The super repertoire of type IV effectors in the pangenome of Ehrlichia spp. provides insights into host-specificity and pathogenesis. by Christophe Noroy, Damien F Meyer

“…We also identified new protein domain combinations, suggesting novel effector functions. This work presenting the predicted effector collection of Ehrlichia spp. can serve as a guide for future functional characterisation of effectors and design of alternative control strategies against these bacteria.…”
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Enigmatic Entities of the Acellular World: Viruses, Viroids, and Virusoids by Sidhant Jain, Soumen Das

“…This work indicates the possibility that different viruses originated distinctly by utilizing different strategies and evolved further. …”
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Modulation of antiviral genes by African swine fever isolates of diverse virulence by Giulia Franzoni, Lorena Mura, Susanna Zinellu, Pedro J. Sanchez-Cordon, Miriam Pedrera, Silvia Dei Giudici

“…In this work, we investigated the expression of 84 antiviral genes in macrophages infected with the virulent strain 26544/OG10 or the attenuated strain NH/P68. …”
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Functionally-informed fine-mapping identifies genetic variants linking increased CHD1L expression and HIV restriction in monocytes by Riley H. Tough, Paul J. McLaren, The International Collaboration for the Genomics of HIV

“…Knockout of the closest gene, CHD1L, enhanced HIV replication in vitro in myeloid cells. However, it remains unclear if HIV spVL associated variants are associated with CHD1L gene expression changes. …”
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Genotypic and phylogeographic insights into a pre-epidemic variant of Wesselsbron virus detected in sylvatic Aedes mcintoshi from Semuliki Forest, Uganda by Georg Joachim Eibner, Selina Laura Graff, Christian Hieke, James Robert Ochieng, Anne Kopp, Christian Drosten, Julius Lutwama, Innocent Bidason Rwego, Sandra Junglen

“…The isolated virus was less infective and showed lower replication ability in vitro compared to an epidemic isolate from South Africa. …”
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Unveiling Wolbachia transcriptomic signature in the arboviral vector Aedes aegypti by Sebastián Mejías, Sebastián Mejías, Natalia E. Jiménez, Natalia E. Jiménez, Natalia E. Jiménez, Carlos Conca, Carlos Conca, J. Cristian Salgado, J. Cristian Salgado, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen, Ziomara P. Gerdtzen

“…Through analysis of previously published datasets, this work identifies promising molecular and functional targets for future studies aimed at elucidating the most fundamental mechanisms of the A. aegypti–Wolbachia symbiosis.…”
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A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity by Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, João Ferreira, Fernando Ferreira, Hovakim Zakaryan

“…The most promising antiviral compound (6b) reduced ASFV replication in a dose-dependent manner (IC50 = 19.5 μM) with no cellular (CC50 > 500 μM) and animal toxicity (up to 100 mg/kg). …”
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From the environment to the host: re-wiring of the transcriptome of Pseudomonas aeruginosa from 22°C to 37°C. by Mariette Barbier, F Heath Damron, Piotr Bielecki, María Suárez-Diez, Jacek Puchałka, Sebastian Albertí, Vitor Martins Dos Santos, Joanna B Goldberg

“…This suggests a distinct change in iron acquisition strategies when the bacterium switches from the external environment to the host. Our work identifies global changes in bacterial metabolism and nutrient acquisition induced by growth at different temperatures. …”
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Isolation and Characterization of a Lytic Phage PaTJ Against <i>Pseudomonas aeruginosa</i> by Jiayu Gu, Xinqiao Zhang, Tianlang Liu, Yunxue Guo

“…Furthermore, our findings demonstrated the PaTJ’s potential in degrading biofilms. This work sheds light on the multifaceted impact of this lytic phage PaTJ on <i>P. aeruginosa</i>, presenting potential applications in both gene expression modulation and biofilm management.…”
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Genome characterization through dichotomic classes: An analysis of the whole chromosome 1 of A. thaliana by Enrico Properzi, Simone Giannerini, Diego Luis Gonzalez, Rodolfo Rosa

“…Such informational content is independent from the global proportion of nucleotides of a sequence. The present work confirms that the recent mathematical model of the genetic code is a new paradigm for understanding the management and the organization of genetic information and is an innovative tool for investigating informational aspects of error detection/correction mechanisms acting at the level of DNA replication.…”
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In-cell NMR reveals the first direct observation of endogenous interaction between HIV Tat protein and Tat RNA aptamer in human cells by Omar Eladl

“…Complementary confocal microscopy validated nuclear co-localization, enabling functionally relevant interaction. This work shows the first direct, real-time evidence for native RNA–protein complex assembly in human cells. …”
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Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy. by Elizaveta Katorcha, Natallia Makarava, Young Jin Lee, Iris Lindberg, Mervyn J Monteiro, Gabor G Kovacs, Ilia V Baskakov

“…In the current study we examined whether prion replication can be induced by cross-seeding by α-synuclein or Aβ peptide. …”
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Self-talk as a mediator in the relationship between perfectionism and body image: a study of Polish women with overweight and obesity in the process of losing weight by Małgorzata M. Puchalska-Wasyl, Sylwia Kamionowska

“…Minimizing self-critical self-talk and replacing it with self-reinforcing self-talk may prove to be a promising path in therapeutic work to improve body image.…”
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The Effect of Medium Substitution on Cavendish Banana Shoot Multiplication (Musa acuminata L.) by Ageng Rineksane Innaka, Putri Pramesti Zahrani, Handayani Etty, Agustina Wulandari Rani, Kemat Nurashikin

“…Each treatment was replicated 3 times, with each replication comprising 3 samples, resulting in a total of 45 treatment units. …”
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Withstand control: standing posture differentially affects space-based and feature-based cognitive control through enhanced physiological arousal by Nuno Busch, Artyom Zinchenko, Martin Halle, Thomas Geyer

“…Abstract Can simply standing upright sharpen our minds? Whereas initial works proposed that standing posture reduces distractor interference in the Stroop task, subsequent replication attempts yielded mixed results. …”
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Identification of potential VP40 inhibitor of Marburg virus through molecular docking, pharmacokinetic analysis and molecular dynamics simulation by Rohit Das, Anil Bhattarai, Buddhiman Tamang, Nagendra Thakur

“…The binding interactions between MARV VP40, a protein essential to viral replication, and a commercial medication, estradiol benzoate, and a natural substance, procyanidin, were examined in this work. …”
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SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanisms by Seán I O’Donoghue, Andrea Schafferhans, Neblina Sikta, Christian Stolte, Sandeep Kaur, Bosco K Ho, Stuart Anderson, James B Procter, Christian Dallago, Nicola Bordin, Matt Adcock, Burkhard Rost

“…We integrated the coverage map into an accompanying online resource ( https://aquaria.ws/covid ) that can be used to find and explore models corresponding to the 79 structural states identified in this work. The resulting Aquaria‐COVID resource helps scientists use emerging structural data to understand the mechanisms underlying coronavirus infection and draws attention to the 31% of the viral proteome that remains structurally unknown or dark.…”
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Charge Diffusion and Repulsion in Semiconductor Detectors by Manuel Ballester, Jaromir Kaspar, Francesc Massanés, Alexander Hans Vija, Aggelos K. Katsaggelos

“…The present work evaluates these two approaches and proposes a novel Monte Carlo technique that offers higher accuracy in exchange for increased computational time. …”
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The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes. by Christine R Collins, Fiona Hackett, Jonathan Atid, Michele Ser Ying Tan, Michael J Blackman

“…Egress is protease-dependent and is temporally associated with extensive proteolytic modification of parasite proteins, including a family of papain-like proteins called SERA that are expressed in the parasite parasitophorous vacuole. Previous work has shown that the most abundant SERA, SERA5, plays an important but non-enzymatic role in asexual blood stages. …”
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Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes. by Sophie Garnier, Vinh Truong, Jessy Brocheton, Tanja Zeller, Maxime Rovital, Philipp S Wild, Andreas Ziegler, Cardiogenics Consortium, Thomas Munzel, Laurence Tiret, Stefan Blankenberg, Panos Deloukas, Jeannette Erdmann, Christian Hengstenberg, Nilesh J Samani, Heribert Schunkert, Willem H Ouwehand, Alison H Goodall, François Cambien, David-Alexandre Trégouët

“…As 24 of the 105 cis eQTL have previously been reported to be disease-associated loci, this work highlights the need for conducting haplotype-based and 1000 G imputed cis eQTL analysis before commencing functional studies at disease-associated loci.…”
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