Mannitol for cerebral oedema after acute intracerebral haemorrhage (MACE-ICH): protocol for a prospective, randomised, open-label, blinded-endpoint phase IIb trial by Jesse Dawson, David J Werring, Nikola Sprigg, Christine Roffe, Zhe Kang Law, Kailash Krishnan, Philip Bath, Rob A Dineen, Diane Havard, Timothy J England, Mary Joan Macleod, Stefan Pszczolkowski, Jennifer Craig, Amanda Buck, David W Hewson, Lisa Woodhouse, Fergus Doubal, Emma Grace, Keenan Wells

“…Reporting will be in line with Consolidated Standards of Reporting Trials recommendations.Trial registration numbers ISRCTN15383301; EUDRACT 2022-000283-22.…”
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Long-term cost-effectiveness of health behaviour intervention to manage type 2 diabetes in Nepal by Padam Kanta Dahal, Corneel Vandelanotte, Lal Rawal, Rashidul Alam Mahumud, Grish Paudel, Melanie Lloyd, Yeji Baek, Biraj Karmacharya, Tomohiko Sugishita, Zanfina Ademi

“…Methods A Markov model in combination with a decision tree was developed to compare the costs and outcomes of the health behaviour intervention against usual care among 481 (238-intervention and 243-control) participants from healthcare system and societal perspectives. …”
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Fall sensors, home emergency system, and social service for ≥ 75-year-olds living at home - a matched control intervention study by Jan C. Zoellick, Sonia Lech, Julie L. O’Sullivan, Eva Jansen, Juliana Supplieth, Ronny Kuhnert, Ulrike Grittner, Johanna Schuster

“…Trial registration DRKS00023171 ( https://drks.de/search/en/trial/DRKS00023171 ).…”
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GENDER ASPECTS FOR THE MANAGEMENT OF PERSISTENT PULMONARY HYPERTENSION IN PREMATURE INFANTS by Т. Клименко, М. Кононович

“…The created algorithm of a differentiated approach to the management of persistent pulmonary hypertension includes the calculated diagnostic coefficient of the male sex (I=1.04) as a predictor of the development of severe pulmonary hypertension by the 3rd-5th day of life. …”
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Epidemiological Analysis of Outcomes of Small Obstetric Operations by I. V. Taranenko, A. V. Lubimova

“…Obstetric operations and soft tissue injuries of the birth canal are also a risk factor for the development of purulent-septic infections in the postpartum period. …”
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Head-to-head comparison of tau PET tracers [18F]PI-2620 and [18F]RO948 in non-demented individuals with brain amyloid deposition: the TAU-PET FACEHBI cohort by Matteo Tonietto, Oscar Sotolongo-Grau, Núria Roé-Vellvé, Santiago Bullich, Juan Pablo Tartari, Ángela Sanabria, Ainhoa García-Sánchez, Edilio Borroni, Christopher Galli, Esther Pérez-Martínez, Joan Castell-Conesa, Isabel Roca, Lluís Tárraga, Agustín Ruiz, Andrew W. Stephens, Mercè Boada, Gregory Klein, Marta Marquié, on behalf of the FACEHBI study group, on behalf of the AMYPAD consortium

“…Trial registration AEMPS EudraCT 2021–000473-83. Registered 30 December 2021.…”
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Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. by Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks

“…We sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning.…”
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Perceptions of COVID-19 among communities of Conakry (Guinea): a qualitative study exploring the context of the ANRS COV33 Coverage-Africa therapeutic trial by Joanna Orne-Gliemann, Alexandre Delamou, Mélanie Plazy, Denis Malvy, Marie-Hélène Doucet, Christine Timbo Songbono, Caroline Martin, Camille Fritzell, Mamadou Saliou Sow, Fodé Amara Traoré, Marie Jaspard, Armel Poda, Olivier Marcy

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A Multicenter Randomized Controlled Study on Pharmacokinetic‐Guided Vancomycin Use in Children With Severe Infections by Fuxiang He, Ya Yang, Bo Zhou, Chengcheng Li, Yu Feng, Xuexin Wang, Haifeng Liu, Yuhang Hu, Hongmin Fu, Yingbo Zou, Guoying Zhang, Jianli Chen, Yueqiang Fu, Shufang Xiao, Lan Hu, Chengjun Liu

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Epidemiology of acute diabetes complications (coma) according to the Federal Diabetes register of the Russian Federation (2013–2016) by Alexander Y. Mayorov, Olga K. Vikulova, Anna V. Zheleznyakova, Mikhail А. Isakov, Olga G. Melnikova, Irina V. Kononenko, Marina V. Shestakova, Ivan I. Dedov

“…Significant interregional differences in the frequency of coma registration require additional analysis.…”
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Findings from a cluster randomised feasibility study of a school-based physical activity role model intervention (CHARMING) for 9–10-year-old girls by Kelly Morgan, Jordan Van Godwin, Rebecca Cannings‑John, Rhiannon Tudor Edwards, Rachel Granger, Britt Hallingberg, Graham Moore, Bethan Pell, Esther van Sluijs, Holly Whiteley, Jemma Hawkins

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Plant and Animal Protein Intake and Transitions From Multimorbidity to Frailty and Mortality in Older Adults by Aitana Vázquez‐Fernández, Francisco F. Caballero, Humberto Yévenes‐Briones, Ellen A. Struijk, Ana Baylin, Teresa T. Fung, Esther Lopez‐Garcia

“…It is unknown which amount and source of protein influences the development of frailty and mortality in patients with multimorbidity. …”
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Multi-environmental traits selection and farmer's participatory assessment of mean performance and stability of orange-fleshed sweet potato genotypes in Benin by Idrissou Ahoudou, Nicodeme V. Fassinou Hotegni, Dêêdi E.O. Sogbohossou, Tania L.I. Akponikpè, Charlotte O.A. Adjé, Françoise Assogba Komlan, Ismail Moumouni-Moussa, Enoch G. Achigan-Dako

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Endovascular thrombectomy in acute stroke with a large ischemic core: A systematic review and meta-analysis of randomized controlled trials. by Chun-Hsien Lin, Meng Lee, Bruce Ovbiagele, David S Liebeskind, Borja Sanz-Cuesta, Jeffrey L Saver

“…Grading of Recommendations Assessment, Development and Evaluations (GRADE) was used to evaluate summaries of evidence for the outcomes. …”
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Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer by Makoto Ueno, Masafumi Ikeda, Do-Youn Oh, Masatoshi Kudo, Christoph Helwig, Changhoon Yoo, Hye Jin Choi, Shunsuke Kondo, Li-Tzong Chen, Motonobu Osada, Isabelle Dussault

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Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials. by Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari

“…GRADE (Grading of Recommendations Assessment, Development, and Evaluation) was used to assess the quality of evidence.…”
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The Effectiveness of Computerized Cognitive Training in Patients With Poststroke Cognitive Impairment: Systematic Review and Meta-Analysis by Min Gao, Lu Huang, Jiang Yi, Tianqi Zhang, Guangyao Zhu, Qi Zhang, Jiaxiao Tian, Rongxuan Zhao, Xiaoqin Duan, Zhongliang Liu

“…In addition, a structured maintenance plan is essential to sustain long-term benefits and prevent regression. Trial RegistrationPROSPERO CRD42024573594; https://www.crd.york.ac.uk/PROSPERO/view/CRD42024573594…”
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Association Between Endothelial Alterations, Cardiac Function, and Outcomes From Health to Heart Failure: Insight From the STANISLAS, MEDIA‐DHF, and BIOSTAT‐CHF Cohorts by Jeremy Lagrange, Mohammad Jahangiri, Guillaume Baudry, Nathalie Mercier, Luca Monzo, Zohra Lamiral, Kévin Duarte, Jozine M ter Maaten, Faiez Zannad, Adriaan A. Voors, Nicolas Girerd

“…Endothelial glycocalyx degradation's role in the development and prognosis of HFpEF remains largely unexplored. …”
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Accuracy of Large Language Models When Answering Clinical Research Questions: Systematic Review and Network Meta-Analysis by Ling Wang, Jinglin Li, Boyang Zhuang, Shasha Huang, Meilin Fang, Cunze Wang, Wen Li, Mohan Zhang, Shurong Gong

“…ObjectiveThis study uses a network meta-analysis (NMA) to assess the accuracy of LLMs when answering clinical research questions to provide high-level evidence-based evidence for its future development and application in the medical field. …”
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Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis by Peng Su, Maofu Li, Jian Xiao, Longbin Bai

“…Limitations include potential heterogeneity in study populations and treatment protocols, and limited long-term safety data. Study registration PROSPEROPROSPERO (CRD42023396110).…”
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