Interventional treatments for chronic, axial or radicular, non-cancer, spinal pain: a protocol for a systematic review and network meta-analysis of randomised trials by Xiaoqin Wang, Jason W Busse, Behnam Sadeghirad, Gordon H Guyatt, Thomas Agoritsas, Ivan D Florez, Yaping Chang, Elena Kum, Y Raja Rampersaud, D Norman Buckley, Andrea J Darzi, Grace Martin, Rachel J Couban, Holly N Crandon, Meisam Abdar Esfahani, Laxsanaa Sivananthan, Fatemeh Mehrabi, Neil K Sengupta, Preksha Rathod, Rami Z Morsi, Christopher J Standaert

“…We will disseminate our findings through publication in a peer-reviewed journal and conference presentations, and our review will support development of a BMJ Rapid Recommendations providing contextualised clinical guidance based on this body of evidence.PROSPERO registration number CRD42020170667.…”
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Study of the Role of the Tumor Microenvironment in Ovarian Cancer (MICO): A Prospective Monocentric Trial by Martina Arcieri, Eleonora Capezzali, Stefano Restaino, Sara Pregnolato, Laura Mariuzzi, Alessandro Mangogna, Maria Orsaria, Angelica Tulisso, Silvia Tonon, Maria De Martino, Miriam Isola, Lorenza Driul, Carlo Pucillo, Giovanni Scambia, Barbara Frossi, Giuseppe Vizzielli

“…This will be a monocentric trial with an involvement of only 43 patients, so further studies will need to confirm our results. Trial Registration The clinical trial has been registered at Clinical‐Trials.gov with the identifier NCT06272240 on 02/14/2024…”
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A retrospective observational study of tetralogy of fallot with pulmonary atresia and ductal-dependent pulmonary circulation focusing on the staged transannular patch procedure: a... by Jae Hong Lee, Hyungtae Kim, Kwang Ho Choi, Si Chan Sung, Hyoung Doo Lee, Hoon Ko, Joung-Hee Byun, Tae Hong Kim, Mi Sook Yun

“…The staged TAP procedure could be a viable option for patients with PA/VSD/PDA and a well-developed main pulmonary artery segment. Trial registration Not applicable.…”
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Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study by Guangyu Lu, Zhixia Su, Xiaoping Yu, Yuhang He, Taining Sha, Kai Yan, Hong Guo, Yujian Tao, Liting Liao, Yanyan Zhang, Guotao Lu, Weijuan Gong

“…Further validation through larger, multicenter studies is necessary to establish their generalizability. Trial Registration: Number ChiCTR2400081283…”
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Integrated assessment of antimicrobial stewardship in carbapenem resistant Klebsiella pneumoniae prevalent hospitals in China: a multidisciplinary surveillance network-based survey by Haishaerjiang Wushouer, Weibin Li, Junxuan Yu, Lin Hu, Xiaodong Guan, Xiaolin Liu, Anhua Wu, Xiaoqiang Yang, Minggui Wang, Yingchun Xu, Yanping Luo, Xun Huang, Luwen Shi

“…We aimed to identify challenges and barriers in antimicrobial stewardship (AMS) development based on this national multidisciplinary surveillance network. …”
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Pilot study to test the feasibility of a trial design and complex intervention on PRIoritising MUltimedication in Multimorbidity in general practices (PRIMUMpilot) by Rafael Perera, Marjan Van Den Akker, Ferdinand M Gerlach, Jose M Valderas, Martin Beyer, Christiane Muth, Lorenz Uhlmann, Corina Güthlin, Antje Erler, Sebastian Harder, Justine Rochon, Birgit Fullerton, André Knottnerus, Walter E Haefeli

“…Objective To improve medication appropriateness and adherence in elderly patients with multimorbidity, we developed a complex intervention involving general practitioners (GPs) and their healthcare assistants (HCA). …”
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Pilot cluster randomised trial of an evidence-based intervention to reduce avoidable hospital admissions in nursing home residents (Better Health in Residents of Care Homes with Nu... by Katherine Froggatt, Rachael Hunter, Louise Marston, Louise Robinson, Greta Rait, John Young, Elizabeth L Sampson, Alexandra Feast, Alan Blighe, Brendan McCormack, Shirley Nurock, Monica Panca, Catherine Powell, Barbara Woodward-Carlton, Murna Downs

“…A full trial is not warranted.Trial registration number ISRCTN74109734 (https://doi.org/10.1186/ISRCTN74109734).Original protocol BMJ Open. 2019;9(5):e026510. doi:10.1136/bmjopen-2018-026510.…”
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Delirium education priorities for healthcare professional students: a modified Delphi study by Tara Anderson, Alice Coffey, James McMahon, Stephanie Craig, Heather E. Barry, Margaret Graham, Jill Murphy, Christine Brown Wilson, Pauline Boland, Dympna Tuohy, Matt Birch, Audrey Tierney, Patrick Stark, Arlene McCurtin, Laura Creighton, Elizabeth Henderson, Lana Cook, Emma Cunningham, Geoffrey M. Curran, Gary Mitchell

“…Increased delirium education within pre-registration healthcare profession curricula may help to address this. …”
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Employing artificial intelligence for optimising antibiotic dosages in sepsis on intensive care unit: a study protocol for a prospective observational study (KI.SEP) by Tim Rahmel, Michael Adamzik, Hartmuth Nowak, Lars Bergmann, Björn Koos, Martin Eisenacher, Barbara Sitek, Britta Marko, Lars Palmowski, Andrea Witowski, Katharina Rump, Julia Bandow, Patrick Günther

“…We will use the collected data to develop multifaceted ML-based algorithms aimed at optimising antibiotic dosing in sepsis. …”
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A randomized trial to evaluate the impact of breast density notification on anxiety, breast cancer worry, and perceived risk among Latinas at a federally qualified health center by Karthik Ghosh, Sarah M. Jenkins, Jennifer L. Ridgeway, Jessica D. Austin, Bijan J. Borah, Bhavika Patel, Deborah J. Rhodes, Aaron D. Norman, Edna P. Ramos, Matt Jewett, Crystal R. Gonzalez, Valentina Hernandez, Davinder Singh, Celine M. Vachon, Vera J. Suman

“…BC worry was reported to be sometimes/ often/ almost all the time among 41.3% of participants. 25.4% reported a perceived lifetime risk of developing BC of > 10%, compared with 6.6% with Gail model estimated lifetime risk score of > 10%. …”
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Pharmacodynamics effects of CDK4/6 inhibitor LEE011 (ribociclib) in high-risk, localised prostate cancer: a study protocol for a randomised controlled phase II trial (LEEP study: L... by Lisa M Butler, Anthony M Joshua, Tahlia Scheinberg, James Kench, Martin Stockler, Kate L Mahon, Lucille Sebastian, Phillip Stricker, H Woo, Ruban Thanigasalam, Nariman Ahmadi, Margaret M Centenera, Lisa G Horvath

“…Introduction Despite the development of new therapies for advanced prostate cancer, it remains the most common cause of cancer and the second leading cause of cancer death in men. …”
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Multicentre adaptive randomised trial of GvHD prophylaxis following unrelated donor stem cell transplantation comparing Thymoglobulin versus calcineurin inhibitor-based or sirolimu... by Simon Gates, Matthew Collin, Victoria Potter, Rebecca Bishop, Ronjon Chakraverty, Kavita Raj, Adrian Bloor, Andrea Hodgkinson, Jeff Davies, Emma Kempshall, Fiona Dignan, Ram Malladi, Siobhan Smith, Charlotte Gaskell, Gabrielle Smith

“…In patients who survive GvHD and or the complications of treatment, about 1 in 3 patients develop chronic GvHD which has a negative impact on quality of life (QoL). …”
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Assessing Patient-Reported Satisfaction With Care and Documentation Time in Primary Care Through AI-Driven Automatic Clinical Note Generation: Protocol for a Proof-of-Concept Study by Josep Vidal-Alaball, Carlos Alonso, Daniel Hugo Heinisch, Alberto Castaño, Encarna Sánchez-Freire, María Luisa Benito Serrano, Carla Ferrer Pascual, Ignacio Menacho, Ruthy Acosta-Rojas, Odda Cardona Gubert, Rosa Farrés Creus, Joan Armengol Alegre, Carles Martínez Querol, Marina Moreno-Martinez, Mercè Gonfaus Font, Silvia Narejos, Anna Gomez-Fernandez

“… BackgroundRelisten is an artificial intelligence (AI)–based software developed by Recog Analytics that improves patient care by facilitating more natural interactions between health care professionals and patients. …”
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Digital Biomarkers for Parkinson Disease: Bibliometric Analysis and a Scoping Review of Deep Learning for Freezing of Gait by Wenhao Qi, Shiying Shen, Chaoqun dong, Mengjiao Zhao, Shuaiqi Zang, Xiaohong Zhu, Jiaqi Li, Bin Wang, Yankai Shi, Yongze Dong, Huajuan Shen, Junling Kang, Xiaodong Lu, Guowei Jiang, Jingsong Du, Eryi Shu, Qingbo Zhou, Jinghua Wang, Shihua Cao

“… BackgroundWith the rapid development of digital biomarkers in Parkinson disease (PD) research, it has become increasingly important to explore the current research trends and key areas of focus. …”
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Participative research for individualised care in cardiovascular diseases (PRIC-CVD): study protocol for a non-interventional, multicentre mixed-methods study as part of iCARE4CVD by Bianca Steiner, Hans-Peter Brunner-La Rocca, Loreena Hill, Bettina Zippel-Schultz, Julia Brandts, Matthew Barrett, Thomas Maria Helms, Sabine Friedl, Marlo Verket, Karolien Baldewijns, Marguerite Murphy, Anne McNulty, Markus Schwertfeger, Iñaki Romero

“…Over 3.5 years, patient panel members are required to complete four tasks: (1) identification of meaningful Patient-Reported Outcome and Experiences Measures, (2) development of a motivational model to increase adherence, (3) feedback on CVD care processes and (4) usability testing of new digital tools developed within iCARE4CVD. …”
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An open-label phase I comparator-controlled clinical trial to assess tolerability and pharmacokinetics of IHL-675 A a fixed dose combination of cannabidiol plus hydroxychloroquine... by George Williams Mbogo, Pia Kroner, Rosemarie Walsh, Jonathan Newchurch, Mark Robert Bleackley

“…These results support the continued clinical development of IHL-675 A. Trial Registration: ACTRN12622000289718.…”
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Multilevel Intervention to Increase Patient Portal Use in Adults With Type 2 Diabetes Who Access Health Care at Community Health Centers: Single Arm, Pre-Post Pilot Study by Robin Whittemore, Sangchoon Jeon, Samuel Akyirem, Helen N C Chen, Joanna Lipson, Maritza Minchala, Julie Wagner

“…Next, a nurse met individually with participants to develop a DSMS plan and then communicated with patients via the portal at least twice weekly during the first 3 months and weekly for the latter 3 months. …”
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Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project by Salma Malik, Zoi Pana Dorothea, Christos D Argyropoulos, Sophia Themistocleous, Alan J Macken, Olena Valdenmaiier, Frank Scheckenbach, Elena Bardach, Andrea Pfeiffer, Katherine Loens, Jordi Cano Ochando, Oliver A Cornely, Jacques Demotes-Mainard, Sergio Contrino, Gerd Felder

“…With system database development coordinated by a single individual and no need for coordination among different trial units, a high degree of uniformity was achieved automatically. …”
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Implementation and Evaluation of a Best Practice Advisory to Reduce Inequities in Technology Use for People With Type 1 Diabetes: Protocol for a Mixed Methods, Nonrandomized Contro... by Nestoras Mathioudakis, Risa Wolf, Abha Choudhary, Georgia Davis, Mary Pat Gallagher, Meenal Gupta, Manmohan Kamboj, Nicole Rioles, Emma Ospelt, Susan Thapa, Ruth S Weinstock, Trevon Wright, Osagie Ebekozien

“…ObjectiveThis study aims to develop and evaluate a best practice advisory (BPA) within the electronic medical record (EMR) to reduce racial and ethnic disparities in ADT use. …”
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Effectiveness of participatory women’s groups scaled up by the public health system to improve birth outcomes in Jharkhand, eastern India: a pragmatic cluster non-randomised contro... by Hassan Haghparast-Bidgoli, Audrey Prost, Andrew Copas, Amit Kumar, Rajkumar Gope, Vikash Nath, Nirmala Nair, Vasudha Chakravarthy, Tanja AJ Houweling, Shibanand Rath, Suchitra Rath, Prasanta K Tripathy, Hemanta Pradhan, Parabita Basu, Amit Ojha, Akay Minz, Pradeep Baskey, Manir Ahmed, Riza Mahanta

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