A maChine and deep Learning Approach to predict pulmoNary hyperteNsIon in newbornS with congenital diaphragmatic Hernia (CLANNISH): Protocol for a retrospective study. by Ilaria Amodeo, Giorgio De Nunzio, Genny Raffaeli, Irene Borzani, Alice Griggio, Luana Conte, Francesco Macchini, Valentina Condò, Nicola Persico, Isabella Fabietti, Stefano Ghirardello, Maria Pierro, Benedetta Tafuri, Giuseppe Como, Donato Cascio, Mariarosa Colnaghi, Fabio Mosca, Giacomo Cavallaro

“…Our findings will be validated in a future prospective multicenter cohort study.<h4>Registration</h4>The study was registered at ClinicalTrials.gov with the identifier NCT04609163.…”
Get full text

A Systematic Review Exploring Empirical Pharmacogenomics Research Within Global Indigenous Populations by Bushra Farah Nasir, Ritwika Vinayagam, Luciana Massi, Shivashankar H. Nagaraj, Maree Toombs, Kym M. Rae

“…It presents several important considerations from Indigenous participants, identifying how researchers can co‐create culturally safe and inclusive design, implementation, analysis, and subsequent outcomes of genomics research involving Indigenous people. …”
Get full text

Engaging pregnant individuals and healthcare professionals in an international mixed methods study to develop a core outcome set for studies on placenta accreta spectrum disorder (... by Janet A Parsons, Rohan D’Souza, John C Kingdom, Jon F R Barrett, Susan E O’Rinn

“…We will aim to publish the study findings in an international peer-reviewed OBGYN journal.Registration details COMET Core Outcome Set Registration: https://www.comet-initiative.org/Studies/Details/1127.PROSPERO registration number CRD42020173426.…”
Get full text

Pressure bag irrigation vs manual pressure and gravity drainage for reducing patient discomfort during flexible cystoscopy, A Study protocol for a randomised double blinded control... by David Armany, Ankur Dhar, Ashan Canagasingham, Lawrence H. C. Kim, Audrey Wang

“…Prospective Registration Number: ACTRN12623000799651. Date of Registration 26/07/2023.…”
Get full text

Drug regulatory affairs under focus: Knowledge and perceptions among pharmacists and pharmacy students. by Manal A Ayyash, Razan I Nassar, Raghad Al-Muhtaseb, Kamel A Jaber

“…<h4>Objectives</h4>Pharmaceutical product development, registration, and post-marketing surveillance are the main concerns of the Regulatory Affairs (RA) profession in regulated pharmaceutical industries. …”
Get full text

Evaluasi Kerentanan Insecure Direct Object Reference pada Aplikasi Pendaftaran Sidang Universitas XYZ by Stefanus Eko Prasetyo, Haeruddin, Tiara

“… This study aims to analyze and evaluate the vulnerability of Insecure Direct Object Reference (IDOR) in the thesis registration web application at XYZ University, as well as to provide improvement recommendations to enhance the security of students' personal data. …”
Get full text

Effect of transcranial magnetic stimulation on perioperative neurocognitive dysfunction: study protocol for a systematic review and meta-analysis of randomised controlled trials by Ying Yang, Yongming Tian, Yulan Luo, Jiarong Zeng

“…The findings will adhere to academic standards and be submitted for publication in reputable international medical journals following a rigorous double-blind peer-review process.Systematic review registration The research protocol has been prospectively registered on the PROSPERO international prospective systematic review registration platform (registration number: CRD42025636978).…”
Get full text

Nurses' occupational fatigue level and risk factors: A systematic review and meta-analysis. by Rong Pi, Yunfang Liu, Rong Yan, Zong De, Yali Wan, Yi Chen, Zihan He, Fang Liu, Yan Wang, Suyun Li

“…Subgroup analysis was conducted to explore sources of heterogeneity. The registration PROSPERO number is CRD42023456337.<h4>Results</h4>After a rigorous selection process, 28 articles were ultimately deemed suitable for inclusion in this article, which encompassed a total of 13,290 registered nurses. …”
Get full text

Protocol for a prospective, controlled, cross-sectional, diagnostic accuracy study to evaluate the specificity and sensitivity of ambulatory monitoring systems in the prompt detect... by Sarah Vollam, Owen Gustafson, Jody Ede, Peter J Watkinson, Akshay Shah, Matthew Rowland, Lionel Tarassenko, Cristian Roman, Philippa Piper, Louise Young, Mauro Santos, Marco A F Pimentel, Mirae Harford

“…However, a major barrier to the implementation of these wearable devices in the ward environment is their uncertain reliability, efficiency and data fidelity. …”
Get full text

Digital transformation of modern corporation management tools: the current state and development paths by V. A. Laptev, S. Yu. Chucha, D. R. Feyzrakhmanova

“…We believe that in the coming years science will have to tackle the issues of assessing the implications of the introduction of digital technologies, determining technical, economic and legal prerequisites for their implementation, and identifying their limits. In addition, issues related to professional training / retraining of personnel capable of working with modern technologies are of importance.Conclusions. …”
Get full text

Effectiveness of a school-based high-intensity interval training intervention in adolescents: study protocol of the PRO-HIIT cluster randomised controlled trial by Yong Liu, Alan R. Barker, Anna-Lynne R. Adlam, Minghui Li, Stephanie L. Duncombe, Andrew O. Agbaje, Yaodong Gu, Huiyu Zhou, Craig A. Williams

“…The study protocol has been retrospectively registered on ClinicalTrials.gov Protocol Registration and Results System (NCT06374732), https://clinicaltrials.gov/study/NCT06374732.…”
Get full text

Serum soluble urokinase type plasminogen activated receptor and focal segmental glomerulosclerosis: a systematic review and meta-analysis by Kehu Yang, Lei Zhu, Tiankui Shuai, Yan Pei Jing, Qiangru Huang, Huaiyu Xiong, Liu Jian

Get full text

Effects of dual-task exercises on cognitive status, disease activity and quality of life in childhood-onset systemic lupus erythematosus by Ozgur Kasapcopur, Sezgin Sahin, Ela Tarakci, Eylul Pinar Kisa, Gokce Leblebici, İrem Yagmur Tonyali, Gulcin Balci, Şehri Dilek, Esma Aslan

“…There is limited research examining the effects of DT exercises on cognitive status, particularly in patients with cSLE.Trial registration number NCT05984316.…”
Get full text

COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved indivi... by Chris Griffiths, Karina Kielmann, Heinke Kunst, Sally Hargreaves, Colin N J Campbell, Adam Brentnall, Dominik Zenner, Tahreem Chaudhry, Patricia Tum, Hui Zhen Tam, Hector Smethurst

“…Therefore, we aim to (1) determine the feasibility and practicality of implementing a patient engagement tool (PET) and gain vital insights to plan a subsequent definitive randomised controlled trial (RCT) to evaluate the effectiveness of this tool for increasing uptake of COVID-19 and influenza vaccinations and (2) define the appropriate level of support needed for healthcare providers at site-level to ensure successful implementation of the PET and to identify supporting activities needed to implement interventions for COVID-19 and influenza vaccinations.Methods and analysis This is a randomised controlled feasibility study evaluating a co-designed PET, involving randomisation at individual and cluster levels. …”
Get full text

Canadian Kidney Transplant Recipients’, Transplant Candidates’, and Caregivers’ Perspectives on Precision Medicine and Molecular Matching in Kidney Allocation: A Qualitative Analys... by Fabian Ballesteros, Aliya Affdal, Mohamad Issa, Marie-Françoise Malo, Savannah-Lou Cochran-Mavrikakis, Carina Sancho, Stirling Bryan, Paul Keown, Ruth Sapir-Pichhadze, Marie-Chantal Fortin

“…However, further studies are needed to determine how to ethically integrate this technology into the kidney allocation scheme. Trial registration: Not registered.…”
Get full text

Levosimendan and Global Longitudinal Strain Assessment in Sepsis (GLASSES 1): a study protocol for an observational study by Iacopo Cappellini, Alessandra Melai, Lucia Zamidei, Maddalena Parise, Simone Cipani, Guglielmo Consales

“…Ethical approval for this study has been given by Comitato Etico Regione Toscana - Area Vasta Centro, Florence, Italy (ethical committee number: 13875_oss) on 25 May 2019 (Chairperson Professor Marco Marchi).Trial registration number NCT04141410.…”
Get full text

Mind the gap: a nested randomised pilot study of culturally inclusive, internet-delivered prolonged exposure for PTSD among immigrants by Olof Molander, Karoline Kolaas, Nitya Jayaram-Lindström, Moa Pontén, Josefin Särnholm, Maria Bragesjö

“…A full-scale randomised controlled trial is needed to assess clinical and cost-effectiveness, as well as implementation across more diverse immigrant populations.Trial registration: ClinicalTrials.gov identifier: NCT06193161..…”
Get full text

One-step ahead: evaluating the efficacy of single-visit rabies pre-exposure prophylaxis against conventional multi-visit protocol: a randomized non-inferiority clinical trial by Aman Dev Singh, Simmi Oberoi, Rohit Batish, Kanwardeep Singh, Maninder Kaur, Shailpreet Kaur Sidhu, Avneet Kaur, Prabhasees Singh

“…Clinical trial number This study was registered and approved prospectively with CLINICAL TRIAL REGISTRY OF INDIA with the following registration number - CTRI APPROVAL NO – CTRI/2024/10/075093 registered on 10/10/2024.…”
Get full text

Integration of healthcare services for HIV and non-communicable diseases in sub-Saharan Africa: protocol for a scoping review of randomised controlled trials by Rifat Atun, Lauren Murphy, Caroline A Bulstra, John T Figi, Anne Fladger

“…Study findings will be shared through discussion with policymakers, implementation science researchers and healthcare providers. …”
Get full text

Benefits and Barriers to mHealth in Hypertension Care: Qualitative Study With German Health Care Professionals by Susann May, Felix Muehlensiepen, Eileen Wengemuth, Frances Seifert, Martin Heinze, Dunja Bruch, Sebastian Spethmann

“…Active engagement of users throughout the design and implementation phases is crucial for ensuring the usability and acceptance of mHealth apps. …”
Get full text