“HEAL together”: a randomized, hybrid type 1 effectiveness-implementation trial protocol of a peer-delivered behavioral activation intervention to improve methadone treatment reten... by Jessica F. Magidson, Jessica F. Magidson, Valerie D. Bradley, Jessica S. Anane, Mary B. Kleinman, Julia W. Felton, Abigail C. Hines, Rithika Baskar, Aaron D. Greenblatt, Dwayne Dean, Morgan S. Anvari, Heather Fitzsimons, Melanie E. Bennett, Annabelle M. Belcher

“…If findings are promising, Peer Activate may provide a platform on which to incorporate an evidence-based behavioral activation approach into PRS training nationally.Clinical trial registrationNCT05299515.…”
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Identifying the needs of natural caregivers caring for a person with dementia: a mixed method study by Clarisse Dibao-Dina, Lydia Nasri, Céline Dagot, Jean-Philippe Fouquet, Sophie Rideau, Vincent Dumas, Guillaume Neff, Véronique Payen, Delphine Rube-Millon, Marie Lemaile, Jacques-Alexis Nkodo, Vincent Camus, Bertrand Fougère, Bruno Giraudeau, Dominique Beauchamp, Laura Fruchard-Foucault, Cécile Renoux, Jean Robert

“…This study aims to evaluate caregivers’ needs with the future goal of developing a tailored, multicomponent intervention to ease caregiver challenges through appropriate caregiver-centred interventions. …”
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Diagnostic accuracy of case-identification algorithms for heart failure in the general population using routinely collected health data: a systematic review by Anita Andreano, Vito Lepore, Pietro Magnoni, Alberto Milanese, Caterina Fanizza, Deborah Testa, Alessandro Musa, Adele Zanfino, Paola Rebora, Lucia Bisceglia, Antonio Giampiero Russo, the PROPHET-I study group

“…Systematic review registration PROSPERO CRD42023487565…”
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Predicting Disease Progression in Inoperable Localized NSCLC Patients Using ctDNA Machine Learning Model by Yuqi Wu, Canjun Li, Yin Yang, Tao Zhang, Jianyang Wang, Wanxiangfu Tang, Ningyou Li, Hua Bao, Xin Wang, Nan Bi

“…Conclusion In conclusion, we developed a cfDNA neomer profiling assay for predicting disease progression in inoperable NSCLC patients. …”
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PlacEntal Acute atherosis RefLecting Subclinical systemic atherosclerosis in women up to 20 years after pre-eclampsia (PEARLS): research protocol for a cohort study by Jérôme Cornette, Wessel Ganzevoort, Casper Mihl, Chahinda Ghossein-Doha, Gwyneth Jansen, Arnoud van ’t Hof, Sanne Gordijn, Salwan Al-Nasiry, Robert-Jan Alers, Laura M Jorissen, Emma BNJ Janssen, Eri Morina - Shijaku, Carmen Severens-Rijvers, J van Drongelen, Ralph R Scholten, Droima Stevens, Bas Kietelaer, Marc EA Spaanderman

“…Results will be shared in peer-reviewed journals and conference presentations.Trial registration number NCT05500989; ClinicalTrials.gov Identifier.…”
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Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Atte... by N. Ikani, A. Tyborowska, N. Kohn, N. Günther, G J. Siegle, A. H. Schene, J. A. S. Vorstman, C. J. Harmer, M. J. Kas, J. N. Vrijsen, H. G. Ruhé

“…Methods Here we describe the protocol for the Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD) study, aiming to investigate different forms of cognitive training programs administered via smartphones, in order to develop a second-generation recurrence prevention program. …”
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Pharmacy Integrated Transitions (PIT) trial: a protocol for a pragmatic cluster-randomised crossover trial by Elizabeth Austin, Catherine Kim, Elizabeth J Austin, Giana H Davidson, Bryan A Comstock, Sarah E Monsell, Bryan Comstock, Mariam N Hantouli, Jocelyn Chaing, Arzu Ahmed Dervish, Nick J Gionet, Shalynn Howard, Nathalia Jimenez, Miriam Liberman, Edwin G Lindo, Zachary A Marcum, Thuan D Ong, Elina Serrano, Katherine Simons, Lydia S Sun, Oleg Zaslavsky

“…Results may also be presented at international conferences.Trial registration number NCT05241951.…”
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Leg Muscle Volume, Intramuscular Fat and Force Generation: Insights From a Computer‐Vision Model and Fat‐Water MRI by Andrew C. Smith, Javier Muñoz Laguna, Eddo O. Wesselink, Zachary E. Scott, Hazel Jenkins, Wesley A. Thornton, Marie Wasielewski, Jordan Connor, Scott Delp, Akshay S. Chaudhari, Todd B. Parrish, Sean Mackey, James M. Elliott, Kenneth A. Weber II

“…Decreases in lower limb muscle volume and increased intramuscular fat (IMF) are common findings in people with impaired mobility. We developed an automated method to extract markers of leg muscle health, muscle volume and IMF, from MRI. …”
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A mechanism-based group psychotherapy approach to aggressive behavior (MAAP) in borderline personality disorder: a multicenter randomized controlled clinical trial by Christine Sigrist, Andreas Bechdolf, Katja Bertsch, Robin Bullenkamp, Martin Busse, Ute gr. Darrelmann, Astrid Dempfle, Martin Driessen, Thomas Frodl, Jan-Michael Kersting, Jessica Kesik, Burkhart Matzke, Corinne Neukel, Eva Niessen, Svenja Nückel, Viola Oertel, Frank Padberg, Alexandra Philipsen, Dorothee Pink, Andreas Reif, Matthias Reinhard, Carolin Steuwe, Larissa Wolkenstein, Sabine C. Herpertz, the MAAP Consortium

“…To address this, we developed a mechanism-based anti-aggression psychotherapy (MAAP) for the group setting that specifically targets the biobehavioral mechanisms underlying outward-directed aggression in BPD. …”
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Effects of Physical Exercise on Executive Function in Schizophrenia: Systematic Review and Meta-Analysis by Nuria Pérez-Romero, Christian Campos-Jara, Caterina Pesce, Sergio Araya Sierralta, Enrique Cerda-Vega, Rodrigo Ramirez-Campillo, Rodrigo Campos-Jara, Cristian Martínez-Salazar, Cristián Arellano-Roco, Victoria Hernández-Cifuentes, Falonn Contreras-Osorio

“…Further research is needed to provide more robust conclusions. PROSPERO registration number: CRD42023392295.…”
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A personal sensing technology enabled service versus a digital psychoeducation control for primary care patients with depression and anxiety: a pilot randomized controlled trial by Colleen Stiles-Shields, Karen M. Reyes, Tanvi Lakhtakia, Shannon R. Smith, Olga E. Barnas, Elizabeth L. Gray, Charles J. Krause, Kaylee P. Kruzan, Mary J. Kwasny, Zara Mir, Sameer Panjwani, Steven K. Rothschild, Lisa Sánchez-Johnsen, Nathan W. Winquist, Emily G. Lattie, Nicholas B. Allen, Madhu Reddy, David C. Mohr

“…The current study: (1) developed a TES tailored for Primary Care patients with depression and/or anxiety, and (2) conducted a pilot randomized controlled trial to assess the efficacy of the TES compared to a digital psychoeducation control app. …”
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Protocol for #iBeatCRC: a community-based intervention to increase early-onset colorectal cancer awareness using a sequential explanatory mixed-methods approach by Mary A De Vera, Charles R Rogers, Tiana N Rogers, Fares Qeadan, Margaret A Handley, Karen Curtin, Ellen Brooks, Ethan Petersen, Phuong Gallagher, Curt Pesmen, Wenora Johnson, Candace Henley, Walter Hickman, Elaine Newcomb, Kevin M Korous

“…Final intervention-specific data will be available on reasonable request from the corresponding author.Trial registration number NCT04715074.…”
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Cost-effectiveness analysis of proactive home visits compared with site-based community health worker care on antenatal care outcomes in Mali: a cluster-randomised trial by Osondu Ogbuoji, Caroline Whidden, Emily Treleaven, Youssouf Keita, Kassoum Kayentao, Ari Johnson, Jenny X Liu, Minahil Shahid, Mohamed Berthé, Armand Zimmerman, David Charles Boettiger, Coumba Traoré, Mahamadou Sogoba, Saibou Doumbia, Amadou Beydi Cissé

“…However, despite the success of CHW programmes in various countries, WHO has called for additional research to develop evidence-based models that optimise CHW service delivery and that can be replicated across geographies.Methods The ProCCM Trial was a cluster-randomised controlled trial to compare proactive home visits by CHWs (intervention, 69 village clusters) to the provision of CHW care at community fixed sites only (control, 68 village clusters) in the Bankass health district in Central Mali. …”
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Electronic Implementation of Patient-Reported Outcome Measures in Primary Health Care: Mixed Methods Systematic Review by Maxime Sasseville, Wilfried Supper, Jean-Baptiste Gartner, Géraldine Layani, Samira Amil, Peter Sheffield, Marie-Pierre Gagnon, Catherine Hudon, Sylvie Lambert, Eugène Attisso, Steven Ouellet, Mylaine Breton, Marie-Eve Poitras, Pierre-Henri Roux-Lévy, James Plaisimond, Frédéric Bergeron, Rachelle Ashcroft, Sabrina T. Wong, Antoine Groulx, Jean-Sébastien Paquette, Natasha D'Anjou, Sylviane Langlois, Annie LeBlanc

“… BackgroundManaging chronic diseases remains a critical challenge in primary health care (PHC) across the Organization for Economic Co-operation and Development countries. Electronic patient-reported outcome measures (ePROMs) are emerging as valuable tools for enhancing patient engagement, facilitating clinical decision-making, and improving health outcomes. …”
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Cardiac adverse events associated with remdesivir in COVID-19 patients: a systematic review and meta-analysis of randomised controlled trials by Matthias Briel, Alain Amstutz, Chengliang Yang, Linda Lapp, Casey P. Shannon, Hedi Zhao, Estefania Espin, Sara Assadian, Mustafa Toma, Scott J. Tebbutt

“…The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was applied to assess the certainty of evidence. …”
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Human papillomavirus vaccine uptake and its determinants among women in Africa: an umbrella review by Berihun Agegn Mengistie, Amlaku Nigusie Yirsaw, Gebeyehu Lakew, Gebrehiwot Berie Mekonnen, Adamu Ambachew Shibabaw, Alex Ayenew Chereka, Gemeda Wakgari Kitil, Wubet Tazeb Wondie, Alemken Eyayu Abuhay, Eyob Getachew

“…Therefore, increasing vaccine uptake requires promoting women’s knowledge and attitudes toward HPV vaccination through facility-based education and counseling, planned campaigns, community-based programs, and advocacy for HPV vaccination and cervical cancer prevention using various mass media platforms.Systematic review registrationBerihun Agegn Mengistie, Muluken Demeke, Abebaw Setegn. …”
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Maximising Embedded Pharmacists in AGed CAre Medication Advisory Committees (MEGA-MAC): protocol for implementing Australia’s new guiding principles for medication management in re... by Amanda J. Cross, Brooke Blakeley, Kate Laver, Terry P. Haines, Sarah N. Hilmer, Atish Manek, Alexandra Bennett, Angelita Martini, Lyntara Quirke, Mary Ann Kulh, Sara L. Whittaker, Dayna R. Cenin, Anthony Hobbs, Joanne Money, Karina Rieniets, Kris Salisbury, Alene Sze Jing Yong, J. Simon Bell

“…The intervention will involve knowledge broker dyads (pharmacist plus a MAC representative [e.g. nurse]) developing, implementing and evaluating RACF-specific local action plans to implement the Guiding Principles in up to 15 RACFs. …”
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Advancing access to substance use prevention for foster youth through digital innovation: an open trial of fostrspace with court appointed special advocate programs by Marina Tolou-Shams, Johanna B. Folk, Margareth V. Del Cid, Jannet Lara Salas, Alison Czopp, Juan Carlos Gonzalez, Tylia Lundberg, Erin Michelle Turner Kerrison, Martha Shumway, Ann Wrixon, Robert Salgado, Jill Duerr Berrick

“…A concurrent 6-session ECHO® substance use prevention telementoring curriculum was co-developed as a FostrSpace implementation strategy with a 6-member CASA Advisory Board. …”
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SToP (See, Treat, Prevent) skin sores and scabies trial: study protocol for a cluster randomised, stepped-wedge trial for skin disease control in remote Western Australia by Marianne J Mullane, Timothy C Barnett, Jeffrey W Cannon, Jonathan R Carapetis, Ray Christophers, Juli Coffin, Frieda Mc Loughlin, Vicki O'Donnell, Rebecca Pavlos, Bec Smith, Andrew C Steer, Steven Y C Tong, Roz Walker, Asha C Bowen

“…Communication and dissemination will require ongoing consultation with Aboriginal communities to determine appropriate formats.Trial registration number ACTRN12618000520235.…”
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GRACE: protocol for a UK, secondary care, multicentre, assessor-blinded randomised controlled trial with a non-inferiority comparison to evaluate graduated compression stockings as... by John Norrie, Rebecca Lawton, Jonathan L Rees, Joseph Shalhoub, Beverley J Hunt, Zaed Hamady, Maria Kyrgiou, Tom Pinkney, Andrew D Beggs, Tamara Everington, Linda Williams, Simon Toh, Francine Heatley, Alun Davies, Matthew Machin, Nick Watkin, Sasha Smith, Sara Jasionowska, Alexander Liddle, Layla Bolton Saghdaoui

“…Patients undergoing surgery are at increased risk of developing VTE within hospital admission and 90 days after hospital discharge are collectively known as hospital-acquired thrombosis (HAT). …”
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