Strategies for involving patients and the public in scaling initiatives in health and social services: A scoping review by Roberta deCarvalho Corôa, Ali Ben Charif, Vincent Robitaille, Diogo G. V. Mochcovitch, Mamane Abdoulaye Samri, Talagbe Gabin Akpo, Amédé Gogovor, Virginie Blanchette, Lucas Gomes Souza, Kathy Kastner, Amélie M. Achim, Robert K. D. McLean, Andrew Milat, France Légaré, The RePOS Network

Get full text

Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study. by Lars Wallentin, Niclas Eriksson, Maciej Olszowka, Tanja B Grammer, Emil Hagström, Claes Held, Marcus E Kleber, Wolfgang Koenig, Winfried März, Ralph A H Stewart, Harvey D White, Mikael Åberg, Agneta Siegbahn

“…<h4>Background</h4>Circulating biomarkers are associated with the development of coronary heart disease (CHD) and its complications by reflecting pathophysiological pathways and/or organ dysfunction. …”
Get full text

Metabolomic Profiling of the Blood of Patients with Chronic Consciousness Disorders by A. A. Orlova, E. A. Kondrat'eva, Ya. A. Dubrovskii, N. V. Dryagina, E. V. Verbitskaya, S. A. Kondratev, A. A. Kostareva, A. N. Kondratev

“…The main variants of chronic consciousness disorder (CCD) developing in adverse coma outcome are vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimal consciousness state (MCS).   …”
Get full text

Recuperação da motricidade voluntária do membro superior de pacientes com hemiplegia após acidente vascular cerebral: avaliação prognostica Recovery of voluntary motion in upper ex... by Abrão Anghinah

“…<br>The study aims the registration and analysis of the main facts which occur during recovery of the voluntary movements in the upper extremity, in patients with hemiplegia following cerebrovascular accident, and it also intends to evaluate the prognosis. …”
Get full text

Neoadjuvant anti-programmed death-1 immunotherapy by pembrolizumab in resectable non-small cell lung cancer: results of the NEOMUN trial by Albrecht Stenzinger, Dirk Jäger, Michael Thomas, Hauke Winter, Helge Bischoff, Uwe Haberkorn, Felix Herth, Pornpimol Charoentong, Petros Christopoulos, Rajkumar Savai, Laura V Klotz, Raffaella Griffo, Martin E Eichhorn, Florian Eichhorn, Benedikt Niedermaier, Philip Baum, Michael Allgäuer, Marc A Schneider, Claus-Peter Heußel, Maria Paula Roberti, Inka Zoernig

Get full text

A scoping review of school-based oral health interventions among adolescents in Nigeria by Abel Nnamdi Chukwuemeka, Abel Nnamdi Chukwuemeka, Abel Nnamdi Chukwuemeka, Richard Oveh, Richard Oveh, Anita Dabar, Anita Dabar, Omorinola Afolabi, Omorinola Afolabi, Saheed Ademola Ibraheem, Saheed Ademola Ibraheem, Folahanmi Tomiwa Akinsolu, Folahanmi Tomiwa Akinsolu, Abideen Olurotimi Salako, Abideen Olurotimi Salako, Omolola Titilayo Alade, Omolola Titilayo Alade, Foluso Owotade, Foluso Owotade, George Uchenna Eleje, George Uchenna Eleje, Oliver Ezechi, Oliver Ezechi, Joanne Lusher, Joanne Lusher, Moréniké Oluwátóyìn Foláyan, Moréniké Oluwátóyìn Foláyan

Get full text

Non-specific effects of different sham acupuncture methods and their impact on true acupuncture effectiveness in migraine: a protocol for systematic review and network meta-analysi... by Fan Jiang, Haifeng Zhang, Lun Li, Qinhong Zhang, Meng Lin, Yongjian Liu, Yong Fu, Jiahui Yang, Qilin Liu, Meiyi Zhu, Xiumei Yan

“…The results will be shared via articles in scholarly journals and during presentations at academic symposiums.PROSPERO registration number CRD42024620550.…”
Get full text

Short- and Long-Term Effectiveness of Brief Intensive Trauma Treatment for Adolescents With Posttraumatic Stress Disorder and Their Caregivers: Protocol for a Multicenter Randomize... by Myrna M Westerveld, Malindi van der Mheen, Rik Knipschild, Kim Maijer, Marieke E de Keizer-Altink, Nina Albisser, Marielle J E Hoekstra, Anne Timmermans-Jansen, Rosa Zijp, Anne A Krabbendam, Francisca J A (Bonny) van Steensel, Kees-Jan Kan, Chaim Huyser, Wouter G Staal, Elisabeth M W J Utens, Ramón J L Lindauer

“…Eight percent to 33% of potentially traumatic event–exposed adolescents develop posttraumatic stress disorder (PTSD), which can cause extreme suffering and coincides with numerous comorbid illnesses and high-risk behaviors. …”
Get full text

Ashwagandha (Withania somnifera (L.) Dunal) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial) by Kamlesh Khunti, Shailen Sutaria, Poppy Alice Carson Mallinson, Sanjay Kinra, Rohini Mathur, Anoop SV Shah, Tim Clayton, Judith Lieber, Alexander Perkins, Shereen Allaham, Nick Birk, Lily Hopkins, Manisha Joshi, Mahesh Mathpathi, Arandeep Dhillon, Sidra S Beg, Archie Khan, Vanessa TW Kam, Galib R, S Rajagopala, Amarjeet Bhamra, Geetha Krishnan G Pillai, Tanuja Nesari

Get full text

A protocol for a pilot randomised controlled trial of a Tailored Intervention for people with moderate-to-severe Chronic Obstructive Pulmonary Disease and Co-morbidities delivered... by Richard Lowrie, David Anderson, Aziz Sheikh, Jane Moir, Andrew McPherson, Bethany Stanley, Gillian Cameron, Lynda Attwood, Donald Noble, Elaine Rankine, Jennifer Anderson, Nicola Greenlaw, Fiona Hughes, Emma McIntosh, Samuel Owusu Achiaw, Caitlin Jones, Frances S. Mair

“…The pilot study aims to recruit at least 70% of invited participants within 4 months; deliver TICC PCP to at least 70% of participants in the intervention arm; retain at least 80% of participants (excluding those who died or developed incapacity before the end of the study) until 21-month data collection; and collect at least 90% of in person data at each study time point. …”
Get full text

Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

Get full text

The Comprehensive Resilience-building psychosocial Intervention (CREST) for people with dementia in the community: a feasibility and acceptability study by Dympna Casey, Priscilla Doyle, Niamh Gallagher, Grace O’Sullivan, Siobhán Smyth, Declan Devane, Kathy Murphy, Charlotte Clarke, Bob Woods, Rose-Marie Dröes, Gill Windle, Andrew W. Murphy, Tony Foley, Fergus Timmons, Paddy Gillespie, Anna Hobbins, John Newell, Jaynal Abedin, Christine Domegan, Kate Irving, Barbara Whelan

Get full text

Pathology-Based Animal Cancer Registry of Abruzzo and Molise Regions (Central Italy): A Ten-Year Retrospective Study (2014–2023) by Giovanni Di Teodoro, Francesca Cito, Romolo Salini, Marina Baffoni, Sabrina V. P. Defourny, Antonio Cocco, Nicola D’Alterio, Chiara Palmieri, Antonio Petrini

“…The risk of developing skin and subcutaneous tissues tumors was higher for dogs and cats that lived mostly outdoor (PMR dogs = 1.21; 95% CI: 1.10–1.33; PMR cats = 1.18; 95% CI: 1.08–1.47), while dogs that live mainly indoor had a greater risk to develop mammary gland tumors (PMR = 0.78; 95% CI: 0.68–0.89). …”
Get full text

Cost-effectiveness analysis of a multiple health behaviour change intervention in people aged between 45 and 75 years: a cluster randomized controlled trial in primary care (EIRA s... by Ignacio Aznar-Lou, Edurne Zabaleta-Del-Olmo, Marc Casajuana-Closas, Alba Sánchez-Viñas, Elizabeth Parody-Rúa, Bonaventura Bolíbar, Montserrat Iracheta-Todó, Oana Bulilete, Tomàs López-Jiménez, Haizea Pombo-Ramos, María Victoria Martín Miguel, Rosa Magallón-Botaya, Jose Ángel Maderuelo-Fernández, Emma Motrico, Juan Bellón, Ruth Martí-Lluch, Maria Rubio-Valera, Antoni Serrano-Blanco

Get full text

Renal resistive index as an early predictor and discriminator of acute kidney injury in critically ill patients; A prospective observational cohort study. by Jelle L G Haitsma Mulier, Sander Rozemeijer, Jantine G Röttgering, Angelique M E Spoelstra-de Man, Paul W G Elbers, Pieter Roel Tuinman, Monique C de Waard, Heleen M Oudemans-van Straaten

“…A combined score including RRI, APACHE III and fluid balance improved AKI prediction, suggesting that vasoconstriction or poor vascular compliance, severity of disease and positive fluid balance independently contribute to AKI development.<h4>Trial registration</h4>ClinicalTrials.gov NCT02558166.…”
Get full text

Reference equations for pulmonary function testing in healthy Chinese children aged 4–18 years by Jinhong Wu, Hao Zhang, Yufen Wu, Qiaoling Zhang, Ming Li, Fuli Dai, Changfu Xu, Yongsheng Shi, Ning Wang, ChunMei Jia, Sha Liu, Yuehua Zhang, Zhongping Zhang, Aihong Liu, Fei Wang, Li Liu, Qiang Chen, Jinrong Wang, Yuling Han, Yuxin Song, Yong Feng, Yun Sun, Huaping Rao, Lili zhong, Quanhua Liu, Liya Wan, Zhen Long, Xiaoyan Dong, Yanli Zhang, Wenhui Jiang, Minghong Ji, Jianfeng Huang, Zhiwei Pan, Dongjun Ma, Suping Tang

“…New prediction equations were developed using multiple linear regression models with age, height, and weight as predictors. …”
Get full text

Breeding of a new mid-to-late ripening apple cultivar Wangyuebingcui by XU Haihong, YANG Kai, LI Guangjin, ZHANG Guoqiang, TIAN Ge, AI Bohao, LI Xuqiang, WANG Junya

“…The 135-140 day fruit development cycle culminates in mid-September maturation in central Shanxi (37°20′36″ N and 112°29′35″ E), demonstrating negligible preharvest drop. …”
Get full text

Kuidas toetab kunst sotsiaal-emotsionaalse pädevuse kujundamist? Lastega perede abil loodud helirännak / How Does Art Support Social and Emotional Learning? A Sound Journey Created... by Hanna-Liis Kont

“…The collaborative artistic development was a fruitful learning experience for the organisers. …”
Get full text

Phase I study of a recombinant attenuated oncolytic virus, MEDI5395 (NDV–GM-CSF), administered systemically in combination with durvalumab in patients with advanced solid tumors by Dmitriy Zamarin, Diwakar Davar, Adel Samson, Kevin J Harrington, Siddharth Sheth, Eric Tu, Mitesh J Borad, Grace K Dy, Evanthia Galanis, Fernanda Arnaldez, Sandip P Patel, Nicholas Durham, Benedito A Carneiro, Sonia Agrawal, Zhongying Chen, Chunling Fan, Maozhen Gong, Jenny Burton, Kevin Laubscher

Get full text

Anakinra for dengue patients with hyperinflammation: protocol for a randomized double-blind placebo-controlled trial [version 1; peer review: 1 approved, 2 approved with reservatio... by Angela McBride, Huynh Thi Le Duyen, Nguyen Thanh Phong, Truong Ngoc Trung, Sophie Yacoub, Ronald Geskus, Tran Bang Huyen, Evelyne Kestelyn, Dang Trong Thuan, Nguyen Thi My Linh, Tran Thi Dong Vien, Nguyen Thi Cam Huong, Phan Vinh Tho, Nguyen Minh Nguyet, Vo Thi My Hoa, Nguyen Lam Vuong, Phan Tu Qui, Dong Thi Hoai Tam, James Watson, Huynh Trung Trieu

“…This trial will assess the safety and efficacy of anakinra in patients with severe dengue or at high risk of developing life-threatening dengue disease. Registration ClinicalTrials.gov (NCT05611710).…”
Get full text