli DNA polymerases I, II and III with DNA Pol IV in stressed cells. by P J Hastings, Megan N Hersh, P C Thornton, Natalie C Fonville, Andrew Slack, Ryan L Frisch, Mellanie P Ray, Reuben S Harris, Suzanne M Leal, Susan M Rosenberg

“…We show that the interactions of Pols I, II and III with Pol IV result neither from, first, induction of the SOS response when particular DNA polymerases are removed, nor second, from proofreading of DNA Pol IV errors by the editing functions of Pol I or Pol III. …”
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Enhancing the purity and intrinsic properties of ovine dermal papilla cells through flow cytometry sorting and cellular interactions by Yuan Gou, Tingyan Hu, Lijuan Zhu, Xiaoyang Lv, Yutao Li, Rui Su, Zhenghai Song, Shanhe Wang, Wei Sun

“…Furthermore, we examined the biological properties of isolated DPCs in conditioned media using CCK-8, EDU, and quantitative reverse transcription polymerase chain reaction assays. …”
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Review projecting shikonin as a therapeutic candidate in female carcinomas: a preclinical perspective by Pratibha Pandey, Sorabh Lakhanpal, K. V. Jamuna, Ajay Singh, Mohammad Abohassan, Mohammad Abohassan, Moon Nyeo Park, Sang-Won Shin, Han Na Kang, Manaal Zahera, Mohd Saeed, Fahad Khan, Bonglee Kim

“…Shikonin (SK) has displayed a broad spectrum of anticancer activities, such as necroptosis, cell cycle invasion, Autophagy, apoptosis, Diabetes, DNA damage induction, and suppression of angiogenesis. It reverses drug resistance and inhibited cancer cell growth by altering their metabolism. …”
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Direct and indirect effects of estrogens, androgens and intestinal microbiota on colorectal cancer by Zihong Wu, Yi Sun, Wenbo Huang, Zhenzhen Jin, Fengming You, Fengming You, Xueke Li, Xueke Li, Chong Xiao, Chong Xiao

“…Specific gut microorganisms produce genotoxins and oncogenic metabolites that damage colonic cell DNA and contribute to cancer induction. Regarding the tumor microenvironment, estrogen mitigates intestinal inflammation, reverses immunosuppression, increases gut microbiome diversity and commensal bacteria abundance, and decreases pathogen enrichment. …”
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Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro by Thomas Stahnke, Beata Gajda-Deryło, Anselm G. Jünemann, Oliver Stachs, Katharina A. Sterenczak, Robert Rejdak, Julia Beck, Ekkehard Schütz, Steffen Möller, Israel Barrantes, Gregor Warsow, Stephan Struckmann, Georg Fuellen

“…The macrolide antibiotic Josamycin (JM) reverses these molecular mechanisms according to data from the CMap, and we thus tested JM as an inhibitor of fibrosis. …”
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Gallium disrupts endoplasmic reticulum iron metabolism to induce lipid metabolic reprogramming in glioblastoma cells by Michael S. Petronek, Jeffrey M. Stolwijk, Amira Zaher, Stephenson B. Owusu, John Cooke, Akalanka B. Ekanayake, Alexei V. Tivanski, Jingyun Lee, Cristina M. Furdui

“…Ga(NO3)3 also enhances the toxicity of the stearoyl CoA desaturase (SCD) inhibition, and its toxicity can be reversed by oleic acid supplementation, suggesting that Ga(NO3)3 can potentially inhibit SCD. …”
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Diospyros mespilifoemis hochst Modulates the Hippocampus and Prefrontal Cortex of Wistar Rat following Lithium chloride pilocarpine-induced Epilepsy by Sunday Yinka Olatunji, Oluwafemi Ezekiel Kale, Oluseyi Abimbola Ogunsola, John Afees Olanrewaju, Ijeoma Esiaba, Taiye Adelodun, Olubunmi Philip Ogunnaike

“…In the open field test, DM reversed the altered activities in the epileptic rats.  …”
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