YTHDF2 influences hepatic fibrosis by regulating ferroptosis in hepatic stellate cells by mediating the expression of ACSL4 in an m<sup>6</s... by Liu Wentao, He Yuan, Chen Kunlun, Ye Jianwen, Yu Long, Zhou Chuang, Zhai Wenlong

“…Hepatic fibrosis (HF) is an abnormal reparative response of the liver to chronic injury and is histologically reversible. In recent years, increasing interest has been given to changes in m⁶A in liver disease. …”
Get full text

Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors by Shashank Shekhar, Charles Tracy, Peter V. Lidsky, Raul Andino, Katherine J. Wert, Helmut Krämer

“…In different Drosophila models with loss of sensory input, we observe non-autonomous induction of the integrated stress response (ISR) deep in the brain, as indicated by eIF2αS50 phosphorylation-dependent elevated levels of the ISR effectors ATF4 and XRP1. …”
Get full text

The therapeutic potential of RNA m(6)A in lung cancer by Jingran Yu, Wei Sun, Xiangxuan Zhao, Yingying Chen

“…Intriguingly, an increasing number of studies have also shown that eliminating RNA m(6)A dysfunction can exert significant anti-cancer effects on LC such as suppression of cell proliferation and viability, induction of cell death, and reversal of treatment insensitivity. …”
Get full text

Protective Effects of Eicosapentaenoic Acid on the Glomerular Endothelium via Inhibition of EndMT in Diabetes by Toshinori Yasuzawa, Tomomi Nakamura, Shigeru Ueshima, Akira Mima

“…Streptozotocin-induced diabetic mice fed a high-fat diet (60% from fat) exhibited mesangial expansion and albuminuria. Induction of EPA-E ameliorated the mesangial expansion and decreased albuminuria without affecting blood pressure, triglyceride and free fatty acid levels, and intraperitoneal glucose. …”
Get full text

OncomiR addiction is generated by a miR-155 feedback loop in Theileria-transformed leukocytes. by Justine Marsolier, Sandra Pineau, Souhila Medjkane, Martine Perichon, Qinyan Yin, Erik Flemington, Matthew D Weitzman, Jonathan B Weitzman

“…We show that Theileria transformation involves induction of the host bovine oncomiR miR-155, via the c-Jun transcription factor and AP-1 activity. …”
Get full text

L-Carnitine Prevents Behavioural Alterations in Ketamine-Induced Schizophrenia in Mice: Possible Involvement of Oxidative Stress and Inflammation Pathways by Mehrasa Ebrahimi, Nematollah Ahangar, Ehsan Zamani, Fatemeh Shaki

“…In addition, l-carnitine prevented and reversed ketamine-induced alterations in the activities of SOD and GPx enzymes in mice’s brains. …”
Get full text

Signalling pathways involved in urotensin II induced ventricular myocyte hypertrophy. by Hadeel S Al Ali, Glenn C Rodrigo, David G Lambert

“…UII resulted in a change in L/W ratio from 4.53±0.10 to 3.99±0.06; (p<0.0001) after 48hours. The response is reversed by the UT-antagonist SB657510 (1μM). UT receptor activation by UII resulted in the activation of ERK1/2, p38 and CaMKII signalling pathways measured by Western blotting; these are involved in the induction of hypertrophy. …”
Get full text

No evidence of leukaemia (NEL) as a response criteria in paediatric AML: a multicentre analysisResearch in context by Evangelia Antoniou, Annika Puschnig, Naghmeh Niktoreh, Lina Marie Hoffmeister, Markus Schneider, Carolin Augsburg, Christel Katerkamp, Denise Kondryn, Tabea Ziedrich, Jan-Henning Klusmann, Michael Dworzak, Ursula Creutzig, Nora Mühlegger, Lux Melanie, Katharina Waack, Nils von Neuhoff, Dirk Reinhardt, Stephanie Sendker

“…The poorest outcome at the end of induction (EOI) was noticed in patients with EL, which could be improved by HSCT. …”
Get full text

Ameliorative effects of avocado oil on bleomycin‐induced lung fibrosis and oxidative stress in rats by Naoures Ochi, Anouar Abidi, Wael Taamalli, Ayda Ayedi, Hichem Sebai

“…Ao treatment reversed all disturbances induced by BLM in oxidative stress parameters and relatively repairs the histological damage caused by BLM by reducing the FS and the II. …”
Get full text

Ways to Reduce the Resistance Torque During the Disk Rotor Spinning and to Increase the Electromotive Force in the Transverse Magnetic Flux Generator in No-Load Mode by Yehorov A.V., Duniev O.O., Masliennikov A.M., Stamann M.

“…It is concluded that the magnetic reversal frequency of the stator cores depends on the number of permanent magnets on the rotor. …”
Get full text

Crumbling Pathogenesis and Biomarkers for Diabetic Peripheral Neuropathy by Zhao Zhong Chong, Nizar Souayah

“…However, the superimpose of acquired demyelination on axonal loss in DSP patients has been observed, implying that DSP may be preventable or reversible, particularly within a subgroup of patients exhibiting early-stage acquired demyelination, underscoring the critical importance of identifying early prognostic markers. …”
Get full text

Angiogenesis impairment in diabetes: role of methylglyoxal-induced receptor for advanced glycation endproducts, autophagy and vascular endothelial growth factor receptor 2. by Hongtao Liu, Shujie Yu, Hua Zhang, Jian Xu

“…Pharmacological or genetic suppression of peroxynitrite (ONOO(-)) generation not only blocked the autophagy but also reversed the reduction of VEGFR2 and angiogenesis. …”
Get full text

Modulation of intracellular calcium waves and triggered activities by mitochondrial ca flux in mouse cardiomyocytes. by Zhenghang Zhao, Richard Gordan, Hairuo Wen, Nadezhda Fefelova, Wei-Jin Zang, Lai-Hua Xie

“…The protonophore carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP) reversibly raised basal Cai (2+) levels even after depletion of SR Ca(2+) in the absence of Cao (2+) , suggesting Ca(2+) release from mitochondria. …”
Get full text

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. by Nirma D Perera, Rebecca K Sheean, John W Scott, Bruce E Kemp, Malcolm K Horne, Bradley J Turner

“…Furthermore, PP2A inhibition by okadaic acid reversed AMPK inactivation by mutant TDP-43 in neuronal cells. …”
Get full text

Prophylactic Antioxidant Potential of Gallic Acid in Murine Model of Sepsis by Harikesh Maurya, Vaishali Mangal, Sanjay Gandhi, Kathiresan Prabhu, Kathiresan Ponnudurai

“…Group III animals were pretreated with Gallic acid at the dose rate of 20 mg/kg body weight for 2 days before induction of sepsis. Animals were sacrificed on 8th day and the tissue samples were obtained for further investigation on lipid peroxidation (LPO), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH). …”
Get full text

Shift in the urinary metabolome associated with 2,3,7,8-tetrachlorodibenzo-p-dioxin activation of the hepatic aryl hydrocarbon receptor by Warren J. Sink, Russell Fling, Ali Yilmaz, Rance Nault, Delanie Goniwiecha, Jack R. Harkema, Stewart F. Graham, Tim Zacharewski

“…In rodents, the prototypical DLC, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), has been shown to induce the progression of reversible hepatic steatosis to steatohepatitis with periportal fibrosis and biliary hyperplasia. …”
Get full text

Dynamic interplay of autophagy and membrane repair during Mycobacterium tuberculosis Infection. by Jacques Augenstreich, Anna T Phan, Charles N S Allen, Anushka Poddar, Hanzhang Chen, Lalitha Srinivasan, Volker Briken

“…Autophagy plays a crucial role in the host response to Mycobacterium tuberculosis (Mtb) infection, yet the dynamics and regulation of autophagy induction on Mtb-containing vacuoles (MCVs) remain only partially understood. …”
Get full text

Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids by Yewei Huang, Jiahao Huang, Jiazi Yu, Songlin Zhuang, Ming Liu

“…RNA-seq revealed NOTUM induction as the key mediator. Combining Wnt5a with 5-FU synergistically enhanced organoid growth inhibition and cell death, reversing 5-FU-driven NOTUM downregulation. …”
Get full text

Development of a hamster model of spontaneous hypertriglyceridemia in diabetes by Ya‐Hong Ma, Yuhui Wang, George Liu

“…Hyperglycemia and HTG in heterozygous hamsters were reversed to pre‐diabetic levels following intraperitoneal insulin administration. …”
Get full text

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana. by Mashael S Al-Mutairi, Laurence C Cadalbert, H Adrienne McGachy, Muhannad Shweash, Juliane Schroeder, Magdalena Kurnik, Callum M Sloss, Clare E Bryant, James Alexander, Robin Plevin

“…MKP-2 deletion also potentiated LPS-stimulated induction of the inflammatory cytokines, IL-6, IL-12p40, TNF-α, and also COX-2 derived PGE(2) production. …”
Get full text