pH- responsive chitosan nanoparticles loaded with lapatinib trigger apoptosis and inhibit P-gp activity in HCT116 and SW480 colorectal cancer cells by Sankha Bhattacharya

“…These findings establish LPTB-CS-NPs as a strong foundation for CRC treatment, integrating targeted delivery, tumor-specific release, and reversal of resistance, setting the stage for in vivo research and clinical application.…”
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The dual promise of oncolytic viruses: selective targeting and therapeutic enhancement in cancer treatment by Alaa A. A. Aljabali, Rasha Bashatwah, Omar Gammoh

“…Oncolytic virotherapy (OVT) employs genetically engineered or naturally occurring viruses to selectively replicate within tumor cells, leading to direct lysis and induction of systemic anti-tumor immune responses. …”
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A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. by Yanfeng Zhao, Xinping Chen, Hong Yang, Lichun Zhou, Emmanuel U Okoro, Zhongmao Guo

“…Enrichment with human ApoE3 reversed the reduced inducibility of ApoE-free lipoproteins. …”
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Calculation of Band-Pass Filters with Fixed Frequencies of Infinite Attenuation by E. N. Chervinskiy

“…Odd-order filters with an additional capacitor in the transverse branch of the П-link and an inductance in the longitudinal branch of the Т-link were used as low-frequency prototypes of the BPF with attenuation poles. …”
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Circular business models: A state-of-the-art systematic literature review and future opportunities by Md Tasbirul Islam, Mahbuba Imroz Khan, Amjad Ali

“…This study presents a systematic literature review of 381 peer-reviewed journal articles to synthesize the state of CBM research. Through inductive and deductive content analysis, the study introduces 22 structural dimensions, including CBM definitions, types, tools and frameworks, business ecosystem perspectives, supply chain segments and others. …”
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Empirical substantiation of the advantage of using the modified method of symmetrical components to estimate the value of zero-sequence current in distribution grids by A. A. Pesterev, S. S. Kostinskiy, N. D. Narakidze

“…One of the criteria for assessing the quality of electric power is the zero-sequence and reverse sequence asymmetry indices. And the zero-sequence asymmetry coefficient is conditioned by the zero-sequence current strength. …”
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Antiangiogenic activity of 2-deoxy-D-glucose. by Jaime R Merchan, Krisztina Kovács, Jaclyn W Railsback, Metin Kurtoglu, Yuqi Jing, Yolanda Piña, Ningguo Gao, Timothy G Murray, Mark A Lehrman, Theodore J Lampidis

“…Inhibition of LLO synthesis activated the unfolded protein response (UPR), which resulted in induction of GADD153/CHOP and EC apoptosis (TUNEL assay). …”
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Bone Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect Articular Cartilage Through Regulating tRF-Gln-TTG-019/UBL3 by Xialin Li, Zheng Huang, Min Shu, Guangxun Hu, Weihong Yi, Yang Duan, Songjia Ni

“…Bone mesenchymal stromal cells (BMSCs) were isolated from male Sprague Dawley (SD) rats, and high-throughput sequencing was used to select tRFs from EVs derived from BMSC which were cultured in chondrogenic induction medium (induced) or stem cell growth medium (control). …”
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Retraction: A Bmi1-miRNAs cross-talk modulates chemotherapy response to 5-fluorouracil in breast cancer cells. by PLOS One Editors

“…MiR-200c and miR-203 overexpression in breast cancer cells downregulated Bmi1 expression accompanied with reversion of resistance to 5-Fu mediated by Bmi1. Inversely, Bmi1 overexpression inhibited miR-200c expression in MCF-7 cells, but not miR-203, however ectopic wild-type p53 expression reversed Bmi1 mediated miR-200c downregulation, suggesting the repressive effect of Bmi1 on miR-200c maybe depend on p53. …”
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Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway. by Catherine Martin, Songbi Chen, Daniela Heilos, Guido Sauer, Jessica Hunt, Alexander George Shaw, Paul Francis George Sims, Dean Andrew Jackson, Josip Lovrić

“…Interestingly while ERK activation is fully reversible, the observed chromatin changes induced by epigenetic modifications are not reversible once established. …”
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Echinacoside alleviates Ang II-induced cardiac fibrosis by enhancing the SIRT1/IL-11 pathway by Yingbiao Wu, Zhongping Ning

“…Nevertheless, ECH’s precise function and mechanisms in addressing cardiac fibrosis are still not fully understood.Materials and Methods: In our current investigation, we induced cardiac fibrosis in mice by administering Angiotensin II (Ang II) and subsequently assessed the effects of ECH treatment four weeks post-fibrosis induction. Additionally, in an in vitro setting, we exposed cardiac fibroblasts (CFs) to Ang II to prove the anti-fibrotic mechanisms of ECH.Results: ECH treatment effectively reversed cardiac fibrosis in the mice model. …”
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Acetate ameliorates ovarian mitochondrial dysfunction in letrozole-induced polycystic ovarian syndrome rat model by improving mitofusin-2 by Kehinde S. Olaniyi, Stephanie E. Areloegbe

“…Herein, the study hypothesized that acetate reverses ovarian mitochondrial dysfunction in experimental PCOS rat model, possibly through modulation of mitofusin-2 (MFn2). …”
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Instability of alloxan-induced diabetes and its impact on sex and thyroid hormones in male wistar rats-a pilot study by Martin Osibemhe, Blessing Orji, Gloria Omaji, Elizabeth Amune, John Ezekiel

“…Alloxan caused alteration in blood glucose levels of both diabetic and reversed diabetic groups. T4 level was lowered significantly in both diabetic (11.32 ± 0.26 μg/ml) and reversed diabetic (11.00 ± 0.16 μg/ml) groups in relation to the control. …”
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Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer by Yusi Luluk Rahmania, Person Pesona Renta, Damar Nurwahyu Bima, Yu-Shan Lin, Ngoc Thang Nguyen, Pin-Yu Wang, Meiny Suzery, Wen-Tai Chiu

“…Combined treatment of cisplatin-resistant cell lines with hyptolide and cisplatin demonstrated a synergistic effect, enhancing apoptosis. Additionally, the reversal of chemoresistance with hyptolide treatment was mediated by β-catenin cytoplasm translocation leading to E-cadherin expression, ultimately promoting mesenchymal-epithelial transition. …”
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Prostate tumor neuroendocrine differentiation via EMT: The road less traveled by Haley Dicken, Patrick J. Hensley, Natasha Kyprianou

“…Neuroendocrine prostate cancer (NEPC) is highly aggressive exhibiting reactivation of developmental programs associated with EMT induction and stem cell-like characteristics. The androgen receptor (AR) is a critical driver of tumor progression as well as therapeutic response in patients with metastatic CRPC. …”
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The effect of intravesical Bacillus Calmette-Guerin (BCG) treatment on sperm parameters in non-muscle-invasive bladder cancer patients by Sergen Sahin, Ismail Ulus, Ibrahim Ogulcan Canitez, Serhat Yentur, Mustafa Zafer Temiz, Atilla Semercioz

“…Semen analyses were performed prior to treatment and three months following the induction course. Hormonal profiles, comprising total testosterone (TT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL), were evaluated. …”
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Aframomum melegueta mitigates seizure severity and neuroinflammation via gut-brain axis modulation in PTZ-induced kindling by Ebenezer Kwesi Biney, Akwasi Oppong, Kwabena Gyampo-Asare, Nana Ofori Adomako, Priscilla Kolibea Mante

“…Animals also, underwent chronic drug treatments of AM and sodium valproate (VPA) which were administered during the induction of kindling. Animals were observed for stages of seizure development. …”
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Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection by Michaela Dvorakova, Ken Mackie, Alex Straiker

“…Notably, once it is established, inhibition is reversed by a CB1, but not a muscarinic, antagonist, suggesting that the inhibition occurs via persistent activation of CB1 receptors. …”
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CAPE activates AMPK and Foxo3 signaling to induce growth inhibition and ferroptosis in triple-negative breast cancer. by Qilu Fang, Qichuan Fang, Rui Cheng, Tingting Feng, Wenxiu Xin

“…Inhibition of both AMPK and Foxo3 by siRNAs or inhibitors (Compc, TIC10) reversed the growth retardation induced by CAPE as well as its pro-apoptotic effects leading to ferroptosis. …”
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Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors. by Melanie Volke, Daniel P Gale, Ulrike Maegdefrau, Gunnar Schley, Bernd Klanke, Anja-Katrin Bosserhoff, Patrick H Maxwell, Kai-Uwe Eckardt, Christina Warnecke

“…The decrease in hepcidin mRNA was not reversed by HIF-1alpha or HIF-2alpha knock-down or by depletion of the HIF and iron regulatory protein (IRP) target transferrin receptor 1 (TfR1). …”
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