Safety and utility of an anesthetic protocol for the collection of biological samples from gopher tortoises by Jessica L. McGuire, Sonia M. Hernandez, Lora L. Smith, Michael J. Yabsley

“…Average time to first effects was 9.7 minutes, to induction was 21.6 minutes, to total recovery after administration of reversal was 92.7 minutes, and the mean time from administration of anesthesia through complete recovery for adult tortoises was 129 minutes but ranged from 40 minutes to 300 minutes. …”
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Effect of a FOXO1 inhibitor on trophoblast differentiation from human pluripotent stem cells and ERV-associated gene expression by Erika Tanaka, Michiyo Koyanagi-Aoi, So Nakagawa, Sayumi Shimode, Hideto Yamada, Yoshito Terai, Takashi Aoi

“…Conclusions: Treatment with a FOXO1 inhibitor during TE induction from naive iPSCs promotes early TE differentiation but hinders the progression of differentiation into ST and EVT. …”
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Oral atogepant mitigates spreading depolarization-induced pain and anxiety behavior in mice by Melih Z. Kaya, Pradeep Banerjee, Cenk Ayata, Andrea M. Harriott

“…Using minimally invasive optogenetic SD induction (opto-SD), we previously showed that SD triggers acute periorbital mechanical allodynia-like behavior, supporting SD-induced activation of migraine-relevant trigeminal pain pathways. …”
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Catechin gallate triggers metabolomic and lipidomic alteration in Toxoplasma gondii by Jazmyn R. Greggs, Homa Nath Sharma, Daniel A. Abugri

“…Methods Here, we assess the effect of CG on human telomerase reverse transcriptase immortalized foreskin fibroblast (hTERT) cells, cytotoxicity, and inhibitory activity of the RH-RFP (type I) strain of T. gondii tachyzoite. …”
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Anti‐androgen enzalutamide enhances prostate cancer neuroendocrine (NE) differentiation via altering the infiltrated mast cells → androgen receptor (AR) → miRNA32 signals by Qiang Dang, Lei Li, Hongjun Xie, Dalin He, Jiaqi Chen, Wenbing Song, Luke S. Chang, Hong-Chiang Chang, Shuyuan Yeh, Chawnshang Chang

“…However, the mechanisms behind the potential side effects involving the induction of the prostate cancer (PCa) neuroendocrine (NE) differentiation remain unclear. …”
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Cloning, sequence and expression analysis of two SOC1 genes from Anthurium by MA Guangying, ZHU Kaiyuan, SHI Xiaohua, ZOU Qingcheng, LIU Huichun, ZHAN Jing, TIAN Danqing

“…SUPPRESSOR OF OVEREXPRESSION OF CO1 (SOC1) is a flowering integration factor that widely existed in flowering plants, which is necessary in multiple flowering induction pathways, including vernalization, photoperiod, gibberellin, and other endogenous or exogenous environmental signals. …”
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MS-275 facilitates osseointegration in osteoporotic rats by mitigating oxidative stress via activation of the miR-200a/Keap1/Nrf2 signaling pathway by Junjie Yan, Qinsong Gu, Jianqiao Li, Zhi Zhou, Wenkai Jiang, Wengang Guan, Bin Chen, Yuhu Chen, Min Yang

“…However, these effects were reversed after interference with miRNA-200a. In vivo,MS-275 effectively enhanced the microstructural features of distal femoral trabecular bone, increased the mineralization capacity of osteoblasts, and promoted bone formation.Discussion MS-275 can reverse oxidative stress-induced cell damage, promote bone healing, and improve osteoporosis by activating the miRNA-200a/Keap1/Nrf2 pathway.…”
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Oral Angiotensin-(1-7) formulation after established elastase-induced emphysema suppresses inflammation and restores lung architecture by Giselle Santos Magalhaes, Giselle Santos Magalhaes, Alicia Villacampa, Alicia Villacampa, Maria Gloria Rodrigues-Machado, Maria Jose Campagnole-Santos, Robson Augusto Souza Santos, Carlos F. Sánchez-Ferrer, Carlos F. Sánchez-Ferrer, Concepción Peiró, Concepción Peiró

“…However, treatment with Ang-(1-7) reversed these changes, reducing collagen deposition, restoring alveolar structure, and suppressing inflammation and senescence. …”
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Extracellular Vesicles (EVs) Derived from Mesenchymal Stem Cells (MSCs) as Adjuvants in the Treatment of Chronic Kidney Disease (CKD) by Paloma Noda, Ana L. R. Francini, Flavio Teles, Samuel J. Júnior, Fernando L. A. Fonseca, Fernanda T. Borges, Adão C. Sobrinho, Noemi Taniwaki, Irene L. Noronha, Camilla Fanelli

“…However, this approach promotes only partial detention of CKD progression and cannot reverse renal damage. The aim of the present study was to investigate whether the therapeutic administration of extracellular vesicles (EVs) derived from adipose stem cells (ASCs), associated to LOS treatment, would promote additional renoprotection in rats underwent the 5/6 renal ablation CKD model. …”
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ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction by Chuanmei Qin, Jiayi Wu, Xiaowei Wei, Xueqing Liu, Yi Lin

“…Quantitative real-time reverse transcription PCR, western blotting, and immunohistochemistry (IHC) confirmed the elevated expression of ALKBH5 in the cytotrophoblasts of patients with RM. …”
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Brucella secretory protein VceA promotes FOXO1 entry into the nucleus to shift host cell metabolism toward glycolysis by Cao Shuzhu, Han Xinxin, Deng Xingmei, Guo Jia, Liu Liangbo, Zhang Yu, Suleimenov Maratbek, Zhao Tianyi, Li Wei, Ding Jian, Xie Songsong, Zhang Hui

“…Increased glycolytic metabolism is a key step in the reproduction of Brucella and the induction of brucellosis, however, little is known about how this process is regulated during infection. …”
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Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hep... by Sara Ahmadi Badi, Hananeh Tavakoli Aval, Hamid Reza Moradi, Amin Malek, Seyed Amirhesam Seyedi, Mehdi Davari, Ahmad Bereimipour, Soghra Khani, Shohreh Khatami, Seyed Davar Siadat

“…In vivo, intervention with F. prausnitzii, particularly its CFS, led to a greater induction of hepatic hepcidin and ferroportin expression compared to A. muciniphila and its CFS. …”
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Doxycycline-Induced Apoptosis in Brucella suis S2-Infected HMC3 Cells via Calreticulin Suppression and Activation of the IRE1/Caspase-3 Signaling Pathway by Wang Z, Yang J, Zhang DE, Qiao X, Yang SL, Wang ZH, Yang Q

“…The same parameters were measured in B. suis S2-infected HMC3 cells following treatment with 160 μM Dox.Results: Treatment with 160 μM Dox for 12 hours resulted in a reduction in CALR protein levels and the induction of apoptosis in HMC3 cells. The downregulation of CALR activated the IRE1/Caspase-12/Caspase-3 signaling pathway, leading to apoptosis. …”
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Mechanisms of alleviating sepsis-induced rat lung and kidney damage by inhibiting expression of miRNA-939 by Anwaier Apizi, Jian Li, Yan Li, Zhaoxia Yu, Ruifeng Chai

“…RESULTS: Compared to the sham group, the rats in the sepsis model group exhibited significantly elevated levels of miRNA-939 in serum, with distinct peaks at 12, 24, and 36 h post-sepsis induction. Similarly, the protein levels of iNOS and sGC (sGCα1 and sGCβ1 subunits) in kidneys and lungs were markedly higher in the sepsis group. …”
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Role of circCCDC138 in early malignant transformation of human lung epithelial cells induced by carbon black nanoparticles by Runfeng LI, Lichun MA, Shulin QIN, Wen LIU

“…More importantly, circCCDC138 may promote the induction of malignant transformation of cells by inhibiting p53 protein expression.…”
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Kluyveromyces marxianus Ameliorates High-Fat-Diet-Induced Kidney Injury by Affecting Gut Microbiota and TLR4/NF-κB Pathway in a Mouse Model by Na Li, Guanjie Zhao, Mingzhu Xu

“…K. marxianus treatment ameliorated HFD-induced metabolic disorders and reversed these parameters (P<0.05). Compared with the control, HFD induction increased the proportion of Firmicutes but reduced the proportion of Bacteroidetes and Lactobacillus. …”
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Estradiol Downregulates MicroRNA-193a to Mediate Its Angiogenic Actions by Lisa Rigassi, Mirel Adrian Popa, Ruth Stiller, Brigitte Leeners, Marinella Rosselli, Raghvendra Krishna Dubey

“…Importantly, Estradiol (E2) exerts its vascular protective actions, in part, by promoting endothelial repair via induction of endothelial cell (EC) proliferation, migration and angiogenesis. …”
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Single-Nucleus RNA Sequencing Reveals the Spatiotemporal Dynamics of Disease-Associated Microglia in Amyotrophic Lateral Sclerosis by Lu-Xi Chen, Mei-Di Zhang, Hai-Feng Xu, Hai-Qin Ye, Dian-Fu Chen, Pei-Shan Wang, Zhi-Wei Bao, Sheng-Mei Zou, Yong-Ting Lv, Zhi-Ying Wu, Hong-Fu Li

“…These findings reveal that the induction of the DAM phenotype is a shared cross-species and cross-subtype characteristic in ALS. …”
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Neuroblastoma response to RAS-MAPK inhibitors and APR-246 (eprenetapopt) co-treatment is dependent on SLC7A11 by Vid Mlakar, Ina Oehme, Ina Oehme, Laurence Lesne, Sara Najafi, Sara Najafi, Sara Najafi, Marc Ansari, Marc Ansari, Fabienne Gumy-Pause, Fabienne Gumy-Pause

“…Combining APR-246 with RAS-MAPK pathway inhibitors can, in some cases, lead to antagonistic action, which can be reversed by combining APR-246 with the clinically approved drug sulfasalazine.…”
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HO-1 Upregulation Attenuates Adipocyte Dysfunction, Obesity, and Isoprostane Levels in Mice Fed High Fructose Diets by Zeid Khitan, Mohit Harsh, Komal Sodhi, Joseph I. Shapiro, Nader G. Abraham

“…Fructose treatment resulted in increased isoprostane production and adipocyte dysfunction, which was reversed by the increased expression of HO-1.…”
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