Two-year scale-up dissemination study of a multi-strategic community-wide intervention promoting physical activity: a single-arm pre-post hybrid effectiveness-implementation trial by Aoi Tsuzuki, Masamitsu Kamada, Shiho Amagasa, Jun Kitayuguchi, Takuma Miyashita, Takafumi Abe, Tatsunosuke Gomi, Kenta Okuyama, Masataka Taguri, Shigeru Inoue

“…The RE-AIM framework assessed intervention dissemination and implementation. Results The two-year intervention was implemented in all communities, reaching and involving various groups. …”
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Implementation of a digital nurse to improve the use of digital health applications (DiGA) for older people with depressive disorders (DiGA4Aged): a randomized proof of concept stu... by Anna Mai, Magdalena Pape, Theresa Sophie Busse, Katharina Kunde, Jennifer Bosompem, Chantal Giehl, Ina Carola Otte, Stephan Herpertz, Georg Juckel, Ida Haussleiter, Rainer Wirth, Horst Christian Vollmar, Nina Timmesfeld, Jan Dieris-Hirche

“…However, older adults face a particular challenge in implementing DiGA since higher age is a decisive predictor of lower digital health literacy. …”
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Implementation of C-reactive protein point of care testing to improve antibiotic targeting in respiratory illness in Vietnamese primary care (ICAT): a study protocol for a cluster... by H Rogier van Doorn, Behzad Nadjm, Yoel Lubell, Rachel Claire Greer, Sabine Dittrich, Sonia Lewycka, Nga Thi Thuy Do, Maida Vandendorpe, Van Anh Nguyen, Pham Ngoc Thach, Ta Thi Dieu Ngan, Nguyen Van Kinh, Cao Hung Thai, Le Thi Kim Dung, Tu Nguyen Thi Cam, Thanh Ha Nguyen

“…Authorship and reporting of this work will follow international guidelines.Trial registration details NCT03855215; Pre-results.…”
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SeaConvNeXt: A Lightweight Two-Branch Network Architecture for Efficient Prediction of Specific IHC Proteins and Antigens on Hematoxylin and Eosin (H&E) Images by Yuli Chen, Guoping Chen, Guoying Shi, Yao Zhou, Jiayang Bai, Germán Corredor, Cheng Lu, Xiujuan Lei

“…Firstly, we have developed a novel registration technique, called Bi-stage Registration based on density Clustering (BiReC), to enhance the registration efficiency between H&E and IHC images. …”
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Implementation, mechanisms of impact and key contextual factors involved in outcomes of the Modification of Diet, Exercise and Lifestyle (MODEL) randomised controlled trial in Aust... by Robin M Daly, Pawel Szulc, Marc Sim, Wai H Lim, John T Schousboe, Douglas P Kiel, Joshua R Lewis, Amanda Devine, Kun Zhu, Peter L Thompson, Simone Radavelli-Bagatini, Catherine P Bondonno, Lauren C Blekkenhorst, Reindolf Anokye, Emma Connolly, Nicola P Bondonno, Ben Jackson, James Dimmock, Markus P Schlaich, Kay L Cox, Mandy Stanley, Jenny Gianoudis, Belinda De Ross, Jonathan M Hodgson, Richard Woodman

“…The study results will be shared with the individuals and institutions associated with this study as well as academic audiences through peer-reviewed publication and probable presentation at conferences.Trial registration number ACTRN12618001087246.…”
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Implementation and effectiveness of a nurse-enabled, shared-care follow-up model for early breast cancer survivors (The IBIS-Survivorship Study): protocol for a stepped-wedge clust... by Karla Hemming, Jane Turner, Meinir Krishnasamy, Nicolas H Hart, Patsy Yates, Helen Skerman, Elizabeth Eakin, Jon Emery, Jane Mahony, Kerry Patford, Bogda Koczwara, Fiona Crawford-Williams, Caroline Kristunas, Raymond J Chan, G Bruce Mann, Mary Azer, Louisa G Collins, Jasotha Sanmugarajah, Bethany Crowe, Gillian Blanchard, Laura Healey, Rhea Liang, Paul Craft, Amy Shorthouse, Ruth McCaffery

“…General and generalised linear mixed models will be used to assess the effectiveness of the intervention versus usual care. Implementation and process outcomes will be assessed using the Reach Effectiveness Adoption Implementation Maintenance framework.Ethics and dissemination Ethical approval was provided by the Metro South Hospital and Health Service Human Research Ethics Committee (HREC/2020/QMS/59892) and reciprocally across the other five trial sites under National Mutual Acceptance arrangements. …”
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Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, imple... by Shelly Karuna, Fatima Laher, Sufia Dadabhai, Pei‐Chun Yu, Doug Grove, Catherine Orrell, Joseph Makhema, Mina C. Hosseinipour, Carrie‐Anne Mathew, William Brumskine, Nyaradzo Mgodi, Philip Andrew, Lucio Gama, Carissa Karg, Gail Broder, Kagisho Baepanye, Jonathan Lucas, Michele Andrasik, Simbarashe Takuva, Manuel Villaran, Azwidihwi Takalani, Randall Tressler, Lydia Soto‐Torres, Amanda S. Woodward Davis, Ames Dhai, Ian M. Sanne, Myron S. Cohen, Lawrence Corey, Glenda Gray, Allan C. deCamp, Katharine J. Bar

“…Clinical Trial Registration NCT04860323…”
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Transforming healthcare by prioritizing qualitative and quantitative clinical trial evidence: evaluating the Aging, Community and Health Research Unit’s Community Partnership Progr... by Kathryn Fisher, Soo Chan Carusone, Rebecca Ganann, Maureen Markle-Reid, Melissa Northwood, Diana Sherifali

“…Abstract Background This study aimed to test the effectiveness and implementation of a complex integrated care intervention for older adults. …”
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High daily dose Short COurse PrimaquinE after G6PD testing for the radical cure of Plasmodium vivax malaria in Indonesia and Papua New Guinea: the SCOPE implementation study protoc... by SCOPE Study Group

“…Stage 1 of the study (800 patients) will be implemented at 4 community clinics across Indonesia and Papua New Guinea (PNG) and will focus on analysis of treatment safety. …”
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Human papillomavirus genotype and cycle threshold value from self-samples and risk of high-grade cervical lesions: A post hoc analysis of a modified stepped-wedge implementation fe... by Jiayao Lei, Kate Cuschieri, Hasit Patel, Alexandra Lawrence, Katie Deats, YouScreen trial team, Peter Sasieni, Anita W W Lim

“…<h4>Methods and findings</h4>A pragmatic modified stepped-wedge implementation feasibility trial was conducted at primary care practices in England. …”
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The effects of implementing a point-of-care electronic template to prompt routine anxiety and depression screening in patients consulting for osteoarthritis (the Primary Care Osteo... by Christian D Mallen, Barbara I Nicholl, Martyn Lewis, Bernadette Bartlam, Daniel Green, Sue Jowett, Jesse Kigozi, John Belcher, Kris Clarkson, Zoe Lingard, Christopher Pope, Carolyn A Chew-Graham, Peter Croft, Elaine M Hay, George Peat

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Patients’ acceptability and implementation outcomes of a case management approach to encourage participation in colorectal cancer screening for people with schizophrenia: a qualita... by Tempei Miyaji, Yosuke Uchitomi, Hiroyuki Okada, Masatoshi Inagaki, Maiko Fujimori, Taichi Shimazu, Masaki Fujiwara, Masafumi Kodama, Ryuhei So, Takanori Matsushita, Yusaku Yoshimura, Shigeo Horii, Hirokazu Takahashi, Naoki Nakaya, Shiro Hinotsu, Keita Harada, Norihito Yamada, Yuto Yamada, Tsuyoshi Etoh

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Modifying exercise and physical therapy in medical rehabilitation to promote a physically active lifestyle: Protocol for a multicenter controlled hybrid type 2 effectiveness-implem... by Eva Grüne, Johannes Carl, Wolfgang Geidl, Johanna Popp, David Victor Fiedler, Natalie Boss, Regina Brinkmann, Juliane von dem Bussche, Gabi Eichner, Kathrin Kleinert, Christoph Löhr, Florian Mex, Paul Schwanitz von Keitz, Till Richter, Joachim Schmidt, Rainer Tischendorf, Gorden Sudeck, Klaus Pfeifer

“…The results of this study will determine the dissemination of long-term physical activity promotion in the German rehabilitation sector and will provide important information for modifying existing therapeutic concepts to improve their effectiveness and implementation at an international level. Trial registration The study was registered on the Open Science Framework on July 8 2024: https://doi.org/10.17605/OSF.IO/2N8UM and https://doi.org/10.17605/OSF.IO/J3KR2 .…”
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Enhancing cognitive function in breast cancer survivors through community-based aerobic exercise training: protocol for a Hybrid Type I effectiveness–implementation study employing... by Paul Estabrooks, Jessica D Austin, Brenda Ernst, Diane K Ehlers, Lindsey L Page, Edward Ofori, Gwenndolyn C Porter, Jason Fanning, Gabriella Hickman, Paul McKim, Melissa Cole, Maliyah Donaldson, B Blair Braden, Katie L Kunze, Richard J Butterfield, Leslie C Baxter, Tim A Ahles

“…Brain structure and function are measured via magnetic resonance imaging (MRI) at baseline and 6 months. Implementation outcomes are defined by the RE-AIM framework, which includes reach, effectiveness, adoption, implementation and maintenance. …”
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PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…This project is part of an effort to expedite the inclusion of new modalities in the Brazilian PrEP Programme, based on the development of studies to evaluate the implementation of LAI-PrEP and ED-PrEP as a choice. The results will be published in peer-reviewed journals and presented to the study participants and communities.Trial registration number https://ensaiosclinicos.gov.br/rg/RBR-104736f4. …”
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Implementation, efficacy and cost effectiveness of the unified protocol in a blended format for the transdiagnostic treatment of emotional disorders: a study protocol for a multice... by Carlos Suso-Ribera, J Osma, Laura Martínez-García, Óscar Peris-Baquero, María Vicenta Navarro-Haro, Alberto González-Pérez

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A randomized trial of adapted versus standard versions of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction implemented via facilitation and delivered by communi... by Allison G. Harvey, Emma R. Agnew, Rafael Esteva Hache, Julia M. Spencer, Marlen Diaz, Estephania Ovalle Patino, Anne Milner, Lu Dong, Amy M. Kilbourne, Daniel J. Buysse, Catherine A. Callaway, Laurel D. Sarfan

“…These findings are interpreted through the lens of the four core constructs of the i-PARIHS framework. Trial registration Clinicaltrials.gov identifier: NCT04154631. …”
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'Do Fever-Sugar-Swallow Protocols improve nurses' and physicians' satisfaction with the management of fever, hyperglycemia and dysphagia in stroke patients: A pre-and post-implemen... by Anne-Kathrin Cassier-Woidasky, Winfried Zinn, Sandy Middleton, Simeon Dale, Waltraud Pfeilschifter

“…T-tests were calculated for significance between pre-post implementation, Cohen’s d was used to measure the effect size. …”
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In-person vs mobile app facilitated life skills education to improve the mental health of internally displaced persons in Nigeria: protocol for the RESETTLE-IDPs cluster randomized... by Ejemai Eboreime, Chisom Obi-Jeff, Rita Orji, Tunde M Ojo, Ihoghosa Iyamu, Bala I Harri, Jidda M Said, Funmilayo Oguntimehin, Abdulrahman Ibrahim, Omolayo Anjorin, Andem Effiong Etim Duke, Umar Baba Musami, Linda Liebenberg, Raquel Crider, Lydia Wagami, Asmau MC Dahiru, Jesse C. Uneke, Sanni Yaya, Vincent IO Agyapong

“…Methods This cluster-randomized hybrid type 2 effectiveness-implementation trial will be conducted in 20 IDP camps or host communities in Maiduguri, Nigeria. …”
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Text message intervention delivered from Australian general practices to improve breast cancer survivors’ physical activity and cardiovascular risk factors: protocol for the EMPOWE... by Karice K Hyun, Christine Mitchell, Julie Redfern, Nashid Hafiz, Rebecca Raeside, Brooke Nickel, Carolyn Ee, Jennifer McIntosh, Elisabeth Elder, Raymond J Chan, David Mizrahi, Stephanie R Partridge, Anna C Singleton, Allyson Ruth Todd, Kirsty E Stuart

“…This randomised controlled trial (RCT) aims to evaluate the effectiveness and implementation of a text message intervention called EMPOWER-SMS-GP in Australian general practices.Methods and analysis Multi-centre single-blind hybrid I RCT (n=678; 1:1 allocation) comparing EMPOWER-SMS-GP (n=339) to usual care (n=339) at 6 months (postintervention), 12, 18 and 24 months (maintenance) and parallel mixed-methods process evaluation using the Reach, Effectiveness, Adoption, Implementation and Maintenance framework. …”
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