Long-term patient satisfaction and durability of laparoscopic anti-reflux surgery in a large Danish cohort: study protocol for a retrospective cohort study with development of a no... by Katrine Hass Rubin, Jonas Sanberg Ljungdalh, Jesper Durup, Kim Christian Houlind

“…The results of the study will be published in peer-reviewed medical journals regardless of whether these are positive, negative or inconclusive.Trial registration number Clinicaltrials.gov (NCT03959020).…”
Get full text

COVER-ME: developing and evaluating community-based interventions to promote vaccine uptake for COVID-19 and influenza in East London minority ethnicity (ME) and underserved indivi... by Chris Griffiths, Karina Kielmann, Heinke Kunst, Sally Hargreaves, Colin N J Campbell, Adam Brentnall, Dominik Zenner, Tahreem Chaudhry, Patricia Tum, Hui Zhen Tam, Hector Smethurst

Get full text

Development of prediction models for screening depression and anxiety using smartphone and wearable-based digital phenotyping: protocol for the Smartphone and Wearable Assessment f... by Sujin Kim, Ah Young Kim, Yu-Bin Shin, Seonmin Kim, Min-Sup Shin, Jinhwa Choi, Kyung Lyun Lee, Jisu Lee, Sangwon Byun, Heon-Jeong Lee, Chul-Hyun Cho

“…Data will be collected using a custom-developed smartphone application called PixelMood. …”
Get full text

Effects of movement behaviors on preschoolers’ cognition: a systematic review of randomized controlled trials by Catalina Pacheco, Victoria Culkin, Amelia Putkaradze, Nan Zeng

“…Future research should focus on integrated interventions that address PA, SB, and sleep to achieve a more comprehensive understanding of their collective impact on cognitive development in early childhood. Trial registration This study was registered with PROSPERO under the registration number CRD42023479156.…”
Get full text

DAWN: Designing Distributed Agents in a Worldwide Network by Zahra Aminiranjbar, Jianan Tang, Qiudan Wang, Shubha Pant, Mahesh Viswanathan

“…These advancements have led to the development of specialized LLM-based agents designed for diverse tasks such as coding and web browsing. …”
Get full text

Association between levothyroxine treatment for maternal subclinical hypothyroidism with negative TPOAb and early child neurodevelopment: A prospective real‐world clinical trial by Zhekun Zhao, Qiongjie Zhou, Huanqiang Zhao, Yu Xiong, Xiaotian Li

“…Child neurodevelopment was assessed by the Gesell development diagnosis scale (GDDS) at one, three, six, 12, and 24 months of age. …”
Get full text

Low-dose dobutamine in acute myocardial infarction with intermediate to high risk of cardiogenic shock development (the DOBERMANN-D trial): study protocol for a double-blinded, pla... by Sarah Louise Duus Holle, Joakim Bo Kunkel, Christian Hassager, Redi Pecini, Sebastian Wiberg, Pernille Palm, Lene Holmvang, Lia Evi Bang, Jesper Kjærgaard, Jakob Hartvig Thomsen, Thomas Engstrøm, Jacob Eifer Møller, Jacob Thomsen Lønborg, Helle Søholm, Martin Frydland

“…Around one third of patients who develop CS are not in shock at the time of hospital admission. …”
Get full text

Music therapy embedded in the life of dementia inpatient care to help prevent and manage distress: a feasibility study to inform a future trial by Naomi Thompson, Naomi Thompson, Helen Odell-Miller, Helen Odell-Miller, Chris Pointon, Chris Pointon, Benjamin R. Underwood, Benjamin R. Underwood, Benjamin R. Underwood, Emma Wolverson, Emma Wolverson, Emma Wolverson, Rachel Hunt, Rachel Hunt, Joanne Inglis, Joanne Inglis, Abdulwarrith Olawale, Lucy Pickering, Lucy Pickering, Alison Wilkinson, Alison Wilkinson, Christine Wise, Christine Wise, Cansu Buyukulas, Robert Dudas, Robert Dudas, Jufen Zhang, Ming-Hung Hsu, Ming-Hung Hsu

“…This protocolised intervention should be tested for clinical effectiveness in a controlled trial.RegistrationISRCTN86317609…”
Get full text

Application of the multiphase optimisation strategy to develop, optimise and evaluate the effectiveness of a multicomponent initiative package to increase 2-to-5-year-old children’... by Rebecca K Golley, Shabnam Kashef, Dorota Zarnowiecki, Jennifer C Arguelles, David N Cox, Astrid AM Poelman, Maeva O Cochet-Broch

“…This study will use the multiphase optimisation strategy to develop, optimise and evaluate the effectiveness of a multicomponent initiative package to increase 2-to-5-year-old children’s vegetable intake in long day care centres.Methods and analysis The preparation phase will use existing literature and best practice guidelines to develop three initiatives aiming to: (1) increase vegetable provision at mealtimes, (2) deliver a vegetable-focused sensory curriculum and (3) use supportive mealtime practices encouraging children’s tasting of vegetables. …”
Get full text

Defining decision thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision (Et... by Pablo Alonso-Coello, Lawrence Mbuagbaw, Elena Parmelli, Feng Xie, Holger J Schünemann, Antonio Bognanni, Nancy Santesso, Wojtek Wiercioch, Elie A Akl, Thomas Piggott, Uwe Siebert, Ilse M Verstijnen, Andrea J Darzi, Jan L Brozek, Gian Paolo Morgano, Zuleika Saz-Parkinson

“…Introduction The Grading of Recommendations Assessment, Development and Evaluation (GRADE) and similar Evidence to Decision (EtD) frameworks require its users to judge how substantial the effects of interventions are on desirable and undesirable people-important health outcomes. …”
Get full text

Financial inclusion of the informal sector of marginalized counties in Kenya by Richard Wamalwa Wanzala, Lawrence Ogechukwu Obokoh

“…However, formal business registration, financial literacy, and the use of digital financial services enhance inclusion. …”
Get full text

Progress, impacts and lessons from market shaping in the past decade: a systematic review by Wenhui Mao, Katharine Olson, Elina Urli Hodges, Krishna Udayakumar

Get full text

Internalisation of the SDGs in the Western Brazilian Amazon: a qualitative study on continuing education processes and health vulnerability by Larissa Pereira de Moura, José Tomás Mateos, Frederyk Kluyvert Ryjkaard Barbosa e Silva, Herleis Maria de Almeida Chagas, Danúzia da Silva Rocha, Rozilaine Redi Lago, Montserrat Gea-Sánchez

“…In alignment with the Sustainable Development Goals (SDGs) on health and well-being, the health situation in the Brazilian Amazon stands out due to the region’s numerous vulnerabilities. …”
Get full text

Initial Psychometric Evaluation of the Barth Syndrome Symptom Assessment (BTHS-SA) for Adolescents and Adults in a Phase 2 Clinical Study by Chad Gwaltney, Alan Shields, Emily Love, Sarah Ollis, Jonathan Stokes, Iyar Mazar, Ethan Arenson, Anthony Aiudi, R. J. Wirth, Carrie Houts

“…The Barth Syndrome Symptom Assessment (BTHS-SA) is a patient-reported outcome questionnaire developed to assess BTHS symptom severity. The current study reflects the first exploration of the assessment’s psychometric performance. …”
Get full text

‘Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus’ by Louise Schmidt, Ozren Sehic, Ursula Theuretzbacher, Daniel Fabian, Claudia Wild

“…The framework, together with work we have done on identifying sources for funding, can be applied to support pharmaceutical price negotiations that reflect the level of public contribution to product development.Trial registration: EU Clinical Trials Register identifier: 0004-2083-2207.Trial registration: EU Clinical Trials Register identifier: 0003-1754-9422.…”
Get full text

First-in-human study of CPL’116 – a dual JAK/ROCK inhibitor – in healthy subjects by Piotr J. Rudzki, Katarzyna Jarus-Dziedzic, Dorota Włodarczyk, Michał Kaza, Piotr Pankiewicz, Agnieszka Gierczak-Pachulska, Martyna Banach, Beata Zygmunt, Cezary Piwowarczyk, Paweł Żero, Daniel Rabczenko, Agnieszka Segiet-Święcicka, Maciej Wieczorek

“…The positive results of this study indicate the possibility of developing a novel class of therapeutics that address both inflammatory and fibrotic processes.Clinical Trial RegistrationMethodsclinicaltrials.gov, identifier NCT04670757.…”
Get full text

The development and validation of HPLC-DMD method for intermediate products impurities determination of morpholinium 2-((4-(2-methoxyphenyl)-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-y... by B. O. Varynskyi, A. G. Kaplaushenko

“…Purpose. A development and validation of new sensitive, high efficient and selective HPLC determination method of intermediates technological contaminations in bulk drug of morpholin-4-ium 2-((4-(2-methoxyphenyl)-5-(pyridine-4-yl)-4H-1,2,4-triazole-3-yl)thio)acetate (active pharmaceutical ingredient – API). …”
Get full text

A protocol paper for the MOTION Study-A longitudinal study in a cohort aged 60 years and older to obtain mechanistic knowledge of the role of the gut microbiome during normal healt... by Sarah Phillips, Rachel Watt, Thomas Atkinson, Shelina Rajan, Antonietta Hayhoe, George M Savva, Michael Hornberger, Ben J L Burton, Janak Saada, Melissa Cambell-Kelly, Simon Rushbrook, Simon R Carding

“…There is a social and economic need to develop strategies to prevent or delay age-related disease and maintain lifelong health. …”
Get full text

Development of a machine learning-based prediction model for extremely rapid decline in estimated glomerular filtration rate in patients with chronic kidney disease: a retrospectiv... by Shingo Fukuma, Yukio Yuzawa, Daijo Inaguma, Hiroki Hayashi, Ryosuke Yanagiya, Akira Koseki, Toshiya Iwamori, Michiharu Kudo

“…The random forest model identified haemoglobin, albumin and C reactive protein as important characteristics.Conclusions The random forest model could be useful in identifying patients with extremely rapid eGFR decline.Trial registration UMIN 000037476; This study was registered with the UMIN Clinical Trials Registry.…”
Get full text

The Russian language in the modern educational space of Lebanon by Anatolu Yu. Ustinov, Elena N. Demesheva, Galina V. Abbas

“…The following research methods were used: analysis and synthesis of scientific sources on the research problem to determine its initial provisions; systematization of data for the analysis and development of organizational and content conditions of Russian language learning in educational institutions in Lebanon; direct observation, collecting information through purposeful perception and registration of organizational forms of Russian language learning; analysis and generalization of pedagogical experience, including the experience of the authors of this study in teaching Russian in Lebanon; analysis and synthesis of pedagogical experience in teaching Russian in the Lebanese State University and the Center for Open Education of the Ministry of Education of the Russian Federation in the Lebanese Republic. …”
Get full text