Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…The study results will be disseminated in scientific conferences and peer-reviewed indexed journals.Trial registration number ClinicalTrials.gov identifier: NCT04923841…”
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Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study by Coralie English, Katinka Nordheim Alme, Anne-Brita Knapskog, Halvor Næss, Mala Naik, Mona Beyer, Hanne Ellekjaer, Hege Ihle Hansen, Camilla Sollesnes Kummeneje, Ragnhild Munthe-Kaas, Ingvild Saltvedt, Yngve Seljeseth, Xiangchung Tan, Pernille Thingstad, Torunn Askim

“…A MATLAB script was developed to extract activity data from 08:00 to 10:00 for 4 days and to categorise the data into four bout-length categories. …”
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First-in-human phase I study of immunomodulatory E7046, an antagonist of PGE2-receptor E-type 4 (EP4), in patients with advanced cancers by Aurélien Marabelle, Aung Naing, Funda Meric-Bernstam, Xingfeng Bao, Andrea Varga, David S Hong, Aparna Parikh, Geoffrey I Shapiro, Özlem Ataman, Larisa Reyderman, Terri A Binder, Min Ren, Mingjie Liu, Satish Dayal, Amy Y Siu, Pallavi Sachdev, Lucy Xu, Vijay Bhagawati-Prasad, Ilian Tchakov, Chean Eng Ooi

“…The 250 and 500 mg doses are proposed for further development in the combination setting.Trial registration number NCT02540291.…”
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Effects of a multicomponent exercise regimen on subchondral bone and cartilage in postmenopausal women with knee osteoarthritis: protocol for a randomized controlled trial by Ville-Markus Konola, Jari Parkkari, Juhani Multanen, Riku Nikander, Timo Rantalainen, Johanna Vesanto, Satu Pekkala, Merja Kalaja, Johanna K. Ihalainen, Benjamin Waller, Matti Munukka, Harri Sievänen, Mika Nevalainen, Hannu Kautiainen, Victor Casula, Juha Paloneva, Tommi Vasankari, Arttu Peuna, Simo Saarakkala, Miika T. Nieminen, Ari Heinonen

“…Subchondral bone and articular cartilage are functionally paired, and information on the responses of these tissues to exercise may help in the development of efficacious and feasible exercise regimens that can potentially improve bone and cartilage properties. …”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…It also has substantial promotional instructive modeling value. Clinical trial registration Not applicable.…”
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Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis-2 (AuToDeCRA-2) study: protocol for a single-centre, experimental medicine study investigating the route of delivery... by Ema-Louise Long, James Stanway, Michael White, Nicola Goudie, Julia Phillipson, Miranda Morton, Asma Abdul Malek, Philip Brown, Geoff Hide, Ralph Jackson, Colin Nice, John Tuckett, Julie Diboll, Amy Anderson, Arthur Pratt, Catharien M. U. Hilkens, John Isaacs

“…Abstract Background Dendritic cells are professional antigen presenting cells with the ability, in their immature state, to induce tolerance in T cells. A protocol to develop phenotypically stable tolerogenic dendritic cells (TolDC) was developed in Newcastle and cells administered to participants in the phase I AuToDeCRA study, demonstrating that TolDC were safe and well tolerated. …”
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Mapping the Evidence on Compassion Skills in Applied Behavior Analysis: Protocol for Scoping Review by Daniele Nunes Longhi Aleixo, Daiton Junior Martins de Souza, Stela Regina Pedroso Vilela Torres de Carvalho, Marcia Regina Furlani, Cíntia Canato Martins, Emerson Roberto dos Santos, João Daniel de Souza Menezes, Matheus Querino da Silva, Sônia Maria Maciel Lopes, Marcos Sanches Rodrigues, Natalia Almeida de Arnaldo Silva Rodriguez Castro, Helena Landim Gonçalves Cristóvão, Josimerci Ittavo Lamana Faria, Vânia Maria Sabadoto Brienze, Alba Regina de Abreu Lima, Patrícia da Silva Fucuta, Denise Cristina Móz Vaz Oliani, Neide Aparecida Micelli Domingos, Maria Cristina Oliveira Santos Miyazaki, Gerardo Maria de Araújo Filho, Júlio César André

“…The findings may inform the development of compassion training programs and influence care policies in ABA. …”
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Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation by Edith Pituskin, Stephen Foulkes, Rachel J. Skow, Thomas McMurtry, Calvin Kruger, Janet E. Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu, Nancy Zhu, Peng Wang, Daniel Sawler, Minakshi Taparia, Marlene Hamilton, Tiffany Comfort-Riddle, Tara Meyer, Gabor T. Gyenes, Ian Paterson, Carla M. Prado, Mark J. Haykowsky, Justin G. Greiner, Margaret L. McNeely, Puneeta Tandon, Richard B. Thompson

“…Ultimately, we hope to transform supportive care in hematopoietic stem cell transplantation. Trial Registration Clinicaltrials.gov ID: NCT05579678.…”
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Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Meta-analysis was performed, and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the quality of the body of evidence. …”
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Efficacy and Safety of Adding Ribavirin to Sofosbuvir-Based Direct-Acting Antivirals (DAAs) in Re-Treating Non-Genotype 1 Hepatitis C—A Systematic Review and Meta-Analysis by Shahd Hamran, Amani A. Al-Rajhi, Kawthar Jasim, Majed A. Al-Theyab, Mohamed Elahtam, Mooza K. Al-Hail, Wadha Al-Fahaidi, Yaman A. Khamis, Yara Dweidri, Abdel-Naser Elzouki, Tawanda Chivese

“…More evidence is needed on the effect of additional ribavirin in achieving SVR in individuals with decompensated cirrhosis. Registration: The protocol is registered on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42022368868).…”
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Incidence of cancer-associated thromboembolism in Japanese gastric and colorectal cancer patients receiving chemotherapy: a single-institutional retrospective cohort analysis (Sapp... by Naoya Sakamoto, Ayane Oba Aonuma, Michio Nakamura, Kentaro Sakamaki, Taichi Murai, Chika Matsuda, Kazufumi Itaya, Takayuki Sone, Masataka Yagisawa, Yuta Koike, Ayana Endo, Yoko Tsukuda, Yuji Ono, Atsushi Nagasaka, Shuji Nishikawa, Takeharu Yamanaka

“…We defined the following patients as ‘active cancer’; patients with unresectable advanced GCC, cancer recurrence during or after completing adjuvant chemotherapy and/or presence of other malignant tumours.Results Of the 500 patients, 70 patients (14.0%) developed TE during the follow-up period. TEi was 9.2% and 17.3% in GCC patients, 18.1% and 3.5% in active and non-active cancer patients, and 24.0% and 12.9% in multiple and single primary, respectively. …”
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Clinical study of adebrelimab in combination with apatinib and irinotecan for PD-1 inhibitor-ineffective advanced-stage gastric cancer: study protocol for a single-arm, single-cent... by Tao Liu, Long Bai, Jiayi Gu, Yujing Guan, Yeqian Zhang, Bo Ni, Hao-yu Zhang, Muerzhate Aimaiti, Shuchang Wang, Ben Yue, Xiang Xia, Zizhen Zhang

“…The results will be disseminated through peer-reviewed manuscripts, reports and presentations.Trial registration number ChiCTR2300077329.…”
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Investigating neuropathological correlates of hyperactive and psychotic symptoms in dementia: a systematic review by Giulia Negro, Giulia Negro, Michele Rossi, Camillo Imbimbo, Alberto Gatti, Andrea Magi, Andrea Magi, Ildebrando Marco Appollonio, Ildebrando Marco Appollonio, Alfredo Costa, Alfredo Costa, Tino Emanuele Poloni, Tino Emanuele Poloni

“…No behavioral symptom is pathognomonic of a specific proteinopathy; rather, the topography and severity of lesions plays a more decisive role than their single molecular composition.Systematic review registrationINPLASY2024100082.…”
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Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis by Andrea M. McGrattan, Eduwin Pakpahan, Mario Siervo, Devi Mohan, Daniel D. Reidpath, Matthew Prina, Pascale Allotey, Yueping Zhu, Chen Shulin, Jennifer Yates, Stella‐Maria Paddick, Louise Robinson, Blossom C. M. Stephan, the DePEC team

“…There was no restriction on the definition of MCI used as long as it was clearly defined. PROSPERO registration: CRD42019130958. Results Ten thousand six hundred forty‐seven articles were screened; n = 11 retained. …”
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Efficacy of psychosocial interventions on social functioning in individuals with childhood maltreatment experiences: a protocol for a systematic review and network meta-analysis by Natalia E. Fares-Otero, Silvia Amoretti, Brisa Solé, Sarah L. Halligan, Eduard Vieta, Stefan Leucht, Soraya Seedat, Mathias Harrer

“…Our results may provide practical guidance concerning the most effective psychosocial interventions to reduce the societal burden associated with CM.Protocol registration: PROSPERO CRD42022347034.…”
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Safety, Tolerability and Pharmacokinetics of Sodium Tungstate (OXO-001) in Healthy Female Volunteers of Childbearing Age: A Randomized, Double-Blind, Dose-Finding, and Placebo-Cont... by Agnes Arbat, Ignasi Canals, Jimena Coimbra, Pol Molina-Perelló, Marta Llorens, Rosa Torres, Josep Perello, Marta Moral-Blanch, Rosa María Antonijoan, Joaquim Calaf

“…These data are sufficient to support further clinical trials (registration number: 2016-001276-30).…”
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The impact of a patient decision aid for patients with advanced laryngeal carcinoma – a multicenter study by Anne N. Heirman, Japke F. Petersen, Abrahim Al-Mamgani, Simone E. J. Eerenstein, Bertram J. de Kleijn, Frank Hoebers, Bernard M. Tijink, Lisette van der Molen, Gyorgy B. Halmos, Richard Dirven, Martijn M. Stuiver, Michiel W. M. van den Brekel

“…To address this, we developed and tested a patient decision aid (PDA), aiming to reduce decisional conflict (DC), and enhance knowledge and perceived shared decision-making (SDM). …”
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Long COVID in people with mental health disorders: a scoping review by Catharina Münte, Manuela Glattacker, Saskia Müller, Andrea E. Zülke, Martin Heinze, Steffi G. Riedel-Heller, Dawid Pieper, Christian Jacke, Stefanie Deckert, Anne Neumann

“…Abstract Background Long COVID, Post COVID Syndrome or PASC (post-acute sequelae of COVID-19), according to the World Health Organization (WHO), is defined as the continuation or development of new symptoms 3 months after the initial SARS-CoV-2 infection, with these symptoms lasting for at least 2 months with no other explanation. …”
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Comparative Analysis of 68Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography and Multiparametric Magnetic Resonance Imaging for Gross Tumor Volu... by Hamed Bagheri, PhD, Seied Rabi Mahdavi, PhD, Parham Geramifar, PhD, Ali Neshasteh-Riz, PhD, Masoumeh Sajadi-Rad, MD, Habibollah Dadgar, PhD, Hossein Arabi, PhD, Habib Zaidi, PhD

“…The prostate-specific membrane antigen (PSMA), which is frequently overexpressed in PCa, has led to the development of 68Ga-labeled PSMA inhibitors for positron emission tomography (PET)/computed tomography (CT), showing promising results in PCa detection. …”
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An electronic health record-based strategy to increase PrEP decision-making among cisgender women in primary care: results of a randomized pilot study by Allison Pack, Rachel O’Conor, Rosanne Vasiloff, David Liebovitz, Mary Clare Masters, Kenya Alcantara, Reneaki Smith, Guisselle Wismer, Rachel Tatz, Fangyu Yeh, Laura M. Curtis, Scott Hur, Stacy C. Bailey

“…To address this gap, we sought to develop and pilot test an electronic health record-based strategy among cisgender women in primary care. …”
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