Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance by Zhang K, Luo Z, Yao X, Lu D, Hong T, Zhu X, Chen M, Wang X

“…Among 2794 IFN-I-related genes from GeneCards, 26 DEGs overlapped, enriched in viral genome replication and IFN-I pathways. 14 hub genes were identified, with 7 genes confirmed in GSE135809: ISG15, IFIT1, OASL, IFI6, RSAD2, IFI44L, and USP18. …”
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Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. by Seung Hoan Choi, Daniela Ruggiero, Rossella Sorice, Ci Song, Teresa Nutile, Albert Vernon Smith, Maria Pina Concas, Michela Traglia, Caterina Barbieri, Ndeye Coumba Ndiaye, Maria G Stathopoulou, Vasiliki Lagou, Giovanni Battista Maestrale, Cinzia Sala, Stephanie Debette, Peter Kovacs, Lars Lind, John Lamont, Peter Fitzgerald, Anke Tönjes, Vilmundur Gudnason, Daniela Toniolo, Mario Pirastu, Celine Bellenguez, Ramachandran S Vasan, Erik Ingelsson, Anne-Louise Leutenegger, Andrew D Johnson, Anita L DeStefano, Sophie Visvikis-Siest, Sudha Seshadri, Marina Ciullo

“…Six discovery cohorts including 13,312 samples were analyzed, followed by in-silico and de-novo replication studies including an additional 2,800 individuals. …”
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Evaluating the Binding Potential and Stability of Drug-like Compounds with the Monkeypox Virus VP39 Protein Using Molecular Dynamics Simulations and Free Energy Analysis by Ahmed M. Hassan, Hattan S. Gattan, Arwa A. Faizo, Mohammed H. Alruhaili, Azzah S. Alharbi, Leena H. Bajrai, Ibrahim A. AL-Zahrani, Vivek Dhar Dwivedi, Esam I. Azhar

“…Monkeypox virus (MPXV) VP39 protein is identified as an essential protein for replication of the virus, and therefore, it is a potential target for antiviral drugs. …”
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Genome-wide CRISPR knockout screen identifies activating transcription factor (ATF1) as an activator of HIV gene expression by Alona Kuzmina, Seraj Wattad, Praveenkumar Murugavelu, Noa Amir, Nili Tickotsky, Liron Levin, Ran Taube

“…Yet, a complete cure of infection is out of reach, as transcriptionally silent but replication-competent proviruses persist in a long-lived reservoir that is resistant to therapy. …”
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Virus-specific host responses and gene signatures following infection with major SARS-CoV-2 variants of concern: role of ZBP1 in viral clearance and lung inflammation by Amany Elsharkawy, Amany Elsharkawy, Hamid Reza Jahantigh, Anchala Guglani, Shannon Stone, Komal Arora, Mukesh Kumar, Mukesh Kumar

“…SARS-CoV-2 can cause severe lung damage due to uncontrolled viral replication or/and excessive inflammation. New variants of concern (VOCs) have raised additional concerns due to disparate pathogenicity and possible enhanced virulence. …”
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Occasional and Rare Lexemes in the Poetic Language of V. A. Zhukovsky (Methodology of Dictionary Interpretation) by D. N. Zhatkin

“…Zhukovsky (1783—1852) in the form of the author’s dictionary, which became possible after the publication of the initial volumes of the “Complete Works and Letters” of the writer. Special attention is paid to poetic neologisms in the works of the first Russian romanticist. …”
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Investigation on Cell Proliferation with a New Antibody against Thymidine Kinase 1 by Naining Wang, Qimin He, Sven Skog, Staffan Eriksson, Bernhard Tribukait

“…The new anti‐TK1 antibody works in archival specimens and is a specific marker of cell proliferation.…”
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Realistic three dimensional fitness landscapes generated by self organizing maps for the analysis of experimental HIV-1 evolution. by Ramón Lorenzo-Redondo, Soledad Delgado, Federico Morán, Cecilio Lopez-Galindez

“…Human Immunodeficiency Virus type 1 (HIV-1) because of high mutation rates, large population sizes, and rapid replication, exhibits complex evolutionary strategies. …”
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Applying the Intervention Mapping Protocol to promote Active Transport to School in primary school students: the ProATs intervention by Ana Corral-Abós, Javier Zaragoza, Alberto Aibar, Eduardo Ibor, José Antonio Julián

“…There is input from experts (Local Working Group), school representatives (Planning Committee), and a facilitator in each school (a member of the research team). …”
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Multi-Omics Analysis and Validation of Cell Senescence-Related Genes Associated with Non-Alcoholic Fatty Liver Disease by Gong J, Qin Z, Xiao Y, Li J, Wang Q, Lei L, Li J

“…Summary statistics for NAFLD were sourced from a previous study (discovery) and the FinnGen database (replication), with additional cohorts for nonalcoholic steatohepatitis and liver fibrosis. …”
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Immune modulation following α and β− radionuclide therapy targeting fibroblast activation protein-α in a preclinical tumor model by Hannelore Ceuppens, Kirsten De Ridder, Thomas Ertveldt, Katty Zeven, Wout De Mey, Ana Rita Pombo Antunes, Laurent Navarro, Nina Dumauthioz, Tony Lahoutte, Jens M. Debacker, Nick Devoogdt, Marleen Keyaerts, Matthias D’Huyvetter, Cleo Goyvaerts, Karine Breckpot

“…α- and β−-emitting radionuclides targeting human fibroblast activation protein-α (hFAP) are under investigation for cancer therapy. In prior work, analysis of the tumor microenvironment 24 h after therapy completion indicated therapy-induced immune activation. …”
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Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics. by Linda M O'Keeffe, Joshua A Bell, Kate N O'Neill, Matthew A Lee, Mark Woodward, Sanne A E Peters, George Davey Smith, Patricia M Kearney

“…The main limitation of this work is its observational nature, and replication in independent cohorts using methods that can infer causality is required.…”
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Exogenous estrogen enhances T cell activation in male primates by Patricia A. Hahn, Joan Escrivà-Font, Eric S. Alexander, Kimberly Weisgrau, Tianling Ou, Wenhui He, Daniel O’Hagan, Laura C.F. Da Silva, Noah J. Gurley, Li Lin, Michael D. Cameron, Eva Rakasz, Michael Farzan, Joe R. Kurian, Saverio Capuano, III, Camila R. Consiglio, Mauricio A. Martins

“…This work highlights the potential of RMs as a model for studying immune interventions in the context of GAHT.…”
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The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study. by Benjamin I Perry, Stephen Burgess, Hannah J Jones, Stan Zammit, Rachel Upthegrove, Amy M Mason, Felix R Day, Claudia Langenberg, Nicholas J Wareham, Peter B Jones, Golam M Khandaker

“…Inflammation and immune pathways may represent novel therapeutic targets for the prevention or treatment of schizophrenia and comorbid insulin resistance. Future work is needed to understand how inflammation may contribute to the risk of schizophrenia and insulin resistance.…”
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Genome-Wide Association Study of Absolute QRS Voltage Identifies Common Variants of TBX3 as Genetic Determinants of Left Ventricular Mass in a Healthy Japanese Population. by Motoaki Sano, Shigeo Kamitsuji, Naoyuki Kamatani, Yasuharu Tabara, Takahisa Kawaguchi, Fumihiko Matsuda, Hiroyuki Yamagishi, Keiichi Fukuda, Japan Pharmacogenomics Data Science Consortium (JPDSC)

“…The transcriptional repressor, TBX3, is proposed to suppress the development of working ventricular myocardium. Our findings suggest that genetic variation of Tbx3 is associated with LV mass in a healthy Japanese population.…”
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Expanding the Cycad Horticulture Toolbox: Air Layer Protocols for <i>Cycas</i> Stems by Thomas E. Marler, Gil N. Cruz

“…No air layer technique has been developed for cycad propagation, so the objective of this study was to develop a working protocol for adding this technique for cycad conservation. …”
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Genetic basis of a cognitive complexity metric. by Narelle K Hansell, Graeme S Halford, Glenda Andrews, David H K Shum, Sarah E Harris, Gail Davies, Sanja Franic, Andrea Christoforou, Brendan Zietsch, Jodie Painter, Sarah E Medland, Erik A Ehli, Gareth E Davies, Vidar M Steen, Astri J Lundervold, Ivar Reinvang, Grant W Montgomery, Thomas Espeseth, Hilleke E Hulshoff Pol, John M Starr, Nicholas G Martin, Stephanie Le Hellard, Dorret I Boomsma, Ian J Deary, Margaret J Wright

“…Using the classical twin model, we estimated the heritability of RC and genetic overlap with intelligence (IQ), reasoning, and working memory in a twin and sibling sample aged 15-29 years (N = 787). …”
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DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer by Benjamin B. Morris, Simon Heeke, Yuanxin Xi, Lixia Diao, Qi Wang, Pedro Rocha, Edurne Arriola, Myung Chang Lee, Darren R. Tyson, Kyle Concannon, Kavya Ramkumar, C. Allison Stewart, Robert J. Cardnell, Runsheng Wang, Vito Quaranta, Jing Wang, John V. Heymach, Barzin Y. Nabet, David S. Shames, Carl M. Gay, Lauren A. Byers

“…Hallmarks of these DDR clusters include differential expression of DNA repair genes, increased replication stress, and heightened G2/M cell cycle arrest. …”
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Developing a data-informed care planning improvement intervention in long-term care in Nova Scotia: protocol for an advisory-led interpretive qualitative study by Andrea Iaboni, Caitlin McArthur, John Hirdes, Olga Theou, Elaine Moody, Steve Iduye, Luke Turcotte, Lori E Weeks, Michael Kalu, Nazanin Nasiri, Parisa Ghanouni, Kathleen Norman, Samuel Searle, Linda Verlinden

“…Subsequently, we will have a 1 day advisory committee meeting to: (1) select the intervention components using the APEASE criteria, which asks whether the function is Affordable, Practicable, Effective, Acceptable, Safe, and promotes Equity; and (2) describe the final intervention using the Template for Intervention Description and Replication checklist to ensure the reproducibility of the intervention in future work. …”
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Legionella pneumophila type II secretome reveals a polysaccharide deacetylase that impacts intracellular infection, biofilm formation, and resistance to polymyxin- and serum-mediat... by Carlton O. Adams, Jackson A. Campbell, Beichang Zhang, Leanne Cleaver, Sarah B. Bier, Joshua Mayoral, Richard C. White, James A. Garnett, Nicholas P. Cianciotto

“…Upon examination of mutants of wild-type strain 130b that lack those exoproteins most conserved across the Legionella genus, we discovered that protein “06635” majorly promotes L. pneumophila replication within amoebae. Immunoblotting, proteomics, and whole-cell enzyme-linked immunosorbent assay (ELISA) confirmed that 06635 exists in culture supernatants and on the bacterial outer surface and does so in a T2SS-dependent manner. …”
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