The Manitoba Personalized Lifestyle Research (TMPLR) study protocol: a multicentre bidirectional observational cohort study with administrative health record linkage investigating... by Navdeep Tangri, Dylan Mackay, Rebecca C Mollard, Matthew Granger, Sharon Bruce, Heather Blewett, Jared Carlberg, Todd Duhamel, Peter Eck, Patrick Faucher, Naomi C Hamm, Ehsan Khafipour, Diana McMillan, Semone Myrie, Amir Ravandi, Meghan Azad, Peter JH Jones

“…Additional information at www.TMPLR.ca.Trial registration number NCT03674957; Pre-results.…”
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Unrecognised rural–urban disparities in epidemiology of metabolic-associated fatty liver disease in the representative area of China by Qing Li, Yi Zhang, Xing Chen, Xiaoyi Li, Tingfeng Wu, Junzhao Ye, Suilin Mo, Miaosheng Ye, Wengeng Wang, Qiaocong Zheng, Ke Luo, Shouwei Tu, Daituan Che, Rulong Gong, Rong Miu, Congxiang Shao, Yanhong Sun, Bihui Zhong

“…We aimed to clarify the prevalence and risk factors in rural areas of China.Methods This cross-sectional study used the most densely populated area with highly unbalanced development differences in China (Guangdong Province) as a representative sample, and multistage stratified random sampling was performed. …”
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SMALL: open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—protocol for a phase III randomised multicentre trial by Sian Taylor-Phillips, Tracy Roberts, Nisha Sharma, Sangeetha Paramasivan, Shelley Potter, Stuart McIntosh, David Dodwell, Julia R Henderson, Hilary Stobart, Sarah Pinder, Jenna Morgan, Matthew G Wallis, Charlotte Coles, Zohal Nabi, Beatrix Elsberger, William Teh, Kenneth Elder, Jessica Foster, Claire Gaunt, Iain Lyburn, Claire Mabena, Sarah Pirrie, Elizabeth Southgate, Amruta Talwalkar, Elliot Turner, Dan Rea

“…Results will be submitted for publication in a peer-reviewed journal, presented, shared with patient partners and with relevant professional organisations to inform future guideline development for the management of screen-detected breast cancer.Trial registration number ISRCTN12240119.…”
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Protocol for an outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mecha... by Joanne R Chalmers, Sanja Kezic, Zarif K Jabbar-Lopez, Nikeeta Gurung, Danielle Greenblatt, Annette Briley, Kim Suzanne Thomas, Tony Frost, John E A Common, Heidi H Kong, Julie A Segre, Simon Danby, Michael J Cork, Janet L Peacock, Carsten Flohr

“…We will send participating families a summary of the pilot trial results.Trial registration number NCT03270566.…”
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Evaluation of the insertion parameters and complications of the i-gel Plus airway device for maintaining patent airway during planned procedures under general anaesthesia: a protoc... by Michal Kral, Jonathan Holland, Ana M Lopez, Jan Bruthans, Pavel Michalek, Olga Klementova, Taranpreet Kaur Bhoday, Jakub Werner, Will Donaldson, Erik Lichnovsky, Tomasz Gaszyński, Tomas Henlin, Jitka Ulrichova, Martin Lukes, Jan Blaha, Lidia Gomez, Raquel Berge, Francis McAleavey, Shiva Arava, Lubica Merjava Skripecka, Sebastian Sobczyk, Tomas Tyll

“…The results will be published in peer-reviewed journals and presented at relevant anaesthesia conferences.Trial registration number ISRCTN86233693;Pre-results.…”
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Reducing medicine-induced deterioration and adverse reactions (ReMInDAR) trial: study protocol for a randomised controlled trial in residential aged-care facilities assessing frail... by Nicole L Pratt, Lisa M Kalisch Ellett, Elizabeth Ellen Roughead, Renly Lim, Megan Corlis, Gaynor Parfitt, Debra Rowett, Luke Bereznicki, Ai Choo Kang, Tracy Merlin, Stacey Torode, Joseph Whitehouse, Andre Q Andrade, Rebecca Bilton, Justin Cousins, Lan Kelly, Camille Schubert, Mackenzie Williams

“…A copy of the final report will be provided to the Australian Government Department of Health.Trial registration number Australian and New Zealand Trials Registry ACTRN12618000766213.…”
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Identification of influenza urban transmission patterns by geographical, epidemiological and whole genome sequencing data: protocol for an observational study by Andreas Buser, Sarah Tschudin-Sutter, Adrian Egli, Claudia Saalfrank, Nina Goldman, Myrta Brunner, Yvonne Hollenstein, Thomas Vogel, Noémie Augustin, Daniel Wüthrich, Helena M.B. Seth-Smith, Elisa Roth, Mohammedyaseen Syedbasha, Nicola F. Mueller, Dominik Vogt, Jan Bauer, Nadezhda Amar-Sliwa, Dominik M. Meinel, Olivier Dubuis, Michael Naegele, Christian H. Nickel, Andreas Zeller, Nicole Ritz, Manuel Battegay, Tanja Stadler, Rita Schneider-Sliwa

“…It is planned to present the results at conferences and publish the data in scientific journals.Trial registration number NCT03010007.…”
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Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol... by Ana Paula Taboada Sobral, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Raquel Agnelli Mesquita Ferrari, Amanda Rafaelly Honório Mandetta, Carolina Carvalho Bortoletto, Renato Araujo Prates, Alessandro Melo Deana, Rita de Cássia Loiola Cordeiro, Lourdes Aparecida Martins dos Santos Pinto

“…Introduction Molar incisor hypomineralisation (MIH) is a qualitative defect of enamel development that occurs in the mineralisation phase. …”
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Tools to improve discharge equity: Protocol for the pilot TIDE trial by Kirsten Austad, Cecilia Thai, Alegna Zavatti, Nhi Nguyen, Diana Bautista-Hurtado, Patrick Kenney, Noelia Lugo, Joo H. Lee, Howard Lanney, Ziming Xuan, Erika G. Cordova-Ramos, Mari-Lynn Drainoni, Brian Jack

“…Result will inform future efforts to improve the safety and equity of the hospital discharge process. Trial registration: clinicaltrials.gov NCT05988229 (August 14, 2023) https://classic.clinicaltrials.gov/ct2/show/NCT05988229.…”
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Transcutaneous auricular vagal nerve stimulation for consciousness recovery in patients with prolonged disorders of consciousness (TAVREC): study protocol for a multicenter, triple... by Jan D Reinhardt, Jin Liu, Ting Luo, Xiao Lu, Zhen-Yu Liu, Long-yun Zhou, Li-jun Peng, Ya-feng Liu, Shu-wei Wang, Yue Qiu, Si-jing Chen, Ming-ming Feng, Shan-shan Wu, Hui-juan Wu, Jiang-ping Ge

“…Findings will be disseminated in a peer-reviewed journal and presented at relevant conferences.Trial registration number ChiCTR2300073950.…”
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Carer perspectives on overweight, obesity and dental caries in early childhood: findings from a systematic qualitative review by Heilok Cheng, Heilok Cheng, Heilok Cheng, Rebecca Chen, Rebecca Chen, Rebecca Chen, Bradley Christian, Bradley Christian, Jessica Appleton, Jessica Appleton, Jessica Appleton, Amit Arora, Amit Arora, Amit Arora, Amit Arora, Amit Arora, Elizabeth Denney-Wilson, Elizabeth Denney-Wilson, Elizabeth Denney-Wilson

“…Understanding these beliefs towards children's teeth and weight can address parents’ priorities and develop prevention messages. This qualitative systematic review (PROSPERO registration #CRD42022348783) aimed to identify parent or carer perspectives on obesity and ECC in children aged ≤6 years.MethodsDatabase searching of CINAHL, Medline and EMBASE, with hand searching, was undertaken. …”
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Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials by Xiao-ying Chen, Chun-li Lu, Qian-yun Wang, Xing-ru Pan, Yang-yang Zhang, Jia-le Wang, Jun-Ya Liao, Nai-chong Hu, Chen-yang Wang, Bing-jie Duan, Xue-han Liu, Xin-yan Jin, Jennifer Hunter, Jian-ping Liu

“…Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). …”
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Randomised controlled trial to evaluate the effectiveness of using the RD-1-based C-Tb skin test as a replacement for blood-based interferon-γ release assay for detection of, and i... by Marc Lipman, Ibrahim Abubakar, Chris Griffiths, Penny Whiting, Robert Horne, Alex Ghanouni, Heinke Kunst, Mike Mandelbaum, Molebogeng X Rangaka, Karen Sanders, Peter J White, Angela Crook, Dominik Zenner, Trinh Duong, Vanessa Hack, Julian Surey, Yohhei Hamada, Henry Bern, Joanna Calvert, Marie Francis, Amy Louise Clarke, Ellen Owen-Powell, Helen L Booth

“…We will share results of the trial in peer-reviewed journals and conferences.Trial registration number EudraCT 2019-002592-34; ISRCTN17936038.…”
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Strategic multimodal intervention in at-risk elderly Indians for prevention of dementia (SMRUTHI INDIA): a cohort multiple randomised controlled trial (cmRCT) protocol by Pooja Sharma, Divyani Garg, Maroof Ahmad Khan, Ayush Agarwal, Manish Barvaliya, Shubham Gupta, Alex Rebello, Ashima Nehra, Anu Gupta, Padma Srivastava, Kritika Sharma, Subrata Baidya, Abhik Sinha, Shampa Das, Sunil Kumar Raina, Sakshi Sharma, Venugopalan Y Vishnu, Varuna Sharma, Subarna Roy, P K Anand, Nilima Nilima, Vaibhav Patil, Rajeev Aggarwal, Aditi Dubey, Hina Narzari, Sneha Sneha, Kamini Kashyap, Krishan Kaushal, Kajal Fulara, Shikha Chaudhary, Divya M R, Vasundhara Misra, Phaniraj Vastrad, Priyadarshanraj N, Sandesh J R, Harshath Ajay V, Aishwarya Bhovi, Mailrappa Padiyappa Hooli, Sagar P M, Ambika Y V, Ripanjit Singh, Naveen M R, Shilpa K, Sharanabasavaraj Devaramani, Sandip Bhattacharjee, Bishakha Sen, Shalina Jamatia, Manish Acharjee, Dipankar Deb, Pameli Jamatia, Munmun Debbarma, Shaily Bhushan, Rishabh Gautam, Rishav Bhatia, Arnav Verma, Kalpna Sharma, Gajraj Singh, Priyanka Kumari Meena, Akhilesh Nagar, Hitesh Tiwari, Tinku Yogi, Vikram Raigar, Vinny Wilson, Shradha Singh, Zubia Nasir, Daksha Kumari, Mallamma Duddagi, Basamma R Alur, Sreetama Bahaduri, Aditya Choudhary, Suhas Murali, Jyoti Kattna, Amita Sengupta, Dolan Roy, Tithi Patra, Bandana Kayestha, Yachana Sharma, Nandini Rawat, Kavita Bairwa, Muskan Sharma, Divyani Rathore

“…The ‘Strategic Multimodal Intervention in at-risk Elderly Indians for Prevention of Dementia (SMRUTHI INDIA)’ study will be conducted to establish a trial-ready cohort of elderly Indians who are at high risk of developing dementia.Methods and analysis The main aim of the study is to create and study a cohort of individuals at high risk of dementia in rural India, where we can do multiple intervention trials. …”
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Effectiveness of combining psychological prevention interventions with interventions that address the social determinants of mental health in low- and middle-income countries: a sy... by Crick Lund, Katherine Sorsdahl, Marianna Purgato, Corrado Barbui, Nagendra Luitel, Mark Jordans, Emily Garman, Rakesh Singh, Emiliano Albanese, Eleonora Prina, Beatrice Bano, Daniela Trujillo, Maria Cecilia Dedios Sanguineti

“…Future research should focus on key intervention components and head-to-head comparisons between different interventions and between their components.PROSPERO registration number CRD42023451072.…”
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Bridging hospital to home for children with medical complexity and their families: an observational prospective cohort study protocol to assess the effectiveness of an innovative t... by Lotte Haverman, Jolanda M Maaskant, Matthijs de Hoog, Job B M van Woensel, Hester Rippen, K F M Joosten, Clara D van Karnebeek, Inge M L Ahout, Heleen N Haspels, Misja C Mikkers, Hennie Knoester, Nicolaas J G Jansen, Liz van de Riet, Karolijn Dulfer, Maartje Haasnoot, Mattijs W Alsem, Bettina Sandbergen, Willemien de Weerd, Jan Peter Rake, Meggi Schuiling, Jacqueline Kasten

“…The insights gained from this study will contribute to the development of a national care pathway to enhance transitional care for CMC and their families in the future.Trial registration number NCT06599398 (ClinicalTrials.gov) - Bridging Hospital to Home for CMC and Their Families.…”
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Association Between Maternal Undernutrition and Pre‐Labor Rupture of Membranes in Ethiopia: A Systematic Review and Meta‐Analysis of Observational Studies by Ebrahim Msaye Assefa, Hussen Abdu, Altaseb Beyene Kassaw, Mekonnen Belete, Amare Abera Tareke, Addis Alem, Mohammed Derso Bihonegn, Abdulaziz Kebede Kassaw, Ahmed Juhar Temam, Gashaw Abebe, Melese Shenkut Abebe, Gosa Mankelkl, Zeleke Geto, Seid Mohammed Abdu

“…Policymakers need to develop public health policies to address maternal nutrition. …”
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Testing a systematically braided alcohol reduction and HIV status neutral intervention among people receiving STI care in Malawi: study protocol for a pilot hybrid type 1 effective... by Kathryn E. Lancaster, Agatha K. Bula, Mitch M. Matoga, Mina C. Hosseinipour, Mina C. Hosseinipour, Irving F. Hoffman, Irving F. Hoffman, Jaslyn A. Grullon, Eric Umar, Jimmy Msolola, Jessica F. Magidson, Jessica L. Bonumwezi, Judith A. Hahn, Angela M. Parcesepe

“…Our study will directly expand alcohol reduction and HIV status-neutral programs for alcohol-impacted populations throughout sub-Saharan Africa and other regions where alcohol contributes to the ongoing HIV epidemic.Clinical trial registrationClinicalTrials.gov, NCT06668363.…”
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Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol by Yue Wang, Xin Li, Ying Wang, Hongmei Zhao, Qian Lu, Yujie Zhou, Liyuan Zhang, Aomei Shen, Jingru Bian, Wanmin Qiang, Jingming Ye, Hongmeng Zhao, Yubei Huang, Zhongning Zhang, Peipei Wu

“…The results of this study will be published in peer-reviewed journals and will be presented at several research conferences.Trial registration number ChiCTR2200057083.…”
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Addressing uncertainty in identifying pregnancies in the English CPRD GOLD Pregnancy Register: a methodological study using a worked example by Yangmei Li, Jennifer J Kurinczuk, Fiona Alderdice, Maria A Quigley, Oliver Rivero-Arias, Julia Sanders, Sara Kenyon, Dimitrios Siassakos, Nikesh Parekh, Suresha De Almeida, Claire Carson

“…The study included all women aged 18-48yrs, registered at an English GP practice within CPRD on 01/01/2017, with a year of prior registration and eligibility for hospital data linkage. …”
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