Calycosin ameliorates albuminuria in nephrotic syndrome by targeting Notch1/Snail pathway by Xiaohong Ma, Binghe Guan, Linrong Pang

“…Methods A rat model of nephrotic syndrome was established through two adriamycin injections within two weeks (4 mg/kg for the first week and 2 mg/kg for the second week). After the induction of renal injury, 10 mg/kg or 20 mg/kg calycosin was intraperitoneally injected into rats for four weeks. …”
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Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis. by Jingyan Yang, Jing Liu, Xiaobo Liu, Dongling Xu, Juan Zhang

“…The suppression of miR-145-5p reversed the effects of OIP5-AS1 depletion in I/R conditions.…”
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The Effects of Aerobic Exercises on Memory, Cerebral Edema, and Extracellular Neuronal Discharge in an Experimental Model of Traumatic Brain Injury: The Role of BDNF Expression by Zahra Bazdidi, Mohammad Ali Mirshekar, Abbas Salehikia

“…TBI was induced using the Marmarou method. After TBI induction, eight weeks of aerobic exercise were performed using a five-line animal treadmill. …”
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Assessment of Ameliorative Effect of Myrica esculenta in a DSS-Induced Murine Model against Ulcerative Colitis by Monika Joshi, Manju Pandey, Akash Ved

“…In addition, hematological and serum biochemical parameters were also determined to assess the treatment effectiveness. Result. During the induction, DAI scores, colon length, and cytokines levels were significantly increased. …”
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Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation. by Alison M Day, Deborah A Smith, Mélanie A C Ikeh, Mohammed Haider, Carmen M Herrero-de-Dios, Alistair J P Brown, Brian A Morgan, Lars P Erwig, Donna M MacCallum, Janet Quinn

“…In addition, our studies reveal an unpredicted, reversible, mechanism that acts to substantially reduce the levels of phosphorylated Hog1 in ypd1Δ cells following long-term sustained SAPK activation. …”
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Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis by Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

“…The PI3K/AKT pathway activator 740Y-P partially reversed the reduced cell proliferation and enhanced cell apoptosis in SC-treated GBM cells. …”
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Understanding the Role of Epithelial Cells in the Pathogenesis of Systemic Sclerosis by Lydia Nagib, Anshul Sheel Kumar, Richard Stratton

“…Accordingly, single cell analysis has confirmed an active signature in SSc keratinocytes, which was partially reversed following a period of JAK inhibitor therapy.…”
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Metabolic reprogramming of Salmonella infected macrophages and its modulation by iron availability and the mTOR pathway by Julia Telser, Chiara Volani, Richard Hilbe, Markus Seifert, Natascha Brigo, Giuseppe Paglia, Günter Weiss

“…Infection of the murine macrophage cell line RAW264.7 with Salmonella resulted in the induction of mTOR activity, anaerobic glycolysis and inhibition of the TCA activity as reflected by reduced pyruvate and increased lactate levels. …”
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Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway by Yawei Tian, Huiming Liu, Xiaoxue Bao, Yukun Li

“…The addition of semaglutide resulted in the partial reversal of the inhibitory effect of DKK1 on osteogenic differentiation, with the administration of LiCl and semaglutide further accelerating the osteogenic process. …”
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Pharmacology and Articular Cartilage Regeneration: A New Strategy for Osteoarthritis by P.S. John, Ann M. John, Ruby Varghese, Prasad Y. Lamrood, Nibu Varghese, Yogesh B. Dalvi

“…Conclusions: In conclusion, the local administration of neurotransmitters was found to be effective in reversing inflammation, improving gait score, and mitigating radiological changes in CFA-induced arthritis in the murine model.…”
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Study of the effect of azithromycin on airway remodeling in asthma via the SAPK/JNK pathway by Dannv Ma, Huaqing Du, Yi Huang, Aiwu Pan, Lu Gan

“…JNK activator partially reversed the protective effect of AZM against OVA-induced asthma in mice. …”
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Epigenetic regulation of a murine retrotransposon by a dual histone modification mark. by Reinhard Brunmeir, Sabine Lagger, Elisabeth Simboeck, Anna Sawicka, Gerda Egger, Astrid Hagelkruys, Yu Zhang, Patrick Matthias, Wolfgang J Miller, Christian Seiser

“…Therefore, we aimed to define the role of reversible histone acetylation, a modification commonly associated with transcriptional activity, in transcriptional regulation of murine TEs. …”
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Evaluation of the Anti-Alzheimer Activity of <i>Lycium barbarum</i> Polysaccharide in Aβ_1–42-Induced Neurotoxicity in Rat Model by Qingxin Lu, Yixin Meng, Haichi Feng, Xin Di, Xiaoli Guo

“…In order to determine the neuroprotective effects of LBP, this study was conducted on an AD rat model induced by intracerebroventricular injection of Aβ_1–42 peptides. From 24 h after induction until the end of the behavioral experiment, rats were orally administered LBP (150 and 300 mg/kg) once a day. …”
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Angiotensin 1–7 and the Non-Peptide MAS-R Agonist AVE0991 Inhibit Breast Cancer Cell Migration and Invasion by Mariam M. Alfoudiry, Maitham A. Khajah

“…This study aims to investigate the expression of Ang 1–7 and MAS-R and evaluate the effects of Ang II, Ang 1–7, and the MAS-R agonist AVE0991 on EMT induction and reversal. <b>Methods:</b> The effects of Ang II and Ang 1–7 on normal and breast cancer cell lines were determined using various techniques for cell proliferation (MTT), motility (scratch assay), and invasion (Cultrex assay). …”
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Targeting Ferroptosis: Acteoside as a Neuroprotective Agent in Salsolinol-Induced Parkinson’s Disease Models by Hongquan Wang, Shuang Wu, Qiang Li, Huiyan Sun, Yumin Wang

“…SAL inducing ferroptosis through upregulating long-chain acyl-CoA synthetase family member 4 (ACSL4) in SH-SY5Y cells, which neurotoxic effect was reversed by ferroptosis inhibitors ferrostatin-1 (Fer-1) and deferoxamine (DFO). …”
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A 180 nm CMOS dual-mode LNA with current reuse and double-resonance load for 2.4 GHz and 3.1–10.6 GHz wireless communication by Thammaneni Snehitha Reddy, Vijay Nath

“…Both modes achieve input and output matching below − 10 dB, reverse isolation below − 40 dB, and power consumption of 25.41 mW (narrowband) and 14.79 mW (ultra-wideband) from a 1.8 V supply. …”
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Regeneration of black ash (Fraxinus nigra Marsh.) in hardwood swamps of the Great Lakes – St. Lawrence Forest Region by Amanda Springer, Jeffery P. Dech

“…An inductive, ordination-based approach was used to explore patterns in the microenvironment and natural regeneration of black ash across a range of representative stands in the central Ontario portion of the Great Lakes -St. …”
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Resources, Potentials and Academic Achievements of Students. Part 2. From Differentiation to Integration of Resources, Potentials and Academic Achievements of Students by L. Ya. Dorfman, A. Yu. Kalugin

“…Initially, this approach involves the identification (differentiation) of the basic components of the system followed by the reverse process - their commonality (integration) into the system. …”
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Comparison of remimazolam–flumazenil versus propofol on delayed emergence from anaesthesia in major spine surgery: protocol for a multicentre, single-blinded, randomised controlled... by Wei Luo, Liang Wen, Jingjing Sun, Yanying Xiao, Ruping Dai

“…In the remimazolam–flumazenil group, remimazolam will be administered for anaesthesia induction and maintenance, followed by flumazenil for reversal after surgery, whereas propofol will be administered in the propofol group. …”
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Sensory neuron–specific block of multifaceted sodium channels mitigates neuropathic pain behaviors of osteoarthritis by Seung Min Shin, Brandon Itson-Zoske, Hao Xu, Hongfei Xiang, Fan Fan, Quinn H. Hogan, Hongwei Yu

“…Expression of NaViPA1 selective in the PSNs produced significant and comparable mitigations of evoked and spontaneous pain behavior and reversal of weight-bearing asymmetry in both male and female MIA-OA rats. …”
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