Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. by Jeffrey A Alten, Ana Moran, Anna I Tsimelzon, Mary-Ann A Mastrangelo, Susan G Hilsenbeck, Valeria Poli, David J Tweardy

“…Thus, cardiac dysfunction, cardiomyocyte apoptosis and induction of apoptosis pathway genes are important components of HCC; IL-6 administration prevented HCC by blocking cardiomyocyte apoptosis and induction of apoptosis pathway genes via Stat3 and warrants further study as a resuscitation adjuvant for prevention of HCC and death in trauma patients.…”
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When math legitimizes knowledge: a step by step approach to Bayes’ rule in diagnostic reasoning by Yung Bruno de Mello Gonzaga, André Demambre Bacchi, Vitor Borin Pardo de Souza

“…METHODS: In this article, we explain the difference between deductive and inductive thinking and how diagnostic reasoning is predominantly inductive, where evidence (the test result) is used to predict the cause (the presence of disease), a path that involves reverse probability, for which our reasoning is hazier. …”
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Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium by Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, The RReSTORe Consortium, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson

“…RGC repopulation is a promising therapeutic approach to reverse vision loss from optic neuropathies if the newly introduced neurons can reestablish functional retinal and thalamic circuits. …”
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Honey-fried licorice decoction ameliorates atrial fibrillation susceptibility by inhibiting the NOX2–ROS–TGF-β1 pathway by Yu Qin, Yu Qin, Jingyan Wang, Rong Chen, Zhiling Tang, Hao Zhi, Xiang Wu, Xiaodong Chen, Jialei Fu, Xueting Cai, Jianping Shen, Peng Cao, Peng Cao, Qian Zhou, Qian Zhou

“…Notably, HFLD treatment could reverse these imbalances. In rat experiments, HFLD was found to reduce oxidative stress and extracellular matrix deposition, thereby effectively reducing AF’s induction rate and duration. …”
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TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy by Juan Xiao, Zhenwang Zhao, Fengqiao Zhou, Jinsong Xiong, Zean Yang, Baoxian Gong, Lei Xiang, Mingming Liu, Fengsheng Cao, Hong Xiao, Huabo Chen, Anbing Zhang, Ke Wang

“…The signaling pathways regulated by TM9SF1 in B cell maturation and antibody production were conducted by plasma cell induction experiment in vitro. Results The Tm9sf1 −/− RA and SLE model mice produced fewer autoantibodies and showed reduced disease severity relative to wild-type (WT) mice. …”
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MiR- 223 alleviates the heat-stress-induced inhibition of cell proliferation by targeting PRDM1 by Siqi Xia, Huimei Fan, Jianghai Xiao, Ci Shen, Yongping Yan, Meigui Wang, Tao Tang, Wenqiang Sun, Jie Wang, Xianbo Jia, Songjia Lai

“…Previous studies have demonstrated that heat stress induction results in a significant downregulation of miR- 223 in MAC-T cells; therefore, miR- 223 may play a crucial role in the response to heat stress. …”
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Elevated IL-6 Expression in Autologous Adipose-Derived Stem Cells Regulates RANKL Mediated Inflammation in Osteoarthritis by Hyun-Joo Lee, Dae-Yong Kim, Hyeon jeong Noh, Song Yi Lee, Ji Ae Yoo, Samuel Jaeyoon Won, Yoon Sang Jeon, Ji Hoon Baek, Dong Jin Ryu

“…The isolated ASCs were cultured and characterized using reverse transcription polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), and flow cytometry to the phenotype and immune regulatory factors of MSCs. …”
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Effect of Ga doping on the catalytic performance of Zn-ZSM-5 for CO2-assisted oxidative dehydrogenation of C2H6 by Haojue Wen, Xinru Han, Lina Zhang, Yongdong Chen, Wei Wei, Nannan Sun

“…With the optimum catalyst (Ga0.27ZnZ5), excellent and stable performance with 22.64 % C2H4 yield and nearly 100 % selectivity could be achieved after an induction period of ca. 100 minutes, these are among the highest values reported so far.…”
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Passage-attenuated Powassan virus LI9P protects mice from lethal LI9 challenge and links envelope residue D308 to neurovirulence by Grace E. Himmler, Megan C. Mladinich, Jonas N. Conde, Elena E. Gorbunova, Marissa R. Lindner, Hwan Keun Kim, Erich R. Mackow

“…We evaluated the roles of Env-Domain III residue changes in LI9 virulence and LI9P attenuation using recombinant POWVs (recPOWVs) generated by reverse genetics. Remarkably, mutating D308N in LI9 completely abolished viral lethality and neuroinvasion in 50-week-old mice, reflecting the avirulent phenotype of LI9P. …”
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Synergistic anticancer effects of camptothecin and sotorasib in KRAS-mutated pancreatic ductal adenocarcinoma by Prasanna Srinivasan Ramalingam, Gayathri Chellasamy, Md Sadique Hussain, Md Sadique Hussain, Gothandam Kodiveri Muthukaliannan, Tajamul Hussain, Tajamul Hussain, Salman Alrokayan, Kyusik Yun, Janaki Ramaiah Mekala, Sivakumar Arumugam

“…Furthermore, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was performed to analyze gene expression patterns in both pancreatic ductal adenocarcinoma cell lines. …”
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Attenuation of indomethacin-induced gastric ulceration by methanolic extract of Cucumis Melo (L. indorous) seeds in male Wistar rats by Grace Adebayo-Gege, James Adiwu, Abednego Ovey Angbashim, Toyin Dorcas Alabi, Murtala Ngabea Audu, Frank Abimbola Ogundolie

“…Treatment with Cucumis melo seed extract reversed tunic mucosal necrosis and significantly induced the proliferation of the gastric mucosal gland. …”
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Cannabichromene: integrative modulation of apoptosis, ferroptosis, and endocannabinoid signaling in pancreatic cancer therapy by Yu-Na Hwang, Ju-Hee Park, Han-Heom Na, Tae-Hyung Kwon, Jin-Sung Park, Sehyun Chae, Young Taek Oh, Keun-Cheol Kim

“…Accordingly, the effects on cell death were reversed after treatment with TRPV1 and CB2 inhibitors, suggesting that receptor expression is necessary for the induction of apoptotic cell death. …”
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An epigenetic memory at the CYP1A gene in cancer-resistant, pollution-adapted killifish by Samantha Carrothers, Rafael Trevisan, Nishad Jayasundara, Nicole Pelletier, Emma Weeks, Joel N. Meyer, Richard Di Giulio, Caren Weinhouse

“…We observed epigenetic control of this reversible memory of generational PAH stress in F1 PAH-tolerant embryos. …”
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Active Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates NMDA Receptor Mediated Postischemic Long-Term Potentiation (i-LTP) by Promoting the Interaction between CaM... by Ning Wang, Linlin Chen, Nan Cheng, Jingyun Zhang, Tian Tian, Wei Lu

“…Disturbing the association between CaMKII and GluN2B subunit of NMDARs with short cell-permeable peptides Tat-GluN2B reversed NMDA i-LTP induced by OGD treatment. The results provide support to a notion that increased interaction between NMDAR and CaMKII following ischemia-induced increased CaMKII activity and autophosphorylation is essential for induction of NMDA i-LTP.…”
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Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice. by Kenji Uno, Takuya Uchino, Takashi Suzuki, Yohei Sayama, Naoki Edo, Kiyoko Uno-Eder, Koji Morita, Toshio Ishikawa, Miho Koizumi, Hiroaki Honda, Hideki Katagiri, Kazuhisa Tsukamoto

“…We find that viral-mediated induction of Rspo3 in hepatic tissue of obesity improves insulin resistance and prevents body weight gain by restoring attenuated organ insulin sensitivities, reducing adipose tissue enlargement and reversing overstimulated adaptive thermogenesis. …”
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Consequences of internalization and phagocytosis of Listeria during an infectious process by Yu. N. Odintsov, V. M. Perelmuter

“…It has been supposed that internalization and phagocytosis variant depended on the stage (inductive stage, IgM synthesis stage, IgG synthesis stage) of immunogenesis developing during an infectious process. …”
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Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma by Jochen Sven Utikal, Viktor Umansky, Kilian Wistuba-Hamprecht, Qian Sun, Rebekka Bitsch, Feyza Gül Özbay Kurt, Daniel Novak, Yuxin Zhang, Shibo Liu, Rui Han, Nina Wang, Juliane Poelchen, Mareike Peter, Huizi Wu, Yiman Wang, Sandra Pardo, Lidong Gong

“…FOXD1 was identified as a direct regulator of interleukin 6 (IL6) expression, which is pivotal for MDSC induction. Blocking IL6 reversed MDSC-associated immunosuppression. …”
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Purification technology design, biochemical and immunological characteristics of the recombinant chimeric antigen for evaluation of T cell immunity against coronavirus infection by V. V. Kopat, A. A. Riabchenkova, E. L. Chirak, E. R. Chirak, A. I. Saenko, I. V. Kudryavtsev, A. S. Trulioff, T. V. Savin, E. V. Zueva, A. S. Simbirtsev, A. A. Totolyan, I. V. Dukhovlinov

“…The biomass yield during cultivation of E. coli CorD_PS in a 30L fermenter was up to 20 g/L for 4 hours of 0.1 mM IPTG induction. Sequential washing of inclusion bodies from bacterial cellular components and their subsequent solubilization in a buffer containing 8 M urea allowed to obtain a solution of denatured antigen with a concentration of 10 mg/mL. …”
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Circ‐myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super‐Enhancers in FOSL2 Expression by Jingya Zhang, Xinru Wang, Xu Wang, Songyue Li, Jianli Hou, Yibin Zhang, Xinyue Song, Shukun Cao, Ya Xu, Jing Qi, Baoshan Zhao, Xiaodong Zheng, Yan Xing

“…This process ultimately contributes to the induction of PANoptosis in PASMCs. These findings elucidate the role of the circ‐myh8/KAT7/SE/FOSL2 axis in the regulation of PANoptosis in PASMCs, thus offering new insights into the pathophysiology of PANoptosis in pulmonary hypertension. …”
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Radiotherapy and MVA-MUC1-IL-2 vaccine act synergistically for inducing specific immunity to MUC-1 tumor antigen by Philippe Slos, Gilda G. Hillman, Lyndsey A. Reich, Shoshana E. Rothstein, Lisa M. Abernathy, Matthew D. Fountain, Kali Hankerd, Christopher K. Yunker, Joseph T. Rakowski, Eric Quemeneur

“…Responding mice were immune to challenge with Renca-MUC1 cells, indicating the induction of specific tumor immunity. Histology studies of regressing tumors at 1 week after therapy, revealed extensive tumor destruction and a heavy infiltration of CD45+ leukocytes including F4/80+ macrophages, CD8+ cytotoxic T cells and CD4+ helper T cells. …”
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