Prevention Of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) trial: protocol for a randomised controlled trial by Robert Clarke, Emma J Crosbie, Basil G Issa, John Belcher, Helen Clarke, Anthony Howell, Michelle Harvie, Hannah Harrison, Cheryl Lombardelli, Suzanne Krizak, Katharine Sellers, Yit Y Lim, Caroline Parkin, Shruthi Patel, Anthony J Maxwell, Julie Wisely, Sacha J Howell

“…This study aims to examine the cellular and molecular changes in breast and endometrial tissue in high-risk women following TDR-induced weight loss, as well as longer-term adherence to a 12-month TDR weight loss intervention.Methods and analysis PROBE-TDR (PRevention Of Breast and Endometrial cancer using Total Diet Replacement) is a prospective, non-blinded, randomised controlled trial of 47 women at increased risk of breast and/or endometrial cancer. …”
Get full text

The effect of prehabilitation for older patients awaiting total hip replacement. A randomized controlled trial with long-term follow up by Odd-Einar Svinøy, Jakob Vangen Nordbø, Are Hugo Pripp, May Arna Risberg, Astrid Bergland, Pål Oliver Borgen, Gunvor Hilde

“…Methods In a two-armed randomized controlled trial we recruited 98 participants aged 70 years or older with a Harris Hip Score less than 60 awaiting elective primary total hip replacement. …”
Get full text

Preliminary application of the Sharesource connect data collection and analysis system in the management of continuous renal replacement therapy in the intensive care unit by Wensan Wu, Jianli Wang, Chen Chen, Junqi Feng, Shuyi Zhang, An Shi, Jing Zhang, Xinyi He, Jiangchen Peng, Mingli Zhu

“…Abstract Background This study investigated the application of software-based data monitoring for quality control (QC) in continuous renal replacement therapy (CRRT) management. …”
Get full text

Epidemic Outbreak of Catheter-Associated Bloodstream Infections among Patients Receiving Renal Replacement Therapy by D. V. Kvashnina, O. V. Kovalishena, O. M. Sutyrina, I. V. Solov’yeva, I. V. Belova, A. G. Tochilina, I. Yu. Shirokova

Get full text

Effectiveness of Tranexamic Acid to Prevent Blood Loss in Patients Undergoing Hip Arthroplasty: A Randomised Controlled Study by Arun Karthik Ravichandran, Rajavel Kalirajan, Gowthaman NaNambiraj, Sabari Vaasan Lakshmi Kanthan, Madhan Raju, Tathagath Tiwary, Saravanan Ravi, Aravindhan Krishnasamy Yuvaraj

“…Aim: To evaluate the effects of TXA in patients undergoing hip arthroplasty to prevent blood loss. Materials and Methods: The present prospective, double-blinded, randomised controlled study was conducted in in the Department of Orthopaedics, SRM Medical College Hospital and Research Institute (a tertiary care facility), Chengalpattu, Tamil Nadu, India, between August 2023 and January 2024. …”
Get full text

The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients by A. A. Turkina, M. V. Maevskaya, M. S. Zharkova, V. T. Ivashkin

Get full text

A prospective randomized placebo-controlled study evaluating the safety and benefits of tranexamic acid injections for primary unilateral total knee replacement by Prashant Bhavani, Suhas Aradhya Bhikshavarthi Math, Mainak Roy, Mulagondla Harshavardhan Reddy, Deepanjan Das, Priyanshu

Get full text

Nanosurgery and Bioengineered Regenerative Protocols for the Treatment of Hip Osteoarthritis: A Double-Blind Randomized Controlled Trial as an Alternative to Surgical Hip Replaceme... by Cezary Wasilczyk, Bartosz Wasilczyk

Get full text

Efficacy of virtual reality-based rehabilitation following total knee replacement: a systematic review and meta-analysis of randomized control trials by Afaf A. M. Shaheen, Maha F. Algabbani, Manar M. Alshahrani, Fatimah A. Z. Alshahrani, Hana I. Alsobayel, Mohammed Taher Ahmed Omar, Abdulrahman M. Alsubiheen

“…Abstract Objective To determine whether VR-based rehabilitation (VRBR) reduced pain and improved balance, proprioception, joint function, gait speed, and health-related quality of life (HRQOL) following Total knee replacement (TKR). Methods The Cochrane, MEDLINE/PubMed, Google Scholar, and the Physiotherapy Evidence Database (PEDro) were searched. …”
Get full text

Analysis of factors associated with the initiation of renal replacement therapy in patients on veno-arterial extracorporeal membrane oxygenation: a case–control study by Michel Perez-Garzon, Ana Castillo-Castillo, Maria Ferro-Peñuela, Claudia Poveda-Henao, Mario Mercado-Diaz, Henry Robayo-Amortegui

“…Methods A retrospective case–control study that included patients who received VA-ECMO and were admitted to the intensive care unit between 2019 and 2023. …”
Get full text

High-dose glucocorticoid treatment vs. glucocorticoid replacement in immune checkpoint inhibitor associated hypophysitis (CORTICI): an open, randomised controlled trial by Verena Theiler-Schwetz, Christian Trummer, Lisa Schmitt, Angelika Terbuch, Barbara Obermayer-Pietsch, Erika Richtig, Stefan Pilz

“…This is the first randomised study to evaluate whether hormonal recovery differs in patients treated with high-dose glucocorticoids versus glucocorticoid replacement therapy.Design/Methods In this single-centre, open, randomised controlled study, patients with ICI associated hypophysitis were randomised 1:1 to high-dose glucocorticoid treatment (1 mg/kg of prednisolone for two weeks, followed by tapering until week 7 and a switch to hydrocortisone 20 mg total daily dose in week 8) or glucocorticoid replacement therapy (hydrocortisone 20 mg total daily dose) over 8 weeks. …”
Get full text

Analysis of results to optimize anticoagulant therapy in patients who underwent mechanical heart valve replacement: a pilot singlecenter controlled study by S. A. Uranova-Tkachenko, A. V. Bogachev-Prokophiev, R. M. Sharifulin, Y. M. Smirnov, A. N. Pivkin, A. S. Zalesov, D. A. Astapov

Get full text

MODEL OF ADAPTIVE VECTOR CONTROL OF STOCHASTIC HYBRID CACHING ALGORITHM by Alexander I. Zhukov

“…The chosen investigative techniques and the performed methods structure are ch aracterized. The comparison r esults of the obtained replacement strat e gies productivity on the non - stationary routes composed of the quasi stationary sections o b tained on the base of 20/80 Zipf’s distribution law are presented.…”
Get full text

Randomized Control Trial Comparing Effects of Tourniquets on Neurology and Functional Outcomes after Total Knee Arthoplasty by Gur-Aziz Singh Sidhu, Saphalya Pattnaik, Mothana Gawad, Rafia Ghani, Harjot Kaur, Neil Ashwood

Get full text

Influence of levothyroxine replacement on metabolic dysfunction-associated steatotic liver disease and dyslipidemia in subclinical hypothyroidism: insights from a randomized contro... by Zainab Gaber Mahran, Salma Mokhtar Osman, Amira Abdelmawgod, Nahed A. Makhlouf, Elham Ahmed Hassan, Ehab F. Moustafa

“…Methods In a randomized, controlled study, 230 patients with MASLD were screened for SCH, and 182 were diagnosed with SCH. …”
Get full text

To replace or not to replace the aortic valve during Type A Aortic Dissection surgery: early and mid-term results by Muhammet Selim Yaşar, Emre Külahcıoğlu, Şeref Alp Küçüker

“…Although it was not statistically significant, the false lumen patency rate was higher and the survival time was lower in the valve replaced group. In the postoperative controls, moderate-to-severe aortic regurgitation was not seen in any of the patients who had preoperative moderate-to-severe aortic regurgitation in the not valve replaced group and there was no sinus valsalva aneurysm in any patient.ConclusionWhen the intraoperative and postoperative results in our study were evaluated, it was concluded that the not valve replaced was superior to the valve replaced procedures for TYPE A AORTIC DISSECTION patients.…”
Get full text

Development of In Vitro Potency Methods to Replace In Vivo Tests for Enterovirus 71 Inactivated Vaccine (Human Diploid Cell-Based/Vero Cell-Based) by Xuanxuan Zhang, Li Yi, Dan Yu, Jun Li, Xintian Li, Xing Wu, Fan Gao, Qian He, Wenhui Wang, Kaiwen Wang, Zejun Wang, Zhengling Liu, Yadong Li, Yong Zhao, Huiyi Li, Xiao Ma, Qingbing Zheng, Longfa Xu, Tong Cheng, Rui Zhu, Jing Guo, Jing Li, Qunying Mao, Zhenglun Liang

“…To align with 3R (Replacement, Reduction, Refinement) principles and enhance quality control, this study referred to WHO guidelines and the European Pharmacopoeia to develop in vitro relative potency (IVRP) methods. …”
Get full text

Minimizing the eccentricity between the centers of mass and stiffness of structures with the optimality criterion method in the structural design process by Reza Akbari, Payam Gholbeigi

Get full text

Improvements in the randomness and security of digital currency using the photon sponge hash function through Maiorana–McFarland S-box replacement by Mohammed Asmaa A., Rahma Abdul Monem S., AbdulWahab Hala Bahjat

Get full text

A Controller for Delta Parallel Robot Based on Hedge Algebras Method by Thanh-Lam Bui, Thanh-Hung Nguyen, Xuan-Thuan Nguyen

“…This technique is easily applied to existing devices in the process control domain. In the proposed control method, the semantically quantitative mapping may replace the verbal values of the fundamental rule in an analogous manner (SQM). …”
Get full text