Survival status and predictors of mortality among patients with breast cancer in Ethiopia: a systematic review and meta-analysis by Hailu Aragie, Lemlemu Maru, Dagnew Getnet Adugna, Habtu Kifle Negash, Nega Dagnew Baye

“…To improve survival outcomes, it is crucial to expand access to early screening, particularly in rural areas, implement comprehensive treatment protocols and strengthen healthcare infrastructure to address these critical factors.PROSPERO registration number CRD42024575074.…”
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Effectiveness of a Videoconference-Based Cognitive Behavioral Therapy Program for Patients with Schizophrenia: Pilot Randomized Controlled Trial by Masayuki Katsushima, Hideki Nakamura, Yuki Shiko, Hideki Hanaoka, Eiji Shimizu

“…This approach is expected to improve accessibility to CBTp for outpatients with schizophrenia and social anxiety regarding transportation use and financial and physical burdens related to transportation, and to contribute to promoting CBTp acceptability by compensating for the shortage of implementers. Trial RegistrationUniversity Hospital Medical Information Network Clinical Trials Registry UMIN000043396; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?…”
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A hand-washing community-based educational intervention to reduce abscess incidence among people who inject drugs: a cluster randomised controlled clinical trial protocol (the HAWA... by Liam Balhan, Marion Aubert, Cynthia Lacoux, Nina Grau, Joachim Levy, Marie-Lou Stefanowski, Lola Perreaut, Luis Sagaon-Teyssier, Sylvie Deuffic-Burban, Anthony Cousien, David Michels, Marie Costa, Perrine Roux

“…Specifically, we shall implement a nationwide, two-arm, multi-centre, cluster randomised controlled trial to evaluate the effectiveness and cost-effectiveness of this intervention in PWID. …”
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The PRECISION study protocol: Can cervical stiffness in the second trimester predict preterm birth in high-risk singleton pregnancies? A feasibility, cohort study. by Elizabeth Medford, Steven Lane, Andrew Sharp, Angharad Care

“…Identifying those at risk of this devastating complication of pregnancy and implementing preventative treatment remains a maternal health priority. …”
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Effects of probiotic supplementation with high-intensity interval training on cardiorespiratory endurance and metabolism in Middle-Aged Obese Women by Yi-Chen Chen, Hsuan-Yun Wang, Futoshi Ogita, Chi-Hsiang Hung, Chia-Hua Kuo, Jie-Ping Wang, Chia-Min Wang, Chien-Wen Hou, Ting-Yao Wang

“…However, when combined with probiotics, the probiotics not only help enhance TTE but also counteract the negative impact on waist circumference and further reduce hip circumference, resulting in a synergistic effect.Clinical trial registration ClinicalTrials.gov, identifier NCT06285578…”
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The efficacy and pharmacological mechanisms of traditional Chinese medicine in the treatment of spinal cord injury by Yu Jiang, Gang Liu, Bowen Deng, Huizhong Bai, Xiaohong Mu

“…Clinical trial number Not applicable. PROSPERO registration number CRD42025641947.…”
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A Personalized, Texting-Based Conversational Agent to Address Sleep Disturbance in Individuals Who Have Survived Breast Cancer: Protocol for a Pilot Waitlist Randomized Controlled... by Chi-shan Tsai, Warren Szewczyk, Michelle Drerup, Jason Liao, Alexi Vasbinder, Heather Greenlee, Jaimee L Heffner, Rachel Yung, Kerryn W Reding

“…Named “Cecebot,” this CA delivers sleep education, implements sleep compression, provides just-in-time interventions for sleep-disrupting behaviors, and includes enhanced support for physical activity (PA) beyond what is typically included in CBTi. …”
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Challenges and strategies for maintaining nutrition services in the Democratic Republic of Congo during COVID-19: a qualitative study by Marc Bosonkie, Benito Kazenza, Rawlance Ndejjo, Marie-Claire Muyer, Eric Mafuta, Ruphin Mbuyi, Branly Mbunga, Paul-Samsom Lusamba, Olufunmilayo I. Fawole, Mala Ali Mapatano

“…BackgroundThe rapid spread of COVID-19 forced governments to urgently implement non-pharmaceutical measures to stop the surge. …”
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Adjusting Early Warning Score by clinical assessment: a study protocol for a Danish cluster-randomised, multicentre study of an Individual Early Warning Score (I-EWS) by Lars Simon Rasmussen, Kasper Karmark Iversen, Theis Lange, Gitte Bunkenborg, Pernille B Nielsen, Martin Schultz, Caroline Sophie Langkjaer, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Michael Dan Arvig, Christian Sahlholt Meyhoff, Morten Bestle, Bibi Hølge-Hazelton, Anne Lippert, Ove Andersen

“…Introduction Track and trigger systems (TTSs) based on vital signs are implemented in hospitals worldwide to identify patients with clinical deterioration. …”
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Scoping review protocol of multicomponent interventions to address cardiometabolic disease risk among Pacific Islander children. by Courtney C Choy, Kate Nyhan, Kima Savusa, Christina Soti-Ulberg, Rochelle K Rosen, Take Naseri, Nicola L Hawley, Mona Sharifi

“…To investigate existing interventions for adaptation and potential use in Pacific Islander communities, we will search Scopus, MEDLINE ALL (Ovid), EMBASE (Ovid), Yale-licensed Web of Science Core Collection, Cochrane Library, CINAHL (EBSCOhost), ProQuest Dissertations & Theses Global, Global Health (EBSCO), non-indexed Pacific journals, grey literature, government reports, and clinical trial registrations. The Joanna Briggs Institute Manual for Evidence Synthesis and the Preferred Reporting Items for Scoping Reviews will guide data extraction, evidence mapping, synthesis, and reporting of information including study population, intervention components, behavioral changes, health and implementation outcomes, theoretical frameworks, and evaluation measures.…”
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Heat Adaptation Benefits for Vulnerable groups In Africa (HABVIA): a study protocol for a controlled clinical heat adaptation trial by Michaela Deglon, Chad Africa, Larske Marit Soepnel, Thandi Kapwata, Ama de-Graft Aikins, Kweku Bedu-Addo, Guy Howard, Estelle Victoria Lambert, Dale Elizabeth Rae, Martha Sibanda, Christopher Gordon, Mark New, Lara Ruth Dugas

“…Trial registration Pan African Clinical Trials Registry (PACTR) PACTR202401521630856, version 1. …”
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Diseño e implementación de un sistema de adquisición de datos sismológicos en tiempo real by Vega V. Pedro A.

“…Starting with LAC type existent seismometer for which was implemented the software and hardware required to obtain the seismological registration station. …”
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Examining Challenges to Co-Design Digital Health Interventions With End Users: Systematic Review by Anthony Duffy, Nazanin Boroumandzad, Alfredo Lopez Sherman, Gregory Christie, Indira Riadi, Sylvain Moreno

“…Several methodologies and frameworks are being implemented to address this challenge to varying degrees of success. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Organisations should implement good, practical models for coproduction to be able to involve people with lived experience, carers and staff to review their services and implement changes. …”
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Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland by J Pitkäniemi, K Seppä, M Hakama, O Malminiemi, T Palva, M-S Vuoristo, H Järvinen, H Paimela, P Pikkarainen, A Anttila, L Elovainio, T Hakulinen, S Karjalainen, L Pylkkänen, M Rautalahti, T Sarkeala, H Vertio, N Malila

“…Even if our findings are still inconclusive, they highlight the importance of randomised evaluation when new health policies are implemented.Trial registration 002_2010_august.…”
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Intervention of muscle-building and antifrailty exercise combined with Baduanjin for frailty of different functional levels: study protocol for a randomised controlled trial by Chao Chen, Fang Wang, Shuaixuan Xu, Zhuyun Gong, Mengyu Cao, Jinwei Liu, Nihui Zhang, Jingwen Kang, Chuang Xu, Nan Peng

“…The control group will implement health education on frailty and maintain the old lifestyle without any intervention.The primary outcomes include the change in frailty and functional capacity, assessed according to the Fried Scale and the Short Physical Performance Battery. …”
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Advance Care Planning: Promoting Effective and Aligned Communication in the Elderly (ACP-PEACE): the study protocol for a pragmatic stepped-wedge trial of older patients with cance... by Yuchiao Chang, Joshua R Lakin, James A Tulsky, Elise N Brannen, Michael K Paasche-Orlow, Charlotta Lindvall, Daniel A Gundersen, Areej El-Jawahri, Angelo Volandes, Julie Goldman, Brian Sipin, Michael J Barry, Kathryn I Pollak, Miji Sofela, Danielle Kennedy, S. Yousuf Zafar, Maria Torroella Carney, Diana Martins-Welch, Michael Qiu, Jody-Ann McLeggon, Craig E Devoe, Jon C. Tilburt, Charles L Loprinzi, Parvez A. Rahman, Jeremiah J. Stout, Aretha Delight Davis, Lisa M. Quintiliani

“…We plan to present findings at national meetings and publish the results.Trial registration number NCT03609177; Pre-results.…”
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Comparing the efficacy and safety of three surgical approaches for total hysterectomy (TSATH): protocol for a multicentre, single-blind, parallel-group, randomised controlled trial by Yanzhou Wang, Ying Zheng, Fan Yang, Li Deng, Jianhong Liu, Yonghong Li, Sijing Chen, Wenxi Zhang, Xiaolin You, Jiani Gou, Dan Zi, Xiaoxue Qi

“…The traditional multiport laparoscopy, transumbilical laparoendoscopic single-site surgery (TU-LESS) and transvaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy approaches have been implemented to varying degrees in clinical practice. …”
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Efficacy and dose–response relationships of antidepressants in the acute treatment of major depressive disorders: a systematic review and network meta-analysis by Shuzhe Zhou, Pei Li, Xiaozhen Lyu, Xuefeng Lai, Zuoxiang Liu, Junwen Zhou, Fengqi Liu, Yiming Tao, Meng Zhang, Xin Yu, Jingwei Tian, Feng Sun, Jing Ni

“…For most antidepressants, the maximum efficacy was achieved at lower or middle prescribed doses, rather than at the upper limit. Registration:. No. CRD42023427480; https://www.crd.york.ac.uk/prospero/display_record.php?…”
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Vitamin D in the prevention of exacerbations of asthma in preschoolers (DIVA): protocol for a multicentre randomised placebo-controlled triple-blind trial by Mohsen Sadatsafavi, Megan E Jensen, Francine M Ducharme, Nathalie Alos, Geneviève Mailhot, Benoît Mâsse, John H White, Ali Khamessan, Sze Man Tse, Reza Alizadehfar, Dirk E Bock, Patrick Daigneault, Chantal Lemire, Connie Yang, Dhenuka Radhakrishnan

“…If proven effective, findings may markedly influence the management of URTI-induced asthma in high-morbidity preschoolers and could be directly implemented into practice with an update to clinical guidelines.Trial registration number NCT03365687.…”
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