Effect of microstructure differences on the thermal and mechanical behaviors of porous cementitious composites using phase change materials by Md Suman Mia, Satya Medepalli, Yuya Takahashi, Koichi Tsuchiya, Tetsuya Ishida

“…Two series of specimens were prepared by using two distinct mixing methods. One involved gentle mixing at a low energy, whereas the other used a high-speed mixer. …”
Get full text

Trajectory-based analysis of early mechanical ventilation PEEP levels and physiological parameter trajectories in ARDS patients and their association with the occurrence of gastroi... by Shi-Tao Huang, Kai-Hua Yu, Xiong-Bin Ma, Yi-Bo Sun, Zhong-Ya Huang, Di Chen, Hong-Lei Li, Li-Ping Liu

“…Aspirin use, heparin therapy, renal replacement therapy, and APACHE II score were identified as independent factors for GI events. …”
Get full text

Impact of codon optimization on vip3Aa11 gene expression and insecticidal efficacy in maize by Shengyan Li, Ning Wen, Wenjie Lv, Wenjie Lv, Mingjun Zhang, Yinxiao Wang, Zhihong Lang, Zhihong Lang

“…The vip3Aa11 gene from Bacillus thuringiensis is a promising candidate for controlling Spodoptera frugiperda.Methods and resultsTo develop insect-resistant maize, we designed two codon-optimized vip3Aa11 variants (vip3Aa11-m1 and vip3Aa11-m2) based on maize codon usage bias. …”
Get full text

Risk Factors for MAFLD and Advanced Liver Fibrosis in Adult-Onset Craniopharyngioma Patients: A Cross-Sectional Study by Chen L, Wu W, Ye H

“…Strategies such as controlling weight gain, maintaining optimal blood glucose and blood pressure levels, appropriate hormone replacement, and avoiding excessive glucocorticoid use should be implemented to prevent and delay the onset and progression of MAFLD and ALF.Keywords: craniopharyngioma, adult-onset, hypopituitarism, metabolic dysfunction-associated fatty liver disease, advanced liver fibrosis…”
Get full text

Utilizing PROSE as a Drug Delivery Device for Preservative-Free Cyclosporine 0.05% for the Treatment of Dry Eye Disease: A Pilot Study by Nakhla MN, Patel R, Crowley E, Li Y, Peiris TB, Brocks D

“…Monica Nabil Nakhla,1 Ria Patel,1 Estelle Crowley,2 Yichen Li,3 Thelge Buddika Peiris,3 Daniel Brocks2 1Tufts University School of Medicine, Boston, MA, USA; 2Department of Ophthalmology, BostonSight, Needham, MA, USA; 3Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA, USACorrespondence: Daniel Brocks, Department of Ophthalmology, BostonSight, Needham, MA, USA, Tel +1 781 726 7337, Fax +1 781 726 7310, Email dbrocks@bostonsight.orgPurpose: To evaluate the tolerability of utilizing Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) as a drug delivery device for preservative-free cyclosporine 0.05% for the treatment of dry eye disease.Patients and Methods: Fourteen current daily PROSE wearers were enrolled, with four screen failures and one subject that did not complete the study protocol due to burning and stinging. …”
Get full text

Effects of exogenous β-glucanase on ileal digesta soluble β-glucan molecular weight, digestive tract characteristics, and performance of coccidiosis vaccinated broiler chickens fed... by Namalika D Karunaratne, Rex W Newkirk, Nancy P Ames, Andrew G Van Kessel, Michael R Bedford, Henry L Classen

“…<h4>Materials and methods</h4>Broilers were fed hulless barley (HB) based diets with BGase (Econase GT 200P from AB Vista; 0 and 0.1%) and medication (Bacitracin and Salinomycin Na; with and without) arranged as a 2 × 2 factorial. …”
Get full text

Successful eradication of acquired factor VIII inhibitors with rituximab: a report of two cases by Ma'in Abumuhfouz, Anas Al-sadi, Awni Alshurafa, Israa Jawarneh, Ruba Y. Taha, Sarah A. Elkourashy

“…Given its potential benefits, further randomized controlled trials are warranted to evaluate rituximab's role as a first-line treatment. …”
Get full text

Retinoblastoma Morphology after Local Chemotherapy by S. V. Saakyan, I. P. Khoroshilova-Maslova, S. S. Tadevosyan, A. Yu. Tsygankov, G. P. Zakharova, O. A. Ivanova, O. G. Panteleeva, A. A. Zharua

“…Determine the nature of tumor regression and possible complications associated with the retinotoxic effect of melphalan and carboplatin with local chemotherapy.Methods. A histological analysis of 19 enucleated eyes from 19 patients with retinoblastoma was performed after combined organ-preserving treatment, including systemic chemotherapy and local chemotherapy in various doses. …”
Get full text

Is It Time to Revisit the Role of Interleukin-1 Inhibitors in Osteoarthritis? by Brom M, Saxer F, Mindeholm L, Schieker M, Conaghan PG

“…Interleukin-1 (IL-1) plays a key role in the development of OA, but the results of clinical trials targeting IL-1 in OA have to date been disappointing.Methods: This narrative review is based on a literature search for publications describing interventions with direct Il-1 pathway inhibitors in patients with knee OA and substantiated by a description of key pre-clinical observations.Results: Randomized controlled studies using IL-1 inhibition as treatment approach to knee OA have read out negatively, although trends for an improvement in pain and impact on biomarkers could be observed. …”
Get full text

Humoral response to mRNA vaccines against SARS-CoV-2 in patients with humoral immunodeficiency disease. by Michaela Bitzenhofer, Franziska Suter-Riniker, Matthias B Moor, Daniel Sidler, Michael P Horn, Anna Gschwend, Cornelia Staehelin, Andri Rauch, Arthur Helbling, Lukas Jörg

“…The aim of this study was to evaluate the humoral immune response after two vaccine doses with BNT162b2 or mRNA-1273 in patients with humoral immunodeficiency disease.<h4>Methods</h4>This cross-sectional study assessed 39 individuals with hypogammaglobulinemia under immunoglobulin replacement therapy. …”
Get full text

Research on Underwater Acoustic Target Recognition Based on a 3D Fusion Feature Joint Neural Network by Weiting Xu, Xingcheng Han, Yingliang Zhao, Liming Wang, Caiqin Jia, Siqi Feng, Junxuan Han, Li Zhang

Get full text

VULVAR AND VAGINAL GRAFT VERSUS HOST DISEASE IN A PATIENT WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION by Esra Pirinççi, M. Orhan Ayyıldız, Abdullah Karakuş, Reyhan Gündüz

“…In addition, studies have shown that hormone replacement therapy is used for the prophylaxis of this condition does not effects development rate of vulvo vaginal GVHD (11). …”
Get full text

Lipid abnormality correction by integrase inhibitor among children taking ARt by A. V. Samarina, N. S. Dyldina, E. K. Fertikh, E. B. Yastrebova, I. A. Abramova, D. A. Gusev

“…Time horizon of observation and laboratory control after boosted PI switch was 24 months. Results. …”
Get full text

Research progress and thinking on specialized drilling technology in underground coal mine by Jianlin LIU, Fei LIU, Quanxin LI, Jun FANG, Guiqin LIU, Siyi WANG, Zhiwei CHU, Jianguo ZHAO, Weifeng YANG

“…The typical application scenarios of specialized drilling technology are summarized, such as precise gas control in soft-fragmented coal seam, replacing tunnel with borehole for relieved gas drainage in roof, mine water detection and release, and grouting reinforcement of water-resisting layer.It delves into the key technical challenges encountered during implementation.Focusing on drilling equipment upgrade, innovative drilling method, and drilling parameter optimization, the study comprehensively reviews the current development status, critical technological advancements, and practical outcomes.The specialized drilling technology suitable for soft-fragmented coal seam, hard rock strata, and fractured and water sensitive strata are outlined, and the existing technical bottlenecks and challenges are identified.Given the evolving trends of diversified demand, equipment intelligence, and region-specific adaptation in underground specialized drilling technology, future research priorities are proposed: ① To enhance air directional drilling technology for soft-fragmented coal seam to improve formation adaptability and process compatibility. ② To advance high-efficiency drilling acceleration technology and tool for hard rock strata to boost rock-breaking efficiency and service life of impact drilling tool. ③ To overcome theoretical and technical barrier in pressure-controlled drilling under near-horizontal condition to strengthen borehole formation capability in fractured and water-sensitive strata of roof or floor. ④ To accelerate the improvement of the reliability and stability of intelligent drilling technology and equipment in underground coal mine, and promote the realization of the transformation of specialized drilling technology from equipment intelligence to engineering intelligence. ⑤ To research and constructe specialized drilling technology system of regional, mining area and mine, and promote their wide application and in-depth development in the coal mining industry.The study can provide an important reference for the technological innovation and efficiency improvement of drilling process in underground coal mine.…”
Get full text

OMB-YOLO-tiny: A Lightweight Detection Model for Damaged <i>Pleurotus ostreatus</i> Based on Enhanced YOLOv8n by Lei Shi, Zhuo Bai, Xiangmeng Yin, Zhanchen Wei, Haohai You, Shilin Liu, Fude Wang, Xuexi Qi, Helong Yu, Chunguang Bi, Ruiqing Ji

“…These results validate its efficacy and practical applicability in agricultural quality control systems.…”
Get full text

Computer case-based reasoning simulation versus traditional lectures for medical interns teaching of diagnosis and antibiotic prescribing for acute respiratory infection: a compara... by Fatemeh Rangraz Jeddi, Mansooreh Momen-Heravi, Razieh Farrahi, Ehsan Nabovati, Hossein Akbari, Maryam Edalati khodabandeh

“…The samples were selected using a convenience method and assigned to the intervention and control groups using a permuted block randomization approach. …”
Get full text

Nutritional Enhancement of Crackers Through the Incorporation of By-Products from the Frozen Pumpkin Industry by Miguel A. Gallardo, M. Esther Martínez-Navarro, Irene García Panadero, José E. Pardo, Manuel Álvarez-Ortí

“…Crackers were prepared by replacing 10% and 20% of wheat flour with pumpkin flour, assessing the effects based on drying method. …”
Get full text

Clinical utility and safety of finerenone in patients with heart failure: Rationale and design of FINE registry by Gonzalo Luis Alonso Salinas, Amaia Martínez León, Diego Aguiar Cano, Alberto Esteban‐Fernández, José María Viéitez Flórez, Susana delPrado Díaz, Juan Górriz‐Magaña, Gregorio deLara Delgado, Rafael González‐Manzanares, Pedro Caravaca‐Pérez, Francisco J. Pastor‐Pérez, Sandra Valdivieso‐Moré, Juan Quiles, Inés Ponz, Vanessa Escolar, Edison Omar Boada Lincango, Néstor Báez‐Ferrer, Gonzalo Gallego, Luis Almenar, Luis Gutiérrez de la Varga, Pau Codina, Alejandro Recio Mayoral, Aleix Fort, María Jesús Pinilla Lozano, David González‐Calle, Inés Gómez‐Otero, Cristina Salazar Mosteiro, Marta Cobo, Jesús Piqueras‐Flores, Clara Bonanad, Ana Huerta, Maria Ferré Vallverdú, Pablo Díez‐Villanueva

“…We aim to assess both the baseline clinical profile and prognostic role of finerenone in patients with HF, irrespective of ejection fraction. Methods and results The study is a multicentre, observational registry, including regional and tertiary hospitals. …”
Get full text

Diesel Engine Urea Injection Optimization Based on the Crested Porcupine Optimizer and Genetic Algorithm by Xu Chen, Changhai Ma, Quanli Dou, Shuzhan Bai, Ke Sun, Zhenguo Li

“…The optimized urea injection volume maximizes the NOx conversion efficiency of the SCR system while controlling the NH₃ slip within 10 ppm. In addition, based on this method, the urea injection pulse spectrum under full operating conditions was obtained, and the optimized urea injection amount can effectively reduce the NOx accumulation of the WHTC cycle by about 7.5%, as shown through bench testing.…”
Get full text

Variability in fennel fruit essential oil, fixed oil and their compositions under organic and inorganic fertilizers by Gulsum Yaldiz, Mahmut Camlica

“…The objective of our study was to compare the fixed and essential oil composition of fennel in organic and conventional farming systems to find out the impact of organic farming system. Method: In this study, different doses of vermicompost and sheep manures (10, 15, 20 t/ha) and ammonium sulphate (40, 80, 120 kg/ha) were applied by sowing and compared to a control group (no manure). …”
Get full text