Prognostic models for cardiovascular and kidney outcomes in people with type 2 diabetes: living systematic review and meta-analysis of observational studies by Veena Manja, Arnav Agarwal, Thomas Agoritsas, Farid Foroutan, Reem A Mustafa, Per Olav Vandvik, Daniel G Rayner, Darsh Shah, Si-Cheng Dai, David Gou, Jason Z X Chen

“…The Prediction Model Risk of Bias Assessment (PROBAST) tool was used to assess the risk of bias of each analysed study cohort and the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach to evaluate our certainty in the evidence.Results 6529 publications were identified, of which 35 studies reporting on 13 models were included, all of which were developed for general populations with type 2 diabetes but no established cardiovascular disease or chronic kidney disease. …”
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Identification of essential topics and procedural skills for inclusion in a contextualised undergraduate anaesthesia and critical care clerkship in Rwanda: results of a modified De... by Callum Forbes, Bruce Mutembe Nzobele, Barnabas T. Alayande, Françoise Nizeyimana, Jean Paul Mvukiyehe, Jocelyn M. Booth, Selam Degu Woldegiorgis, Benoucheca Pierre, James Littlejohn, Sheida Tabaie, Abebe Bekele, Craig D. McClain, Gaston Nyirigira, The African Anaesthesia Education Delphi Group

“…Trial registration Not applicable (study described is not a clinical trial). …”
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Adapting a Mobile Health App for Smoking Cessation in Black Adults With Anxiety Through an Analysis of the Mobile Anxiety Sensitivity Program Proof-of-Concept Trial: Qualitative St... by Marshall K Cheney, Adam C Alexander, Lorra Garey, Matthew W Gallagher, Emily T Hébert, Anka A Vujanovic, Krista M Kezbers, Cameron T Matoska, Michael J Zvolensky, Michael S Businelle

“…Trial RegistrationClinicalTrials.gov NCT04838236; https://clinicaltrials.gov/ct2/show/NCT04838236…”
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Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial. by Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

“…<h4>Conclusions</h4>In this study, we found that for women who develop a short cervix, cerclage, pessary, and vaginal progesterone were equally efficacious at preventing PTB, as judged with a 20% equivalence margin. …”
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Modelling diabetes and depression in Pakistan: using economic modelling to inform intervention design and a clinical trial of a behavioural activation intervention by Najma Siddiqi, Rowena Jacobs, Edward Fottrell, Naveed Ahmed, Simon Walker, Zia Ul-Haq, David Ekers, Abdul Basit, Asher Fawwad, Naomi Gibbs, Gerardo A Zavala, Faiza Aslam, Richard Ian Gregory Holt, Saima Afaq, Asima Khan Niazi, David Glynn, Pedro Saramago

“…Objectives The ‘Developing and evaluating an adapted behavioural activation intervention for depression and diabetes in South Asia (DiaDeM)’ trial investigates a psychological intervention, behavioural activation (BA), on people with both diabetes and depression in Bangladesh and Pakistan. …”
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Skills for adolescent WELLbeing (SWELL): protocol for a preventive effectiveness randomised controlled trial for young people at high-familial risk of depression with treatment opt... by Graham Moore, Neil A Harrison, Daniel Michelson, Lucy Brookes-Howell, Rebecca Playle, Anita Thapar, Frances Rice, Judy Garber, Kim Munnery, Rachel McNamara, Jonathan Bisson, Ajay Thapar, Olga Eyre, Victoria Powell, Elizabeth Randell, Detelina Grozeva, Rhys Bevan Jones, Stephan Collishaw, Jac Airdrie

“…Introduction Young people (YP) whose parents have depression are at elevated risk for developing depression themselves and could benefit from preventive interventions. …”
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Evaluating the Effectiveness of a Roblox Video Game (Super U Story) in Improving Body Image Among Children and Adolescents in the United States: Randomized Controlled Trial by Nicole Paraskeva, Sharon Haywood, Jason Anquandah, Paul White, Mahira Budhraja, Phillippa C Diedrichs, Heidi Williamson

“… BackgroundBody dissatisfaction is a global public health issue negatively impacting young people’s mental and physical well-being, underscoring an urgent need to develop early interventions. Emerging evidence suggests that microinterventions are acceptable and effective in delivering mental health interventions. …”
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Culturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial by Jia-Yan Pan, Jonas Rafi

“…MethodsAn 11-week guided iCBT program, “Confront and Navigate Depression Online” (CANDO), consisting of 8 online modules, was developed and implemented for Hong Kong residents. …”
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Risk factors for contrast-induced acute kidney injury (CI-AKI): protocol for systematic review and meta-analysis by Yan Liang, Yong Liu, Ning Tan, Jiyan Chen, Xingcheng Liang, Shaojun Xin, Jin Liu, Guoli Sun, Shiqun Chen, Xiaolin Cen, Yibo He, Feier Song, Yuying Hu, Yingling Zhou, Zhujun Chen

“…We will disseminate the findings of this systematic review and meta-analysis via publications in peer-reviewed journals.PROSPERO registration number CRD42019121534…”
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Treatment options applied to the preclinical studies using animal models for Chagas Disease: a systematic review and meta-analysis [version 3; peer review: 2 approved] by Haruna Luz Barazorda-Ccahuana, Mayron Antonio Candia-Puma, Miguel Angel Chavez-Fumagalli, Luis Daniel Goyzueta-Mamani, Rodolfo Cordeiro Cordeiro Giunchetti, Ricardo Andrez Machado-de-Ávila, Alexsandro Sobreira Galdino, Brychs Milagros Roque-Pumahuanca, Eduardo Antonio Ferraz Coelho, Laura Yesenia Machaca-Luque

“…Inplasy registration INPLASY202430101 (25/03/2024)…”
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Prediction of Seronegative Hashimoto's thyroiditis using machine learning models based on ultrasound radiomics: a multicenter study by Wenjun Wu, Shengsheng Yao, Daming Liu, Yuan Luo, Yihan Sun, Ting Ruan, Mengyou Liu, Li Shi, Chang Liu, Mingming Xiao, Qi Zhang, Zhengshuai Liu, Xingai Ju, Jiahao Wang, Xiang Fei, Li Lu, Yang Gao, Ying Zhang, Liying Gong, Xuanyu Chen, Wanli Zheng, Xiali Niu, Xiao Yang, Huimei Cao, Shijie Chang, Jianchun Cui, Zuoxin Ma

“…Ethics No. [2023] H013 Trial registration Chinese Clinical Trial Registry;CTR2400092179; 12 November 2024.…”
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Statistical analysis plan for the 24-week randomised trial of hypoglycaemia prevention, awareness of symptoms, and treatment: HypoPAST by Sharmala Thuraisingam, Jennifer A. Halliday, Uffe Søholm, Elizabeth Holmes-Truscott, Christel Hendrieckx, Timothy C. Skinner, Vincent L. Versace, Jane Speight

“…The analysis methods were developed by statisticians, with input from trial investigators. …”
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Study protocol for the COMET study: a cluster-randomised, prospective, parallel-group, superiority trial to compare the effectiveness of a collaborative and stepped care model vers... by Hans-Helmut König, Olaf von dem Knesebeck, Karl Wegscheider, Martin Härter, Jörg Dirmaier, Bernd Löwe, Bernd Schulte, Daniela Heddaeus, Christian Brettschneider, Anne Daubmann, Thomas Grochtdreis, Kerstin Maehder, Sarah Porzelt, Moritz Rosenkranz, Ingo Schäfer, Martin Scherer, Angelika Weigel, Silke Werner, Thomas Zimmermann

“…Within the superordinate research project Hamburg Network for Health Services Research, the results will be communicated to relevant stakeholders in mental healthcare.Trial registration number NCT03226743.…”
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Quasiexperimental intervention study protocol to optimise the use of new antibiotics in Spain: the NEW_SAFE project by Jesús Rodríguez-Baño, Zaira R Palacios-Baena, Clara M Rosso-Fernández, Pilar Retamar, Lucia Valiente de Santis, Natalia Maldonado, Irene Borreguero, Carmen Herrero-Rodríguez, Salvador López-Cárdenas, Franciso J Martínez-Marcos, Andrés Martín-Aspas, Patricia Jiménez-Aguilar, Juan J Castón, Guillermo Ojeda-Burgos, M Pilar Aznarte-Padial, Julia Praena-Segovia, Juan E Corzo-Delgado, M Ángeles Esteban-Moreno

“…Second, a quasiexperimental intervention study will be developed with an interrupted time-series analysis (2020–2021). …”
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Early Start Denver Model effectiveness in young autistic children: a large multicentric randomised controlled trial in two European countries by Marie-Maude Geoffray, Sandrine Sonié, Mario Speranza, Bruno Falissard, Sandrine Touzet, Angelique Denis, Lucie Jurek, Marie-Joelle Oreve, Carmen Schroder, Amélie Zelmar, Sabine Manificat, Stephane Bahrami, Flavia Mengarelli, Véronique Delvenne, Sophie Carlier, Mikail Nourredine, Jay Agathe, Gallifet Natacha, Nicolas Petit, Laetitia Bouveret, Sara Linda Dochez, Pauline Auphan, Olivia Febvey-Combes

“…Further research is required to evaluate the long-term effectiveness of ESDM and identify subgroups that may benefit more, thereby guiding optimal implementation strategies.Trial registration number NCT02608333.…”
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Intestinal Microbiota Transplant Prior to Allogeneic Stem Cell Transplant (MAST) trial: study protocol for a multicentre, double-blinded, placebo-controlled, phase IIa trial by Julian R Marchesi, Emma Nicholson, Benjamin H Mullish, Renuka Palanicawandar, Graham Wheeler, Francesca Kinsella, Andrew J Innes, Lauren A Roberts, Shian Anim-Burton, Lee Webber, Nicholas A Johnson, Rohma Ghani, Pakhshan Farshi, Anjum B Khan, Panagiotis Kottaridis, Pramila Krishnamurthy, Frances Davies, Jiří Pavlů

“…Dissemination of results will be in concert with patient and public involvement group input and is expected to be primarily via abstract presentation at conferences and manuscripts in peer-reviewed journals.Trial registration numbers NCT6355583; EudraCT: 2022-003617-10.…”
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Community-based interventions targeting multiple forms of malnutrition among adolescents in low-income and middle-income countries: protocol for a scoping review by David Guwatudde, Till Bärnighausen, Ina Danquah, Elisabetta Ferrero, Yemane Berhane, Ali Sie, Clarisse Dah, Jabulani Ncayiyana, Mosa Moshabela, Shannon McMahon, Jacob Burns, Wafaie W. Fawzi, Michael Laxy, Japhet Killewo, Deda Ogum Alangea, Bruno Sunguya, Sara Pedron, Amani Tinkasimile, Uttara Partap, Adi Lukas Kurniawan, Marijana Ranisavljev, Sachin Shinde, Sergej Ostojic, Ntombizodumo Mkwanazi, Christine Neumann, Shuyan Liu, Mary Mwanyika Sando, Ayoade Oduola, Adom Manu, Jan A.C. Hontelez, Magda Rosenmöller, Irene Brandt, Matthias Kern, Joy Mauti, Hanna Y. Berhane, Mashavu Yussuf, Innocent Yusufu, Laetitia Paumard, Millogo Ourohiré, Erick Agure, Tiwatayo Lasebikan, Marina Taonda, Sylvain Somé, Katian Napon, Moussa Ouédraogo

“…Background Adolescent malnutrition is a significant public health challenge in low-income and middle-income countries (LMICs), with long-term consequences for health and development. Community-based interventions have the potential to address multiple forms of malnutrition and improve the health outcomes of adolescents. …”
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Screening and intervention for intimate partner violence at trauma centers and emergency departments: an evidence-based systematic review from the Eastern Association for the Surge... by Hee Soo Jung, Rishi Rattan, Anna Goldenberg, Erin Chang, Stephanie Bonne, D'Andrea Joseph, Amanda L Teichman, Patrick B Murphy, Courtney Edwards, Christina Colosimo, Anna Liveris, Emily Lawson, Kathleen Fox, Jennifer J Freeman, Krista L Haines, Linda Dultz, Farheen A Qurashi, Nathan Polite, Rachel L Choron, Sandra Arabian, Andrew T Schramm, Hassan Naser A Mashbari, Randi N Smith

“…The Grading of Recommendations, Assessment, Development and Evaluations methodology was used to determine the quality of evidence. …”
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Low & Anaplastic Grade Glioma Umbrella Study of MOlecular Guided TherapieS (LUMOS-2): study protocol for a phase 2, prospective, multicentre, open-label, multiarm, biomarker-direct... by Marshall Pitz, Eng-Siew Koh, Elizabeth H Barnes, Lucille Sebastian, Mandy L Ballinger, David M Thomas, Christopher O'Callaghan, John Simes, Hui K Gan, Sonia Yip, Hao-Wen Sim, Desma Spyridopoulos, Richard De Abreu Lourenco, Cynthia Hawkins, Kristen McParland, Benjamin Kong, Subotheni Thavaneswaran, Patrick J Wheeler

“…A report describing the results of the study will be submitted to international meetings and peer-reviewed journals.Trial registration number ACTRN12623000096651.…”
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TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis by Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K. Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S. Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro

“…The 12-week nutritional intervention includes a personalised dietary plan following the MedDiet + pattern, along with educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. …”
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