Identifying most important predictors for suicidal thoughts and behaviours among healthcare workers active during the Spain COVID-19 pandemic: a machine-learning approach by Itxaso Alayo, Oriol Pujol, Jordi Alonso, Montse Ferrer, Franco Amigo, Ana Portillo-Van Diest, Enric Aragonès, Andrés Aragon Peña, Ángel Asúnsolo Del Barco, Mireia Campos, Meritxell Espuga, Ana González-Pinto, Josep Maria Haro, Nieves López-Fresneña, Alma D. Martínez de Salázar, Juan D. Molina, Rafael M. Ortí-Lucas, Mara Parellada, José Maria Pelayo-Terán, Maria João Forjaz, Aurora Pérez-Zapata, José Ignacio Pijoan, Nieves Plana, Elena Polentinos-Castro, Maria Teresa Puig, Cristina Rius, Ferran Sanz, Cònsol Serra, Iratxe Urreta-Barallobre, Ronny Bruffaerts, Eduard Vieta, Víctor Pérez-Solá, Philippe Mortier, Gemma Vilagut

“…Future clinical implementations of this model could enable the early detection of HCWs at the highest risk for developing adverse mental health outcomes. Study registration NCT04556565 …”
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The implementation of Safety Management Systems in healthcare: a systematic review and international comparison by Zhivko Zhelev, Sian de Bell, Alison Bethel, Maria Clarke, Rob Anderson, Jo Thompson Coon

“…Study registration This study is registered as PROSPERO CRD42023487512. …”
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Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effec... by Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith

“…We assessed the cost-effectiveness of treatments by developing an economic model to estimate the incremental cost per quality-adjusted life-year (QALY) gained. …”
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Opportunities and practices supporting responsive health care for forced migrants: lessons from transnational practice and a mixed-methods systematic review by Amy Robinson, Protus Musotsi, Ziaur Rahman A Khan, Laura Nellums, Bayan Faiq, Kofi Broadhurst, Gisela Renolds, Michael Pritchard, Andrew Smith

“…Cambridge: Polity Press; 2011), to a ‘capability to be healthy’. We developed a tentative set of responsive principles, which we explored through four stakeholder ‘conversations’. …”
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Variation within and between digital pathology and light microscopy for the diagnosis of histopathology slides: blinded crossover comparison study by David RJ Snead, Ayesha S Azam, Jenny Thirlwall, Peter Kimani, Louise Hiller, Adam Bickers, Clinton Boyd, David Boyle, David Clark, Ian Ellis, Kishore Gopalakrishnan, Mohammad Ilyas, Paul Kelly, Maurice Loughrey, Desley Neil, Emad Rakha, Ian SD Roberts, Shatrughan Sah, Maria Soares, YeeWah Tsang, Manuel Salto-Tellez, Helen Higgins, Donna Howe, Abigail Takyi, Yan Chen, Agnieszka Ignatowicz, Jason Madan, Henry Nwankwo, George Partridge, Janet Dunn

“…Future work The use of digital pathology for cytology samples remains an area for further research. Study registration: This study is registered as ISRCTN14513591. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Stakeholders contributed to protocol development, report drafting and interpretation of review findings. …”
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Impact of frailty in older people on health care demand: simulation modelling of population dynamics to inform service planning by Bronagh Walsh, Carole Fogg, Tracey England, Sally Brailsford, Paul Roderick, Scott Harris, Simon Fraser, Andrew Clegg, Simon de Lusignan, Shihua Zhu, Francesca Lambert, Abigail Barkham, Harnish Patel, Vivienne Windle

“…Objectives To explore the incidence, prevalence, progression and impact of frailty within an ageing general practice population and model the dynamics of frailty-related healthcare demand, outcomes and costs, to inform the development of guidelines and tools to facilitate commissioning and service development. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The study findings support progression to impact research by development of tools to optimise assessment methods, educational elements of interpreting results and quality of service delivery. …”
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Consequences, costs and cost-effectiveness of workforce configurations in English acute hospitals by Peter Griffiths, Christina Saville, Jane Ball, David Culliford, Jeremy Jones, Francesca Lambert, Paul Meredith, Bruna Rubbo, Lesley Turner, Chiara Dall’Ora

“…These findings lend support to policy initiatives aimed at increasing the supply of RNs. Study registration This study is registered as Current Controlled Trials ClinicalTrials.gov NCT04374812. …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…The study findings support progression to impact research by development of tools to optimise assessment methods, educational elements of interpreting results and quality of service delivery. …”
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Clinical and cost-effectiveness of paramedics working in general practice: a mixed-methods realist evaluation by Matthew Booker, Sarah Voss, Nicky Harris, William Hollingworth, Nouf Jeynes, Hazel Taylor, Kirsty Garfield, Helen Baxter, Jonathan Benger, Andy Gibson, Trudy Goodenough, Justin Jagosh, Kim Kirby, Cathy Liddiard, Alyesha Proctor, Sarah Purdy, Behnaz Schofield, Hannah Stott, Grace Scrimgeour, Nicola Walsh

“…Nevertheless, PGP provides opportunities for the paramedic profession to develop and evolve. Study registration This study is registered as ISRCTN56909665 https://doi.org/10.1186/ISRCTN56909665. …”
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Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT by CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson

“…People who had received active treatment were 65% less likely to develop ulcer bleeding in the first 2.5 years compared to those who had received placebos. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…The methodology of fidelity assessments for complex healthcare interventions requires further development. Trial registration This trial is registered as Current Controlled Trials ISRCTN51154948 (WP5) and ISRCTN17062524 (WP6). …”
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Intersecting factors of disadvantage and discrimination and their effect on daily life during the coronavirus pandemic: the CICADA-ME mixed-methods study by Carol Rivas, Amanda P Moore, Alison Thomson, Kusha Anand, Zainab Zuzer Lal, Alison Fang-Wei Wu, Ozan Aksoy

“…We found some differences in the devolved nations, which need elucidation. Study registration This study is registered as ISRCTN40370, PROSPERO CRD42021262590 and CRD42022355254. …”
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Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…Results Workstream 1: developing the Embedding Package We developed the intervention as planned. …”
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Supporting antiretroviral therapy uptake and adherence: the SUPA research programme and RCT by Rob Horne, Caroline Sabin, Trudie Chalder, Vanessa Cooper, Lucy Campbell, Elizabeth Glendinning, Iris Mosweu, Paul McCrone

“…The intervention, intervention manual and animations were developed by an Intervention Development Group, including experts in adherence, behaviour change theory, CBT, HIV medicine, nursing, pharmacy and HIV patient advocacy. …”
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Software with artificial intelligence-derived algorithms for detecting and analysing lung nodules in CT scans: systematic review and economic evaluation by Julia Geppert, Peter Auguste, Asra Asgharzadeh, Hesam Ghiasvand, Mubarak Patel, Anna Brown, Surangi Jayakody, Emma Helm, Dan Todkill, Jason Madan, Chris Stinton, Daniel Gallacher, Sian Taylor-Phillips, Yen-Fu Chen

“…Artificial intelligence-based software has been developed to reduce the number of missed or misdiagnosed lung nodules on computed tomography images. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Disseminate the findings and develop a definitive trial bid. Design A programme to develop an enhanced recovery pathway for people with hip fracture and cognitive impairment, tested for implementation and refined in the clinical environment. …”
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Clinical and cost-effectiveness of detailed anomaly ultrasound screening in the first trimester: a mixed-methods study by Jehan N Karim, Helen Campbell, Pranav Pandya, Edward C F Wilson, Zarko Alfirevic, Trish Chudleigh, Elizabeth Duff, Jane Fisher, Hilary Goodman, Lisa Hinton, Christos Ioannou, Edmund Juszczak, Louise Linsell, Heather L Longworth, Kypros H Nicolaides, Anne Rhodes, Gordon Smith, Basky Thilaganathan, Jim Thornton, Gillian Yaz, Oliver Rivero-Arias, Aris T Papageorghiou

“…A consensus procedure (n = 172) developed an anatomical protocol and minimum targets for diagnosis. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…This has the potential to affect fetal brain development, increase infant reactivity to stress, and impair sensitive mother–infant bonds from developing. …”
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