CANBERRA: A Phase II Randomized Clinical Trial to Test the Therapeutic Potential of Oral Vicasinabin in Diabetic Retinopathy by Beatriz G. Armendariz, PhD, Ulrich F.O. Luhman, PhD, Brian Berger, MD, Jules Hernandez-Sanchez, PhD, Katrijn Bogman, PhD, Nikolaos Mitrousis, PhD, Martina Wollenhaupt, MD, David Kent, MD, Andreas Wenzel, PhD, Sascha Fauser, MD, PhD

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Radiomic Feature Characteristics of Ovine Pulmonary Adenocarcinoma by David Collie, Ziyuan Chang, James Meehan, Steven H. Wright, Chris Cousens, Jo Moore, Helen Todd, Jennifer Savage, Helen Brown, Calum D. Gray, Tom J. MacGillivray, David J. Griffiths, Chad E. Eckert, Nicole Storer, Mark Gray

“…Comparisons between scans within sheep were facilitated through fiducial registration and spatial transformations. Initially, 9/36 RFs differed significantly from non-tumour lung tissue of similar density. …”
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Novel Relaxin Receptor RXFP1 Agonist AZD3427 in the Treatment of Heart Failure: A Phase 1a/b, First‐in‐Human, Randomized, Single‐Blind, Placebo‐Controlled Study by Kathleen Connolly, Richard George, Sami Omar, Elin Matsson, Magnus Åstrand, Magnus Althage, Daniel Pettersen, Esha Mohamed, Kelly Fang, Joao A. C. Lima, Mirjana Kujacic, Helena Ödesjö, Michelle Turton, Petra Johannesson, Anders Gabrielsen, Marcin Ufnal

“…Registration URL: https://www.clinicaltrials.gov; Unique Identifier: NCT04630067.…”
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OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study): a protocol for a prospective diagnostic accuracy study of multimodality testing in patients... by Frank F Smithuis, Anneke J van der Kooi, Joost Raaphorst, Ivo N van Schaik, Marianne de Visser, Paul A Baars, Patrick M M Bossuyt, Eleonora Aronica, Johannes H T M Koelman, Camiel Verhamme, Hannah A W Walter, Renske G Kamperman, Wouter V Potters, Ester M M van Leeuwen

“…The results will be distributed through conference presentations and peer-reviewed publications.Trial registration number Netherlands trial register; NL8764.…”
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Vagus nerve stimulation therapy for treatment-resistant PTSD by Mark B. Powers, Seth A. Hays, David Rosenfield, Amy L. Porter, Holle Gallaway, Greg Chauvette, Jasper A.J. Smits, Anne Marie Warren, Megan Douglas, Richard Naftalis, Jane G. Wigginton, M Foreman, Michael P. Kilgard, Robert L. Rennaker

“…Background: Posttraumatic stress disorder (PTSD) is common and debilitating, and many individuals do not respond to existing therapies. We developed a fundamentally novel neuromodulation-based therapy for treatment-resistant PTSD. …”
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Prolonged dual hypothermic oxygenated machine preservation (DHOPE-PRO) in liver transplantation: study protocol for a stage 2, prospective, dual-arm, safety and feasibility clinica... by Aad P van den Berg, Hans Blokzijl, Marieke T de Boer, Frans van der Heide, Ruben H J de Kleine, Otto B van Leeuwen, Ton Lisman, Vincent E de Meijer, Anne Loes Van den Boom, Joost M Klaase, Peter Meyer, Robert J Porte, Frederike G I van Vilsteren, Frans J C Cuperus, Martijn P D Haring, Isabel M A Brüggenwirth, Veerle A Lantinga, Michel Rayar, Koen M E M Reyntjens, Carlijn I Buis, Suomi MG Fouraschen, Frederik JH Hoogwater, Mark Meerdink, Maarten W Nijkamp, A Michel Rayar, Ilhama F Abbasova, Meine H Fernhout, Ernesto R R Muskiet, Jaap J Vos, Miriam Zeillemaker, Bianca Lascaris, Carol C Pamplona, Adam M Thorne, Silke B Bodewes

“…In addition to graft reconditioning, DHOPE may also be used to prolong preservation time, which could facilitate logistics for allocation and transplantation globally.Methods and analysis This is a prospective, pseudo-randomised, dual-arm, IDEAL-D (Idea, Development, Exploration, Assessment, Long term study-Framework for Devices) stage 2 clinical device trial designed to determine safety and feasibility of prolonged DHOPE (DHOPE-PRO). …”
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Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol by Wenxiang Guo, Leonardo Bencivenga, Bruno Micael Zanforlini, Chiara Curreri, Maria Cristina Ferrara, Benedetta Maisano, Luca Tinelli, Laura Andreea Ceparano, Raffaella Merenda, Chiara Cosma, Lucia Manfron, Nicolò Gentili, Silvia Sturani, Monica Cardi, Alice Campion, Benedetta Berardi, Martina Lombardi, Elisabetta D’Aversa, Francesca Salvatori, Veronica Tisato, Joanne Vanessa Vargas, Grazia Daniela Femminella, Donato Gemmati, Giuseppe Sergi, Giuseppe Bellelli, Paolo Mazzola, Caterina Trevisan, Stefano Volpato, the INFRAGEN working group

“…Discussion INFRAGEN will contribute to exploring the complex pathophysiologic mechanisms of frailty in the context of infections in older adults through a translational approach. Trial registrations NCT06430073 (ClinicalTrials.gov); Registration date: 2024–05-28.…”
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Efficacy, Safety, and Cost-effectiveness of Zinc Oxide Nanoparticles in Whitfield’s Spirit Solution for Treating Superficial Fungal Foot Infections: A Randomized Controlled Trial by Charussri Leeyaphan, Primana Punnakitikashem, Bordeesuda Suiwongsa, Phojana Komesmuneeborirak, Piriyaporn Chongtrakool, Nattanichcha Kulthanachairojana, Pichaya Limphoka, Thrit Hutachoke, Phuwakorn Saengthong-aram, Pantaree Kobkurkul, Supisara Wongdama, Bawonpak Pongkittilar, Lalita Matthapan, Chatisa Panyawong, Waranyoo Prasong, Akkarapong Plengpanich, Natsuda Kunwong, Kamonlatth Rodponthukwaji, Sumanas Bunyaratavej

“…Abstract Introduction A novel antifungal formulation combining zinc oxide nanoparticles and Whitfield’s spirit solution (ZnO-WFs) was developed to enhance the treatment of superficial fungal foot infections. …”
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Coronary artery calcium and cardiovascular risk factors analysis after radiotherapy for breast cancer (the CLARIFIER: a gender-based preventive medicine study) by Daniela Trabattoni, Maria Cristina Leonardi, Maria Elisabetta Mancini, Barbara A. Jereczek-Fossa, Barbara A. Jereczek-Fossa, Federica Cattani, Giulia Santagostino Baldi, Alice Bonomi, Arianna Galotta, Saima Mushtaq, Saima Mushtaq, Andrea Annoni, Davide Alio, Maria Giulia Vincini, Cristiana Iuliana Fodor, Ludovico La Grutta, Piero Montorsi, Piero Montorsi, Gianluca Pontone, Gianluca Pontone

“…The risk of cardiac events was associated with increased age, early menopause, hypertension, high cholesterol levels, and smoking habits at the time of RT.ConclusionThis study helps to identify women at high-risk for cardiovascular events before RT and implement the best possible prevention of late post cancer treatment events. Clinical Trial RegistrationClinicalTrials.gov, Identifier (NCT05775822).…”
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PREdiction and Diagnosis using Imaging and Clinical biomarkers Trial in Traumatic Brain Injury (PREDICT-TBI) study protocol: an observational, prospective, multicentre cohort study... by Siva Senthuran, Lewis Campbell, Jennifer Fleming, Virginia Newcombe, Michael Reade, Silvia Manzanero, James Walsham, Nathan Brown, Xuan Vinh To, Clifford Pollard, Fatima Nasrallah, Judith Bellapart, Esther Jacobson, Jason Meyer, Janine Stuart, Tracey Evans, Shekhar S Chandra, Jason Ross, James McCullough

“…Study findings will be disseminated by peer-review publications and presented at national and international conferences and clinical networks.Trial registration number ACTRN12620001360909.…”
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Acceptability of risk-based breast cancer screening among professionals and healthcare providers from 6 countries contributing to the MyPeBS study by Alexandra Roux, Lucile Hervouet, Francesca Di Stefano, David P. French, Livia Giordano, David Ritchie, Marie-Eve Rougé Bugat, Debbie Keatley, Rachel Cholerton, Lorna McWilliams, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Marta Roman, Cécile Vissac-Sabatier, Daniel Couch, Suzette Delaloge, Sandrine de Montgolfier, On behalf of the MyPeBS Investigators and the MyPeBS Consortium

“…As professional acceptability is key for successful implementation, training for all professionals and tools to help them communicate risk to women will be necessary to develop risk assessment in BCS. Trial registration Study sponsor: Unicancer. …”
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Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial by Yi Liu, Yitong Liu, Jingchao Hu, Jianhui Han, Lin Song, Xu Liu, Nannan Han, Xia Xia, Jia He, Hongfang Meng, Meng Wan, Haojie Wang, Xiaodan Liu, Zhanyi Gao, Xiao Wang, Chutse Wu, Songlin Wang

“…In this study, a human dental pulp stem cell (DPSC; hDP-MSC) injection was developed to promote periodontal regeneration through a non-invasive procedure. …”
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Improving regional care in the last year of life by setting up a pragmatic evidence-based Plan–Do–Study–Act cycle: results from a cross-sectional survey by Lena Ansmann, Holger Pfaff, Ingrid Schubert, Ludwig Kuntz, Stephanie Stock, Sheila Payne, Nadine Scholten, Ute Karbach, Stefanie Hamacher, Raymond Voltz, Christian Albus, Frank Jessen, Christian Rietz, Frank Schulz-Nieswandt, Julia Strupp, Gloria Dust, Nicolas Schippel

“…Results and further improvement projects will be discussed in a working group with the city of Cologne, and repeating this survey in 2 years will be able to measure regional achievements.Trial registration number DRKS00011925.…”
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Mapping outcomes for recovery of consciousness in studies from 1986 to 2020: a scoping review protocol by Monica Steiner, Elizabeth Burns, Trudy Mallinson, Joshua Rosenow, Jennifer Weaver, Alison Cogan, Parie Bhandari, Erica Jacobs, Ariana Pape, Chantal Nguyen, Ann Guernon, Tom Harrod, Theresa Bender Pape, Marilyn Pacheco, Catherine Burress Kestner, Kelsey Watters, Elizabeth Yost, Henk Eilander, Berno Overbeek, Sophie Leeds, Kelly Krese, Haylee Winden, Mary Philbin, Stefani Cleaver, Vanessa Silva, Konner Nelson, André Lindsey, Angela Hartman, Kristen Maisano, Erika Cooley, Jessica Rudin Portnoff, Bailey Widener, Sarah Hollingsworth, Coty Wardwell, Julianne Angel, Ladan Hakima, Jennifer Nebel, Bint-e Zainab Awan

“…Results will be presented at national conferences and published in peer-reviewed journals.Trial registration number CRD42017058383.…”
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Peer-Assisted Lifestyle (PAL) intervention: a protocol of a cluster-randomised controlled trial of a health-coaching intervention delivered by veteran peers to improve obesity trea... by Stephanie L Orstad, Melanie Jay, Victoria Sweat, Sandra Wittleder, Scott E Sherman, Jeannette M Beasley, Shea Smith, Binhuan Wang, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner

“…We will disseminate the results via peer-reviewed publications, conference presentations and meetings with stakeholders.Trial registration number NCT03163264; Pre-results.…”
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Derivation and internal–external validation of clinical prediction model for postoperative clinically important hypotension in patients undergoing noncardiac surgery: an internatio... by Stephen Su Yang, German Malaga, Maria Lazo-Porras, Patricia Busta-Flores, Aida del Carmen Rotta-Rotta, Pavel S. Roshanov, Daniel I. Sessler, Amal Bessissow, Thomas Schricker, Vicky Tagalakis, Diane Heels-Ansdell, Shirley Pettit, P.J. Devereaux

“…Conclusions: Postoperative clinically important hypotension may be estimated before surgery using our primary model and a simple four-element model. Clinical trial registration: NCT00512109.…”
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PANDA study: subtyping of Parkinson’s disease – cohort study protocol by Yan Li, Rui Yang, Zihao Li, Mengfei Cai, Chentao He, Siming Rong, Ziqi Gao, Qibing Luo, Xilie Cui, Piao Zhang, Yuhu Zhang

“…The classification of PD into distinct subtypes remains a major challenge, limiting the development of precision medicine approaches. Existing subtyping methods have relied on clinical features, genetic markers or isolated biomarkers, but an integrated classification system incorporating neuroimaging and fluid biomarkers is lacking. …”
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Randomised placebo-controlled multicentre trial to evaluate the efficacy and safety of JTR-161, allogeneic human dental pulp stem cells, in patients with Acute Ischaemic stRoke (J-... by Hideo Hara, Nobuyuki Sakai, Shinichi Yoshimura, Masafumi Ihara, Satoshi Suda, Chikako Nito, Kazumi Kimura, Yuji Matsumaru, Taketo Hatano, Masaki Takao, Takeshi Yoshimoto, Masahiro Yasaka, Masafumi Morimoto, Akira Tsujino, Takeshi Inoue, Seiji Okubo, Mitsuyasu Kanai, Kenichi Morita, Yuka Terasawa, Yasuyuki Iguchi, Takao Urabe, Masataka Takeuchi, Shinichi Takahashi, Yasuhisa Akaiwa, Norihiro Ishii, Takao Kanzawa, Eiichiro Kamatsuka, Takeshi Iwanaga, Ryuzaburo Kanazawa, Norimichi Nakamura, Yutaka Honma, Tomohiko Izumidani, Shoji Arihiro, Takayuki Mizunari

“…It is currently under development as a cell-based therapy for ischaemic stroke. …”
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INTERNATIONAL COLLABORATION: STRENGTHENING ADOLESCENT HEALTH PROGRAMS THROUGH GLOBAL PARTNERSHIPS IN EMPOWERING SCHOOL HEALTH PROGRAM CADRES AND PEER TUTORS by Ivon Diah Wittiarika, Ratna Dwi Jayanti, Andriyanti, Dewi Setyowati, Riri Aprianti, Nenccy Mirasari, Mulia Dian Sumbawati, Siti Nurul Komariah, Deby Artika P, Pupus Ultraluana, Ngatwati, Yublina Rambu Mbali Idi, Nurhayati Fitria Amin, Mohamed Alif Haikal Bin Mohamed Iskandar, Fatin Nazurah Izzati Binti Hamdani, Siti Norhikmah Binti Abd. Razak

“…The long-term positive impact is expected to contribute to the achievement of the 3rd Sustainable Development Goals (SDGs), namely ensuring healthy lives and well-being for all ages by 2030. …”
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Synchronous metastases from colorectal cancer. Treatment and long-term survival compared to patients with metachronous metastases: a population-based study from Central Norway 2001... by Per Even Storli, Rachel Genne Dille- Amdam, Gaute Havik Skjerseth, Mads Vikhammer Gran, Tor Åge Myklebust, Jon Erik Grønbech, Erling A. Bringeland

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