Culture-sensitive lifestyle intervention tailored to non-Western migrant older adults improves physical performance: A randomized controlled trial by Esmée J.M. Biersteker, Jantine van den Helder, Nannette van der Spek, Mieke Holwerda, Hinke Kruizenga, Peter J.M. Weijs, Michael Tieland

“…The aim of this study was to assess the effects of a newly developed culture-sensitive lifestyle intervention on physical performance in non-Western Surinamese older adults. …”
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Dendritic cells pulsed with multifunctional Wilms’ tumor 1 (WT1) peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in... by Machi Suka, Hiroyuki Yanagisawa, Nobuhiro Sato, Shigetaka Shimodaira, Masayuki Saruta, Shigeo Koido, Junichi Taguchi, Masamori Shimabuku, Shin Kan, Tuuse Bito, Takeyuki Misawa, Zensho Ito, Kan Uchiyama, Shintaro Tsukinaga, Toshifumi Ohkusa, Haruo Sugiyama

“…Background We aimed to develop a chemoimmunotherapy regimen consisting of a novel Wilms’ tumor 1 (WT1) peptide-pulsed dendritic cell (WT1-DC) vaccine and multiagent chemotherapy and to investigate the safety, clinical outcomes, and WT1-specific immune responses of patients with unresectable advanced pancreatic ductal adenocarcinoma (UR-PDAC) who received this treatment.Methods Patients with UR-PDAC with stage III disease (locally advanced (LA-PDAC; n=6)), stage IV disease (metastatic (M-PDAC; n=3)), or recurrent disease after surgery (n=1) were enrolled in this phase I study. …”
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Efficacy of a Personalized Mobile Health Intervention (BedTime) to Increase Sleep Duration Among Short-Sleeping Patients With Type 2 Diabetes: Protocol for a Pilot Randomized Contr... by Yuki Ban, Kayo Waki, Ryohei Nakada, Akihiro Isogawa, Kengo Miyoshi, Hironori Waki, Shunsuke Kato, Hideaki Sawaki, Takashi Murata, Yushi Hirota, Shuichiro Saito, Seiji Nishikage, Atsuhito Tone, Mayumi Seno, Masao Toyoda, Shinichi Kajino, Kazuki Yokota, Yuya Tsurutani, Toshimasa Yamauchi, Masaomi Nangaku, Kazuhiko Ohe

“…The sleep extension intervention, BedTime, is developed using the Theory of Planned Behavior (TPB) and focuses on TPB’s constructs of perceived and actual behavioral control (ABC). …”
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Breeding report of a new table Phyllanthus emblica cultivar Lütianyougan by LAI Duo, XIAO Weiqiang, QIN Jian, ZHUANG Qingli, PENG Kanghong, SHAO Xuehua

“…Currently, fresh variety of P. emblica has high economic benefit and great development potential. Herein, Lütianyougan, a new table variety of P. emblica with excellent traits, was selected from the wild seedling population. …”
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Fertility, time to pregnancy, and pregnancy outcomes among women with recurrent miscarriages in the UK: a prospective observational longitudinal studyResearch in context by Constandina Koki, Rebecca Shields, Rebecca Sweetman, James Boyle, Omar Khan, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis, Adam J. Devall, Nigel John Burroughs, Siobhan Quenby

“…We used Bayesian inference for the latter model.Trial registration number: The prospective data collections were pre-registered ISRCTN17732518; https://doi.org/10.1186/ISRCTN17732518. …”
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Mitochondrial DNA Polymorphisms of Peripheral Blood Mononuclear Cells Associated with Sustained Ventricular Tachycardia in Patients with Cardioverter-Defibrillator Implantation Ind... by Tariel Atabekov, Viacheslav Korepanov, Sergey Krivolapov, Mikhail Khlynin, Sergey Afanasiev, Maria Golubenko, Roman Batalov, Sergey Popov

“…Based on our data, we developed a risk model for SVT. …”
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Clinical effectiveness and cost-effectiveness of the rehabilitation enablement in chronic heart failure facilitated self-care rehabilitation intervention for people with heart fail... by John G F Cleland, Kate Jolly, Christi Deaton, Louise Taylor, Rod S Taylor, Aynsley Cowie, Alex McConnachie, Julia Frost, Colin Greaves, Chim C Lang, Emma McIntosh, Valerie Smith, Samantha van Beurden, Patrick J Doherty, Hasnain M Dalal, Tracy Ibbotson, Melvyn Hillsdon, Anna Placzek, Jessica C Bollen, Iain Squire, Emma Burrell, Nick Hartshorne-Evans, Elizabeth A Thomson, Claire O’Hare, Katie Dudman, Heather Fraser, Mohammad Jarallah

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Effect of prior and first-line immunotherapy on baseline immune biomarkers and modulation of the tumor microenvironment in response to nivolumab and relatlimab combination therapy... by James Larkin, Evan J Lipson, Charlie Garnett-Benson, Ignacio Melero, Reinhard Dummer, Paolo A Ascierto, Vanna Chiarion-Sileni, Marta Nyakas, Hao Tang, Inge Marie Svane, Margaret Callahan, Eva Muñoz-Couselo, Jean Jacques Grob, Katriina Peltola, Sonia Dolfi, Carlos Alberto Gomez-Roca, Patrick Djidel, Deepti Warad, Diane Reusser-Wolf

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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccha... by Tao Chen, Duolao Wang, Konstantinos Liatsikos, Stephen B Gordon, Hassan Burhan, Ben Morton, Tinashe K Nyazika, Bradford D Gessner, Helen Hill, Andrea Collins, Josh Hamilton, Kelly Davies, Fred Fyles, Phoebe Hazenberg, Elizabeth Begier, Angela Hyder-Wright, Sherin Pojar, Christopher Myerscough, Jesus Reine, Ryan E Robinson, Britta Urban, Elena Mitsi, Carla Solorzano, Angela Quinn, Kaijie Pan, Annaliesa S Anderson, Christian Theilacker, Daniela M Ferreira, Kelly Convey, James Court, Madlen Farrar, Lisa Hitchins, Ashleigh Howard, Lauren Kerruish, Samuel Latham, Annabel Murphy, Elissavet Nikolaou, Angelina Peterson

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FTACMT study protocol: a multicentre, double-blind, randomised, placebo-controlled trial of faecal microbiota transplantation for autism spectrum disorder by Li Ling, Wei Wei, Li Lin, Li Ke, Ye Chen, Li Ning, Wang Yu, Zhang Xin, Yang Rong, Zhang Xueying, Cui Jiaqu, Chen Qiyi, Qin Huanlong, Du Yasong, Zhao Xiaoxin, Lu Jubao, Lv Xiaoqiong, Ma Chunlian, Chen Shidong, Kuang Guifang, Zhao Dongmei, Fang Shuanfeng, Zhang Xujing, Yang Binrang, Wang Yanxia, Yuan Song, Zhou Xiang, Zhang Beihua, Jiang Lin, Ji Hong, Yan Yinmei, Yan Peihua, Huang Linsheng, Zhang Shaoyi, Ma Chenhuan, Miao Yun, Ling Wenqi, Geng Bojing, Feng Xueying, Li Huilin, Liu Liyan, Wu Weijia, Li Dexin, Jiang Qianru

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Arm Based on LEg blood pressures (ABLE-BP): can systolic ankle blood pressure measurements predict systolic arm blood pressure? An individual participant data meta-analysis from th... by Una Martin, Luigi Ferrucci, James White, Fiona C Warren, Kate Boddy, Matthew Allison, Raimund Erbel, Victor Aboyans, Jan Westerink, James Peter Sheppard, Sinead T J McDonagh, Leon Farmer, Helen Shore, Phil Williams, Philip S Lewis, Michael Criqui, Carlos Lahoz, Maëlenn Guerchet, Mary McDermott, Mark Espeland, Marie Dahl, Angela Shore, Rafel Ramos Blanes, Christopher Elles Clark, Jackie Price, A Jayne Fordham

“…This model, operationalised in an online calculator (https://ablebp.research.exeter.ac.uk/), could facilitate hypertension management and cardiovascular care for people unable to have arm SBP measured.PROSPERO registration number CRD42015031227.…”
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Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease by Wen Hu, Ziyu Liu, Weinan Yu, Surong Wen, Xiaoqing Wang, Xing Qi, Hairong Hao, Yanwen Lu, Jing Li, Shayan Li, Hongwen Zhou

“…The incidences of CVD and non-alcoholic fatty liver disease (NAFLD) in subjects with rs1440581 CC genotype were higher than in those with TT genotype; the incidence of CVD in subjects with rs7678928 TT genotype was higher than in those with CC (p < .05) genotype.Conclusions Allele C of PPM1K rs1440581 was associated with elevated serum Val, total BCAAs and CVD risks. rs1440581 CC genotype may be a better marker than baseline serum BCAAs in predicting the risk for CVD.Trial registration Diabetes Prevention Programme in Huai’an of Huai’an Second People's Hospital, ChiCTR-TRC-14005029.KEY MESSAGEAllele C of PPM1K rs1440581 was relevant to elevated serum Val and total BCAAs.PPM1K rs1440581 CC and rs7678928 TT genotypes were associated with CVD risk.PPM1K rs1440581 CC genotype carriers were more likely to have liver injury and develop NAFLD.…”
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Patient-Reported Outcome Measures in Patients with Rheumatoid Arthritis, Psoriasis, or Psoriatic Arthritis Treated with GP2015, an Etanercept Biosimilar: Results from Two Phase III... by Diamant Thaçi, Sascha Gerdes, Hendrik Schulze-Koops, Yannick Allanore, Arthur Kavanaugh, Charlotte Both, Sreekanth Gattu, Sohaib Hachaichi, Marco Matucci-Cerinic

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What Are Reasons for the Large Gender Differences in the Lethality of Suicidal Acts? An Epidemiological Analysis in Four European Countries. by Roland Mergl, Nicole Koburger, Katherina Heinrichs, András Székely, Mónika Ditta Tóth, James Coyne, Sónia Quintão, Ella Arensman, Claire Coffey, Margaret Maxwell, Airi Värnik, Chantal van Audenhove, David McDaid, Marco Sarchiapone, Armin Schmidtke, Axel Genz, Ricardo Gusmão, Ulrich Hegerl

“…Moreover, the detection of attempted suicides and the registration of completed suicides might have differed across the four countries. …”
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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and ma... by Leanne J Robinson, Rahel Wampfler, Inoni Betuela, Stephan Karl, Michael T White, Connie S N Li Wai Suen, Natalie E Hofmann, Benson Kinboro, Andreea Waltmann, Jessica Brewster, Lina Lorry, Nandao Tarongka, Lornah Samol, Mariabeth Silkey, Quique Bassat, Peter M Siba, Louis Schofield, Ingrid Felger, Ivo Mueller

“…A basic stochastic transmission model was developed to estimate the potential effect of mass drug administration (MDA) for the prevention of recurrent P. vivax infections. …”
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High PrEP uptake and objective longitudinal adherence among HIV-exposed women with personal or partner plans for pregnancy in rural Uganda: A cohort study. by Lynn T Matthews, Esther C Atukunda, Moran Owembabazi, Kato Paul Kalyebera, Christina Psaros, Pooja Chitneni, Craig W Hendrix, Mark A Marzinke, Peter L Anderson, Oluwaseyi O Isehunwa, Kathleen E Hurwitz, Kara Bennett, Winnie Muyindike, David R Bangsberg, Jessica E Haberer, Jeanne M Marrazzo, Mwebesa Bosco Bwana

“…Pre-exposure prophylaxis (PrEP) reduces HIV acquisition for women and, therefore, infants. We developed the Healthy Families-PrEP intervention to support PrEP use as part of HIV prevention during periconception and pregnancy periods. …”
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Metastatic recurrence in women diagnosed with non-metastatic breast cancer: a systematic review and meta-analysis by Eileen Morgan, Colette O’Neill, Richa Shah, Oliver Langselius, Yaqi Su, Clara Frick, Hanna Fink, Aude Bardot, Paul M. Walsh, Ryan R. Woods, Lou Gonsalves, Jan F. Nygård, Serban Negoita, Esmeralda Ramirez-Pena, Karen Gelmon, Nicoleta Antone, Miriam Mutebi, Sabine Siesling, Fatima Cardoso, Julie Gralow, Isabelle Soerjomataram, Melina Arnold

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Efficacy and safety of human umbilical cord-derived mesenchymal stem cells versus placebo added to second-line therapy in patients with steroid-refractory acute graft-versus-host d... by Erlie Jiang, Kun Qian, Lu Wang, Donglin Yang, Yangliu Shao, Liangding Hu, Yuhang Li, Chen Yao, Mingzhe Han, Xiaoqiang Hou, Daihong Liu

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Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review by Sarah Koch, Milo Alan Puhan, Anja Frei, Kristin Taraldsen, A Stefanie Mikolaizak, Clemens Becker, Ronny Bergquist, Beatrix Vereijken, Lynn Rochester, Basil Sharrack, Claudia Mazza, Ashley Marie Polhemus, Magda Bosch de Basea, Gavin Brittain, Sara Catherine Buttery, Gloria dalla Costa, Laura Delgado Ortiz, Heleen Demeyer, Kirsten Emmert, Heiko Gassner, Nicholas Hopkinson, Jochen Klucken, Felix Kluge, Letizia Leocani, Paolo Piraino, Christian Schlenstedt, Thierry Troosters, Ioannis Vogiatzis

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Protocol for the economic evaluation alongside the PARTICIPATE (PArticipatory Research model for medicaTIon adherenCe In People with diAbetes and hyperTEnsion) multicenter cluster... by Vivek Verma, Denny John, Tanu Anand, Dinesh Kumar, K Sunitha, Tanveer Rehman, Pooja Reddy, Anuja Jha, Harshal Gupta, Avi Kumar Bansal, Smita Mahapatra, Sudhira Kumar Parida, Mamata Jena, A Charles Pon Ruban, Shantaraman Kalyanaraman, Jerin Jose Cherian

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