Comorbidity and health-related quality of life in people with a chronic medical condition in randomised clinical trials: An individual participant data meta-analysis. by Elaine W Butterly, Peter Hanlon, Anoop S V Shah, Laurie J Hannigan, Emma McIntosh, Jim Lewsey, Sarah H Wild, Bruce Guthrie, Frances S Mair, David M Kent, Sofia Dias, Nicky J Welton, David A McAllister

“…Therefore, clinicians and guideline developers are uncertain about the applicability of trial findings to people with multimorbidity. …”
Get full text

Effectiveness of an Innovative Mobile-Based Perioperative Care Program for Women Undergoing Breast Cancer Surgery (iCareBreast): Randomized Controlled Trial by Yan Pang, Honggu He, Ruey-Pyng Ng, Nicole Kim Luan Lee, Me Me Win Htein, Xiao-Xin Zhao, Ying-Hong Li, Elizabeth Jiahui Chan, Lixia Zhu, Guang Yu Liu, Minna Pikkarainen, Swee-Ho Lim

“…ObjectiveThis study aimed to develop and evaluate the effectiveness of an innovative, mobile-based, perioperative care program for women undergoing breast cancer surgery (iCareBreast). …”
Get full text

Long-Term Safety and Efficacy of Macitentan in Inoperable Chronic Thromboembolic Pulmonary Hypertension: Results from MERIT and its Open-Label Extension by Nick H. Kim, Andrea M. D’Armini, Luke S. Howard, David P. Jenkins, Zhi-Cheng Jing, Eckhard Mayer, Liliya Chamitava, Gabriela Lack, Hany Rofael, Maria Solonets, Hossein-Ardeschir Ghofrani

Get full text

Personalized neoantigen-based immunotherapy for advanced collecting duct carcinoma: case report by Wei Zhang, Xiaoping Su, Yongyi Zeng, Zhenli Li, Youshi Zheng, Yingchao Wang, Geng Chen, Liman Qiu, Kun Ke, Zhixiong Cai, Jingfeng Liu, Xiaolong Liu

Get full text

Are maternal vaccines effective and safe for mothers and infants? A systematic review and meta-analysis of randomised controlled trials by Kitty Bloemenkamp, Louis Bont, Fariba Ahmadizar, Miriam Sturkenboom, Odette de Bruin, Emily Phijffer, Nicoline van der Maas, Joanne Wildenbeest

“…Quality appraisal was performed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE).Results Six RCTs on four maternal vaccines, influenza, tetanus, diphtheria and pertussis (Tdap), pneumococcal and respiratory syncytial virus (RSV) were eligible. …”
Get full text

Information Mode–Dependent Success Rates of Obtaining German Medical Informatics Initiative–Compliant Broad Consent in the Emergency Department: Single-Center Prospective Observati... by Felix Patricius Hans, Jan Kleinekort, Melanie Boerries, Alexandra Nieters, Gerhard Kindle, Micha Rautenberg, Laura Bühler, Gerda Weiser, Michael Clemens Röttger, Carolin Neufischer, Matthias Kühn, Julius Wehrle, Anna Slagman, Antje Fischer-Rosinsky, Larissa Eienbröker, Frank Hanses, Gisbert Wilhelm Teepe, Hans-Jörg Busch, Leo Benning

“… BackgroundThe broad consent (BC) developed by the German Medical Informatics Initiative is a pivotal national strategy for obtaining patient consent to use routinely collected data from electronic health records, insurance companies, contact information, and biomaterials for research. …”
Get full text

Effect of Probiotic Supplementation on Maternal Depression, Anxiety and Attachment in Gestational Diabetes by Improving Mediterranean Diet Quality: A Randomized Controlled Trial by Fatma Bengü Kuyulu Bozdoğan, Seray Kabaran, Aybala Tazeoğlu

“…Evidence shows that women with gestational diabetes (GDM) are at higher risk of developing depression during pregnancy. Despite extensive research carried out by the probiotic industry in recent years, there is a lack of consensus on the available evidence on how best to use probiotics in mental health. …”
Get full text

DIAMONDS—a diabetes self-management intervention for people with severe mental illness: protocol for an individually randomised controlled multicentre trial by Tim Doran, Najma Siddiqi, Simon Gilbody, Rowena Jacobs, Patrick Doherty, Catherine Hewitt, Laura Mandefield, Simon Walker, Ian Kellar, Sarah Alderson, David Osborn, Vicki Johnson, Judith Watson, Gregor Russell, Steve Parrott, Jan Rasmus Boehnke, Peter A Coventry, Jinshuo Li, Richard Ian Gregory Holt, Judy Wright, David Shiers, Michelle Hadjiconstantinou, Keith Double, Claire Carswell, Jennifer V E Brown, Lucy Sheehan, Grace Catherine O’Carroll, Charlie Peck, R A Ajjan, Angela Ross, Mark Dawson

Get full text

Effects of YouTube Health Videos on Mental Health Literacy in Adolescents and Teachers: Randomized Controlled Trial by Rebekka Schröder, Tim Hamer, Victoria Kruzewitz, Ellen Busch, Ralf Suhr, Lars König

“… BackgroundAdolescence is a critical period for mental health development, yet prevalences of mental health problems are high among young people. …”
Get full text

Accuracy of a 2-minute eye-tracking assessment to differentiate young children with and without autism by Kristelle Hudry, Lacey Chetcuti, Diana Weiting Tan, Alena Clark, Alexandra Aulich, Catherine A. Bent, Cherie C. Green, Jodie Smith, Kathryn Fordyce, Masaru Ninomiya, Atsushi Saito, Shuji Hakoshima, Andrew J. O. Whitehouse

“…Industry employees who developed the final Algorithm were non-blinded to child group, and considered only gaze fixation durations. …”
Get full text

A Virtual Self-Management Intervention for Adolescents With Juvenile Idiopathic Arthritis: Protocol for the VISTA-JIA Randomized Controlled Trial by Jessica Booth, Kathryn A Birnie, Kelsey Chomistek, Maria Santana, Jennifer N Stinson, Babatope O Adebiyi, Julia Brooks, Jaime Guzman, Robin Hellweg, Lily SH Lim, Dax Rumsey, Brian M Feldman, Jamie Tagseth, Jennifer Wilson, Heinrike Schmeling

“… BackgroundNeeds assessments in patients with juvenile idiopathic arthritis (JIA) have revealed a need for disease information, self-management skills, and peer support. We previously developed and tested the acceptability of an in-person and videoconference-based self-management program (SMP) to address these needs. …”
Get full text

Efficacy and safety of first-line avelumab in patients with advanced non-small cell lung cancer: results from a phase Ib cohort of the JAVELIN Solid Tumor study by James L Gulley, Jaafar Bennouna, Guy Jerusalem, Janice Mehnert, Matthew Taylor, Karen Kelly, David Spigel, Marcis Bajars, Claire F Verschraegen, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Franklin L Chen, John C Morris, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi

Get full text

Regional Blood Flow Spectral Parameters as Predictors of Epidural-Related Maternal Fever: A Prospective Observational Study by Fei Shuai, Junxiang Jia, Peng Lin, Yicong Liao, Yuemei Xie

“…Thirteen participants (17.8%) in the study developed ERMF. PSV was significantly higher in the febrile group than the non-febrile group at 10 min after ELA (p < 0.05). …”
Get full text

A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protoc... by Amy A Herrold, Alexandra L Aaronson, Dulal Bhaumik, Timothy Durazzo, Sherri L Livengood, Alma Ramic, Patrick Riordan, Neil Jordan, Todd Parrish, Trudy Mallinson, Ibuola O Kale, Andrea Billups, Kelly Krese, Sandra Kletzel, Noah S Philip, Theresa L Bender Pape

“…A 6-year research plan timeline was developed, including cost and no-cost extensions due to the COVID-19 pandemic. …”
Get full text

Lay health worker-delivered and technology-based interventions for sexual and reproductive health among adolescents and young adults in low- and middle-income countries: protocol f... by David Guwatudde, Till Bärnighausen, Ina Danquah, Yemane Berhane, Wafaie Fawzi, Ali Sie, Mosa Moshabela, Shannon McMahon, Jacob Burns, Justine Bukenya, Michael Laxy, Japhet Killewo, Abbas Ismail, Shraddha Bajaria, Amani Tinkasimile, Adi Lukas Kurniawan, Sachin Shinde, Christine Neumann, Mary Mwanyika Sando, Ayoade Oduola, Adom Manu, Matthias Kern, Joy Mauti, Mashavu Yussuf, Innocent Yusufu, Benjamin Bosompim, Dorit Ann, Nolwazi Dlamini, Sarah Nabukeera, Sphindile Machanyangwa, Dagmawit Tewahido, Said Ali Vuai

Get full text

Effect of propofol combined with remimazolam besylate on blood pressure during general anesthesia induction in patients undergoing gynecological laparoscopic surgery: single-centre... by Xinmin Zhao, Haigen Xu, Shuping Wang, Yuanyuan Chen, Shuyu Yue

“…Conclusions Both Propofol plus remimazolam besylate and remimazolam besylate alone can reduce PIH, but propofol plus remimazolam besylate smooths the heart rate after general anesthesia undergoing gynecological laparoscopic. Trial registration This trial was retrospectively registered at http://www.chictr.org.cn (06/06/2024, ChiCTR-2400085401).…”
Get full text

Experiences Receiving and Delivering Virtual Health Care For Women: Qualitative Evidence Synthesis by Karen M Goldstein, Sharron Rushton, Allison A Lewinski, Abigail Shapiro, Tiera Lanford-Davey, Jessica N Coleman, Neetu Chawla, Dhara B Patel, Katherine Van Loon, Megan Shepherd-Banigan, Catherine Sims, Sarah Cantrell, Susan Alton Dailey, Jennifer M Gierisch

“…Our eligibility criteria were developed using the Sample, Phenomenon of Interest, Design, Evaluation, Research type tool to identify qualitative studies addressing synchronous virtual care for women. …”
Get full text

Implementing a structured model for osteoarthritis care in primary healthcare: A stepped-wedge cluster-randomised trial. by Nina Østerås, Tuva Moseng, Leti van Bodegom-Vos, Krysia Dziedzic, Ibrahim Mdala, Bård Natvig, Jan Harald Røtterud, Unni-Berit Schjervheim, Thea Vliet Vlieland, Øyvor Andreassen, Jorun Nystuen Hansen, Kåre Birger Hagen

“…<h4>Background</h4>To improve quality of care for patients with hip and knee osteoarthritis (OA), a structured model for integrated OA care was developed based on international recommendations. The objective of this study was to assess the effectiveness of this model in primary care.…”
Get full text

Coronary Computed Tomographic Angiography to Optimize the Diagnostic Yield of Invasive Angiography for Low-Risk Patients Screened With Artificial Intelligence: Protocol for the Car... by Jeremy Petch, Juan Pablo Tabja Bortesi, Tej Sheth, Madhu Natarajan, Natalia Pinilla-Echeverri, Shuang Di, Shrikant I Bangdiwala, Karen Mosleh, Omar Ibrahim, Kevin R Bainey, Julian Dobranowski, Maria P Becerra, Katie Sonier, Jon-David Schwalm

“…The AI-based decision support tool was developed using referral information from over 37,000 patients and uses a light gradient boosting machine model to predict the probability of obstructive CAD based on 42 clinically relevant predictors, including patient referral information, demographic characteristics, risk factors, and medical history. …”
Get full text

Effect of CYP3A4 inhibitor and induction on the pharmacokinetics and safety of FHND9041, a novel EGFR T790M inhibitor, in healthy Chinese by Chang Lu, Dongmei Cheng, Yunqiu Xie, Minghong Shang, Rongzhen Chen, Yongqiang Zhu, Jian Gong, Huan Zhou

“…FHND9041 is a new irreversible EGFR T790M mutation-selective small molecule kinase inhibitor, a third-generation EGFR inhibitor developed by Nanjing Chuangte Pharmaceutical Technology Co., Ltd. …”
Get full text