Development of Real-Time Surveillance for Serious Adverse Events in a Pragmatic Clinical Trial Using National Registers in Finland by Nieminen TA, Palmu AA, Auvinen R, Kulathinal S, Auranen K, Syrjänen RK, Nieminen H, Mallett Moore T, Pepin S, Jokinen J

“…Tuomo A Nieminen,1,2 Arto A Palmu,1,3 Raija Auvinen,4 Sangita Kulathinal,2 Kari Auranen,5 Ritva K Syrjänen,1,6 Heta Nieminen,1,6 Tamala Mallett Moore,7 Stephanie Pepin,8 Jukka Jokinen1 1Data and Analytics, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; 2Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland; 3Management Team, FVR – Finnish Vaccine Research, Tampere, Finland; 4Internal Medicine, Helsinki University Hospital, Helsinki, Finland; 5Mathematics and Statistics and Clinical Medicine, University of Turku, Turku, Finland; 6RWE Unit, FVR – Finnish Vaccine Research, Tampere, Finland; 7Global Pharmacovigilance, Sanofi, Swiftwater, PA, USA; 8Global Clinical Development, Sanofi, Marcy-l’Étoile, FranceCorrespondence: Tuomo A Nieminen, Data and Analytics, Finnish Institute for Health and Welfare, Mannerheimintie 166, Helsinki, 00271, Finland, Tel +358 29  524 7534, Email tuomo.nieminen@thl.fiPurpose: We developed a hybrid safety surveillance approach for a large, pragmatic clinical trial of a high-dose quadrivalent influenza vaccine (QIV-HD), using both active and passive data collection methods. Here, we present the methods and results for the passive register-based surveillance of serious adverse events (SAEs), which replaced conventional SAE reporting during the trial.Patients and Methods: The trial recruited over 33,000 older adults of whom 50% received the QIV-HD while the rest received a standard-dose vaccine (QIV-SD) as a control vaccine. …”
Get full text

The case of professors in 1821 at St. Petersburg University: New interpretations by T.N. Zhukovskaya

“…In 1821, an attempt was made to replace the secular university with the clerical one, fully controlled from the outside, by the police department. …”
Get full text

6D Pose Estimation Algorithm Based on Improved YOLOv5 With Asymptotic Feature Pyramid Network and Attention Mechanism by Yan Zhang, Hanyu Ye

Get full text

Two electrical engineers, one problem, and evolution produced the same solution: A historical note by Louis Dell'Osso

“…Thus, two humans used their brains to: 1) determine how the human brain produced human saccades; and 2) invent a control-system method to produce fast and accurate chemical mixing. …”
Get full text

Role of individual and combined impact of simvastatin and α-TCP in rat calvarial bone defect: An experimental study by Surendar Sugumaran, Deepak Selvam, M.S. Nivedhitha, Karthik Ganesh Mohanraj, Bader O. Almutairi, Selvaraj Arokiyaraj, Ajay Guru, Jesu Arockiaraj

“…Aim: This study aims to compare a control group of standard critical bone defect models treated without any bone transplants to critical size calvarial bony defects treated with various bone replacements, including simvastatin and α-tricalcium phosphate, while analyzing the healing patterns. …”
Get full text

Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence by Jiajun Wei, Jinyu Wu, Hongyue Kong, Liuquan Jiang, Yong Wang, Ying Guo, Quan Feng, Jisheng Nie, Yiwei Shi, Xinri Zhang, Xiaomei Kong, Xiao Yu, Gaisheng Liu, Fan Yang, Jun Dong, Jin Yang

Get full text

Combination of Essential Oils and Extracts Enriched with Tocopherols in Diet of Holstein Steers and Its Effect on Ruminal Fermentation, Antioxidant and Anti-Inflammatory Response,... by João Gustavo Weschenfelder Wandscheer, Natalia Turcatto, Guilherme Luiz Deolindo, Mateus Henrique Signor, Alexandro Fritzen, Marcelo Vedovatto, Camila Ten Kathen Jung, Gilberto Vilmar Kozloski, Ana Carolina Hadlich Xavier, Roger Wagner, Bianca Fagan Bissacotti, Priscila Marquezan Copetti, Aleksandro Schafer da Silva

“…Background: This experiment evaluated whether the combination of essential oils (thyme, rosemary, orange) with extracts of <i>Cinnamomum</i> and <i>Quillaja saponaria</i> (enriched with tocopherols) in steers’ diet has positive effects on the health, digestibility, growth, oxidative stress, and fatty acid profile of meat. Methods: The experiment included 24 Holstein steers, divided into two groups, randomly divided (treated = phytogenic mixture (n = 12); control = monensin (n = 12)), undergoing a growth phase of 120 days and 90 days of finishing in individual pens, with a monthly collection of blood, rumen fluid, feces, and feed. …”
Get full text

Effect of thermal processing on the degradation of pesticides in a banana jam partially formulated with banana peel flour by Magnólia Carneiro de Oliveira, John Kelvyn de Oliveira, Joselito Brilhante Silva, Luana Guabiraba Mendes, Felipe Sousa da Silva, Mairlane da Silva Alencar, Crisiana de Andrade Nobre, Mayra Garcia Maia Costa, Micael de Andrade Lima, Maria Aparecida Liberato Milhome

“…Therefore, this study evaluated the effect of thermal processing on the degradation of the pesticides azoxystrobin, bifenthrin, difenoconazole, and simazine in samples of caramelized banana jam added of banana peel flour (4% w/w) in partial replacement of the fruit pulp. QuEChERS (quick, easy, cheap, effective, rugged, and safe) method and gas chromatography coupled to mass spectrometry (GC-MS) wa used to analyze the above compounds. …”
Get full text

BIONIC PROSTHESES - FEATURES, KINDS AND POSSIBILITIES by Nikola Sabev, Ivan Ralev

“…Materials/Methods: The social aspect and need for the use of bionic prostheses is discussed. …”
Get full text

Cost optimization on example of hotel-restaurant complex enterprises by Volkovska I.V.

“…It is established that cost optimization is the process of planning, accounting, analysis, cost control for searching and selecting of the most effective methods of managing of the conditions of limited resources. …”
Get full text

Synergistic Effects of Vermicompost and Biochar Amendments on Soil Fertility and Wheat Productivity in Bangladesh Floodplain Soils by Ahmed Khairul Hasan, Shams Shaila Islam, Marina Jahan, Sinthia Afsana Kheya, Md. Romij Uddin, Md. Shafiqul Islam, Thanet Khomphet

“…It may also promote more sustainable farming methods. This study evaluated the combined effects of biochar, vermicompost, and inorganic fertilizers on soil characteristics, growth, and yield in wheat. …”
Get full text

Use of Dispersible Fixed-Dose Combinations in Chemotherapy of Drug Susceptible Tuberculosis: Results of the Observational Study by E. S. Nikitina, O. S. Ilyina, O. D. Baronova

“…In Main Group, patients received the fixed-dose combination (isoniazid 150 mg, rifampicin 150 mg, pyrazinamide 375 mg), while in Control Group, patients were treated with the regimen consisting of single anti-tuberculosis drugs.Results. …”
Get full text

Effect of geographical directions, height and the color of yellow traps in capture of Mediterranean fruit fly, Ceratitis capitata (Wiedemann, 1824) in citrus orchards by Amir Hossein TOORANI, Habib ABBASIPOUR

“….: Tephritidae) is one of the most destructive agricultural pests in the world. To replace chemical control methods, as well as the timing of the peak population of Mediterranean fruit fly, the yellow sticky vertical traps were used in this study. …”
Get full text

Optimal Configuration of Intelligent Soft Switches in Active Distribution Networks Based on Locational Marginal Price by QIU Cheng, ZHAO Wanjian, LI Xincong, ZHANG Mingze, FEI Fei, PENG Haohua, ZHOU Jianqiao, SHI Gang, ZHANG Jianwen

“…During normal operation, SOPs can achieve real-time voltage regulation and tide control, provide fast fault isolation and power supply restoration, and improve the controllability of the distribution network. …”
Get full text

State Policy of Improving Medical Care for Newborns in Conditions of Medical Reform in Ukraine by Iryna Didenko, Tetyana Moroz, Lesya Prasol

“…The transition from measures that replace the quality control activities of already provided medical care to a quality management system will ensure continuous, targeted improvement of newborns' results, prognosis, and health indicators.…”
Get full text

The impact of graded levels of fermented plant protein (Proteger®) in extruded foods on fecal quality, nutrient digestibility, and colonic fermentation in beagle dogs by Youhan Chen, Charles Gregory Aldrich

“…The control diet without FPP contained 15% soybean meal (SBM); soybean meal was replaced by FPP at 5%, 10%, and 15% to create three diets with graded levels of FPP (5FPP, 10FPP, and 15FPP). …”
Get full text

CFR-YOLO: A Novel Cow Face Detection Network Based on YOLOv7 Improvement by Guohong Gao, Yuxin Ma, Jianping Wang, Zhiyu Li, Yan Wang, Haofan Bai

“…Traditional contact cattle identification methods are costly; are easy to lose and tamper with; and can lead to a series of security problems, such as untimely disease prevention and control, incorrect traceability of cattle products, and fraudulent insurance claims. …”
Get full text

Use of whole grain wheat-triticale flour for production bakery products by Roman Kh. Kandrokov, Sergey A. Katin, Aleksey O. Sivtsev, Dmitry N. Veremyev, Ekaterina V. Pestova

“…The purpose of the work is to develop technological solutions for the use of whole-ground wheat-triticale flour of various ratios in the production of bakery products. Methods. Using generally accepted physicochemical and organoleptic methods, we analyzed the objects of study - samples of whole-ground wheat-triticale flour of various ratios and bakery products made from them. …”
Get full text

Disease Burden and Associated Risk Factors of Early-Onset Lung Cancer in China and Worldwide by CAI Lin, ZHU Chenxin, YUAN Jiani, ZHANG Xinglong, FANG Yi, YANG Haiyan, GUO Lanwei

“…Policymakers should prioritize equitable resource allocation and targeted interventions, particularly in tobacco control and air pollution mitigation, to enhance cancer prevention and control efforts.…”
Get full text

Cardiomyocyte‐Specific Overexpression of Activated Yes‐Associated Protein Modified‐RNA Promotes Cardiomyocyte Proliferation and Myocardial Regeneration by Yongyu Wang, Yalin Wu, Yu Jiang, Huilan Tan, Bijay Guragain, Thanh Nguyen, Jianli Zhao, Yang Zhou, Yuji Nakada, Jianyi Zhang

“…Both cardiomyocyte proliferation and myocardial regeneration can be improved via the overexpression of a constitutively active variant of YAP5SA (Yes‐associated protein, 5SA [active] mutant), but persistent overexpression of proliferation‐inducing genes could lead to hypertrophy and arrhythmia, whereas off‐target expression in fibroblasts and macrophages could increase fibrosis and inflammation. Methods and Results Transient overexpression of YAP5SA or GFP (green fluorescent protein; control) was targeted to cardiomyocytes via our cardiomyocyte‐specific modified mRNA translation system (YAP5SACM‐SMRTs or GFPCM‐SMRTs, respectively). …”
Get full text