Infection characteristics among Serratia marcescens capsule lineages by Mark T. Anderson, Stephanie D. Himpsl, Leandra G. Kingsley, Sara N. Smith, Michael A. Bachman, Harry L. T. Mobley

“…The capsule polysaccharide of S. marcescens is a bacteremia fitness determinant, and previous work defined capsule locus (KL) diversity within the species. …”
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Experimental Justification of Reprofiling of the Drug Maxar® for the Treatment of Viral Infections by T. S. Zaporozhets, N. V. Krylova, S. A. Fedoreyev, O. V. Iunikhina, A. B. Pott, D. V. Tarbeeva, N. P. Mishchenko, M. Yu. Shchelkanov

“…The advantages of repositioning are, among other things, in reducing the time and cost of some of the necessary stages of research.The aim of the work is to study the antiviral activity of the polyphenol complex (PPC) from Maackia amurensis, the active substance of the drug Maksar®, as well as to expand the field of medical application of the drug.Material and methods. …”
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Development of a complex palliative care intervention for patients with heart failure and their family carers: a theory of change approach by Bader Nael Remawi, Nancy Preston, Amy Gadoud

“…It outlined how the complex intervention could work and identified the active ingredients necessary for replication. …”
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Bridging big data in the ENIGMA consortium to combine non-equivalent cognitive measures by Eamonn Kennedy, Shashank Vadlamani, Hannah M. Lindsey, Pui-Wa Lei, Mary Jo-Pugh, Paul M. Thompson, David F. Tate, Frank G. Hillary, Emily L. Dennis, Elisabeth A. Wilde, for the ENIGMA Clinical Endpoints Working Group

“…Abstract Investigators in neuroscience have turned to Big Data to address replication and reliability issues by increasing sample size. …”
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Heterogeneity analysis provides evidence for a genetically homogeneous subtype of bipolar-disorder. by Caroline C McGrouther, Aaditya V Rangan, Arianna Di Florio, Jeremy A Elman, Nicholas J Schork, John Kelsoe, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium

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Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers. by Fanny Chereau, Yoann Madec, Caroline Sabin, Niels Obel, Ezequiel Ruiz-Mateos, Georgios Chrysos, Sarah Fidler, Clara Lehmann, Robert Zangerle, Linda Wittkop, Peter Reiss, Osamah Hamouda, Vicente Estrada Perez, Manuel Leal, Amanda Mocroft, Patricia Garcia De Olalla, Adriana Ammassari, Antonella D'Arminio Monforte, Cristina Mussini, Ferran Segura, Antonella Castagna, Matthias Cavassini, Sophie Grabar, Philippe Morlat, Stéphane De Wit, Olivier Lambotte, Laurence Meyer, HIV Controllers Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCOORD

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Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring by Yaswanthi Yanamadala, Chandra Mohan Reddy Muthumula, Kuppan Gokulan, Kumari Karn, Vicki Sutherland, Helen Cunny, Janine H. Santos, Sangeeta Khare

“…The antiretroviral (ARV) drug combination of abacavir sulfate, dolutegravir, and lamivudine [ABC/DTG/3TC; Tri combination Anti-retroviral therapy (TC-ART)] has revolutionized HIV treatment by effectively targeting different stages of viral replication. Despite its therapeutic efficiency for maintaining low viremia in the mother during pregnancy, there are concerns for long-term liabilities in offspring that are indirectly exposed during vulnerable periods of development. …”
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Proteomic characterization of Mycobacterium tuberculosis subjected to carbon starvation by Kaylyn L. Devlin, Damon T. Leach, Kelly G. Stratton, Gyanu Lamichhane, Vivian S. Lin, Kimberly E. Beatty

“…Mtb excels at surviving in the human host by entering a non-replicating, dormant state. The current work investigated the proteomic changes that Mtb undergoes in response to carbon starvation, a culture condition that models dormancy. …”
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A comparative evaluation of 23 projects on mental health and wellbeing for veterans and first responders by S. Lukersmith, C. Woods, L. Salvador-Carulla, T. Niyonsenga, I. Mohanty, M.R. Gutierrez-Colosia, D. Diaz-Milanes, C.R. Garcia-Alonso, C.J. Büsst

“…Background: Veterans and First Responders (VFR) are at risk of developing a range of mental health disorders because of cumulative exposure to critical incidents at work. Two Philanthropic organisations funded 15 organisations, which collectively implemented 23 highly heterogeneous and international early intervention mental ill-health and suicide prevention Projects. …”
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Descondensación de la heterocromatina en bovinos criollos portadores de la translocación Robertsoniana (rob1; 29). Acción del inductor 5-azacitidina-C Heterochromatin decondesation... by Rody Artigas, Wanda Iriarte, Leticia de Soto, Andrés Iriarte, Silvia Llambí, Miguel de Bethencourt, Alicia Postiglioni

“…The DNA hypometilation is found in the inactive X chromosome of late replication as it is incorporated during the last hours of cell culture. …”
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Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children by Yuyao Wang, Yuzhou Zhang, Haoyu Chen, Xiu Juan Zhang, Riping Zhang, Tsz Kin Ng, Jenson A. Tham, Ka Wai Kam, Pancy O. S. Tam, Alvin L. Young, Yingying Wei, Mingzhi Zhang, Chi Pui Pang, Clement C. Tham, Jason C. Yam, Li Jia Chen

“…Significant interaction between genetic risk scores (GRS) and near work on SE was also detected (βinteraction = 0.14, P interaction = 0.0003). …”
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Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors by Dominika Kołodziej-Sobczak, Łukasz Sobczak, Wojciech Płaziński, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Klaudia Hołub, Barbara Zdzisińska, Karol Jaroch, Barbara Bojko, Krzysztof Z. Łączkowski

“…Abstract This work presents a rational synthesis of 14 innovative methyl salicylate based thiazole (MSBT) derivatives, designed as protein tyrosine phosphatase 1B (PTP1B) inhibitors with potent anticancer activity. …”
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COVID-19 Pandemic as an Indicator of «Blank Spots» in Epidemiology and Infectious Pathology by M. V. Supotnitskiy

“…High transmissibility of SARS-CoV-2 is possible because: the binding energy of S1 protein of the virus with its receptor ACE2 is higher than that of viruses of closely related species; the virus penetrates into the endosomes of the cells more efficiently; because of the work of the replication-transcription complex, which counteracts the innate protective response of cells. …”
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Three-Dimensionally Printed Mini Air Scrubbing Cartridges Based on Nano-Graphite for Air Pollution Monitoring by Emiliano Zampetti, Mattia Ammiraglia, Marco Conti, Cassandra Montiroli, Paolo Papa, Daniele Bianconi, Antonella Macagnano

“…In the last decade, the advancements of 3D printing technology have pushed researchers to exploit, in different fields of applications, the advantages offered, such as rapid prototyping and low-cost replication of complex sample treatment devices. In this work, we present the fabrication and testing of 3D printed cartridges based on both commercial photopolymer and a modified version with the intrusion of nano graphite. …”
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Mapping HIV-1 RNA structure, homodimers, long-range interactions and persistent domains by HiCapR by Yan Zhang, Jingwan Han, Xie Dejian, Wenlong Shen, Ping Li, Jian You Lau, Jingyun Li, Lin Li, Grzegorz Kudla, Zhihu Zhao

“…These domains, enriched at homodimer interfaces, likely serve as structural scaffolds ensuring fidelity during genome packaging. This work establishes HiCapR as a robust tool for probing RNA interactomes and provides mechanistic insights into how HIV-1 exploits RNA topological heterogeneity to regulate its life cycle. …”
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Bidirectional Two-Sample Mendelian Randomization Study Reveals Causal Associations Between Aging and Endometriosis by Chen L, Yan H, Nie J

“…Limei Chen,1,* Han Yan,2,* Jichan Nie2 1Hysteroscoy Center, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, People’s Republic of China; 2Department of General Gynecology, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jichan Nie, Shanghai Obstetrics and Gynecology Hospital, Fudan University, 419 Fangxie Road, Shanghai, 200011, People’s Republic of China, Email niejichan@fudan.edu.cnBackground: Previous studies have suggested that aging may influence reproductive functions of female. …”
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Construction of novel pJRD215-derived plasmids using chloramphenicol acetyltransferase (cat) gene as a selection marker for Acidithiobacillus caldus. by Rui Wang, Chunmao Lin, Jianqiang Lin, Xin Pang, Xiangmei Liu, Chengjia Zhang, Jianqun Lin, Linxu Chen

“…Therefore, finding a new selection marker and constructing new plasmids have become an urgent and fundamental work for A. caldus.<h4>Results</h4>Effective inhibitory effect of chloramphenicol on the growth of A. caldus was elucidated for the first time. …”
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A Novel Framework for Saraiki Script Recognition Using Advanced Machine Learning Models (YOLOv8 and CNN) by Hafiz Muhammad Raza Ur Rehman, Syed Arfan Haider, Hiba Faisal, Kook-Yeol Yoo, M. Z. Jhandir, Gyu Sang Choi

“…By combining these two domains, machine learning has emerged as a potent instrument in linguistics, improving our capacity to comprehend semantics, analyze verbal patterns, and even simulate human-like replies. This work represents a major breakthrough in the use of machine learning models for the detection and replication of Saraiki handwritten text as Saraiki is one of the important language. …”
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Environmental risk factors for self-harm during imprisonment: A pilot prospective cohort study. by Thomas Stephenson, Imogen Harris, Charlotte Armstrong, Seena Fazel, Roxanna Short, Nigel Blackwood

“…Information concerning environmental factors, including staff numbers, cell placement and movements, and engagement in work and activities were collected from prison records. …”
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Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function by Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen

“…Acute small molecule perturbations of SWI/SNF altered the amount of both SWI/SNF and cohesin on chromatin, particularly affecting cohesin binding to CTCF sites. Conclusions This work represents the most comprehensive investigation of cohesin-interacting proteins to date. …”
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