Analyzing Racial Differences in Imaging Joint Replacement Registries Using Generative Artificial Intelligence: Advancing Orthopaedic Data Equity by Bardia Khosravi, MD, MPH, MHPE, Pouria Rouzrokh, MD, MPH, MHPE, Bradley J. Erickson, MD, PhD, Hillary W. Garner, MD, Doris E. Wenger, MD, Michael J. Taunton, MD, Cody C. Wyles, MD

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Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women by Qisijing Liu, Yi Guo, Bo Peng, Dancai Fan, Jing Wu, Jin Wang, Ruican Wang, Jing-Min Liu, Jian Wu, Shuo Wang, Yanrong Zhao

“…Traditional weight loss methods often struggle with adherence due to restrictive diets and metabolic adaptations. …”
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Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis by Peng Xue, Yan Wang, Jie Yang, Yukun Li

“…Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. …”
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Is peri-operative steroid replacement therapy necessary for the pituitary adenomas treated with surgery? A systematic review and meta analysis. by Mamatemin Tohti, Junyang Li, Yuan Zhou, Yuebing Hu, Zhuang Yu, Chiyuan Ma

“…<h4>Methods</h4>We searched studies addressing peri-operative steroids coverage for pituitary adenomas in the Web of Science, Medline and the Cochrane Library. …”
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Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation by Marie Julien, Cédric Rafat, Loïc Raffray, Henri Vacher-Coponat, Nicolas Allou, Jérôme Allyn, Julien Jabot, Yannis Lombardi

“…Abstract Background Anecdotal evidence suggests that early renal replacement therapy (RRT) may improve the mortality associated with acute kidney injury (AKI) in patients with leptospirosis. …”
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Surgical and transcatheter aortic valve replacement align survival with general population expectations: insights from standardized mortality ratios by Marin Boute, Marin Boute, David De Azevedo, David De Azevedo, Christophe de Terwangne, Christophe de Terwangne, Anne-Catherine Pouleur, Anne-Catherine Pouleur, Agnès Pasquet, Agnès Pasquet, Bernhard L. Gerber, Bernhard L. Gerber, Laurent de Kerchove, Laurent de Kerchove, Christophe Beauloye, Christophe Beauloye, Christophe Beauloye, Joëlle Kefer, Joëlle Kefer, Frédéric Maes, Frédéric Maes, Sophie Pierard, Sophie Pierard, Sophie Pierard, David Vancraeynest, David Vancraeynest

“…BackgroundComparative long-term survival outcomes between transcatheter (TAVR) and surgical (SAVR) aortic valve replacement remain debated. While randomized controlled trials support TAVR's non-inferiority, real-world data indicate the opposite. …”
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Valve-in-valve transcatheter aortic valve replacement (TAVR) leads to lower device success compared to TAVR in native stenosis by Michael Paukovitsch, Bartu Dilaver, Dominik Felbel, Marvin Krohn-Grimberghe, Dominik Buckert, Johannes Moerike, Leonhard Moritz Schneider, Christian Liewald, Wolfgang Rottbauer, Birgid Gonska

“…BackgroundDespite the lack of randomized-controlled trials in patients with failed bioprosthetic valves, valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) is increasingly used.MethodsOutcomes of consecutive patients treated with ViV-TAVR (N = 100) at our tertiary heart center between 2014 and 2022 were compared to TAVR (N = 2216) in native valves.ResultsPatients median age was 78.5 years (IQR 70.0–84.0) in ViV-TAVR compared to 81.0 (IQR 77.0–85.0) in patients with native aortic stenosis (p &lt; 0.01) with a similar percentage of females in both groups (42% vs. 49.3%, p = 0.18). …”
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Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…This meta-analysis evaluates the outcomes of TAVI in younger, low-risk patients, in whom SAVR is currently the gold standard.MethodsFollowing PRISMA guidelines, we systematically searched randomized controlled trials (RCTs) comparing TAVI with SAVR in younger (mean age &lt;75 years) low-risk patients (STS score &lt;4%) with severe AS. …”
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Variations in bone mineral density after joint replacement: A systematic review examining different anatomical regions, fixation techniques and implant design by Domenico Alesi, Raffaele Zinno, Maria Scoppolini Massini, Giuseppe Barone, Davide Valente, Erika Pinelli, Stefano Zaffagnini, Agostino Igor Mirulla, Laura Bragonzoni

“…Methods Database search was conducted on MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL for studies analyzing bone remodelling after joint replacement (March 2002–January 2024). …”
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Evaluating long-term outcomes and the impact of small aortic annulus on valve replacement—a novel systematic review and meta-analysis comparing surgery vs. transcatheter interventi... by Aamir Amin, Cara Mohammed, Sten Kajitani, Khalid AlMashari, Rajanikant Kumar, Alifa Sabir, Paulina Briz-Echeverria, Shiva Mokhtassi, Shashi Kumar Kallikere Lakshmana, Ahmed Bokhari, Muhammad Ehsan, Hasan Ahmad, Raheel Ahmed, Toufan Bahrami

“…SAVR in aortic stenosis patients, as well as their respective impact on patients with small aortic annulus (SAA).MethodsMEDLINE, Embase, Cochrane Library, and ClinicalTrials.gov were searched for randomized controlled trials (RCTs) and comparative observational studies on TAVI vs. …”
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COMPARATIVE STUDY BETWEEN ATK 1a WITH CONSTRICTED POLYETHYLENE VERSUS POSTERO-STABILIZED by Fabiana Alves Costa Menegassi, Guilherme Blois Vasconcelos Pereira, Gabriel Alves Freitas, Rodrigo Balieiro, Sandra Tie Nishibe Minamoto, Alan de Paula Mozella, Rodrigo Sattamini Pires e Albuquerque

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Comparative Analysis of Multidisciplinary Complementary Intervention Versus Routine Physiotherapy Rehabilitation to Reduce Kinesiophobia in Patients with Knee Osteoarthritis Underg... by Hung Tzu-Han, Liu Mei-Chun, Kuo Ya-Wen, Lee Jiann-Der

“…The aim of this systematic review was to compare the effectiveness of multidisciplinary care intervention with that of conventional physical therapy in mitigating kinesiophobia in patients with knee osteoarthritis undergoing joint replacement. Methods This study was registered with the International Prospective Register of Systematic Reviews (registration no. …”
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The Effect of Serish Root Gum (Eremurus luteus) as Fat Replacer on Rheological, Physical and Sensory Properties of Low Fat Ice Cream by Fatemeh Sabzmeidani, Masoud Taghizadeh, Mohammad Saleh Hemati Hasan Poor

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Generalizability of motor modules across walking-based and in-place tasks – a distribution-based analysis on total knee replacement patients by Mahziyar Darvishi, Sajjad Daroudi, Shahabedin Tavasoli, Ali Shafiezadeh, Farzam Farahmand

“…It was concluded that there are shared motor modules across walking-based and in-place tasks in TKR individuals, with their generalizability and representability depending upon the analysis method. This finding highlights the importance of the analysis method in identifying the shared motor modules, as the main building blocks of motor control.…”
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Effect of volume replacement during combined experimental hemorrhagic shock and traumatic brain injury in prostanoids, brain pathology and pupil status by Fernando Campos Gomes Pinto, Matheus Fernandes de Oliveira, Ricardo Prist, Maurício Rocha e Silva, Luiz Fernando Ferraz da Silva, Antonio Capone Neto

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Effect of graft sizing in valve-sparing aortic root replacement for bicuspid aortic valve: The Goldilocks ratioCentral MessagePerspective by Perry S. Choi, MD, Amit Sharir, BA, Yoshikazu Ono, MD, Masafumi Shibata, MD, Alexander D. Kaiser, PhD, Yuanjia Zhu, MD, PhD, Alison L. Marsden, PhD, Y. Joseph Woo, MD, Michael R. Ma, MD, Joon Bum Kim, MD, PhD

“…Objective: To investigate the effect of graft sizing on valve performance in valve-sparing aortic root replacement for bicuspid aortic valve. Methods: In addition to a diseased control model, 3 representative groups—free-edge length to aortic/graft diameter (FELAD) ratio <1.3, 1.5 to 1.64, and >1.7—were replicated in explanted porcine aortic roots (n = 3) using straight grafts sized respective to the native free-edge length. …”
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Manual Dilution of Continuous Renal Replacement Therapy Fluids in Anuric Patients with Severe Hyponatremia: A Case Report and Systematic Review by Mark V. Koning, Lassima Reijnen, Femy Kemperman, Eugenie Schipper-Reintjes

“…Manual dilution of the fluids during continuous renal replacement therapy (CRRT) is a method that can lead to a controlled correction of sodium. …”
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Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model by Chunxiao Tang, Yuanheng Li, Xinxian Fan, Jiamei Guo, Yifeng Lin, Yifan Gao, Lin Yang

“…This study evaluates TNFR efficacy in restoring denervated muscle function across different postoperative intervals in a rat model. Methods Thirty Sprague–Dawley rats (220–250 g) were divided into five equal groups (n = 6 per group): control (no transection), denervated (transection without repair), immediate TNFR after median nerve transection, 2-week delayed TNFR, and 4-week delayed TNFR. …”
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The effect of hormone replacement therapy on cervical cancer risk in perimenopausal women: a systematic review and meta-analysis of observational studies by Yingna Zhou, Jie Wei, Youqin Ruan

“…BackgroundHormone replacement therapy (HRT) alleviates menopausal symptoms in perimenopausal women and help improve their quality of life, but its increased risk of cervical cancer (CC) remains to be evaluated.MethodsA system review and meta-analysis was conducted to retrieve literature related to HRT and CC risk by searching Pubmed, Embase, Science Direct, Web of Science, and Google Scholar databases. …”
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Single-nucleus RNA sequencing reveals the specific molecular signatures of myeloid cells responding to brain injury after microglial replacement by Xiao-Yi Xiong, Xiao-Yi Xiong, Xiao-Yi Xiong, Haicheng Yuan, Ying Mu, Yi He, Fang Xie, Xiao-Shuang Feng, Jia-Xin Xie, Xin-Ru Pan, Yu-Fei Wang, Jian Gong, Xiaoming Zheng, Peng-Fei Wang

“…Then, a single-nucleus transcriptomic analysis of acutely injured brains in aged mice with microglial replacement was performed.ResultsWe observed similarities but strong divergence in the composition and molecular change features of myeloid cells between the replacement (Rep) and control (Con) groups, indicating retention of the core transcriptome and development of differential genes in myeloid cells after microglial replacement in response to brain injury. …”
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