ENHANCE-D: protocol for a pragmatic, 3-arm, randomised controlled trial comparing the impact of enhanced smoking cessation interventions to very brief advice for adult smokers in d... by Richard Holliday, Nina Wilson, Vicky Ryan, Chrissie Butcher, Tara Homer, Philippa Watts, Dorcas Kareithi, Paul Blaylock, Laura Ternent, Roland Finch, Susan M. Bissett, Adam Todd, Helen Hancock, Fiona Ellwood, David I. Conway, Nicholas S. Jakubovics, Ralf Kist, Richard D. Holmes, Linda Bauld, Philip M. Preshaw, Elaine McColl

“…A large definitive trial is needed to confirm whether this would lead to improved smoking quit rates, improved oral health, and be good value for money. Methods The ENHANCE-D trial is a multi-centre, pragmatic, definitive, 3-arm, parallel group, individually randomised controlled superiority trial, including an internal pilot, conducted in NHS dental settings. …”
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Effect of continuous renal replacement therapy on micro-inflammatory state and renal function in patients with severe acute renal failure by XUE Mang

“…Objective To investigate the effect of continuous renal replacement therapy on micro inflammatory state and renal function in patients with severe acute renal failure.Methods Eighty-four cases of severe acute renal failure were treated in our hospital from November 2014 to November 2016,and randomly divided into two groups:the observation group receiving continuous renal replacement therapy,and the control group given intermittent hemodialysis treatment.The curative effectiveness of the two groups was compared after treatment.The levels of inflammatory factors such as IL-6,IL-8,hs-CRP,TNF-αand SCr,CCr,BUN,CHE and other renal function indexes were observed and compared.APACHE II score and complications were observed.Results After treatment,the total effective rate in the observation group was significantly higher than that in the control group(92.86% vs. 76.19%,P<0.05).After treatment,the levels of IL-6,IL-8,hs-CRP and TNF-αin the two groups were significantly lower than those before the treatment,and those in the observation group were significantly lower than in the control group(P<0.05).The SCr and BUN levels after treatment in the two groups were significantly lower,and Ccr and CHE levels were significantly higher than those before treatment,more significantly in the observation group(P<0.05).There were no significant differences in APACHE II scores between the observation group and the control group before treatment(P>0.05).After treatment,APACHE II scores in the observation group were lowerthan those in the control group(14.83±3.84 vs.22.73±6.97,P<0.05).The common adverse reactions were hypotension and arrhythmia.The incidence of hypotension and arrhythmia in the observation group was significantly lower than that in the control group(4.76% vs. 14.29%,and 2.38% vs. 11.90%,P<0.05).Conclusions Continuous renal replacement therapy in patients with severe acute renal failure can significantly improve the state of micro inflammation and renal function,and control complications,and the curative effectiveness is remarkable.…”
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Clinical Efficacy of Continuous Renal Replacement Therapy in Patients with Pulmonary Tuberculosis Complicated with Sepsis: A Retrospective Observational Study by Chen X, Lin X, Cheng F, Zheng S, Zhang Q, Wu T, Shi J

“…Xin Chen, Xiaoqing Lin, Fang Cheng, Shilin Zheng, Qiang Zhang, Te Wu, Jichan Shi Department of Infectious Disease, Wenzhou Central Hospital, Dingli Clinical College of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jichan Shi, Department of Infectious Disease, Wenzhou Central Hospital, Dingli Clinical College of Wenzhou Medical University, No. 252 Baili East Road, Lucheng District, Wenzhou City, Zhejiang Province, 325000, People’s Republic of China, Tel +86 0577 88882121, Email shijichan1822@163.comObjective: To explore the clinical efficacy of continuous renal replacement therapy (CRRT) in patients with pulmonary tuberculosis (TB) complicated with sepsis, particularly focusing on 28-day mortality (primary objective), and to assess the impact of CRRT on inflammatory response, renal function, haemodynamics and overall prognosis (secondary objectives).Methods: A total of 98 patients with pulmonary TB complicated by sepsis were included: 49 patients were enrolled in the control group and received routine treatment, whereas 49 patients were enrolled in the CRRT group and received CRRT based on the control group. …”
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Externalized transapical guidewire technique after artificial aortic valve replacement during complete endovascular aortic arch repair by Tomasz Jędrzejczak, Paweł Rynio, Maciej Lewandowski, Arkadiusz Kazimierczak

“…This report contains technical notes regarding a new method of steering the guidewire from the apex inside the artificial aortic valve during total endovascular aortic arch repair after AVR and the details crucial in preparation for this mini-invasive procedure. …”
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Advancing Heart Valve Replacement: Risk Mitigation of Decellularized Pulmonary Valve Preparation for Its Implementation in Public Tissue Banks by Rodríguez Martínez JI, Castells-Sala C, Piteira AR, Montagner G, Trojan D, Martinez-Legazpi P, Acosta Ocampo A, Fernández-Santos ME, Bermejo J, Jashari R, Pérez ML, Agustí E, Tabera J, Vilarrodona A

“…The present study aims to document the work performed for the safe implementation in public tissue banks of a new decellularization method for human pulmonary heart valves, based on previous risk evaluation.Methods: After assessing new preparation method associated risks, using EuroGTP-II methodologies, an extensive array of in vitro studies were defined to validate the new technique, mitigate the risks and provide quality and safety data.Results: Initial evaluation of risks using EuroGTP II tool, showed Final Risk Score of 23 (high risk), and four studies were devised to mitigate identified risks: (i) tissue structure integrity; (ii) cell content; (iii) microbiological safety; and (iv) cytotoxicity evaluation in final tissue preparation. …”
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Efficacies of continuous renal replacement therapy for severe patients with chronic renal failure and the influencing factors of long-term prognosis by Ma Qin-qin, Zhou Ying, Zhang Yan-nan, Chen Chen, Yu Ying-hua, Li Tian-min

“…ObjectiveTo explore the clinical efficacy of continuous renal replacement therapy （CRRT） for severe patients with chronic renal failure （CRF） and examine the influencing factors of long-term prognosis.MethodsFrom September 2018 to April 2021， 160 hospitalized severe CRF patients were selected as research subjects. …”
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Clinical application of plasma exchange combined with early continuous renal replacement therapy in patients with multiple injuries and high myoglobinemia by REN Hongbing, ZHANG Yuansong, ZHU Haoran

“…Methods‍　‍A non-randomized controlled study was conducted on 60 patients with severe polytrauma and myoglobinemia hospitalized in our department from January 2021 to December 2024. …”
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Pain intensity and stress indicators after cemented total knee replacement with epidural application of morphine: prospective randomized study by S. V. Sokolov, V. A. Glushchenko

“…The objective to perform the objective assessment of the intensity of pain syndrome after cemented total knee replacement with epidural analgesia with 0.2% ropivacaine solution and epidural analgesia with a combination of 0.2% ropivacaine solution with morphine was performed.Materials and methods. …”
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Effectiveness of stretching and bracing for the treatment of osteoarthritis-associated joint contractures prior to joint replacement: a systematic review protocol by Vivian A Welch, T Mark Campbell, Bahareh Bahram Ghaedi, Elizabeth Tanjong Ghogomu, Marie Westby

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Metabolic Effects of Testosterone Replacement Therapy in Patients with Type 2 Diabetes Mellitus or Metabolic Syndrome: A Meta-Analysis by Shu-ying Li, Ya-ling Zhao, Yu-fan Yang, Xi Wang, Min Nie, Xue-yan Wu, Jiang-feng Mao

“…A meta-analysis has been conducted to evaluate the effects of TRT on cardiovascular metabolic factors. Methods. We conducted a systemic search on PubMed, Embase, Cochrane Library, Wanfang, and CNKI and selected randomized controlled trials (RCTs) to include. …”
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Therapeutic validity and effectiveness of preoperative exercise on functional recovery after joint replacement: a systematic review and meta-analysis. by Thomas J Hoogeboom, Ellen Oosting, Johanna E Vriezekolk, Cindy Veenhof, Petra C Siemonsma, Rob A de Bie, Cornelia H M van den Ende, Nico L U van Meeteren

“…<h4>Methods</h4>(Quasi) randomised clinical trials on preoperative therapeutic exercise in adults awaiting TJR on postoperative recovery of functioning within three months after surgery were identified through database and reference screening. …”
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Analyzing Racial Differences in Imaging Joint Replacement Registries Using Generative Artificial Intelligence: Advancing Orthopaedic Data Equity by Bardia Khosravi, MD, MPH, MHPE, Pouria Rouzrokh, MD, MPH, MHPE, Bradley J. Erickson, MD, PhD, Hillary W. Garner, MD, Doris E. Wenger, MD, Michael J. Taunton, MD, Cody C. Wyles, MD

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Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women by Qisijing Liu, Yi Guo, Bo Peng, Dancai Fan, Jing Wu, Jin Wang, Ruican Wang, Jing-Min Liu, Jian Wu, Shuo Wang, Yanrong Zhao

“…Traditional weight loss methods often struggle with adherence due to restrictive diets and metabolic adaptations. …”
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Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis by Peng Xue, Yan Wang, Jie Yang, Yukun Li

“…Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone deficient adults. …”
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Is peri-operative steroid replacement therapy necessary for the pituitary adenomas treated with surgery? A systematic review and meta analysis. by Mamatemin Tohti, Junyang Li, Yuan Zhou, Yuebing Hu, Zhuang Yu, Chiyuan Ma

“…<h4>Methods</h4>We searched studies addressing peri-operative steroids coverage for pituitary adenomas in the Web of Science, Medline and the Cochrane Library. …”
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Immediate or delayed initiation of renal replacement therapy in patients with leptospirosis and acute kidney injury: a target trial emulation by Marie Julien, Cédric Rafat, Loïc Raffray, Henri Vacher-Coponat, Nicolas Allou, Jérôme Allyn, Julien Jabot, Yannis Lombardi

“…Abstract Background Anecdotal evidence suggests that early renal replacement therapy (RRT) may improve the mortality associated with acute kidney injury (AKI) in patients with leptospirosis. …”
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Valve-in-valve transcatheter aortic valve replacement (TAVR) leads to lower device success compared to TAVR in native stenosis by Michael Paukovitsch, Bartu Dilaver, Dominik Felbel, Marvin Krohn-Grimberghe, Dominik Buckert, Johannes Moerike, Leonhard Moritz Schneider, Christian Liewald, Wolfgang Rottbauer, Birgid Gonska

“…BackgroundDespite the lack of randomized-controlled trials in patients with failed bioprosthetic valves, valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) is increasingly used.MethodsOutcomes of consecutive patients treated with ViV-TAVR (N = 100) at our tertiary heart center between 2014 and 2022 were compared to TAVR (N = 2216) in native valves.ResultsPatients median age was 78.5 years (IQR 70.0–84.0) in ViV-TAVR compared to 81.0 (IQR 77.0–85.0) in patients with native aortic stenosis (p &lt; 0.01) with a similar percentage of females in both groups (42% vs. 49.3%, p = 0.18). …”
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Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…This meta-analysis evaluates the outcomes of TAVI in younger, low-risk patients, in whom SAVR is currently the gold standard.MethodsFollowing PRISMA guidelines, we systematically searched randomized controlled trials (RCTs) comparing TAVI with SAVR in younger (mean age &lt;75 years) low-risk patients (STS score &lt;4%) with severe AS. …”
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Surgical and transcatheter aortic valve replacement align survival with general population expectations: insights from standardized mortality ratios by Marin Boute, Marin Boute, David De Azevedo, David De Azevedo, Christophe de Terwangne, Christophe de Terwangne, Anne-Catherine Pouleur, Anne-Catherine Pouleur, Agnès Pasquet, Agnès Pasquet, Bernhard L. Gerber, Bernhard L. Gerber, Laurent de Kerchove, Laurent de Kerchove, Christophe Beauloye, Christophe Beauloye, Christophe Beauloye, Joëlle Kefer, Joëlle Kefer, Frédéric Maes, Frédéric Maes, Sophie Pierard, Sophie Pierard, Sophie Pierard, David Vancraeynest, David Vancraeynest

“…BackgroundComparative long-term survival outcomes between transcatheter (TAVR) and surgical (SAVR) aortic valve replacement remain debated. While randomized controlled trials support TAVR's non-inferiority, real-world data indicate the opposite. …”
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Variations in bone mineral density after joint replacement: A systematic review examining different anatomical regions, fixation techniques and implant design by Domenico Alesi, Raffaele Zinno, Maria Scoppolini Massini, Giuseppe Barone, Davide Valente, Erika Pinelli, Stefano Zaffagnini, Agostino Igor Mirulla, Laura Bragonzoni

“…Methods Database search was conducted on MEDLINE, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL for studies analyzing bone remodelling after joint replacement (March 2002–January 2024). …”
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