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  3. 5203

    Rapid tests to inform triage and antibiotic prescribing decisions for adults presenting with suspected acute respiratory infection: a rapid evidence synthesis of clinical effective... by Katie Scandrett, Jill Colquitt, Rachel Court, Fiona Whiter, Bethany Shinkins, Yemisi Takwoingi, Emma Loveman, Daniel Todkill, Paramjit Gill, Daniel Lasserson, Lena Al-Khudairy, Amy Grove, Yen-Fu Chen

    Published 2025-05-01
    “…Future work Research is needed to explore the impact of point-of-care tests on triaging decisions across different clinical settings and to quantify the longer-term health and cost consequences. Study registration This study is registered as PROSPERO CRD42023429515. …”
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  4. 5204
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    Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial by Vicky Goh, Susan Mallett, Manuel Rodriguez-Justo, Victor Boulter, Rob Glynne-Jones, Saif Khan, Sarah Lessels, Dominic Patel, Davide Prezzi, Stuart Taylor, Steve Halligan

    Published 2025-04-01
    “…Background Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. Current prognostic models are criticised because they are based on standard staging and omit novel biomarkers. …”
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  6. 5206

    Multidisciplinary Delphi consensus on challenges and key factors for an optimal care model in chronic kidney disease by José Luis Górriz, Roberto Alcázar Arroyo, Patricia Arribas, Sara Artola, Sergio Cinza-Sanjurjo, Rafael de la Espriella, Javier Escalada, Lisardo García-Matarín, Luis Martínez, Juan Carlos Julián, José Pablo Miramontes-González, Félix Rubial, Mercedes Salgueira, María José Soler, José Luis Trillo

    Published 2024-09-01
    “…Results: 38 key factors were identified for an optimal CKD patient care model, organised into four challenges: (1) Development of CKD management models and increased visibility of the disease, (2) Prevention, optimisation of screening, early diagnosis and registration of CKD at all levels of care, (3) Comprehensive, multidisciplinary and coordinated monitoring, ensuring therapeutic optimisation and continuity of care, and (4) Reinforcement of CKD training for health care professionals and patients. 35 key factors were assessed by the panel as adequate and clearly necessary, and of these, 14 were considered highly imperative. …”
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  7. 5207

    Predictive Value of Viable Myocardium of Papillary Muscle-Ventricular Wall Complex for Improvement in Moderate Ischemic Mitral Regurgitation by Zhiepng Wei, MD, Enjun Zhu, MD, Zhiyong Shi, MD, Tong Tan, MD, Ke Zhang, MD, Zhihui Zhu, MD, Shengwei Wang, MD, Xiaoli Zhang, MD, Yongqiang Lai, MD

    Published 2025-03-01
    “…This study aimed to assess the benefit of isolated CABG and to develop a new index of viable myocardium within the papillary muscle-ventricular wall complex (VM-PM-VWC) to predict the improvement of IMR by CABG alone. …”
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  8. 5208

    HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa by Giuseppe Pantaleo, Glenda Gray, Pontiano Kaleebu, Said Aboud, David Dunn, Merlin Robb, Janet Seeley, Sheena McCormack, Julie Fox, Jim Rooney, Tom Miller, Agricola Joachim, Ilesh Jani, Mary Amondi, Peter Hughes, Sarah Joseph, Eugene Ruzagira, Vincent Basajja, Jonathan Weber, Cherry Kingsley, Eligius Lyamuya, Lucas Maganga, Doreen Pamba, Edna Viegas, Charlotta Nilsson, Arne Kroidl, Angela Crook, Anne Gumbe, Phindile Khanyile, Jennifer Serwanga, Carter Lee, Kundai Chinyenze, Song Ding, Muhammad Bakari, Neetha Morar, Ayoub Kakande, Tumaini Nagu, Henry Bern, Sylvia Kusemererwa, Patricia Munseri, Lwitiho Sudi, Jorge Ribeiro, Igor Capitine, Diana Faini, Edna Nhacule, Kubashni Woeber, Yolanda Manganhe, Abisai Kisinda, Wiston William, Rujeko Samanthia Chimukuche, Londiwe Shandu, Silindile Zulu, Nishanta Singh, Zakir Gaffoor, Rachel Kawuma, Thandiwe Sithole, Samantha Siva, Eldinah Hwengwere, Rujeko Samanthia Chidawanyika, Nteboheleng Mahapa, Isabel Remane, Odete Bule, Patricia Ramgi, Raquel Chissumba, Eduardo Namalango, Carmelia Massingue, Emmanuel Kapesa, Elizabeth Danstan, Marco Missanga, Amani Kway, Lilian Njovu, Revocatus Kunambi, Frank Msafiri, Edith Tarimo, Deus Buma, Freddie Mukasa Kibengo, Christian Hansen Holmes, Sheila Kansiime, Sylvia Masawi, Tobias Vudriko, Shamim Nabukenya, Gertrude Mutonyi, Rita Nakiboneka, Susan Mugaba, Aminata Sy, Liz Brodnicki, Claire Wenden, Jacqueline Musau, Mabela Matsoso, Paramesh Chetty, Gustavo Doncel, Allison Matthews

    Published 2025-04-01
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  10. 5210

    Clinical and cost-effectiveness of percutaneous nephrolithotomy, flexible ureterorenoscopy and extracorporeal shockwave lithotripsy for lower pole stones: the PUrE RCTs by Oliver Wiseman, Daron Smith, Kath Starr, Lorna Aucott, Rodolfo Hernández, Ruth Thomas, Steven MacLennan, Charles Terry Clark, Graeme MacLennan, Dawn McRae, Victoria Bell, Seonaidh Cotton, Zara Gall, Ben Turney, Samuel McClinton

    Published 2025-08-01
    “…What effect does miniaturisation of keyhole surgery have on postoperative pain, length of stay, complications, stone-free rates and costs? Trial registration This trial is registered as ISRCTN98970319. …”
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  11. 5211

    Carvedilol to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by liver stiffness: study protocol for a randomied, double-... by Jie Li, Yan Wang, Fang Wang, Tianyu Liu, Xiao Liang, Yiling Li, Xiaolong Qi, Liting Zhang, Ping Chen, Jian Fan, Ju Huang, Zhujun Cao, Xiaofeng Wu, Chuan Liu, Xiaoguo Li, Zhongji Meng, Da Zhu, Qing-Lei Zeng, Wei Gou, Jiaojian Lv, Qingge Zhang, Zhaowei Tong, Junliang Fu, Cidan Zhuoga, Dong Ji, Shuairan Zhang, Yu-Jun Wong, Xuan Liang, Shengjuan Hu, Guohong Ge, Mingxing Huang, Tao Ren, Deping Ding, Basang Zhuoga, Dianjie Dang, Liang Miao, Zhaomin Song, Xingguo Xiao, Huili Wu, Kai Jiang, Youfang Gao, Lan Ma, Tao Fang, Yuehua Wang, Qianhua Zhang, Yufang Wei, Zhongsi Hong, Yuemin Nan

    Published 2024-07-01
    “…The secondary outcomes include development of each complication of portal hypertension individually (ascites, variceal bleeding or overt hepatic encephalopathy), development of spontaneous bacterial peritonitis and other bacterial infections, development of new varices, growth of small varices to large varices, delta changes in LS and spleen stiffness, change in hepatic dysfunction assessed by Child-Pugh and model for end-stage liver disease score, change in platelet count, development of hepatocellular carcinoma, development of portal vein thrombosis and adverse events with a 3-year follow-up. …”
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  12. 5212

    Public health engagement in alcohol licensing in England and Scotland: the ExILEnS mixed-method, natural experiment evaluation by Niamh Fitzgerald, Matt Egan, Rachel O’Donnell, James Nicholls, Laura Mahon, Frank de Vocht, Cheryl McQuire, Colin Angus, Richard Purves, Madeleine Henney, Andrea Mohan, Nason Maani, Niamh Shortt, Linda Bauld

    Published 2024-02-01
    “…Using structured interviews (n = 66), documentation analysis, and expert consultation, we developed and applied the Public Health Engagement In Alcohol Licensing (PHIAL) measure to quantify six-monthly activity levels from 2012 to 2019. …”
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    COVIDTrach: a prospective cohort study of mechanically ventilated patients with COVID-19 undergoing tracheostomy in the UK by A Thompson, S Wilkinson, N Kumar, G Wong, J Smith, F Franco, P Smith, A Wilson, S Ghosh, S Shepherd, A Kumar, R Brown, D Williams, M Griffiths, J Sen, M Roberts, A McGrath, D Kumar, A Walker, A Gupta, N Sharma, P Shah, M Kumar, H Jones, P Paul, I Gonzalez, A Shah, V Srinivasan, M Kelly, P Surda, K Valchanov, S Saha, R Bentley, C Hall, J Ng, C Pearce, R Harris, H Wilson, N Amin, J Phillips, D Park, C Jennings, L Wren, B McGrath, D Walker, J Ahmed, S Menon, N Jain, R Mistry, E Jackson, W Rutherford, E France, S Mahalingam, C Hogan, A Burns, T Exall, J Rodrigues, C Xie, M Rouhani, E Paramasivam, A WILLIAMSON, K STEELE, D Dawson, S Linton, M Cameron, S Biswas, S Hodges, J Collier, J Collins, S Bennett, T Ali, N Bhatti, S Suresh, J Williamson, G Ambler, C Cook, D Baker, J Bates, J Blair, P Mukherjee, A Howard, B Cosway, M Anwar, S Fang, S Meghji, H Griffiths, M Keil, F GREEN, K Hussain, A Schache, C Lockie, S Winter, J Westwood, A Hormis, P Ward, C Walker, G Sandhu, T Davies, A Lloyd, L Linhartova, C SPENCER, A Courtney, L Bates, T Martín, T Tatla, L Ritchie, P Gill, S Shannon, A Arora, R Pinto, H Turner, J Whittaker, E Warner, L Leach, A Menon, J Higginson, G Warner, A Balfour, F Cooper, A Li, S Berry, R Gohil, M Celinski, J McEwan, E Riley, S Webster, I Ahmad, M Idle, K Jolly, S Burrows, S Parmar, B Morris, A Arya, S Mustafa, E Tam, D Chakravarty, M De, A Daudia, B Tehan, R Temple, J Broad, P Andrews, D Pennell, C Smart, R D’Souza, P Praveen, DJ Lin, M Osborne, A Coombs, T Hunt, M Singer, C Smyth, R Saha, G Walton, P Bishop, U Sheikh, R O'Brien, R Bhandari, A Rovira, S Sanyal, E Yeung, A Tse, N Lawrence, P Stimpson, H Saeed, K Fan, M Ashcroft, T Jacob, J Hadley, K Goodwin, Z Abdi, D Nair, B Hill, D Whitmore, N Macartney, P Sykes, N Mercer, R Sykes, S Siddiq, Nick JI Hamilton, AGM Schilder, MM George, GM Jama, J Goulder, C Schilling, S Laha, MA Birchall, NS Tolley, P Nankivell, O Breik, P Pracy, J Osher, C Huppa, P Stenhouse, F Ryba, EK Bhargava, D Ranford, A Takhar, C Tornari, M Verkerk, C Al-Yaghchi, M Jaafar, N Cereceda-Monteoliva, A Holroyd, K Ghufoor, H O'Mahony, H Drewery, A Mulcahy, T Magos, I Balasundaram, M Heliotis, A Loizidou, D York, R Exley, KA Solanki, P Kirticumar, A Shirazian, Y Bhatt, R Natt, N Banga, K Dhadwal, I Ekpemi, R Roplekar-Bance, N Glibbery, K Karamali, T Munroe-Gray, P Sethukumar, R Vasanthan, H Lee-Six, B Misztal, S Millington, M Musalia, A Cardozo, M Dunbobbin, S Shahidi, M Chachlani, J Fussey, M Misurati, S Ashok, H Aboulgheit, S Khwaja, R Anmolsingh, B Al-Dulaimy, E Omakobia, T Browning, L Lignos, P Twose, J Heyman, D Kathwadia, T Hwara, O Judd, W Parker, TP Davis, T Stubington, H Koumoullis, E Willcocks, L Skelly, G Dempsey, K Liatsikos, B Borgatta, A Glossop, V Politidis, D Dhariwal, A Kara, G Tattersall, W Udall, P Kirkland, J Staufenberg, H Buglass, NW Wahid, A Amlani, P Deutsch, K Markham, O Barker, A Easthope, S Glaze, D Bondin, D Thorley, K Kapoor, S Sirajuddin, F van Damme, O Mattoo, E Kershaw, S Dewhurst, S Blakeley, C Chivers, L Lindsey, R Glore, H Cunniffe, D Moult, D Zolger, J Bakmanidis, S Kandiah, A Pericleous, R Sheikh, U Nagalotimath, E El-Tabal, S Ghaffar, M Dallison, E Leakey, O Sanders, A Gomati, L Moir, CB Groba, C Davies-Husband, N Seymour, R Lovett, J Lunn, A Armson, K Hilliard, S Ladan, P Tsirevelou, V Ratnam, A Muddaiah, J Coakes, R Borg, A Tsagkovits, O Mulla, N Stobbs, D Pratap, Z Ghani, J Rocke, S Snape, A Hassaan, S Beckett, R Siau, C Lamont, C Blore, D Zakai, R Moorthy, P Bothma, A Syndercombe, N Keates, M Junaid, T Antonio, A Vijendren, V Venkatachalam, M Lechner, D Chandrasekharan, J Whiteside, S Dennis, A Eldahshan, H Paw, M Colomo-Gonzalez, N Mani, B Ranganathan, N Amiruddin, A Sladkowski, AK Abou-Foul, S Kishwan, P Naredla, A Al-Ajami, S Okhovat, E Carey, N Vallabh, A. Alatsatianos, R Townsley

    Published 2021-10-01
    “…Six reports were received of operators testing positive for SARS-CoV-2 within 2 weeks of the procedure.Conclusions Tracheostomy appears to be safe in mechanically ventilated patients with COVID-19 and to operators performing the procedure and we identified clinical parameters that are predictive of mortality.Trial registration number The study is registered with ClinicalTrials.Gov (NCT04572438).…”
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  17. 5217

    PreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagn... by Raman R Gangakhedkar, Ravindra Mohan Pandey, Rakesh Kumar, Randeep Guleria, Manjula Singh, Soumya Swaminathan, George D’Souza, Rashmi Rodrigues, Anand Krishnan, Sanghamitra Pati, Sudipta Mohakud, Anant Mohan, Ramesh Kumar, Prasanta Raghab Mohapatra, Parul Kodan, Rohit Sarin, Baijayantimala Mishra, Geeta Yadav, Deepak Gupta, Anuj Bhatnagar, Sriram Selvaraju, Ritu Gupta, Sandeep Patil, Sourin Bhuniya, Sanjay Mehendale, Samiran Panda, Subrata Kumar Palo, Debasish Hota, Sangeeta Sharma, Srikanth Tripathy, Kiran Katoch, Sindhu Joshi, Somashekar Narasimhaiah, Sangeeta Bhaskar, Rajni Rani, Abdul Mabood Khan, Urvashi B Singh, D K Mitra, Neelam Roy, Amitva Sen Gupta, Vikram Vohra, Neeta Singla, Vijaya Valluri Ansari, Chitra Iravatham, Shilpa Rakh, D K Prudhula, Chala Devi, N Rupa, K Sailaja, Sheela Godbole, Seema Sahay, Suchit Kamble, Megha Mamulwar, Arati Kishor Mane, Ashwini Vinod Shete, Abhijit Vasantrao Kadam, Vineet Chadha, S Uma Shankar, C Ravichandra, S K Tripathy, Dasarathi Das, Tahziba Hussain, B Dwibedi, P R Mohapatra, S C B Cuttack, M R Pattnaik, Sabita Mohapatra, Banu Rekha, Mohan Natarajan, P K Bhavani, D Bella Devaleenal, Syed Hisar, S Devarajulu Reddy, Paul Kumaran, Makhesh Kumar, Poorna Ganga Devi, Sunny Omkar Singh, Devi Pratyush, Vidushi Gupta, Parvathi

    Published 2024-08-01
    “…The results of this clinical trial will be presented at scientific conferences and disseminated through publications in peer-reviewed journals, conference presentations and shared with Ministry of Health and Family Welfare, policy-makers and other stakeholders.Trial registration number CTRI/2019/01/017026.…”
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