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A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary...
Published 2024-12-01“…Findings from this study will be disseminated via publication, reports and conference presentations.Trial registration number NCT05577754…”
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5182
Influence of socioeconomic status on functional recovery after ARDS caused by SARS-CoV-2: a multicentre, observational study
Published 2022-04-01“…Findings will be published in peer-reviewed journals and presented at national and international congresses.Trial registration number NCT04556513…”
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5184
Master protocol for a series of cohort-based randomized controlled trials to test tools to communicate research results to study participants and others with relevant lived experie...
Published 2025-05-01“…In each RCT, people with SSc and researchers will select a recent SSc research study to disseminate. Tools will be developed by experienced tool developers and people with SSc. …”
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5185
Immunogenicity and Safety of ChAdOx1 nCoV-19 (AZD1222) as a Homologous Fourth-Dose Booster: A Substudy of the Phase 3 COV003 Trial in Brazil
Published 2025-08-01“…Trial Registration: clinicaltrials.gov Identifier: NCT04536051…”
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5186
Cancer in English prisons: a mixed-methods study of diagnosis, treatment, care costs and patient and staff experiences
Published 2025-02-01“…The aim was to develop and agree priority recommendations for healthcare practice and policy for patients with cancer in English prisons. …”
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5187
Using natural experiments to evaluate population health interventions: a framework for producers and users of evidence
Published 2025-03-01“…Firstly they developed a working draft of the framework, with each member of the group being responsible for drafting one or more chapter. …”
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5188
Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT
Published 2024-12-01“…Future work On the basis of the current findings, an application for a full trial will be prepared and submitted with a number of amendments. Trial registration This trial is registered as ISRCTN83610691. …”
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5189
MRI Compatibility Research of Ultrasonic Motor and Material for DBS Surgical Robot
Published 2025-05-01“…This process is time-consuming and laborious and introduces issues such as contamination of the surgical area, surgery interruption, and re-registration of positioning. Developing a novel MRI-compatible surgical robot system for precise electrode implantation in DBS surgeries is of significant clinical importance and promising application prospects. …”
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5190
Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel...
Published 2022-03-01“…The promoter will be the only access to the participant-level data, although it can be shared within the legal situation.Trial registration number 2020-000130-18; NCT04798755.…”
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5191
Enhancing early detection and treatment of psychosis in Germany: a protocol for the health economic evaluation of an artificial intelligence-guided complex intervention
Published 2025-06-01“…The implementation cost analysis will follow a mixed-methods approach to capture facility-specific costs.A dark logic model, emphasising negative outcomes, will be developed to investigate long-term consequences. Further, the initial economic logic model will be refined using trial data and expert interviews. …”
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5192
Adjuvant dendritic cell-based immunotherapy in melanoma: insights into immune cell dynamics and clinical evidence from a phase II trial
Published 2025-04-01“…Trial registration ClinicalTrials.gov NCT02718391; EudraCT no. 2014-005123-27.…”
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5193
Clinical and cost-effectiveness of parenting intervention for mothers experiencing psychosocial stress: insights from the early closure of the Mellow Babies RCT
Published 2024-12-01“…Health economic (service use and quality of life) and child development (language development and mental well-being) outcomes were also examined. …”
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5195
Designing a comprehensive behaviour change intervention to promote and monitor exclusive use of liquefied petroleum gas stoves for the Household Air Pollution Intervention Network...
Published 2020-09-01“…In the HAPIN trial, we will monitor and reinforce exclusive LPG use through temperature data loggers, LPG fuel delivery tracking, in-home observations and behavioural reinforcement visits.Conclusion Our formative research and behavioural strategies can inform the development, implementation, monitoring and evaluation of theory-informed strategies to promote exclusive LPG use in future stove programmes and research studies.Trial registration number NCT02944682, Pre-results.…”
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5196
Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta...
Published 2025-01-01“…PROSPERO registration: CRD42024547905. Findings: A total of 154 randomised controlled trials (n = 112,515 participants) were included. …”
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Glycaemic control in labour with diabetes: GILD, a scoping study
Published 2025-08-01“…Most have gestational diabetes, which develops during pregnancy and disappears after birth, the rest have diabetes before pregnancy. …”
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Understanding the potential factors affecting carers’ mental health during end-of-life home care: a meta synthesis of the research literature
Published 2022-12-01“…Understanding what factors may affect carers’ mental health is important in developing strategies to maintain mental health, through identifying carers at risk who may need added monitoring and support or developing interventions to change modifiable factors. …”
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