Efficacy and safety of HYYK formula for residual follicle revival in premature ovarian insufficiency: a multicenter, randomized, double-blind, placebo-controlled trial protocol by Yin Peng, Jian Liu, Yang Li, Guangning Nie, Fangping Cheng, Daning Feng, Qiaolin Du, Jian Huang, Hongyan Yang

“…This study aims to evaluate the efficacy and safety of the HYYK formula, a traditional Chinese medicine (TCM) approach, in enhancing residual follicle activity in POI patients. Methods This multicenter, randomized, double-blind, placebo-controlled trial will enroll 102 women with POI, who will be randomly assigned to receive either the HYYK formula or a placebo for 24 weeks. …”
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Radiological and clinical outcomes of combined wedge versus lateral closing wedge high tibial osteotomy for medial osteoarthritis of the knee: a randomized controlled trial by Maarten R. Huizinga, A. J. de Vries, T. M. van Raaij, R. W. Brouwer

“…Secondary, the anatomical changes and patient reported outcomes measurements (PROMS) after one year were assessed. Methods In a non-blinded mono-center randomized controlled trial, patients eligible for HTO were randomized to CW or LCW HTO. …”
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Interactive Computer-Adaptive Chronic Kidney Disease (I-C-CKD) Education for Hospitalized African American Patients: Protocol for a Randomized Controlled Trial by Akilah King, Tayo Omoniyi, Lindsay Zasadzinski, Cynthia Gaspard, Denesha Gorman, Milda Saunders

“…This includes 50 patients in the control group and 46 patients in the intervention group. …”
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Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor by Cédric Bruel, Christophe Guitton, Jean-Pierre Frat, Jeremy Bourenne, Guylaine Labro, Jean-Pierre Quenot, Gwenhaël Colin, Arnaud W Thille, Christophe Guervilly, Kada Klouche, Laurence Dangers, Jean Reignier, Agathe Delbove, Nicholas Sedillot, Jean-Paul Mira, Laurent Argaud, Martin Dres, Jérôme Roustan, Elsa Parot-Schinkel, Pierre Bailly, Pierre Asfar, Jean-Philippe Rigaud, Jean-Claude Lacherade, Grégoire Muller, Guillaume Geri, Jean-Baptiste Lascarrou, Julio Badie, Julien Maizel, Frédéric Martino, Gaetan Plantefeve, Francis Schneider, Alain Cariou, Xavier Wittebole, Denis Doyen, Bruno Francois, Pierre-Francois Dequin, Francois Barbier, Ferhat Meziani, David Schnell, Hamid Merdji, Jonathan Chelly, Olivier Lesieur, Caroline Sejourne, Wulfran Bougouin, Nicolas Pichon, Mehran Monchi, Charlotte Salmon Gandonniere, Saber Davide Barbar, Juliette Audibert, Sophie Jacquier, Julien Lorber, Marine Goudelin, Nicolas Chudeau, Nicolas Brechot, Thomas Klein, Eglantine Rouanet, Patrick Saulnier, Olivier Nigeon, Nicolas De Schryver, Fabien Jarousseau, Marine Paul, Benoît Painvin, Damien Du Cheyron, Antoine Marchalot, Tristan Morichau-Beauchant, Patrick Girardie, W Bougouin, Mathieu Jozwiak, Frédéric Foret, Djillali Annane F-CRIN, Asaël Berger PierreBulpa, Nicolas Barbarot, Nicolas Mongardon CédricDaubin, Asael Berge, Simon Bourcier, Guillaume Geri Jean-BaptisteLascarrou, Jean-Herle Raphalen, Florence Blossier, Fanny Bounes, William Buffières

“…The ongoing METAPHORE (mean arterial pressure after out-of-hospital cardiac arrest) trial aims to compare a standard MAP threshold (MAP ≥65 mm Hg) with a high MAP threshold (MAP ≥90 mm Hg) to evaluate whether implementing a higher MAP threshold can improve neurological outcomes in patients admitted to ICU after cardiac arrest.Methods and analysis METAPHORE is a randomised, controlled, multicentre, open-label trial with a blinded primary outcome assessor, comparing two parallel groups of patients 18 years of age or older, receiving invasive mechanical ventilation for coma defined by a Glasgow Coma Score ≤8/15 after out-of-hospital cardiac arrest and sustained ROSC. …”
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Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study by Gary Butler, Anders Juul, Judith L Ross, Jørgen Holm Petersen, Kurt Kristensen, Ann-Margrethe Rønholt Christensen, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Niels Birkebæk, Anders Jørgen Schou, Shanlee Davis, Sophie van Rijn, Lise Aksglaede

“…Secondary endpoints include changes in pubertal development and virilisation, growth and body proportions, bone mineralisation, muscle strength, lipid and glucose metabolism, systemic inflammation, methylation, fertility and effects on the cognitive and psychopathological features of KS.Methods and analysis The TIPY study is a multicentre, national, randomised, double-blind, placebo-controlled intervention study. …”
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Synergistic effect of particle packing method, aggregate saturation levels, and paste content in improving the performance of high volume fine recycled aggregate concrete by Namratha V. Khanapur, Bhavna Tripathi, Subhasis Pradhan, Tarush Chandra

“…Additionally, the treatment methods are not cost-effective. To address these limitations and upscale the use of FRCA, this study introduces the particle packing method (PPM) for mix proportioning, a modified presoaking method for concrete mixing, and presents the effect of aggregate saturation level and paste content on the performance of concrete. …”
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Antimicrobial usage assessment and the factors associated among small-scale household dairy farms in a district of southern India by Shwetha Prabhu, Rinila Das, Arun Kharate, Ajith M. Nayak, Navya Vyas

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THE AERODYNAMIC CHRACTERISTICS CALCULATION METHODOLOGY OF TWO-SHELL PARAGLIDERS by V. V. Ovchinnicov, Yu. V. Petrov

“…The aerodynamic characteristics data of TSP steady-state shapes allow to identify the regularities of their changes depending on parachute cutting shape, the deformations of its surface caused by the incoming flow or control actions. To solve the problem of gliding parachute stall, with a stream of air, the discrete vortex method with closed frameworks is used. …”
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Validation and implementation of whole-genome sequencing-based analytical methods for molecular surveillance and relatedness analysis of Mycobacterium tuberculosis complex isolates... by Diana Espadinha, Emma Roycroft, Peter R. Flanagan, Simone Mok, Eleanor McNamara, Thomas R. Rogers, Margaret M. Fitzgibbon

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Positioning Technology Without Ground Control Points for Spaceborne Synthetic Aperture Radar Images Using Rational Polynomial Coefficient Model Considering Atmospheric Delay by Doudou Hu, Chunquan Cheng, Shucheng Yang, Chengxi Hu

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Quadrature-Phase-Locked-Loop-Based Back-Electromotive Force Observer for Sensorless Brushless DC Motor Drive Control in Solar-Powered Electric Vehicles by Biswajit Saha, Aryadip Sen, Bhim Singh, Kumar Mahtani, José A. Sánchez-Fernández

“…A back-electromotive force (EMF) observer integrated with an enhanced quadrature-phase-locked-loop (QPLL) structure is proposed for accurate rotor position estimation, addressing limitations of existing control methods at low speeds and under dynamic conditions. …”
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Hybrid Efficient Fast Charging Strategy for WPT Systems: Memetic-Optimized Control with Pulsed/Multi-Stage Current Modes and Neural Network SOC Estimation by Marouane El Ancary, Abdellah Lassioui, Hassan El Fadil, Yassine El Asri, Anwar Hasni, Abdelhafid Yahya, Mohammed Chiheb

“…Simulations and experimental validation demonstrate faster charging compared to that using the conventional constant current–constant voltage (CC-CV) methods while effectively preserving the battery’s state of health (SOH)—a critical advantage that reduces the environmental impact of frequent battery replacements and minimizes the carbon footprint associated with raw material extraction and battery manufacturing. …”
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Impact of decreasing the proportion of higher energy foods and reducing portion sizes on food purchased in worksite cafeterias: A stepped-wedge randomised controlled trial. by James P Reynolds, Minna Ventsel, Daina Kosīte, Brier Rigby Dames, Laura Brocklebank, Sarah Masterton, Emily Pechey, Mark Pilling, Rachel Pechey, Gareth J Hollands, Theresa M Marteau

“…The current study aimed to estimate the effect of decreasing the proportion of higher energy (kcal) foods, with and without reducing portion size, on energy purchased in worksite cafeterias.<h4>Methods and findings</h4>This stepped-wedge randomised controlled trial (RCT) evaluated 2 interventions: (i) availability: replacing higher energy products with lower energy products; and (ii) size: reducing the portion size of higher energy products. …”
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The effects of instability core training on balance ability and paddling performance among young male Chinese flatwater sprint kayakers: a randomized controlled trial by Jianxin Gao, Zhigang Gong, Shamsulariffin Samsudin, Borhannudin Bin Abdullah, Roxana Dev Omar Dev

“…The study aimed to examine the impact of ICT performed on unstable surfaces (BOSU balls, Swiss balls, and Wobble boards) versus traditional core training (TCT) performed on stable surfaces (floor and bench) on balance ability and paddling performance among young male Chinese kayakers. Method A randomized controlled trial (RCT) recruited 63 eligible kayakers aged 16–19 years from the Nanchang Yao Lake kayaking training base in Jiangxi province, China. …”
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Effects of chronic low-frequency pulsed magnetic fields exposure on the contractility and morphology of biceps brachii in healthy adults–a randomized controlled, double-blind trial... by Zhongshan Li, Zhongshan Li, Wenhao Li, Shi Bai, Tieli Yang

“…BackgroundLow-frequency pulse magnetic fields (PEMF) has been proven by classic transient receptor potential channel 1 (TRPC 1) transcription activation peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) increase upstream of the mitochondria calcium - axis to increase muscle and mitochondria function, and recreates the consistent with exercise induced metabolic adaptations and power to ascend.MethodsEighty healthy subjects with a mean age of 20 years were recruited and randomly divided into a PEMF group receiving magnetic field stimulation and a control group receiving sham treatment, with 40 patients in each group. …”
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Efficacy of shared decision making in tobacco cessation among health facilities of Haryana, India – A double blinded, parallel group Randomized Controlled trial Protocol by Pranav Kshtriya, Sonu Goel, Abhishek Ghosh

“…Thus, the study will attempt to identify the efficacy of shared decision making in tobacco dependence treatment. Methods: 1) Design: a two-arm parallel group randomized controlled trial (RCT) 2) Setting: Three selected government health centers of Haryana, India. 3) Participants: 596 tobacco users aged ≥18 visiting the outpatient department/Tobacco cessation centers (TCC) of selected health centers. 4) Intervention and Comparator: The intervention group will receive shared decision process for prescribing pharmacotherapy (Nicotine replacement therapy, Bupropion) using specially designed decision aid based on three-talk model for tobacco cessation, while the control group will get standard care. 5) Measurements: Primary outcomes include urinary cotinine analysis for evaluating 7-day point prevalence abstinence. …”
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Altered co-expression patterns of synovial fluid proteins related to the immune system and extracellular matrix organization in late stage OA, compared to non-OA controls by Jenny Lönsjö, Martin Rydén, Aleksandra Turkiewicz, Velocity Hughes, Jon Tjörnstand, Patrik Önnerfjord, Martin Englund, Neserin Ali

“…ObjectiveSynovial fluid contains proteins that may have been released from surrounding tissues, our aim was to gain new insights into the proteomic profiles of human synovial fluid in knees with and without osteoarthritis (OA).MethodsWe used synovial fluid from 11 patients with end-stage medial compartment knee OA, aspirated during total knee replacement, and from 13 deceased donors who had no prior history of knee OA (healthy controls). …”
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Optimizing UAV performance with IoT and fuzzy linear fractional transportation models by Samaher Al-Janabi, Nawras G. Seyhood

“…Unmanned aerial vehicles (UAVs) have become indispensable in replacing human pilots for high-risk, high-intensity operations, including search-and-rescue missions, infrastructure inspection, and environmental monitoring. …”
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Randomised controlled trial comparing hydroxyapatite coated uncemented hemiarthroplasty with cemented hemiarthroplasty for the treatment of displaced intracapsular hip fractures: a... by Nicholas Parsons, Matthew L Costa, Juul Achten, Melina Dritsaki, Robin Gillmore Lerner, Alwin McGibbon, Miguel Antonio Fernandez, Katy Mironov, May E Png, Jenny Gould, Xavier Griffin

“…Controversy, therefore, remains about which type of hemiarthroplasty offers patients the best outcomes.This is the protocol for a multicentre randomised controlled trial comparing cemented hemiarthroplasty versus uncemented hemiarthroplasty for patients 60 years and over with a displaced intracapsular hip fracture.Methods and analysis Multicentre (a minimum of seven UK hospitals), multisurgeon, parallel group, two-arm, superiority, randomised controlled trial. …”
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Association between physical activity and executive function of Chinese adolescents aged 13–18 by Yuan Liu, Xiaojian Yin, Yi Sun, Feng Zhang, Feng Zhang, Cunjian Bi, Yaru Guo, Yaru Guo, Pengwei Sun, Pengwei Sun, Hong Jun, Hong Jun, Yanyan Hu, Yanyan Hu, He Liu, He Liu

“…Replacing 30 min of sedentary behaviour (SB) with MVPA was significantly shorter RTs in inhibitory control (P &lt; 0.05), 2back tasks (P &lt; 0.01), and cognitive flexibility (P &lt; 0.01). …”
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