Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Two participant cohorts, for development and validation, underwent simple index tests and a reference standard (invasive urodynamics). …”
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mHealth tool to improve community health agent performance for child development: study protocol for a cluster-randomised controlled trial in Peru by Christopher Michael Westgard, Natalia Rivadeneyra, Patricia Mechael

“…The results of the study will provide evidence on the potential of a mHealth tool to improve child health and development indicators in the region.Ethics and dissemination The study received approval from National Hospital ‘San Bartolome’ Institutional Ethics Committee on 8 November 2018 (IRB Approval #15463–18) and will be disseminated via peer-reviewed publications.Trial registration number ISRCTN43591826.…”
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Developing the ‘Life Threads’ approach to support families after traumatic brain injury in UK community settings: protocol for a qualitative prefeasibility study by Caroline Ellis-Hill, Fergus Gracey, Mark Holloway, Charlotte Jane Whiffin, Alyson Norman, Morag Lee, Parmjeet Kaur Singh, Jo Clark-Wilson, Audrey Daisley, Natasha Yasmin Felles, Sara Rose

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Effectiveness of a continuous training program on knowledge and professional development of healthcare providers in healthy community clinics in Jordan: a quasi-experimental study by Khitam Alsaqer, Amal Ireifij, Duaa Fayiz Al-Maghaireh, Mariam Kawafha, Abdullah Al Nsour, Rami Farraj, Sara Abu Hashish, Saif Fakhoury, Ramadan Farajat, Asma Khresat, Mahmoud Nabulsi

“…Trial registration : Clinical trial number: not applicable.…”
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Interface management concepts in healthcare for rare diseases in Germany: a study protocol for a mixed-methods study to develop best practice recommendations by Martin Härter, Laura Inhestern, Corinna Bergelt, David Zybarth, Ramona Otto, Maja Brandt

“…In phase 1, we will develop a tool to assess existing concepts of interface management for rare diseases based on a literature search and an expert workshop. …”
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Development and validation of a prediction model for post-induction hypotension in elderly patients undergoing non-cardiac surgery: a prospective cohort study by Zhen Bian, Wei Dou, Yaoyu Ying, Haijing Shi, Fuhai Ji, Jinghui Hu, Ke Peng

“…Conclusion A PIH prediction model with four predictors was developed and validated for elderly patients undergoing non-cardiac surgery. …”
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Polymorphisms of the KCNS1, COMT and OPRM1 genes and development of postoperative pain in patients with osteoarthritis who underwent total knee or hip replacement by K. E. Glemba, I. A. Guseva, A. E. Karateev, M. A. Makarov, E. Yu. Samarkina, N. V. Konovalova, D. A. Varlamov

“…There was no significant correlation between the development of POP and the carrier of different genotypes and alleles of the COMT (rs6269) and OPRM1 (rs1799971) genes.Conclusions. …”
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Development and validation of an improved prediction model for vaginal birth after previous cesarean section: a retrospective cohort study of a Chinese population by Haiyan Liu, Yi Yu, Xiaoyue Zhang, Jiangnan Pei, Yao Tang, Rong Hu, Weirong Gu

“…The development dataset comprised 481 women, while the other 239 women constituted the temporal validation dataset. …”
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The German national cohort study on the development of motor performance, physical activity and health in children and adolescents: the MoMo 2.0-Study protocol by Alexander Burchartz, Claudia Niessner, Klaus Bös, Sarah Heinisch, Alexander Woll, Leon Klos, Annette Worth, Anke Hanssen-Doose, Thomas Hinz, Manuel Völkle, Birte von Haaren-Mack, Larissa Heißler, Darko Jekauc, Simon Kolb, Claudia Lazarides, Carina Nigg, Elke Opper, Elena Brehm, Steffen Schmidt, Lara Tschuschke, Carmen Volk, Susanne Weyland, Hagen Wäsche, Hannah Zimmermann, Clara Zöller

“…The relationships between PA, motor performance, health and their respective determinants, as well as their individual development throughout childhood and adolescence, are not yet fully understood. …”
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Nursing-centered development of an AI-based decision support system in pressure ulcer and incontinence-associated dermatitis management - a mixed methods study by Khalid Majjouti, Vanessa Priester, Michaela Tapp-Herrenbrueck, Alexander Brehmer, Hannah Pinnekamp, Michael Aleithe, Uli Fischer, Jens Kleesiek, Bernadette Hosters

“…Conclusions The integration of evidence from nursing science and practice into the AI development process using a mixed-methods approach, established a robust, evidence-based foundation. …”
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Development and Validation of Risk Stratification for Heart Failure After Acute Coronary Syndrome Based on Dynamic S100A8/A9 Levels by Jie Ma, Ke Ma, Jing Chen, Xinying Yang, Fei Gao, Hai Gao, Hui Zhang, Xin‐Liang Ma, Jie Du, Ping Li, Yulin Li

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Protocol for the development of a transdiagnostic core outcome set for mental health disorders in adults: the Patient Important Outcomes in Psychiatry (PIO-Psych) Initiative by Christian Gluud, Lehana Thabane, Zainab Samaan, Lawrence Mbuagbaw, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Morten Hylander Møller, Sophie Juul, Mark Horowitz, Rikke Hermann, Pascal Faltermeier, Markus Harboe Olsen, Johanne Juul Petersen, Caroline Barkholt Kamp, Michael P. Hengartner

“…The aim of the Patient Important Outcomes in Psychiatry (PIO-Psych) Initiative is to develop an overarching, transdiagnostic research-based and consensus-based core outcome set for adult mental health disorders.Methods and analysis The development of the PIO-Psych transdiagnostic core outcome set will include three phases: (1) a systematic scoping review of the literature to develop the initial list of outcomes for the Delphi study; (2) a Delphi study in three rounds including people with lived experience of mental health disorders and their relatives, clinicians, researchers and others (administrators, mental healthcare policymakers, philosophers); (3) a hybrid consensus meeting to agree on the final overarching, transdiagnostic core outcome set and corresponding time points of assessment of each outcome.Ethics and dissemination Ethical approval is not applicable to this study according to the Research Ethics Committee of the Capital Region of Denmark, as it is not an interventional study. …”
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Development and Validation of Virtual Reality Cognitive Training for Older Adults with Mild Cognitive Impairment: Protocol for a Mixed-Methods Program Evaluation Study by Chen IC, Wu CY, Hu YL, Huang YM

“…This study aims to address these uncertainties by developing and validating a fi-VRCT program focused on IADL, with the goal of enhancing both cognitive function and IADL performance in older adults with MCI.Methods and Analysis: This mixed methods program evaluation study consists of three phases: feasibility, intervention, and extension. …”
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Development of a Voice-Activated Virtual Assistant to Improve Insomnia Among Young Adult Cancer Survivors: Mixed Methods Feasibility and Acceptability Study by Hunter Groninger, Hannah Arem, Lylian Ayangma, Lisa Gong, Eric Zhou, Daniel Greenberg

“…Trial RegistrationClinicalTrials.gov NCT05875129; https://clinicaltrials.gov/study/NCT05875129…”
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A Deep Learning Model for Identifying the Risk of Mesenteric Malperfusion in Acute Aortic Dissection Using Initial Diagnostic Data: Algorithm Development and Validation by Zhechuan Jin, Jiale Dong, Chengxiang Li, Yi Jiang, Jian Yang, Lei Xu, Ping Li, Zhun Xie, Yulin Li, Dongjin Wang, Zhili Ji

“…ObjectiveThis study aims to develop and validate a deep learning–based model that integrates multimodal data to identify patients with AAD at high risk of MMP. …”
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Development and Implementation of MyPainHub, a Web-Based Resource for People With Musculoskeletal Conditions and Their Health Care Professionals: Mixed Methods Study by Kerrie Evans, Jonathan Ko, Dragana Ceprnja, Katherine Maka, Darren Beales, Michele Sterling, Kim L Bennell, Gwendolen Jull, Paul W Hodges, Marnee J McKay, Trudy J Rebbeck

“…MyPainHub was then developed through an iterative process and implementation strategies were tailored to different health care settings. …”
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Non-invasive breath testing to detect colorectal cancer: protocol for a multicentre, case–control development and validation study (COBRA2 study) by Michael G. Fadel, James Murray, Georgia Woodfield, Ilaria Belluomo, Ivan Laponogov, Aaron Parker, Valerio Converso, James K. Ellis, Pete Wheatstone, Julie Hepburn, Chris Groves, Kevin Monahan, Brian P. Saunders, Patrik Španěl, Kirill Veselkov, Amanda J. Cross, Christos Kontovounisios, Linda D. Sharples, George B. Hanna, COBRA2 Collaborators

“…This protocol describes the COBRA2 study which aims to develop and validate the clinical prediction model (CPM) in the detection of CRC based on the breath test. …”
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A holistic approach to promoting early child development: a cluster randomised trial of a group-based, multicomponent intervention in rural Bangladesh by Stephen P Luby, Mahbubur Rahman, Fahmida Tofail, Lia CH Fernald, Esther O Chung, Helen O Pitchik, Fahmida Akter, Jesmin Sultana, Abul Kasham Shoab, Tarique Md. Nurul Huda, Tania Jahir, Md Ruhul Amin, Md Khobair Hossain, Jyoti Bhushan Das, Kendra A Byrd, Farzana Yeasmin, Laura H Kwong, Jenna E Forsyth, Malay K Mridha, Peter J Winch

“…Compared with the control arm, children in the group arm had higher total ASQi scores (adjusted mean difference in standardised scores: 0.39, 0.15 to 0.64), while in the combined arm scores were not significantly different from the control (0.25, –0.07 to 0.54).Conclusion Our findings suggest that group-based, multicomponent interventions can be effective at improving child development outcomes in rural Bangladesh, and that they have the potential to be delivered at scale.Trial registration number The trial is registered in ISRCTN (ISRCTN16001234).…”
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Health-related SDGs in the national science agendas of Latin America and the Caribbean: a scoping review by Martín Alberto Ragusa, Fernando Tortosa, Maristela Monteiro, Sebastian Garcia Saiso, Ludovic Reveiz

“…Health-related targets aligned with SDG-3 were highlighted, particularly in areas such as communicable diseases and drug and vaccine development, but there was limited representation in public health and health systems. …”
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The transfusion of prematures early school age follow-up (TOP 5): protocol for a longitudinal cohort study by Amy L. Conrad, Sara B. DeMauro, Haresh Kirpalani, Kristina Ziolkowski, Susan R. Hintz, Betty R. Vohr, Victoria Watson, Tarah T. Colaizy, Edward F. Bell, Jane E. Brumbaugh, Carla M. Bann, Sylvia M. Tan, Jamie E. Newman, Abhik Das

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