OCCUPATIONAL HEALTH AND SAFETY (K3) RISK ANALYSIS USING HIRADC AND JSA METHODS IN BRIDGE REPLACEMENT PROJECTS by Risma Khoiri, Risma Dwi Admajayani, Trisno Widodo

“…The purpose of the research is to determine the type and level of risk in construction activities of the Bridge. Replacement Project, risk control and application of control methods in the field. …”
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Can Large-Language Models Replace Humans in Agile Effort Estimation? Lessons from a Controlled Experiment by Luka Pavlič, Vasilka Saklamaeva, Tina Beranič

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Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. by Theresa M Marteau, Paul Aveyard, Marcus R Munafò, A Toby Prevost, Gareth J Hollands, David Armstrong, Stephen Sutton, Chloe Hill, Elaine Johnstone, Ann Louise Kinmonth

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The Impact of Replacing Sugar in Sweets by Isomalt on Blood Glucose Management: Evidence from Recent Randomized, Controlled Trials by Lisa Schweitzer, Stephan Theis

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Nutrient Displacement Associated with Replacing Intake of Usual Snacks with Pecans: An Exploratory Analysis of a Randomized Controlled Trial by Tricia L Hart, Penny M Kris-Etherton, Kristina S Petersen

“…Objectives: This analysis aimed to investigate nutrient displacement and changes in food pattern component intake that occur with instructions to consume 57 g/d of pecans in place of usual snacks in adults at increased risk of cardiometabolic diseases after 6 wk and 12 wk. Methods: Data from a 12-wk randomized controlled trial were used for this exploratory analysis. …”
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Early Aortic Valve Replacement of Asymptomatic Severe Aortic Stenosis: A Meta‐Analysis of Randomized Controlled Trials by Qingchun Song, Ruilin Liu, Kai Yang, Xiaokang Tu, Haoyu Tan, Chengming Fan, Xiaoxiao Li

“…The appropriate timing of intervention for these patients remains controversial, and any decision requires careful assessment. Methods We searched PubMed, Web of Science, EMBASE, and Cochrane Library for randomized controlled trials comparing early aortic valve replacement with conservative management in asymptomatic patients with severe aortic stenosis until December 2024. …”
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Objective Sliding Mode Control for the Flotation Motor Replacement Process Based on a Stepwise Stochastic Configuration Network by Yunze Tang, Jinghui Qiao, Ningkang Xiong

“…This advancement offers a promising new method for the precise control of robotic systems in challenging environments.…”
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Author Correction: Establishing a universal IVRP method for quadrivalent HPV vaccines to replace in vivo potency tests by Jinpan Hu, Zijing Jia, Meng Wang, Lingling Nie, Wangjun Fu, Qingfeng Zhang, Haiyang Qin, Jianhui Nie, Xiaoyu Xu, Lingjie Xu, Fengze Wang, Yingping Chen, Bo Xing, Tao Li, Danfeng Li, Shaowei Li, Ningshao Xia, Xiangxi Wang, Weijin Huang

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Research on the Support-Free Replacement Method of Suspenders for Long-Span Self-Anchored Rail Special Suspension Bridges by Xiaogang Li, Minglin Zhou, Peng Ding, Ling Luo, Xiangsheng Huang, Xiang Li

“…When the train is fully loaded, the maximum increase of the cable force of the adjacent boom is 150 kN, the stress increment of the operating boom is far less than the design strength, the increase of the downtorsion of the main cable is only 2.22%, and the displacement of the stiffening beam is within the allowable range. The safety control index and real bridge test results show that the unsupported replacement method is feasible and safe in the replacement of the suspenders of long-span rail suspension bridges, which provides an important reference for related projects.…”
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Impact of an in-consult patient decision aid on decisional quality, involvement, and health outcome for patients with severe hip or knee osteoarthritis – a study protocol for a mul... by Trine Ahlmann Pedersen, Martin Lindberg-Larsen, Charlotte Myhre Jensen, Signe Timm, Karina Dahl Steffensen, Claus Varnum

“…Specifically, it investigates whether an in-consult patient decision aid (PtDA) enhances decisional quality, involvement, and health outcomes for patients with severe hip or knee OA. Methods This protocol outlines a pragmatic two-armed multicentre cluster-randomised controlled trial (C-RCT), chosen for its ability to assess the combined effect of shared decision-making (SDM) and a newly developed in-consult patient decision aid (PtDA) in routine clinical practice. …”
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Evaluation of the effect of testosterone replacement therapy with a transdermal testosterone on glycemic control in men with type 2 diabetes mellitus by R. V. Rozhivanov, M. O. Chernova, V. A. Ioutsi, G. A. Mel’nichenko, M. V. Shestakova, E. R. Rozhivanova, E. N. Andreeva, N. G. Mokrysheva

“…BACKGROUND: It is important to evaluate the effect of androgen replacement therapy on glycemic control.AIMS: Assessment of the effect of transdermal testosterone therapy on glycemic control in men with hypogonadism and T2DM.MATERIALS AND METHODS: The prospective, comparative study included 300 men aged 55[49;61] years: men receiving both glucose-lowering therapy (GLT) and transdermal testosterone; and patients receiving only GLT. …”
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Self-perception of health and quality of life in patients on renal replacement therapy undergoing hemodialysis: a case-control study by Diego José Gambin, Felipe Gomes Dallepiane, Leonardo Saraiva, Marciele Cristiane Spanenberg Führ, Fabiana Piovesan, Caroline Mirek, João Paulo De Carli, Micheline Sandini Trentin

“…METHODS: This study included two patient groups: 1) Case group with CKD (CGA) comprising 116 patients; 2) Control group without CKD (CGO) composed of 124 patients. …”
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Regional citrate anticoagulation for intermittent renal replacement therapy in critically ill patients: a retrospective case-control study by Tao Zhao, Jie Yang, Zhongyuan Liu, Qizhuang Jin, Tao Su

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Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial. by Jennifer S Walsh, Helen Marshall, Isabelle L Smith, Diana M Greenfield, Jayne Swain, Emma Best, James Ashton, Julia M Brown, Robert Huddart, Robert E Coleman, John A Snowden, Richard J Ross

“…We have undertaken a double-blind, placebo-controlled, 6-month trial of testosterone replacement in young male cancer survivors with borderline low testosterone (7-12 nmol/l).…”
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Optimization of substrate formulation for Hericium erinaceus by replacing wood by straw and their effect on enzyme activities by Zhu Lu, Zhu Lu, Lingyun Liu, Ziming Ren, Shuang Hu, Yue Wang, Shujuan Ji, Xu Wang, Zhongwei Du, Yanni Liu, Yang Yang, Yanshen Yu

“…The utilization of straw in the cultivation of edible fungi partially resolves the resource conflicts between mushroom cultivation and forest industry and also contributes to environmental protection.MethodsIn this study, based on the technology of replacing wood by grass, the straw formula for mycelial culture of Hericium erinaceus was optimized with Simplex-lattice method commonly used in mixture design. …”
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The Effectiveness of 1 g Intravenous Tranexamic Acid in Reducing Blood Loss in Total Hip and Knee Replacement Surgeries: A Double-blind Controlled Study in a Regional Hospital by Michael Ebiyon Ugbeye, Kehinde Adesola Alatishe, Sulaimon Olatunji Olanrewaju, Wakeel Olaide Lawal, Ine Prattson Adadevoh, Imeh James Akpan, Uche C. Nwose

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Target-controlled dialysis for antibiotics (TCD-ABx) by Alexander Dejaco, Christoph Dorn, Constantin Lier, Daniel Fleischmann, Alexander Kratzer, Katharina Habler, Michael Paal, Michael Gruber, Johanna Rosenberger, Martin G. Kees

“…To address this problem, we investigate a target-controlled dialysis by in vitro experiments — a novel technique in which drug is spiked into the dialysis solution to make use of the physicochemical properties of renal replacement therapy for solute transport, with the goal to reduce the risk of inadequate drug exposure. …”
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Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review) by L. A. Gaiderova, N. A. Alpatova, O. V. Golovinskaya, A. M. Guskov, E. K. Lipatova, M. N. Lavrova

“…Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement). …”
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Perioperative metformin use in patients undergoing total joint replacement surgery: protocol for a randomised, placebo-controlled pilot study by Aidan Morrell, Steven Shelofsky, Hannah Hoffman, Cole McCallister, Thomas W Huff, Kathryn L Schabel, Avital Y O’Glasser, Ryland P Kagan

“…Although correction of hyperglycaemia has been shown to improve patient outcomes, there is a lack of consensus regarding optimal perioperative glucose management after total joint replacement surgery. This pilot study aims to assess the feasibility of performing a multicentre randomised controlled trial to investigate the effect of perioperative metformin use on glycaemic control in the setting of total joint arthroplasty.Methods and analysis This blinded, placebo-controlled, pilot randomised controlled trial will enrol 40 participants aged 18–99 years undergoing total hip or knee arthroplasty at a single academic tertiary centre. …”
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Evaluation of the SAMe-TT2R2 score to predict the quality of anticoagulation control in patients after mitral valve replacement by Yilin Li, Yang Gao, Qiuming Hu, Xu Meng, Shubin Li

“…BackgroundThis study aimed to evaluate the role of the SAMe-TT2R2 score in the prediction of anticoagulation control after mechanical mitral valve replacement.Methods and resultsWe retrospectively reviewed clinical data of 160 patients who received mechanical mitral valve replacement at Beijing Anzhen Hospital from January to December 2013. …”
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