Integrating Transcriptomic and Proteomic Data: IL‐27B as a Key Protein in the Development of Septic Cardiomyopathy—A Retrospective Study by Yifeng Mao, Qingqing Chen, Yongpo Jiang, Xijiang Zhang, Qin Si, Panpan Xu, Zhongheng Zhang, Cheng Zheng, Ronghai Lin

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Development of a patient decision aid on subacromial decompression surgery and rotator cuff repair surgery: an international mixed-methods study by Rachelle Buchbinder, Christopher Maher, Tammy Hoffmann, Ian Harris, Rachel Thompson, Joshua Zadro, Denise A O'Connor, Caitlin Jones, Sascha Karunaratne, Min Jiat Teng

“…Objective To develop and user test a patient decision aid for people with subacromial pain syndrome that presents evidence-based information on the benefits and harms of subacromial decompression surgery and rotator cuff repair surgery.Design Mixed-methods study outlining the development of a patient decision aid.Setting We assembled a multidisciplinary steering group, and used existing decision aids and decision science to draft the decision aid. …”
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Development of Powerly, unguided mobile app intervention preventing postpartum depression and anxiety & study protocol of randomized clinical trial by Marta A. Marciniak, Judith Rohde, Kenneth S.L. Yuen, Harald Binder, Henrik Walter, Matthias J. Wieser, Raffael Kalisch, Karin Roelofs, Birgit Kleim

“…At the same time, 15–20 % of new mothers develop postpartum depression, and 25–35 % experience postpartum anxiety. …”
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A protocol to study the effect of targeted parental education intervention to identify early childhood development disorder – multisite interventional study by Vadivelan Kanniappan, Prakash Muthuperumal, P. Venkataraman, Anuradha Murugesan, Balaji Chinnasami, Manikumar Muthiah, Subramanian Sethuraman, Abishek J. R., Shrisruthi Suresh, Murali Krishnan Nambirajan, Angeline Grace G., Veeragoudhaman T. S., Kuberan Deivasigamani

“…These delays contribute to neurological and motor development delays, placing a significant financial burden on families. …”
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Development and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment by Du S, Wu Y, Tao J, Shu L, Yan T, Xiao B, Lv S, Ye M, Gong Y, Zhu X, Hu P, Wu M

“…Then, the prediction models developed have revealed that LightGBM algorithm has a superior performance with an AUC-ROC value of 0.842 in the validation cohort, while the SHAP results showed that age is the most important risk factor affecting functional outcomes.Conclusion: The LightGBM model holds immense potential in facilitating risk stratification for poor-grade aSAH patients undergoing endovascular treatment who are at risk of adverse outcomes, thereby enhancing clinical decision-making processes.Trial Registration: PROSAH-MPC. …”
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Development and external validation of machine learning models for the early prediction of malnutrition in critically ill patients: a prospective observational study by Yi Liu, Yehua Xu, Lixia Guo, Zhongbin Chen, Xueqin Xia, Feng Chen, Li Tang, Hua Jiang, Caixia Xie

“…The development data were partitioned into training (80%) and testing (20%) sets. …”
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Integrated Psychosocial Care in Intensive Care (IPS-Pilot): Protocol for the Systematic, Multimethod Development of a Complex Intervention (Phase A) by Sophie Felicitas Nickel, Simone Korger, Wencke Schindler, Heike Heytens, Gironimo Krieg, Karl-Philipp Drewitz, Katrin Schürmann, Leon Schössow, Julianna Gehrig, Marius Binneböse, Christian Hirning, Klaus Hönig, Rolf Konstantin Niessen, Julia Kirschbaum, Laurence Erdur, Sophie Peter, Florian Junne, Matthias Rose, Christian Apfelbacher, Harald Gündel

“…Data collection and analysis for the intervention development were completed by June 2024, including substudy 1 (n=104 included articles), substudy 2 (n=22 interviews and n=18 participants in focus groups), substudy 3 (n=237 survey participants), and substudy 4 (n=11, n=15, and n=20 participants in 3 consecutive workshops), with further analyses still ongoing beyond the scope of intervention development. …”
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Prognostic value of a composite physiologic index developed by adding bronchial and hyperlucent volumes quantified via artificial intelligence technology by Michihiro Uyama, Tomohiro Handa, Ryuji Uozumi, Seishu Hashimoto, Yoshio Taguchi, Kohei Ikezoe, Kiminobu Tanizawa, Naoya Tanabe, Tsuyoshi Oguma, Atsushi Matsunashi, Takafumi Niwamoto, Hiroshi Shima, Ryobu Mori, Tomoki Maetani, Yusuke Shiraishi, Tomomi W. Nobashi, Ryo Sakamoto, Takeshi Kubo, Akihiko Yoshizawa, Kazuhiro Terada, Yuji Nakamoto, Toyohiro Hirai

“…Abstract Background The composite physiologic index (CPI) was developed to estimate the extent of interstitial lung disease (ILD) in idiopathic pulmonary fibrosis (IPF) patients based on pulmonary function tests (PFTs). …”
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PREDICTORS OF THE DEVELOPMENT OF HYPOXIC-ISHEMIC ENCEPHALOPATHY IN FULL-TERM AND PREMATURE INFANTS BORNFROM MOTHERS WITH METABOLIC SYNDROME IN THE EARLY NEONATAL PERIOD by А. Давиденко, В. Похилько, О. Ковальова, Ю. Чернявська, С. Цвіренко, Г. Соловйова

“…The work was carried out within the research project of the Department of Paediatrics No. 1 with Neonatology of Poltava State Medical University ’’To develop clinical and laboratory criteria, methods for predicting and preventing metabolic disorders in young children’’ (state registration number 0120U102856, term of completion 2020-2024). …”
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Kangaroo Mother Care implementation research to develop models for accelerating scale-up in India and Ethiopia: study protocol for an adequacy evaluation by Anteneh Asefa, Rajiv Bahl, Sarmila Mazumder, Nita Bhandari, Jose Martines, Lynn M Sibley, Nalini Singhal, Khalid Aziz, Thomas Brune, Araya Abrha Medhanyie, Hibret Alemu, Selemawit Asfaw Beyene, Fisseha Ashebir Gebregizabher, Habtamu Beyene, Grace Chan, John N Cranmer, G Darmstadt, Dereje Duguma, Addisalem Fikre, Bizuayehu Gashaw Andualem, Abebe Gebremariam Gobezayehu, Tedros Hailu Abay, H L Mohan, Arun Jadaun, K Jayanna, F N U Kajal, Arin Kar, Raghav Krishna, Aarti Kumar, Vishwajeet Kumar, Tarun Kumar Madhur, Mulusew Lijalem Belew, Rajini M, Hajira Amin, Prem K Mony, Mekonnen Muleta, Cynthia Pileggi-Castro, Suman Pn Rao, Abiy Seifu Estifanos, Henok Tadele, Abraham Tariku, Ephrem Tekle Lemango, Birkneh Tilahun Tadesse, Ravi Upadhyay, Bogale Worku, Marta Yemane Hadush, Grace J Chan, Gary Lee Darmstadt, HL Mohan, Krishnamurthy Jayanna, M Rajini, Jose Carlos Martines, Hajira Mohammed Amin, Suman Rao, Ravi Prakash Upadhyay

“…Consequently, only a small fraction of newborns that could benefit from KMC receive it.Methods and analysis This implementation research project aims to develop and evaluate district-level models for scaling up KMC in India and Ethiopia that can achieve high population coverage. …”
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Improving Stem Cell Clinical Trial Design and Conduct: Development of a Quality Assessment Tool for Stem Cell Clinical Trials by Yixuan Li, Li Xie, Jie Wang, Jinghang He, Ying Qian, Weituo Zhang, Zhaohui Wu, Biyun Qian

“…This study is aimed at developing a handy quality assessment tool for stem cell clinical trials, enhancing capacity of the self-regulate overall quality, and participating protection. …”
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CONSTITUTIONAL AND LEGAL RESPONSIBILITY OF POLITICAL PARTIES IN THE CONTEXT OF TODAY'S CHALLENGES by Nataliia M. Batanova

“…The author analyzes the normative grounds for applying such constitutional and legal sanctions as a ban on the formation and activities of a political party or cancellation of a political party's registration in case of unlawful acts. A retrospective analysis of the practice of banning political parties and canceling their registration in Ukraine generally indicates a positive trend in the development of national legislation on political parties and their responsibility in recent years. …”
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Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique by Chris Littlewood, Marcus Bateman, Jonathan C Hill, Benjamin Saunders

“…Other treatment options including electrotherapy, acupuncture and manual therapy were excluded.Conclusion An optimised physiotherapist-led treatment protocol for people with LET was successfully developed using an online NGT consensus approach. This intervention is now ready for testing in a future pilot/feasibility RCT to contribute much needed evidence about the treatment of LET.Trial registration number This is the pre-cursor to the OPTimisE Pilot and Feasibility Randomised Controlled Trial. …”
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Exploring the benefits of a psychomotor intervention mediated by creative dance in community-dwelling older adults: development of new coordination and rhythm tests by Hugo Rosado, Patrícia Motta, Gabriela Almeida, Ana Cruz-Ferreira, Catarina Pereira

“…Date of registration: March 17, 2020.…”
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RUSSIAN FEDERATION POPULATION RADIATION PROTECTION DURING THE EXPOSURE FROM NATURAL IONIZING IRRADIATION SOURCES: MODERN STATE AND DIRECTIONS FOR DEVELOPMENT AND OPTIMIZATION by I. P. Stamat, T. A. Kormanovskaya, G. A. Gorskiy

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General Legal Characteristics of Peasant (Farmer’s) Economy in the Conditions of Modernization of Civil Legislation by A. V. Tagirova

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Design, development and randomised controlled trial protocol of a smartphone-delivered version of ‘SOLAR’ for emergency service workers to manage stress and trauma by Meaghan O'Donnell, Olivia Metcalf, Kari Gibson, Julia Fredrickson, Laura Finlayson-Short, Tracey Varker

“…Methods and analyses First, focus groups and codesign activities with mental health professionals and emergency service workers will be conducted to develop and test the prototype smartphone version of SOLAR (ie, SOLAR-m). …”
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Pan-cancer predictive survival model development and evaluation using electronic health record and genetic data across 10 cancer types by Jurgita Gammall, Alvina G. Lai

“…The aim of this study is to develop and evaluate prognostic cancer survival models across ten common cancer types based on a large patient sample. …”
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Inclusive, supportive and dignified maternity care (SDMC)-Development and feasibility assessment of an intervention package for public health systems: A study protocol. by Bilal Iqbal Avan, Waqas Hameed, Bushra Khan, Muhammad Asim, Sarah Saleem, Sameen Siddiqi

“…The study has been registered with clinicaltrials.gov (Registration number: NCT05146518).…”
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Intervention Development for Tailored Education for Aging and Cognitive Health (TEACH) for Dementia Prevention in Midlife Adults: Protocol for a Randomized Controlled Trial by Laura E Korthauer, Rochelle K Rosen, Geoffrey Tremont, Jennifer D Davis

“…ObjectiveIn keeping with stage I of the National Institutes of Health (NIH) Stage Model for Behavioral Intervention Development, this study will use mixed methods to (1) develop an enhanced health education intervention, including an explanatory method for communicating information about dementia risk and personal health beliefs, and (2) conduct a pilot randomized controlled trial (n=20 per intervention arm) over 8 weeks to assess the feasibility of delivering the enhanced intervention versus basic health education alone. …”
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