A Randomized, Double-Blind, Placebo-Controlled Phase II Trial Investigating the Safety and Immunogenicity of Modified Vaccinia Ankara Smallpox Vaccine (MVA-BN®) in 56-80-Year-Old S... by Richard N Greenberg, Christine M Hay, Jack T Stapleton, Thomas C Marbury, Eva Wagner, Eva Kreitmeir, Siegfried Röesch, Alfred von Krempelhuber, Philip Young, Richard Nichols, Thomas P Meyer, Darja Schmidt, Josef Weigl, Garth Virgin, Nathaly Arndtz-Wiedemann, Paul Chaplin

“…<h4>Background</h4>Modified Vaccinia Ankara MVA-BN® is a live, highly attenuated, viral vaccine under advanced development as a non-replicating smallpox vaccine. In this Phase II trial, the safety and immunogenicity of Modified Vaccinia Ankara MVA-BN® (MVA) was assessed in a 56-80 years old population.…”
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Immune-mediated thrombotic thrombocytopenic purpura with systemic lupus erythematosus: clinical features and outcome by David Ribes, Nihal Martis, Jehane Fadlallah, Ygal Benhamou, Veronique Le Guern, Virginie Rieu, Gabriel Choukroun, Raïda Bouzid, Agnès Veyradier, Paul Coppo, Bérangère S Joly, Júlia Weisinger, François Provôt, Pascale Poullin, Yahsou Delmas, Sylvain Chantepie, Manon Marie, Ranta Dana

“…Among patients with ANAs without other clinical features of SLE, 33 (8%) were diagnosed with SLE 27 months (IQR: 7–65 months) following iTTP diagnosis; 32 additional patients (7%) developed another systemic autoimmune disease. No patient from the idiopathic iTTP group developed clinical SLE during follow-up.Conclusion Patients with iTTP are prone to develop autoimmune features, and patients with SLE-iTTP have distinct clinical features and outcome. …”
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Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study by Øystein Karlstad, Alexander Egeberg, Kari Furu, Ulrike Haug, Wiebke Schäfer, Johan Reutfors, Mette Reilev, Jesper Hallas, Ron Herings, Valeria Belleudi, Gianluca Trifirò, Rosa Gini, Ursula Kirchmayer, Henrik Støvring, Peter Bjødstrup Jensen, Lise Skov Ranch, Karin Gembert, David Hagg, Sarina Schwartz, Elisabeth Smits, Emily Holthius, Alessandro Cesare Rosa

“…Results will be published in peer-reviewed journals.Trial registration number EUPAS30280.…”
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Finerenone cardiovascular and kidney outcomes by age and sex: FIDELITY post hoc analysis of two phase 3, multicentre, double-blind trials by George L Bakris, Peter Rossing, Stefan D Anker, Gerasimos Filippatos, Bertram Pitt, Shweta Bansal, Maria E F Canziani, Rita Birne, Luis M Ruilope, Alfredo E Farjat, Peter Kolkhof, Andrea Lage, Meike Brinker

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Digitalisasi Model Sistem Akuntansi Terintegrasi Bagi Usaha Bersama Simpan Pinjam di Kota Kupang by Yustina Alfira Nay, Selfiana Goetha, Maria Goreti Malut

“…The aim of this research is to digitize an integrated accounting system model that suits UBSP's needs. The system development method used is the System Development Life Cycle (SDLC) model, consisting of system analysis, conceptual design, system selection, detailed design, testing and programming, and implementation. …”
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Digital Therapeutics in China: Comprehensive Review by Nan Jiang, Xiru Yu, Yuxi Yang, Guanqiao Li, Chanchan He, Man Ping Wang, Yih Chung Tham, Tien Yin Wong, Keqin Rao

“…Trial RegistrationPROSPERO CRD42024615584; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024615584…”
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Traditional herbal medicine legislative and regulatory framework: a cross-sectional quantitative study and archival review perspectives by Sileshi Dubale, Rashed Edris Usure, Yesuneh Tefera Mekasha, Gemmechu Hasen, Firdos Hafiz, Dereje Kebebe, Sultan Suleman

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Potential therapeutic benefits of curcumin in depression or anxiety induced by chronic diseases: a systematic review of mechanistic and clinical evidence by Jiyuan Yuan, Jiyuan Yuan, Jiyuan Yuan, Chao Pi, Hongping Shen, Bi Zhou, Yumeng Wei, Nathupakorn Dechsupa, Ling Zhao, Ling Zhao

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FitSkills: protocol for a stepped wedge cluster randomised trial of a community-based exercise programme to increase participation among young people with disability by Nicholas F Taylor, Nora Shields, Andrea M Bruder, Claire Willis, Christine Imms, Luke A Prendergast, Jennifer J Watts, Ben van Dorsselaer, Georgia McKenzie, Luke Prendergast, Jason Calleja, David Strickland, Shawn Stephenson, Michael P Walker, Justine Robbins, Melissa Barkley, Cameron Geddes, Shane Lee, Richard Amon, Juliet Ryan, Ayden Shaw, Simone Power, Rebecca McCabe, Shannon Cheal, Vicki Cavelieros, Debby Fraumano, Sue Blandford, Lucy Bain, Sonia Bonadio, Sue O’Riley, Bernadette Roberts, John Summers, Troy Walker, Fiona Kriaris, Sam Taylor, Tom Scanlan, Abigail Elliot, Lachlan O’Brien, Jenni Smith, Stacey Cleary, Brooke Adair, Melissa Moore, Jess Kuek

“…FitSkills was developed to support young people with disability to exercise. …”
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Protocol of the Tailored Evidence-based Enhancements in Mental Health-Gamified and Individualized Follow-Up Treatment for Suicide (TEEM-GIFTS): a Multiphase Optimization Strategy (... by Bo Peng, Jinghua Li, Fengsu Hou, Huiming Liu, Guanjie Chen, Yuanhan Bai, Yingli Zhang, Donghui Wu, Tiantian Fu, LuYao Hu

“…Following the MOST framework, we will develop the gamified mHealth app (Tailored Evidence-based Enhancements in Mental Health (TEEM)) with four intervention components in the selection phase. …”
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Evaluation of timed dexamethasone eye drops to prevent proliferative retinopathy of prematurity: a study protocol for a randomized intervention, multi-centre, double-blinded trial... by Ann Hellström, Mariya Petrishka-Lozenska, Aldina Pivodic, Anders K. Nilsson, Ulrika Sjöbom, Ingrid Hansen Pupp, David Ley, Lotta Gränse, Hanna Maria Öhnell, Gunnar Jakobsson, Karin Sävman, Lois E. H. Smith, Pia Lundgren, the DROPROP collaboration group

“…Abstract Background As the survival rate of preterm infants continues to rise worldwide, more infants are at risk of developing sight-threatening retinopathy of prematurity (ROP). …”
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Longitudinal graphics of patient-reported physical function in patients treated for hematologic malignancies by Gita Thanarajasingam, Vishal Bhatnagar, Brie N. Noble, Ting-Yu Chen, Mallorie H. Fiero, Ron Hoffman, Molly Jeffery, Gina L. Mazza, John Mascarenhas, Ruben Mesa, Meena Murugappan, Joseph Ross, Surbhi Sidana, Rahma Warsame, Paul G. Kluetz, Amylou C. Dueck

“…The objectives of this study were to develop analytic methods and visualizations of patient-reported PF in patients with cancer. …”
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Safety, immunogenicity, efficacy, and effectiveness of Lassa fever vaccines in pregnant persons, children, and adolescents: a protocol for a living systematic review and meta-analy... by Jamile Ballivian, Mabel Berrueta, Agustín Ciapponi, Juan Manuel Sambade, Katharina Stegelmann, Agustina Mazzoni, Ariel Bardach, Martin Brizuela, Daniel Comandé, Noelia Castellana, Edward P. K. Parker, Andy Stergachis, Xu Xiong, Flor M. Munoz, Pierre M. Buekens

“…While several vaccine candidates have been developed, none have received regulatory approval. …”
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Trends in cancer incidence and mortality in the process of metropolitanization of Shanghai, 1973–2017 by Jiejie Qin, Jiejie Qin, Jiejie Qin, Jiejie Qin, Mengyin Wu, Shulin Zhao, Shulin Zhao, Shulin Zhao, Kai Gu, Renzhi Cai, Ziwei Tang, Defeng Zhu, Jingyan Tian, Jingyan Tian, Wei Yao, Baiyong Shen, Baiyong Shen, Baiyong Shen, Yan Shi

“…A more comprehensive understanding of cancer incidence and mortality rates and socioenvironmental factors is explored to develop effective cancer control policies in Shanghai.MethodsCancer registration data are currently collected in Shanghai from 1973 to 2017, and socioenvironmental factors were obtained from the Shanghai statistical yearbook. …”
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Effects of household concrete floors on maternal and child health: the CRADLE trial – a randomised controlled trial protocol by Mahbubur Rahman, Rashidul Haque, Fahmida Tofail, Ying Lu, Mustafizur Rahman, Jason R Andrews, Jade Benjamin-Chung, Farjana Jahan, Suhi Hanif, Afsana Yeamin, Abul Kashem Shoab, Sarah Billington, Nils Pilotte, Ireen S Shanta, Mohammed Jubair, Mamun Kabir, Md Sakib Hossain, Zahid H Mahmud, Ayse Ercumen

“…We will report findings on ClinicalTrials.gov, in peer-reviewed publications and in stakeholder workshops in Bangladesh.Trial registration number NCT05372068.…”
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Time-lapse imaging systems for embryo incubation and assessment to improve reproductive outcomes in women undergoing in vitro fertilisation: study protocol for an individual partic... by Hannah Park, Cornelis B Lambalk, Madelon van Wely, Shakila Thangaratinam, Laura Del Campo, Peter Kovacs, Javier Zamora, Khalid Saeed Khan, Carlijn G Vergouw, Patricia Fauque, Priya Bhide, David Yiu Leung Chan, Aisling Ahlström, Dorit Kieslinger, Kersti Lundin, Semra Kahraman

“…We plan to disseminate the findings of the research to all stakeholders, including the National Institute for Health and Care Excellence and other international guideline development groups, through publication in peer-reviewed journals, presentation at conferences, newsletters, meetings and websites of the funders, fertility charities and patient support groups.PROSPERO registration number CRD42024564332.…”
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Diagnostic Accuracy of Computational Fluid Dynamics‐Based Fractional Flow Reserve Derived From Coronary Angiography: The ACCURATE Study by Jun Jiang, Yumeng Hu, Changling Li, Liang Dong, Jian Xu, Lijiang Tang, Wenbing Jiang, Changqing Du, Xuejun Jiang, Yongnan Lyu, Xiaochang Leng, Chengguang Li, Bon‐Kwon Koo, Jianping Xiang, Junbo Ge, Jian’an Wang

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Diagnosis of Sarcopenia Using Convolutional Neural Network Models Based on Muscle Ultrasound Images: Prospective Multicenter Study by Zi-Tong Chen, Xiao-Long Li, Feng-Shan Jin, Yi-Lei Shi, Lei Zhang, Hao-Hao Yin, Yu-Li Zhu, Xin-Yi Tang, Xi-Yuan Lin, Bei-Lei Lu, Qun Wang, Li-Ping Sun, Xiao-Xiang Zhu, Li Qiu, Hui-Xiong Xu, Le-Hang Guo

“…Three monomodal models based on each data type were developed in the training cohort. The data type with the best diagnostic performance was selected to develop the bimodal and multimodal model by adding another one or two data types. …”
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Detour-Straddle 3D-like path planning of unmanned mining truck in open pit mines based on optimized ant colony algorithm by Mingyu GAO, Jiusheng BAO, Yan YIN, Deping HU, Kekun ZHANG, Chenzhong ZHU, Maosen WANG, Kai WANG

“…With the continuous advancement of intelligent mine construction in China, the unmanned transportation link has developed into an important part of the intelligent mine system. …”
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Breeding of a new grape rootstock variety Yunzhen 5 by LUO Renbin, ZHANG Wu, LI Yongping, WANG Na, BAI Mingdi, XIA Qionglan, WANG Pei, ZHANG Yonghui, HOU Kaixiong, TANG Qingyan

“…The internode is long and the cane hardness is good. Tendrils are well developed. The survival rate of cutting is more than 90%, and the grafting compatibility is well with Shine Muscat and Kyoho. …”
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