The spiritual needs and care of children and young people with life-threatening or life-shortening conditions, and parents (SPARK): a mixed-method investigation by Bryony Beresford, Natalie Richardson, Suzanne Mukherjee, Rebecca Nye, Jan Aldridge, Karl Atkin, Mark Clayton, Faith Gibson, Julia Hackett, Richard Hain, Mohammed Arshad, Paul Nash, Bob Phillips

“…The factors affecting assimilation and implementation of learning should also be investigated, including comparisons of alternative teaching/training approaches. …”
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A group psychological intervention for postnatal depression in British mothers of South Asian origin – the ROSHNI-2 RCT by Nusrat Husain, Karina Lovell, Carolyn A Chew-Graham, Farah Lunat, Penny Bee, Matthias Pierce, Najia Atif, Saadia Aseem, Kamaldeep Bhui, Peter Bower, Traolach Brugha, Nasim Chaudhry, Akbar Ullah, Linda Davies, Nadeem Gire, Deepali Sharma, Jahanara Miah, Waqas Ahmed, Joe Kai, Ilyas Mirza, Jillian Morrison, Naeem Mohmed, Atif Rahman, Shanaya Rathod, Najma Siddiqi, Waquas Waheed, Christopher Williams, Nosheen Zaidi, Richard Emsley, Richard Morriss

“…Economic evaluation Positive Health Programme implementation was estimated to cost an average of £408 per participant. …”
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The impact of enhancing nutrition and antenatal infection treatment on birth outcomes in Amhara, Ethiopia: a pragmatic factorial, cluster-randomised clinical effectiveness study by Alemayehu Worku, Sheila Isanaka, Yemane Berhane, Chunling Lu, Grace J Chan, Luke C Mullany, Blair J Wylie, Michelle Eglovitch, Anne CC Lee, Parul Christian, Estifanos Baye, Krysten North, Tigest Shifraw, Yoseph Yemane Berhane, Mulatu Melese Derebe, Nebiyou Fasil, Workagegnehu Tarekegn Kidane, Fisseha Shiferie, Sitota Tsegaye, Kalkidan Yibeltal, Yunhee Kang, Mandefro M Mengistie, Fred Van Dyk, Amare Worku Tadesse, Rose L Molina, Firehiwot Workneh, Ingrid Olson

“…While stillbirth rates were lower in the group receiving both packages, these findings need to be supported by additional studies.Trial registration number ISRCTN15116516.…”
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LUMOS - Low and Intermediate Grade Glioma Umbrella Study of Molecular Guided TherapieS at relapse: Protocol for a pilot study by Zarnie Lwin, Eng-Siew Koh, Mustafa Khasraw, Elizabeth H Barnes, Hui K Gan, Anna K Nowak, Cleo Robinson, Benhur Amanuel, Michael E Buckland, Sonia Yip, Benjamin Y Kong, Hao-Wen Sim, Bryan W Day, Roel Verhaak, Terrance Johns, Marc A Thomas, Tindaro Giardina, Andrew M Scott, Jonathon Parkinson, Rosalind Jeffree, Richard de Abreu Lourenco, Elizabeth J Hovey, Lawrence M Cher, Ganessan Kichendasse, Merryn Hall, Emily Tu

“…Results will be disseminated using a range of media channels including newsletters, social media, scientific conferences and peer-reviewed publications.Trial registration number ACTRN12620000087954; Pre-results.…”
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Enhancing referrals to Child and Adolescent Mental Health Services: the EN-CAMHS mixed-methods study by Kathryn M Abel, Pauline Whelan, Lesley-Anne Carter, Heidi Tranter, Charlotte Stockton-Powdrell, Kerry Gutridge, Lamiece Hassan, Rachel Elvins, Julian Edbrooke-Childs

“…Identify complexities of implementing sustainable solutions across CAMHS settings. …”
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Procalcitonin to guide antibiotic use during the first wave of COVID-19 in English and Welsh hospitals: integration and triangulation of findings from quantitative and qualitative... by Neil Powell, Emma Thomas-Jones, Paul Dark, Tamas Szakmany, Susan Hopkins, Jonathan Sandoe, Margaret Ogden, Robert M West, Enitan Carrol, Lucy Brookes-Howell, Philip Pallmann, Bethany Shinkins, Dominick Shaw, Philip Howard, Stacy Todd, Thomas P Hellyer, David G Partridge, Mahableshwar Albur, Martin Llewelyn, Helena K Parsons, Detelina Grozeva, Joanne Euden, Iain J McCullagh, Josie Henley, Wakunyambo Maboshe, Stuart E Bond

“…Data, methodological and investigator triangulation, and a transparent triangulation protocol give validity to this finding.Trial registration number ISRCTN66682918.…”
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Antibiotic prescribing practices according to the AWaRe classification among children under 5 of age attending public primary care centres in four West African countries: a cross-s... by Valéry Ridde, S Shepherd, Valériane Leroy, L Barry, M Bah, A Maïga, S Diallo, G Noel, T Sidibé, V Ridde, F Bah, Désiré Kargougou, A Baldé, D Diarra, D Zongo, F Lamontagne, M Traoré, A Ouedraogo, A Ouattara, V Leroy, R Becquet, L Catala, Ibrahima Sory Diallo, S Sani, Emelyne Gres, Cédric Besnier, Abdoul Aziz Diakité, Zineb Zair, Solange Ouédraogo Yugbaré, Gildas Boris Hedible, Abdoul Guaniyi Sawadogo, Jacques Séraphin Kolié, Bertrand Meda, Sandrine Busière, Franck Lamontagne, S Yugbaré Ouédraogo, VM Sanon Zombré, M Sama Cherif, I S Diallo, D F Kaba, A A Diakité, A Sidibé, H Abarry Souleymane, F Tidjani IssaganaDikouma, H Agbeci, D L Dahourou, S Desmonde, E Gres, G B Hedible, L Peters Bokol, J Tavarez, Z Zair, S Louart, A Cousien, V Briand, V Journot, S Lenaud, C N’Chot, B Seri, C Yao, G Anago, D Badiane, M Kinda, D Neboua, P S Dia, N di Mauro, K Nyoka, W Taokreo, OB Coulidiati Lompo, M Vignon, P Aba, N Diallo, M Ngaradoum, S Léno, A T Sow, A Soumah, B Baldé, K C Millimouno, M Haba, M Soumah, M Guilavogui, M N Sylla, S F Dounfangadouno, T I Bah, C Gnongoue, S Gaye, JPY Guilavogui, A O Touré, J S Kolié, A S Savadogo, F Sangala, T Konare, A Coulibaly, A Keita, H Traoré, I Sangaré, I Koné, S Diarra, V Opoue, F K Keita, M Dougabka, B Dembélé, M S Doumbia, G D Kargougou, S Keita, S Bouille, S Calmettes, K H Harouna, B Moutari, I Issaka, S O Assoumane, S Dioiri, M Sidi, K Sani Alio, S Amina, R Agbokou, M G Hamidou, S M Sani, A Mahamane, Aboubacar Abdou, B Ousmane, I Kabirou, I Mahaman, I Mamoudou, M Baguido, R Abdoul, A Sahabi, F Seini, Z Hamani, L-Y B Meda, Mactar Niome, X Toviho, I Sanouna, P Kouam, S Busière, F Triclin, A Hema, M Bayala, L Tapsoba, J B Yaro, S Sougue, R Bakyono, A G Sawadogo, Y A Lompo, B Malgoubri, F Douamba, G Sore, L Wangraoua, S Yamponi, S I Bayala, S Tiegna, S Kam, S Yoda, M Karantao, D F Barry, O Sanou, N Nacoulma, N Semde, I Ouattara, F Wango, Z Gneissien, H Congo, Y Diarra, B Ouattara, F Diabate, O Goita, S Gana, S Sylla, D Coulibaly, N Sakho, K Kadio, J Yougbaré, S Tougouma, A Dicko, Z Nanema, I Balima, S E Coulibaly, H Baldé, E Duparc Haba, Y Sangare, B Traore, A E Dagobi, S Salifou, B Gana MoustaphaChétima, I H Abdou

“…Nevertheless, in every country, the proportion prescribed in the Access group reached the minimum threshold of 60% of all antibiotic prescriptions, as recommended by WHO.Trial registration number PACTR202206525204526.…”
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Management of non-traumatic abdominal pain in the emergency department: a multicentre, stepped-wedge, cluster-randomised trialResearch in context by Anna Slagman, Liane Schenk, Dörte Huscher, Lisa Arnold, Harald Dormann, Johannes Drepper, Larissa Eienbröker, Antje Fischer-Rosinský, Johann Frick, Lukas Helbig, Dirk Horenkamp-Sonntag, Freddy Irorutola, Tim Klinge, Thomas Reinhold, Peter Schily, Britta Stier, Katharina Verleger, Andreas Wagenknecht, Yves Noel Wu, Martin Möckel

“…Exploratory safety outcomes were serious adverse events within 30 days. Trial registration: DRKS00021052. Findings: Of 2119 patients, 1017 were enrolled in the control group, and 1102 in the intervention group. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

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Multidisciplinary Delphi consensus on challenges and key factors for an optimal care model in chronic kidney disease by José Luis Górriz, Roberto Alcázar Arroyo, Patricia Arribas, Sara Artola, Sergio Cinza-Sanjurjo, Rafael de la Espriella, Javier Escalada, Lisardo García-Matarín, Luis Martínez, Juan Carlos Julián, José Pablo Miramontes-González, Félix Rubial, Mercedes Salgueira, María José Soler, José Luis Trillo

“…The purpose of this study was to analyse the care patterns for these patients and to reach a consensus on the key factors that should be implemented for an optimal care model in CKD, through a multidisciplinary and integrative vision. …”
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The Dietary Biomarkers Development Consortium: An Initiative for Discovery and Validation of Dietary Biomarkers for Precision Nutrition by Hrishikesh Chakraborty, Qi Sun, Shilpa N Bhupathiraju, Jeannette M Schenk, Darya O Mishchuk, James R Bain, Xuan He, Jianghao Sun, James Harnly, William Simmons, Daniel Raftery, Liming Liang, John W Newman, Oliver Fiehn, Clary B Clish, Johanna W Lampe, Brian J Bennett, Sandi L Navarro, Ying Wang, Cheng Zheng, Yasmin Mossavar-Rahmani, Marjorie L McCullough, Ying Huang, Ali Shojaie, Wentao Zhu, Danijel Djukovic, Frank Sacks, Jonathan Williams, Francene M Steinberg, Sean H Adams, Frank B Hu, Marian L Neuhouser, Carolyn M Slupsky, Padma Maruvada

“…To achieve this goal, a 3-phase approach will be implemented to identify, evaluate, and validate food biomarkers. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…A cost-effectiveness study of implementing the PriMUS tool in routine general practice is required. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Research is also needed on the resource implications of MCED tests on NHS services, risk of overtreatment and cost-effectiveness of implementing MCED tests for screening in the UK. Study registration This study is registered as PROSPERO CRD42023467901. …”
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Pramipexole in addition to mood stabilisers for treatment-resistant bipolar depression: the PAX-BD randomised double-blind placebo-controlled trial by Hamish McAllister-Williams, Nicola Goudie, Lumbini Azim, Victoria Bartle, Michael Berger, Chrissie Butcher, Thomas Chadwick, Emily Clare, Paul Courtney, Lyndsey Dixon, Nichola Duffelen, Tony Fouweather, William Gann, John Geddes, Sumeet Gupta, Beth Hall, Timea Helter, Paul Hindmarch, Eva-Maria Holstein, Ward Lawrence, Phil Mawson, Iain McKinnon, Adam Milne, Aisling Molloy, Abigail Moore, Richard Morriss, Anisha Nakulan, Judit Simon, Daniel Smith, Bryony Stokes-Crossley, Paul Stokes, Andrew Swain, Zoë Walmsley, Christopher Weetman, Allan H Young, Stuart Watson

“…Future work Replication in a larger population and research to investigate the impact of coadministration of antipsychotics alongside pramipexole. Trial registration This trial is registered as ISRCTN72151939 and EudraCT 2018-2869-18. …”
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Intersecting factors of disadvantage and discrimination and their effect on daily life during the coronavirus pandemic: the CICADA-ME mixed-methods study by Carol Rivas, Amanda P Moore, Alison Thomson, Kusha Anand, Zainab Zuzer Lal, Alison Fang-Wei Wu, Ozan Aksoy

“…We found some differences in the devolved nations, which need elucidation. Study registration This study is registered as ISRCTN40370, PROSPERO CRD42021262590 and CRD42022355254. …”
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Mean arterial pressure after out-of-hospital cardiac arrest (METAPHORE): study protocol for a multicentre controlled trial with blinded primary outcome assessor by Cédric Bruel, Christophe Guitton, Jean-Pierre Frat, Jeremy Bourenne, Guylaine Labro, Jean-Pierre Quenot, Gwenhaël Colin, Arnaud W Thille, Christophe Guervilly, Kada Klouche, Laurence Dangers, Jean Reignier, Agathe Delbove, Nicholas Sedillot, Jean-Paul Mira, Laurent Argaud, Martin Dres, Jérôme Roustan, Elsa Parot-Schinkel, Pierre Bailly, Pierre Asfar, Jean-Philippe Rigaud, Jean-Claude Lacherade, Grégoire Muller, Guillaume Geri, Jean-Baptiste Lascarrou, Julio Badie, Julien Maizel, Frédéric Martino, Gaetan Plantefeve, Francis Schneider, Alain Cariou, Xavier Wittebole, Denis Doyen, Bruno Francois, Pierre-Francois Dequin, Francois Barbier, Ferhat Meziani, David Schnell, Hamid Merdji, Jonathan Chelly, Olivier Lesieur, Caroline Sejourne, Wulfran Bougouin, Nicolas Pichon, Mehran Monchi, Charlotte Salmon Gandonniere, Saber Davide Barbar, Juliette Audibert, Sophie Jacquier, Julien Lorber, Marine Goudelin, Nicolas Chudeau, Nicolas Brechot, Thomas Klein, Eglantine Rouanet, Patrick Saulnier, Olivier Nigeon, Nicolas De Schryver, Fabien Jarousseau, Marine Paul, Benoît Painvin, Damien Du Cheyron, Antoine Marchalot, Tristan Morichau-Beauchant, Patrick Girardie, W Bougouin, Mathieu Jozwiak, Frédéric Foret, Djillali Annane F-CRIN, Asaël Berger PierreBulpa, Nicolas Barbarot, Nicolas Mongardon CédricDaubin, Asael Berge, Simon Bourcier, Guillaume Geri Jean-BaptisteLascarrou, Jean-Herle Raphalen, Florence Blossier, Fanny Bounes, William Buffières

“…Results will be submitted for publication in peer-reviewed journals.Trial registration number ClinicalTrials.gov: NCT05486884.…”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…ETPB appeared to be easier to implement as theorised, at least during the antenatal phase, but fidelity was by no means perfect, and attendance was concerning for both interventions. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Study 1D: we undertook a process evaluation to examine the implementation of the planned intervention in the SELPHI RCT. …”
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Rationale and Trial Design of Feedbacks Using Behavioural Economic Theories on STEP Counts (FOOTSTEPS) Trial in Patients With Cardiovascular Disease by Takahiro Suzuki, MD, MPH, Jiro Aoki, MD, PhD, Kohei Abe, MD, Taku Asano, MD, PhD, Daisuke Yoneoka, PhD, Shuntaro Sato, PhD, Jeffrey Rewley, PhD, Kotaro Miyata, MD, Masafumi Ono, MD, PhD, Akira Saito, MD, MPH, Takayoshi Kanie, MD, Kenta Okui, MD, Akinari Takahashi, MD, Koichiro Isa, MD, Satoshi Takasago, MD, Yumi Shiina, MD, PhD, Yosuke Nishihata, MD, PhD, Hiroyuki Niinuma, MD, PhD, Keita Masuda, MD, PhD, Yasufumi Kijima, MD, PhD, Hidefumi Nishida, MD, Nobuyuki Komiyama, MD, PhD, Keiko Sugibuchi, RN, Yoko Suzuki, RN, Aoi Igarashi, RN, Sachiko Suzumura, PT, Nanami Tsurugi, PT, Daisuke Okamura, PT, Atsushi Mizuno, MD, PhD

“…Interventions for nonsupervised exercise therapy have not been broadly implemented, and few patients with CVD achieve the recommended activity levels (eg, 8000 daily steps). …”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…The EAG also implemented an additional exploratory scenario to investigate the impact of ELX/TEZ/IVA preventing any long-term lung decline post treatment initiation. …”
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