A review on Iberian and Italian occurrences of Quaternary lions by Joan Madurell-Malapeira, Ibon Barrasa-Morondo, Saverio Bartolini-Lucenti, Maria Prat-Vericat, Ainara Badiola, Antonio Rodríguez-Hidalgo, Asier Gómez-Olivencia, Lorenzo Rook

“…Furthermore, these regions are key to understanding the replacement or substitution of cave lions by the extant lion species. …”
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Substituting photoautotrophic with heterotrophic Chlorella species for water quality regulation and microbial community modification in Litopenaeus vannamei pond culture by Chu-er Song, Zhen Meng, Bangyin Zhang, Lin Yang, Xiaoxuan Sun, Zheng Zhang, Xiaojin Song

“…The study aimed to assess the replacement of photoautotrophic cultivated Chlorella vulgaris with heterotrophic cultivated C. pyrenoidosa as the inoculated algal fluid for analyzing effluent nutrient removal and regulating bacterial community dynamics in Litopenaeus vannamei outdoor pond culture system. …”
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A Review on Biomechanics of Anterior Cruciate Ligament and Materials for Reconstruction by M. Marieswaran, Ishita Jain, Bhavuk Garg, Vijay Sharma, Dinesh Kalyanasundaram

“…Briefly, we also review mechanical characterization composition and anatomy of the anterior cruciate ligament as well as graft materials used for replacement/reconstruction surgeries. The key conclusions of this review are as follows: (a) the highest shear forces on the anterior cruciate ligament occur during hyperextension/low flexion angles of the knee joint; (b) the characterization of the anterior cruciate ligament at variable strain rates is critical to model a viscoelastic behavior; however, studies on human anterior cruciate ligament on variable strain rates are yet to be reported; (c) a significant disparity on maximum stress/strain pattern of the anterior cruciate ligament was observed in the earlier works; (d) nearly all synthetic grafts have been recalled from the market; and (e) bridge-enhanced repair developed by Murray is a promising technique for anterior cruciate ligament reconstruction, currently in clinical trials. …”
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Magnitude and Factors Associated With Risky Sexual Behaviours among Undergraduate Students in Selected Universities in Kigezi Sub Region by Amon, Bahati

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Secular trends of bloodstream infections in hemodialysis patients: insights from a longitudinal Swiss study by Nasreen Hassoun-Kheir, Niccolò Buetti, David Jaques, Valérie Olivier, Marie-Noelle Chraiti, Monique Perez, Marlieke EA de Kraker, Holly Jackson, Jacques Schrenzel, Patrick Saudan, Stephan Harbarth

“…This study aimed to evaluate secular trends, identify causative organisms, assess resistance patterns, and determine the sources of hemodialysis-associated BSIs at Geneva University Hospitals, where Staphylococcus aureus screening and decolonization of hemodialysis patients have been implemented since the year 2000. …”
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Clinical management and analysis of immune-related adverse events in neoadjuvant immunotherapy for locally advanced rectal cancer by AN Yang, WANG Chentong, QIU Xiaoyuan, ZHOU Jiaolin, LIN Guole

“…Descriptive statistics were used to summarize irAEs patterns and management approaches. Results: A total of 41 irAE episodes occurred among the 30 patients. …”
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In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis by H. Platzer, M. Wellbrock, G. Pourbozorg, R. Mayakrishnan, S. Gantz, B. Khamees, S. Maciej, B. Moradi

“…Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.…”
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Nursing Students' Perspectives on Integrating Artificial Intelligence Into Clinical Practice and Training: A Qualitative Descriptive Study by Moustaq Karim Khan Rony, Sumon Ahmad, Dipak Chandra Das, Sabren Mukta Tanha, Tuli Rani Deb, Mosammat Ruma Akter, Mst. Amena Khatun, Md Ibrahim Khalil, Umme Rabeya Peu, Mst. Rina Parvin, Daifallah M. Alrazeeni, Fazila Akter

“…Data were analyzed using thematic analysis to identify patterns and themes. Credibility was ensured through member checking, dependability via an audit trail, and confirmability through peer debriefing. …”
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Mechanistic in vitro–in vivo extrapolation (IVIVE) approach using a biomimetic in vitro system for the prediction of hepatic clearance by Seongwon Park, Sun-Sook Song, Woojin Jung, Hwi-yeol Yun, Soyoung Lee, Sun-Woong Kang, Jung-Woo Chae

“…This integrated strategy enhances IVIVE accuracy and supports the 3 R (replacement, reduction, and refinement) principle by reducing the reliance on animal testing. …”
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Distributed Hydrological Modeling With Physics‐Encoded Deep Learning: A General Framework and Its Application in the Amazon by Chao Wang, Shijie Jiang, Yi Zheng, Feng Han, Rohini Kumar, Oldrich Rakovec, Siqi Li

“…Trained simultaneously with streamflow observations and Gravity Recovery and Climate Experiment satellite data, the hybrid model yielded median Nash‐Sutcliffe efficiencies of 0.83 and 0.77 for dynamic and distributed simulations of streamflow and total water storage, respectively, 41% and 35% higher than those of the original HydroPy model. Replacing the original Penman‒Monteith formulation in HydroPy with a replacement NN produces more plausible potential evapotranspiration (PET) estimates, and unravels the spatial pattern of PET in this giant basin. …”
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‘Strawberry Star’ – A Spotted, Fancy-Leaved Caladium for Use in Containers and Landscapes by Zhanao Deng

“…It is similar to 'Marie Moir' in leaf color and coloration pattern but different from 'Marie Moir' in petiole color. …”
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‘Strawberry Star’ – A Spotted, Fancy-Leaved Caladium for Use in Containers and Landscapes by Zhanao Deng

“…It is similar to 'Marie Moir' in leaf color and coloration pattern but different from 'Marie Moir' in petiole color. …”
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Non-Targeted Metabolomics Reveals Tobacco Metabolites Associated with Roasted Tobacco Quality Under Organic Substitution by Feng Tian, Li Zhang, Lina Niu, Xinglong Fan, Yongliang Han, Yuanshang Liu, Jiancai Qian, Shihang Huang, Xixian Ou, Qiang Li

“…Results: The targeted metabolomic analysis identified 991 metabolites in the positive ion pattern and 673 in the negative ion pattern across all treatments. …”
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Mechanisms underlying differential helium enrichment in shale gas of varying structural styles in the southeastern Sichuan Basin by Zhiyuan XIN, Jianfa CHEN, Jie WANG, Yong MA

“…ObjectiveShale gas reservoirs hold considerable helium reserves despite relatively low helium abundance, establishing them as a critical replacement for helium production growth. The southeastern Sichuan Basin exhibits diverse structural styles with varying preservation conditions, leading to an unclear understanding of the distribution characteristics and enrichment patterns of helium in shale gas. …”
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[Translated article] ICHTHYOSIS: Clinical and Molecular Update. Part 2: Syndromic Ichthyosis. Diagnostic and Therapeutic Approach of Ichthyosis by C. Gutiérrez-Cerrajero, R. González-Sarmiento, Á. Hernández-Martín

“…While it will almost invariably involve facilitating desquamation and maintaining skin hydration using topical exfoliants and emollients, recently, replacement therapies aiming at substituting the proteins and lipids specifically altered in each patient are being developed and gene therapy approaches with the ultimate goal of curing the disease are being assessed. …”
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ICTIOSIS: Actualización clínica y molecular. Parte 2: ictiosis sindrómicas. Abordaje diagnóstico y terapéutico de las ictiosis by C. Gutiérrez-Cerrajero, R. González-Sarmiento, Á. Hernández-Martín

“…While it will almost invariably involve facilitating desquamation and maintaining skin hydration using topical exfoliants and emollients, recently, replacement therapies aiming at substituting the proteins and lipids specifically altered in each patient are being developed and gene therapy approaches with the ultimate goal of curing the disease are being assessed. …”
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Biomechanical stability and stress distribution before talus prosthesis design: effects of ligament removal and cartilage overlay thickness using finite element analysis by Gang Zeng, Yujun Sun, Min Liang, Wenzhou Liu, Yanbo Chen, Jionglin Wu, Jiayuan Zheng, Taolue Zhou, Huiying Zhao, Weidong Song, Yue Ding

“…Adjacent joint arthritis is the most common complication after total talar replacement (TTR). While intervention is rarely required, varying degrees of postoperative degenerative changes have been reported in surrounding joints. …”
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Introducing a new model of evolutionary rural housing design based on the principles of indigenous architecture in the Oramanat region by Sajad Mozafariyan, Ghazaleh Mohammadpour, Raha Hoseinpour, Saeed Shahriyan Varnousfaderani

“…Therefore, it is crucial and important, firstly, to document existing patterns, and then to design new patterns and modernize past ones. …”
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Altered actin centripetal retrograde flow in physically restricted immunological synapses. by Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves

“…In one experimental strategy, the APC is replaced with a synthetic supported membrane. An advantage of this configuration is that solid structures patterned onto the underlying substrate can guide immunological synapse assembly into altered patterns. …”
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Hydroxychloroquine-Induced Dilated Cardiomyopathy: A Case Report by Diana Otero, Marija Petrovic, Narayana Sarma V. Singam, Eyas M. Hattab, Alisya Solankhi, Naresh Solankhi

“…In patients undergoing renal replacement therapy, the daily dose should be lower than recommended by the manufacturer to avoid toxic effects.…”
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