Clinical signs of possible serious infection and associated mortality among young infants presenting at first-level health facilities. by Yasir Bin Nisar, Antoinette Tshefu, Adrien Lokangaka Longombe, Fabian Esamai, Irene Marete, Adejumoke Idowu Ayede, Ebunoluwa A Adejuyigbe, Robinson D Wammanda, Shamim Ahmad Qazi, Rajiv Bahl

“…New treatment strategies that consider differential mortality risks for the place of treatment and duration of inpatient treatment could be developed and evaluated based on these findings.<h4>Clinical trial registration</h4>This trial was registered with the Australian New Zealand Clinical Trials Registry under ID ACTRN 12610000286044.…”
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First-in-human clinical study of an embryonic stem cell product for urea cycle disorders by Akihiro Umezawa, Akinari Fukuda, Reiko Horikawa, Hajime Uchida, Shin Enosawa, Yoshie Oishi, Naoko Nakamura, Kengo Sasaki, Yusuke Yanagi, Seiichi Shimizu, Toshimasa Nakao, Tasuku Kodama, Seisuke Sakamoto, Itaru Hayakawa, Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Palaksha Kanive Javaregowda, Masashi Toyoda, Hidenori Nonaka, Kazuaki Nakamura, Yoshikazu Ito, Yasuyuki Fukuhara, Osamu Miyazaki, Shunsuke Nosaka, Kazuhiko Nakabayashi, Chizuko Haga, Takako Yoshioka, Akira Masuda, Takashi Ohkura, Mayu Yamazaki-Inoue, Masakazu Machida, Rie Abutani-Sakamoto, Shoko Miyajima, Hidenori Akutsu, Yoichi Matsubara, Takashi Igarashi, Mureo Kasahara

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Effectiveness of an educational asthma management program (CuidAR): the protocol for a cluster-randomized trial in the Brazilian primary healthcare setting by Ana Paula Tussi Leite, Géssica Luana Antunes, Amanda Paz Santos, Ingrid Rodrigues Fernandes, Lauren Sezerá Costa, Tássia Rolim Camargo, Camila Bonalume Dall’ Aqua, Fernando Rovedder Boita, Alessandra da Silva Mota, Mariana Motta Dias da Silva, Mariah Prata Soldi Passos Taube, Bruna Silveira da Rosa, Marcus Herbert Jones, Álvaro A. Cruz, Frederico Friedrich, Paulo M. Pitrez

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Management of Children with Speech Disorders via Transcranial Magnetic Stimulation: Non-Randomized Controlled Study by Julia V. Nesterova, George A. Karkashadze, Leonid M. Yatsik, Leyla S. Namazova-Baranova, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva, Daria A. Bushueva, Tinatin Yu. Gogberashvili, Tatiana A. Konstantinidi, Natalia E. Sergeeva, Safarbegim H. Sadilloeva, Marina A. Kurakina, Julia E. Kazanceva, Inessa A. Povalyaeva, Nadezhda A. Ulkina, Tatiana A. Salimgareeva, Natalia S. Sergienko, Oksana D. Mescheryakova, Viktor V. Altunin, Elizaveta V. Leonova, Elena S. Zibrova

“…Furthermore, we carried out side reactions / adverse events registration according to patients and/or their parents complaints confirmed by physical examination, patient’s behavior observation, data from specially developed questionnaire for assessing child’s behavior and well-being (filled up by parents). …”
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Rectify the impact of shorter red blood cell lifespan upon HbA1c detection values in T2DM patients: modeling and internal-external verification by Li Zhang, Li Zhang, Ximan Gao, Ximan Gao, Xuying Meng, Xuying Meng, Guangyang Ma, Guangyang Ma, Jing Li, Jing Li, Weilin Wang, Weilin Wang, Sisi Chen, Sisi Chen, Yongjian Ma, Pei Yu, Pei Yu, Saijun Zhou, Saijun Zhou

“…AimsTo determine the effect of red blood cell (RBC) lifespan variability on glycosylated hemoglobin (HbA1c) measurements in type 2 diabetes mellitus (T2DM) individuals and develop a mathematical model for adjusting HbA1c values.MethodsWe tracked glucose levels in 516 T2DM patients from Chu Hsien-I Memorial Hospital, categorized into Construction (n = 416) and Internal (n = 100) cohorts. …”
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The safety and feasibility of multiple intrathecal injections of allogenic NK cells in pediatrics with refractory/recurrent brain tumors by Hamid Mahdizadeh, Amirhossein Izadpanah, Yasaman Nouri, Parisa Shams, Delbar Daneshjou, Alireza Aziz Ahari, Alireza Tabibkhooei, Hamidreza Haghighatkhah, Massoud Vosough, Pooya Faranoush, Masoumeh Azimi, Saba yousefi, Atefeh Barzegari, Alireza Khosravani, Niloufar Shayan Asl, Mohammad Faranoush, Marzieh Ebrahimi

“…In the retrospective control group, five out of six patients developed PD and leptomeningeal spread (LMS), four of whom died, and one patient showed radiological evidence of a complete response (CR). …”
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Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial by Abideen Salako, Adesola Musa, Fehintola Ige, Adam Abdullahi, Ayorinde James, Sabdat Ekama, Oluwatosin Odubela, Ifeoma Idigbe, Olusola Ajibaye, Mazharul Altaf, Kazeem Adeneye, Folahanmi T. Akinsolu, Ifedola Olojo, Azuka Okwuraiwe, Henry Egharevba, Magaret Ekpenyong, Uchenna Elemuwa, Ifeoma Ezenyi, Fraden Bitrus, Olayemi Odubela, Abdulrasheed Oba, Ganiu Idris, Jimoh Yusuf, Ibukun Akande, Stephine Nwaiwu, Louisa Omale, Oluwatobiloba Oyewunmi, Adedoyin Agbabiaka, Olajumoke Eyinade, Joy Ogunwale, Abdullah Garba, Yahya Bello, Baba Musa, Ogochukwu Ezejiofor, Ben Ejiro, Bamidele Iwalokun, Leah Rosenzweig, Obi Adigwe, Christianah Adeyeye, Faisal Shuaib, Witold Wicek, Yohhei Hamada, Oliver Ezechi, Ravindra Gupta, Babatunde Salako

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A phase 1 randomized controlled trial of a peptide-based group A streptococcal vaccine in healthy volunteers by Vanessa Meier-Stephenson, Michael T. Hawkes, Catherine Burton, Ainslie Calcutt, Chris Davis, Jessica Dooley, Michael Good, Michael Houghton, Eloise Keeffe, Kelly Kim, Ailin Lepletier, Conar O’Neil, Ijeoma Ogbuehi, Victoria Ozberk, Manisha Pandey, Simone Reynolds, Avi Seth, William Stokes, Alena Tse-Chang, Ben Tyrrell, D. Lorne Tyrrell, Gregory J. Tyrrell, Maryna Yaskina

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Target product profiles for digital health technologies including those with artificial intelligence: a systematic review by Trystan B. Macdonald, Trystan B. Macdonald, Trystan B. Macdonald, H. D. Jeffry Hogg, H. D. Jeffry Hogg, Jacqueline Dinnes, Jacqueline Dinnes, Lucy Verrinder, Gregory Maniatopoulos, Sian Taylor-Phillips, Bethany Shinkins, J. Kevin Dunbar, Ameenat Lola Solebo, Ameenat Lola Solebo, Hannah Sutton, John Attwood, Michael Pogose, Rosalind Given-Wilson, Felix Greaves, Felix Greaves, Carl Macrae, Carl Macrae, Russell Pearson, Adnan Tufail, Adnan Tufail, Xiaoxuan Liu, Xiaoxuan Liu, Xiaoxuan Liu, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston, Alastair K. Denniston

“…Our findings emphasise the need for guidelines for TPP development, could help inform these, and could be used as a basis to develop future DHT TPPs.Systematic Review Registration: https://www.researchprotocols.org/2024/1/e50568/authors.…”
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Anemia From Inflammation After Intracerebral Hemorrhage and Relationships With Outcome by David J. Roh, Fernanda Carvalho Poyraz, Eric Mao, Qi Shen, Vedant Kansara, Azzurra Cottarelli, Sandy Song, Travis Nemkov, Aditya Kumar, Krystalyn E. Hudson, Shivani Ghoshal, Soojin Park, Sachin Agarwal, Edward Sander Connolly, Jan Claassen, Lisa Baumann Kreuziger, Eldad Hod, Sharon Yeatts, Lydia D. Foster, Magdy Selim

“…However, underlying drivers for anemia and whether anemia development after ICH impacts clinical outcomes are unknown. …”
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Association of humidity and precipitation with asthma: a systematic review and meta-analysis by Wangyang Gu, Wangyang Gu, Dan Xie, Dan Xie, Qinpeng Li, Qinpeng Li, Huike Feng, Huike Feng, Yihao Xue, Yihao Xue, Yang Chen, Jingyi Tang, Yushi Zhou, Yushi Zhou, Dan Wang, Dan Wang, Shilu Tong, Shilu Tong, Shijian Liu, Shijian Liu, Shijian Liu, Shijian Liu

“…And the influence of precipitation on asthma persons over the age of 18, developing countries or regions, and middle latitudes significantly. …”
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Use of sedative drugs in specialist palliative care (iSedPall): a multi-modal intervention pilot study protocol by Christoph Ostgathe, Claudia Bausewein, Eva Schildmann, Jeremias Bazata, Maria Heckel, Saskia Kauzner, Carsten Klein, Sabine H. Krauss, Alexander Kremling, Manuela Schneider, Andreas Seifert, Kerstin Ziegler, Christian Jäger, Jan Schildmann

“…However, disseminating recommendations alone does not necessarily lead to changes in clinical practice. In the project “Development and piloting of a multi-modal intervention for the use of sedative drugs in specialist palliative care (iSedPall)”, we will develop a multi-modal intervention that implements these national recommendations into practical tools for healthcare professionals in specialist inpatient and home care settings. …”
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Efficacy and safety of dapagliflozin in patients hospitalized with COVID-19 with and without type 2 diabetes: a prespecified analysis of the DARE-19 randomized trial by Mohammad Abdel Jawad, Remo H. M. Furtado, Russell Esterline, Jan Oscarsson, Samvel B. Gasparyan, Gary G. Koch, Felipe Martinez, Omar Mukhtar, Subodh Verma, Anna Maria Langkilde, Philip Ambery, Shachi Patel, Kensey Gosch, Sheryl L. Windsor, Ronaldo V. P. Soares, Diogo D. F. Moia, Matthew Aboudara, Ali Javaheri, J. F. Kerr Saraiva, Lilia Nigro Maia, Otavio Berwanger, Andrew J. Sauer, Mikhail N. Kosiborod

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An Interdisciplinary Ecosystem for the Prevention of Cardiotoxicity in Older Patients With Breast Cancer: Protocol for a Prospective and Multicentric Study by Gaia Giulia Angela Sacco, Ketti Mazzocco, Anastasia Constantinidou, Andri Papakonstantinou, Davide Mauri, Grigorios Kalliatakis, Manolis Tsiknakis, Domen Ribnikar, Dorothea Tsekoura, Valantis Aidarinis, Kalliopi Keramida, Panagiotis Oikonomopoulos, Athos Antoniades, Cameron Brown, Federica Rizzi, Anca Bucur, Elsa Pacella, Georgia Karanasiou, Daniela Cardinale, Carlo Cipolla, Elisabetta Munzone, Dimitrios Fotiadis, Giuseppe Curigliano, Gabriella Pravettoni

“…ConclusionsThe CARDIOCARE prospective study will contribute to developing new best practice guidelines for managing older patients with breast cancer and multimorbidity while preserving their intrinsic capacity and improving their QoL. …”
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Cost-consequence analysis of an e-health intervention to reduce distress in dementia carers: results from the iSupport randomised controlled trial by Aimee Spector, Zoë Hoare, Rhiannon Tudor Edwards, Patricia Masterson-Algar, Gill Windle, John Connaghan, Greg Flynn, Kieren Egan, Gwenllian Hughes, Nia Goulden, Joshua Stott, Bethany Anthony, Kodchawan Doungsong, Catherine MacLeod, Kiara Jackson, Suman Kurana, Ryan Innes, Danielle Proctor, Fatene Abakar Ismail

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The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial by Cale A. Jacobs, Morgan H. Jones, Jamie E. Collins, Lily M. Waddell, Xiaojuan Li, Carl S. Winalski, Brian Pietrosimone, Virginia Byers Kraus, Miguel Otero, Elizabeth Wellsandt, Laura C. Schmitt, Kurt P. Spindler, Donald D. Anderson, Scott A. Rodeo, Robert A. Magnussen, Brian R. Wolf, Joe M. Hart, Austin V. Stone, Caitlin E. Conley, Yvonne M. Golightly, Gregory D. Myer, Lynn Snyder-Mackler, Martin K. Lotz, Jason S. Kim, Michelle M. McLeod, Janet L. Huebner, Caroline Lisee, Faith Selzer, Jeffrey N. Katz, Kyna Long, Kelly C. Frier, Daniel J. Betensky, David T. Felson, Elena Losina

“…Discussion: This manuscript outlines the rationale, study design, and implementation of the PIKASO trial aiming to prevent the onset of PTOA after ACLR. Trial registration: clinicaltrials.gov NCT06096259.…”
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Prevalence of post-acute sequelae of SARS-CoV-2 infection in people living with HIV: a systematic review with meta-analysisResearch in context by Dimitra V. Pouliopoulou, Nicole Billias, Joy C. MacDermid, Erin Miller, Kelly K. O'Brien, Kieran L. Quinn, Monali S. Malvankar-Mehta, Tiago V. Pereira, Angela M. Cheung, Fahad Razak, Saverio Stranges, Pavlos Bobos

“…Summary: Background: Given the chronic immune activation and inflammatory milieu associated with Long COVID and HIV, we assessed the prevalence of Long COVID in adults living with HIV; and investigated whether adults living with HIV were associated with increased chance of developing Long COVID compared to adults living without HIV Methods: In this systematic review and meta-analysis, we searched Medline, EMBASE, CINHAL, PubMed and CENTRAL from inception until June 14th, 2024, for observational studies that measured the prevalence of Long COVID in adults living with HIV and the odds of developing Long COVID following a SARS-CoV-2 infection in people living with HIV compared to people living without HIV. …”
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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis [version 2; peer review: 1 approve... by Spyridon Siafis, Johannes Schneider-Thoma, Alexandra Bannach-Brown, Oliver D. Howes, Virginia Chiocchia, Ulf Tölch, Natascha I. Drude, Sabine M. Hölter, Andrea de Bartolomeis, Anthony C. Vernon, Georgia Salanti, Sridhar Natesan, Stefan Leucht, Irene Bighelli, Sameer Jauhar, Ioannis Mantas, Josef Priller, Francesca Tinsdeall, Wulf-Peter Hansen, Fiona J. Ramage, Nobuyuki Nomura, Malcolm R. Macleod

“…Protocol registration PROSPERO-ID: CRD42024520914…”
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Efficacy of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum mal... by Abel Nhama, Arlindo Chidimatembue, Lídia Nhamussua, Quique Bassat, Clemente da Silva, Arsénio Nhacolo, Paulo Arnaldo, Crizolgo Salvador, Annette Cassy, Baltazar Candrinho, Mércia Dimene, Eva Carvalho, Abuchahama Saifodine, Flavio Wate, Hélio Mucavele, Yaritbel Torres-Mendoza, Breanna Horton, Mateusz Plucinski, Pau Cistero, Alfredo Mayor, Pedro Aide

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Frequency and Prognostic Value of Acute Periprocedural Myocardial Injury in Elective Percutaneous Coronary Interventions by E. O. Nalesnik, A. N. Repin

“…Conclusion. Registration of periprocedural increase in cardiac biomarkers should be carried out during planned PCI not only for the purpose of diagnosing and predicting acute and late ischemic events, but also for assessing the risk of developing stent occlusion, clinically significant bleeding and prognostically important comorbidities in the long-term (5-year) period in order to identification of groups of patients requiring active monitoring, additional examination and selection of an optimal treatment regimen at the outpatient stage of rehabilitation.…”
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