Social and clinical vulnerability in stroke and STEMI management during the COVID-19 pandemic: a registry-based study by Jérome Berge, Gaultier Marnat, Emmanuel Ellie, Igor Sibon, Basile Ondze, Ludovic Lucas, Xavier Combes, Catherine Pradeau, Pierre Coste, Jean-Luc Banos, Nicolas Delarche, François Rouanet, Pierre Fournier, Patricia Bernady, David Higue, Julie Péron, Stephanie Bannier, Virginie Heydel, Nathalie Goulois, Francois Orcival, Stephanie Vandentorren, Jean-Louis Leymarie, Bernard Karsenty, Emilie Lesaine, Sandrine Domecq, Laura Cetran, Sahal Miganeh-Hadi, Floriane Sevin, Stéphanie Demasles, Régis Hubrecht, Florence Francis, Florence Saillour, Jean Faucheux, Elena Leca Radu, Gaëlle Seignolles, Cécile Chazalon, Maria Dan, Laurent Wong-So, Miquel Martinez, Claire Nocon, Véronique Hostyn, Jérémy Papin, Philippe Bordier, Philippe Casenave, Laurent Maillard, Isabelle Argacha, Eliane Tidahy, Lucie Ferraton, Yousra Mostefai, Djoumana Bakpa, Christine Bartou, Catherine Goze-Dupuy, Hélène Lavocat, Frédéric Senis, Virginie Delonglee, Didier Darraillans, Tarak Mokni, Bertrand Bataille, Jean Lorendeau, Anncy Eclancher, Bruno Trogoff, Véronique Chartroule, Philippe Touchard, Hervé Leyral, Fogue Ngounou, Catherine Scouarnec, Bertrand Tahon, Emmanuel Py, Sorina Bidian, Jean Fabre, Nidhal Cherhabil, Leila Baha, Pierre-Arnaud Fort, Vincent Maisonnave, Luc Verhoeven, Paul Claveries, Emma Ansart, Brice Lefevre, Marie-Pierre Liepa, Marc Lacrouts, Jean-Baptiste Coustere, Philippe Jarnier, Nicolas Marque, Jean-Marie Perron, Akil Hassan, Francois Casteigt, Bernard Larnaudie, Guillaume Laplace

“…We found no significant association between vulnerabilities and the admission imaging time for stroke patients, and no interaction with respect to the COVID-19 period (age, p=0.81; neurocardiovascular history, p=0.34; deprivation, p=0.95).Conclusions This study revealed pre-existing inequalities in care management times for vulnerable STEMI and stroke patients; however, these inequalities were neither accentuated nor reduced during the first COVID-19 wave. Measures implemented during the crisis did not alter the structured emergency pathway for these patients.Trial registration number NCT04979208…”
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Sustained Improvements After Intervention to Prevent Contrast‐Associated Acute Kidney Injury: A Randomized Controlled Trial by Michael E. Matheny, Elizabeth Carpenter‐Song, Iben M. Ricket, Richard J. Solomon, Meagan E. Stabler, Sharon E. Davis, Lisa Zubkoff, Dax M. Westerman, Chad Dorn, Kevin C. Cox, Freneka F. Minter, Hani Jneid, Jesse W. Currier, S. Ahmed Athar, Saket Girotra, Calvin Leung, Thomas J. Helton, Ajay Agarwal, Mladen I. Vidovich, Mary E. Plomondon, Stephen W. Waldo, Kelly A. Aschbrenner, Virginia McKay, A. James O'Malley, Jeremiah R. Brown

“…Process improvement education, care process standardization, and automated outcome feedback may be effective and durable methods for reducing AKI. Registration URL: https://clinicaltrials.gov/; Unique Identifier: NCT03556293.…”
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Direct oral penicillin challenge in secondary care with low-risk patients: the SPACE mixed-methods study with cost-effectiveness analysis by Mamidipudi Thirumala Krishna, Yogini H Jani, Iestyn Williams, Ruben Mujica-Mota, Rebecca Bestwick, Michele Siciliano, Robert Michael West, Rashmeet Bhogal, Bee Yean Ng, Kornelija Kildonaviciute, Rachel Pollard, Nicola Jones, Louise Dunsmure, Mairead McErlean, Neil Powell, Chidanand C Hullur, Ariyur Balaji, Jonathan Sandoe, Amena Warner, Ron Daniels, Caroline Thomas, Siraj A Misbah, Louise Savic

“…Future studies with opportunistic de-labelling may offer better value for money by designing the intervention as a non-allergy specialist pharmacist-led DPC along the lines of the model implemented at the Oxford study site. Study registration This study is registered as ISRCTN55524365. …”
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Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…Study registration This study is registered as PROSPERO CRD42018111781 and CRD42018112434. …”
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Group psychological counseling-based growth mindset intervention to promote active aging behaviors in older people: protocol for a randomized controlled trial by Xiaohua Xiao, Yunying Zhu, Dongdong Jiang, Anna Vinnikova, Jin Zhang, Ruotong Zhang, Wenxiao Chen, Sisi Li, Jingwen Wang, Mingyuan Sheng, Joseph T. F. Lau, Qian Yang

“…This study addresses this gap by using group psychological counseling technique to implement growth mindset interventions, aiming to stimulate older people’s autonomy and foster their active aging behaviors. …”
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Promoting smoking cessation and preventing relapse to tobacco use following a smoke-free mental health inpatient stay (SCEPTRE feasibility study): a multicentre randomised controll... by Simon Gilbody, Catherine Hewitt, John Britton, Lion Shahab, Tim Coleman, Elena Ratschen, Judith Watson, Alex Mitchell, Gregor Russell, Steve Parrott, Lesley Sinclair, Peter A Coventry, Paul Galdas, Michelle Horspool, Samantha Brady, Emily Shoesmith, Petal Petersen Williams, Lisa Huddlestone, Victoria Exley, Fraser Wiggins, Jodi Pervin, Moira Leahy, Claire Paul, Lesley Colley, Simon Hough

“…Mental health Trusts presently invest substantial effort and resources to implement smoke-free policies and to deliver tobacco dependence treatment to patients. …”
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Assessing the efficacy of 3D window double screens (3D-WDS) in reducing malaria transmission in northeastern Tanzania: Study protocol for a two-arm cluster-randomised controlled tr... by William N. Kisinza, Subam Kathet, Victor Mwingira, Maija Meri, Frank S. Magogo, Veneranda M. Bwana, Hanna Granroth-Wilding, Pendael Machafuko, Patrick Tungu, Mikko Aalto, Tomi Hakala, Markku Honkala, Seppo Meri, Ayman Khattab

“…This study aims to evaluate the epidemiological, entomological, and social impacts of implementing 3D-Screens in community settings. Methods/design: A two-arm, cluster-randomised controlled trial (cRCT) was conducted to assess whether houses equipped with both 3D-WDS and long-lasting insecticidal nets (LLINs) provide enhanced protection against malaria compared to LLINs alone. …”
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Music therapy for the treatment of anxiety: a systematic review with multilevel meta-analysesResearch in context by Martina de Witte, Sonja Aalbers, Annemieke Vink, Stijn Friederichs, Anne Knapen, Thomas Pelgrim, Amit Lampit, Felicity A. Baker, Susan van Hooren

“…Music therapy involves personally tailored music interventions that are designed and implemented by qualified music therapists to meet the specific health needs of individual patients. …”
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Multicentre randomised trial of screening with sFlt1/PlGF and planned delivery to prevent pre-eclampsia at term: protocol of the PE37 study by M Timmermans, Josefina Mora, Francesc Figueras, I Casas, H Castillo, Eduard Gratacos, Ladislav Krofta, Francesca Crovetto, Fatima Crispi, Carmina Comas, Alicia Martínez-Varea, Anna Kajdy, Elisa Llurba, Lina Youssef, Juan Luis Delgado, Isabel Puig, Katerina Mackova, Albert Tubau, Aina Ruiz, Antoni Paya, Maria Prat, Frederic Chantraine, Maria Fernanda Lopez-Tinajero, RJ Campos, V Parriego, D Sys, J Modzelewski

“…The study results will be published in peer-reviewed journals and disseminated at international conferences.Trial registration number NCT04766866.…”
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Strengthening open disclosure in maternity services in the English NHS: the DISCERN realist evaluation study by Mary Adams, Natalie Sanford, Charlotte Bevan, Maria Booker, Julie Hartley, Alexander Heazell, Elsa Montgomery, Maureen Treadwell, Jane Sandall

“…We found PMRT implementation sometimes lacked relational care for families. …”
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Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Future work The use of digital pathology for cytology samples remains an area for further research. Study registration: This study is registered as ISRCTN14513591. …”
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Cervical ripening at home or in hospital during induction of labour: the CHOICE prospective cohort study, process evaluation and economic analysis by Mairead Black, Cassandra Yuill, Mairi Harkness, Sayem Ahmed, Linda Williams, Kathleen A Boyd, Maggie Reid, Amar Bhide, Neelam Heera, Jane Huddleston, Neena Modi, John Norrie, Dharmintra Pasupathy, Julia Sanders, Gordon C S Smith, Rosemary Townsend, Helen Cheyne, Christine McCourt, Sarah Stock

“…Future research should focus on: Further exploration and implementation of system features that lead to positive experiences of home cervical ripening. …”
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Feasibility of a tailored, combined intervention with mind-body elements to prevent burnout in healthcare professionals (LAGOM) in a mixed-methods multicenter single-arm trial by Marleen Schröter, Anna K. Koch, Julia Berschick, Julia K. Schiele, Martin Bogdanski, Melanie Steinmetz, Judith Czakert, Wiebke Stritter, Christian S. Kessler, Georg Seifert

“…The study supports the acceptability and feasibility of implementing LAGOM in the healthcare setting, with initial indications of effectiveness. …”
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Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Normalisation process theory was used as a framework to identify issues related to implementing the interventions in practice beyond the trial. …”
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Sexual Health Determinants During the Life Course and Migration of Haitian-Origin People in French Guiana: Protocol for the Parcours d’Haïti Biographical and Transdisciplinary Stud... by Leslie Alcouffe, Marc-Alexandre Tareau, Gabriel Brun Rambaud, Aude Lucarelli, Mathilde Boutrou, Camille Thorey, Greta Cantalupi, Karl Kpossou, Florence Huber, Sébastien Rabier, Dévi Rita Rochemont, Théo Blaise, Estelle Thomas, Guerline Jean, Ruth Pierre Louis, Annette Zephirin, Célia Basurko, Félix Djossou, Hawa Cissé, William Faurous, Quentin Drouaud, Mayka Mergeay-Fabre, Antoine Adenis, Mathieu Nacher, Nicolas Vignier

“…ResultsOver 20 months between 2021 and 2023, the Parcours d’Haïti study was implemented in French Guiana. Anticipated results suggest that the main reasons for migration include insecurity and fleeing violence. …”
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Adverse Event Management in Patients with Platinum-Resistant Ovarian Cancer Treated with Niraparib and Anlotinib: Updates from the Phase II, Multi-Center ANNIE Study by Deng T, Yan L, Li J, Liu G, Yin A, Feng Y, Zheng M, Zhang C, Huang H, Huang Q, Lin A, Jiang J, Kong B, Liu J

“…Protocol amendment was implemented to reduce the incidence of hand-foot syndrome, while topical glucocorticoids and non-steroidal anti-inflammatory drugs were used in patients with apparent symptoms.Conclusion: The updated OS analysis showed sustained long-term efficacy of niraparib-anlotinib in PROC patients. …”
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Health risk perception and behavioral decision-making among online-dating MSM in Shandong, China: perspectives on HIV and new psychoactive substances by Yuyao Chen, Haiying Yu, Xiaoyan Zhu, Ling Li, Lin Wang, Yangji Zhuoma, Na Zhang, Guoyong Wang, Wei Ma, Meizhen Liao

“…It is recommended to implement subpopulation-targeted interventions, increase warning education, promote informed partnering practices, strengthen NPS harm awareness campaigns targeting youth, reinforce online regulation and health education, leverage online platforms and community organizations to expand intervention coverage, and achieve coordinated HIV prevention and control.…”
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FACTORS ASSOCIATED WITH HEARING IMPAIRMENT IN INFANTS WHO RECEIVED THERAPEUTIC HYPOTHERMIA by М. Соломенко, О. Харитонова

“…A three-phase audiological screening protocol was implemented (initial two phases employing transient evoked otoacoustic emissions, followed by comprehensive diagnostic audiometry in the third phase). …”
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PTSD Coach as an early mobile intervention to improve cancer-related anxiety and psychosocial oncology uptake in patients newly diagnosed with head and neck cancer: pilot randomize... by Laurence Ducharme, Chris Lo, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Michael Antoni, Eric Kuhn, Jason E. Owen, Daren Heyland, Robert Platt, Fabienne Fuehrmann, Nader Sadeghi, Zeev Rosberger, Saul Frenkiel, Khalil Sultanem, George Shenouda, Fabio Cury, Melissa Henry

“…PTSD Coach could be a valuable self-management tool as an initial stepped-care approach intervention in patients newly diagnosed with HNC. Trial registration ClinicalTrials.gov, NCT03651570 . Registered June 26, 2018.…”
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An Interdisciplinary Ecosystem for the Prevention of Cardiotoxicity in Older Patients With Breast Cancer: Protocol for a Prospective and Multicentric Study by Gaia Giulia Angela Sacco, Ketti Mazzocco, Anastasia Constantinidou, Andri Papakonstantinou, Davide Mauri, Grigorios Kalliatakis, Manolis Tsiknakis, Domen Ribnikar, Dorothea Tsekoura, Valantis Aidarinis, Kalliopi Keramida, Panagiotis Oikonomopoulos, Athos Antoniades, Cameron Brown, Federica Rizzi, Anca Bucur, Elsa Pacella, Georgia Karanasiou, Daniela Cardinale, Carlo Cipolla, Elisabetta Munzone, Dimitrios Fotiadis, Giuseppe Curigliano, Gabriella Pravettoni

“…Such a health care approach will also benefit the health care system, which currently spends almost 40% of its resources on patients aged >60 years, with long-term care and hospital admissions being the primary cost drivers. Trial RegistrationClinicalTrials.gov NCT06334445; https://clinicaltrials.gov/study/NCT06334445 International Registered Report Identifier (IRRID)DERR1-10.2196/63455…”
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