Protocol for a mixed-methods feasibility study for the surviving opioid overdose with naloxone education and resuscitation (SOONER) randomised control trial by Peter Jüni, Carol Strike, Rita Shahin, Kevin Thorpe, Douglas Campbell, Aaron Orkin, Shaun Hopkins, Michelle Klaiman, Janet A Parsons, Kate Sellen, Geoffrey Milos, Amy Wright, Mercy Charles, Ruby Sniderman, Leigh Chapman, Nick Goso, Richard Hunt, Vicky Stergiopoulos, Daniel Werb

“…Introduction The surviving opioid overdose with naloxone education and resuscitation (SOONER) project uses co-design and trial methods to develop and evaluate a point-of-care overdose education and naloxone distribution (OEND) tool. …”
Get full text

Theory-based chatbot for promoting colorectal cancer screening in a community setting in Hong Kong: study protocol of a randomised controlled trial by Samuel Yeung Shan Wong, Dong Dong, Yue Hu, Thomas Yuen Tung Lam, Xixin Wu, Wai Man Lau, Zixin Johnson Wang, Raymond Shing Yan Tang, Phoenix Kit Han Mo, Mei Ling Helen Meng, Joseph Jao You Sung

“…The intervention group will deliver Chinese culturally tailored education texts and videos developed based on the Health Belief Model and the Trans-Theoretical Model. …”
Get full text

Does completion of radical hysterectomy improve oncological outcomes of women with clinical early-stage cervical cancer and intraoperative detection of nodal involvement?: protocol... by Hui Xu, Qing Liu, Yu Xu, Yi Du, Ai Zheng, Cui Hu, Ya Jia, Qianwen Zhang, Yue-Dong He, Shuang-Shuang Cui, Yong Tian, Lin Ran, Fengmei Ke

“…The findings of this proposed study will be published in an international peer-reviewed journal.PROSPERO registration number CRD42021273527.…”
Get full text

Compassion Fatigue and Burnout Among Health Care Professionals: Protocol for a Scoping Review by Christian Guilherme Capobianco dos Santos, Martins Fideles dos Santos Neto, Stela Regina Pedroso Vilela Torres de Carvalho, Márcia Regina Furlani, Cíntia Canato Martins, Emerson Roberto Santos, João Daniel Souza Menezes, Matheus Querino da Silva, Loiane Letícia Santos, Thaysa Castro Molina, Natalia Almeida de Arnaldo Silva Rodriguez Castro, Helena Cristóvão., Randolfo Santos Júnior, Vânia MS Brienze, Alba Regina de Abreu Lima, Patricia da Fucuta, Denise Vaz-Oliani, Neide Aparecida Domingos, Maria Cristina Miyazaki, Gerardo Araújo Filho, Júlio César André

“…The review is expected to be completed by December 2025, and the search strategy has been developed and pilot-tested. ConclusionsOur findings will help identify gaps in the literature with respect to compassion fatigue and burnout prevention strategies for health care professionals. …”
Get full text

Understanding the trends, and drivers of emigration, migration intention and non-migration of health workers from low-income and middle-income countries: protocol for a systematic... by Oghenebrume Wariri, Paul Ikhurionan, Yakubu Kevin Kwarshak, Ekhosuehi T Agho, Itua C G Akhirevbulu, Josephine Atat, Franca Erhiawarie, Emmanuel O Gbejewoh, Chinelo Iwegim, Ukachi Nnawuihe, Uyoyo Odogu, Jermaine Okpere, Efe E Omoyibo, Efetobo Victor Orikpete, Uwaila Otakhoigbogie, Avwebo Ukueku, Patience Ugwi

“…Key findings will be presented at local and international conferences.PROSPERO registration number CRD42022334283.…”
Get full text

Adjusting Early Warning Score by clinical assessment: a study protocol for a Danish cluster-randomised, multicentre study of an Individual Early Warning Score (I-EWS) by Lars Simon Rasmussen, Kasper Karmark Iversen, Theis Lange, Gitte Bunkenborg, Pernille B Nielsen, Martin Schultz, Caroline Sophie Langkjaer, Anne Marie Kodal, Niels Egholm Pedersen, John Asger Petersen, Michael Dan Arvig, Christian Sahlholt Meyhoff, Morten Bestle, Bibi Hølge-Hazelton, Anne Lippert, Ove Andersen

“…Individual Early Warning Score (I-EWS) is a newly developed TTS with an aggregated score based on vital signs that can be adjusted according to the clinical assessment of the patient. …”
Get full text

Interventions to improve the quality of cataract services: protocol for a global scoping review by Nathan Congdon, João M Furtado, Matthew J Burton, Jacqueline Ramke, Stephen Gichuhi, Helen Burn, Iris Gordon, William H Dean, John Buchan, Ada Aghaji, Miho Yoshizaki, Ana P Marques

“…We will publish our findings in an open-access peer-reviewed journal and develop an accessible summary of the results for website posting. …”
Get full text

Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol by Mary Shelton, Humphrey Mulenga, Stanley Kimbung Mbandi, Simon C Mendelsohn, Mark Hatherill, Fatoumatta Darboe, Thomas J Scriba

“…Results will be disseminated through peer-reviewed publication and conference presentation.PROSPERO registration number CRD42021224155.…”
Get full text

Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME) by Archya Dasgupta, Saranga Sawant, Abhishek Chatterjee, Vikram Gota, Arpita Sahu, Amitkumar Choudhari, Kajari Bhattacharya, Ameya Puranik, Indraja Dev, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Nandini Menon, Sridhar Epari, Ayushi Sahay, Aekta Shah, Nazia Bano, Farnaz Shaikh, Aabha Jirage, Tejpal Gupta

“…Adults (> 18 years) with a histological diagnosis of diffuse glioma developing radionecrosis will be eligible for the study. …”
Get full text

The Evaluation of Patient‐Controlled Analgesia Compared to Standard Opioid Analgesic Therapy in Pain Management Among Patients With Sickle Cell Disease: A Systematic Review and Met... by Maria Pramila D'Costa, Melita Sheela Alva, Seyed Aria Nejadghaderi, Salha Humaid Al Bloushi, Wafa Ibrahim Saleh Al Shizawi, Nikhil Muduli, Sana Ahuja, Salma Al‐Amri, Alireza Mosavi Jarrahi, Nabeel Al‐Yateem, Syed Azizur Rahman, Amina Mohammed Al‐Marzouqi

“…Trial Registration CRD42024573178.…”
Get full text

Efficacy of recombinant thrombomodulin for poor prognostic cases of acute exacerbation in idiopathic interstitial pneumonia: secondary analysis of the SETUP trial by Yoshikazu Inoue, Satoshi Marumo, Toru Arai, Hiroshi Kida, Yoshitaka Ogata, Hiroto Matsuoka, Iwao Gohma, Suguru Yamamoto, Masahide Mori, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira

“…Survival was improved with the rhTM therapy (p<0.05) in the poor prognostic cases (score ≥2), but not in the good prognostic cases (score=0).Conclusions Treatment with rhTM might improve survival in AE-IIP cases with poor prognoses.Trial registration numberUMIN000014969,date: 28 August 2014.…”
Get full text

Safety of ezetimibe in lipid-lowering treatment: systematic review and meta-analysis of randomised controlled trials and cohort studies by Ling Li, Jing Li, Yang Wang, Bert Aertgeerts, Gordon Guyatt, Per Olav Vandvik, Qiukui Hao, Heyue Du, Na Su, Haoming Tian, Sheyu Li, Safi U Khan, Nicolas Delvaux, Shipeng Zhan, Geertruida Bekkering, Irbaz Riaz

“…The certainty of evidence was assessed using the Grading of Recommendation Assessment, Development, and Evaluation.Results 48 randomised controlled trials with 28 444 participants (median follow-up 34 weeks, range 24-312 weeks) and four observational studies with 1667 participants (median follow-up 282 weeks, range 72-400 weeks) were included. …”
Get full text

Simulation-based infection prevention and control training for medical and healthcare students: a systematic review by Akira Yoshikawa, Hiroyuki Ohtsuka, Keiichiro Aoki, Naonori Tashiro, Shusuke Togo, Kazuki Komaba, Satoshi Nogawa, Miwa Osawa, Megumi Enokida

“…Therefore, it is essential to choose educational strategies based on specific learning objectives and outcomes.Systematic review registrationThis systematic review protocol was preregistered in the Open Science Framework: https://osf.io/uj623/.…”
Get full text

Motivations and experiences of patients with respiratory disease and their caregivers in a multinational trial of mirtazapine for severe breathlessness: a qualitative study (BETTER... by Adejoke O. Oluyase, Luca Ghirotto, Harry Watson, Massimo Costantini, Sabrina Bajwah, Charles Normand, Silvia Tanzi, Jeremias Bazata, Karen Ryan, Elena Turola, Irene J. Higginson, Matthew Maddocks, On behalf of the BETTER-B consortium

“…Abstract Background Drug repurposing offers advantages over traditional drug development, such as shorter time and reduced costs. …”
Get full text

Adherence to ready-to-use therapeutic food in older children with sickle cell anaemia and severe acute malnutrition: a mixed-methods study in a low-income setting by David G Schlundt, Shehu U Abdullahi, Virginia A Stallings, Safiya Gambo, Amanda Brechko, Hassan Adam Murtala, Halima Kabir, Khadija A Shamsu, Mark Rodeghier, Ahalya Ramesh, Ashley Sellers, Michael R DeBaun, Lauren J Klein

“…Insights from this study may guide the development of tailored strategies, family education and empowerment initiatives to enhance adherence to malnutrition interventions for children with SCA.Trial registration number SAMS trial (NCT03634488).…”
Get full text

Oncologic oUTcomes of neoadjuvant chemotherapy for obSTructive colon cAncer after steNt decompression (OUTSTAND trial); A study protocol of multicenter non-inferiority randomized c... by Bong-Hyeon Kye, Ji-Hoon Kim, Hyung-Jin Kim, Yoon-Suk Lee, In-Kyu Lee, Won Kyung Kang, Hyeon-Min Cho, Jong-Kyung Park, Chang-Hyeok Ahn, Jae-Im Lee, Seong-Taek Oh, Byung Jo Choi

“…Based on the results of this trial, a patient-tailored treatment strategy can be developed for obstructive colon cancer. Registration This study is registered on ClinicalTrials.gov Identifier: NCT04889820, registered on May 17, 2021 in clinicaltrials.gov; Protocol ID: XC21MIDI0004.…”
Get full text

Prostate cancer androgen receptor splice variant 7 biomarker study - a multicentre randomised feasibility trial of biomarker-guided personalised treatment in patients with advanced... by John Marshall, Ruth Wood, Denise Howel, Emma Clark, Rakesh Heer, John Staffurth, Miranda Morton, Shriya Sharma, Holly Fisher, Jenn Walker, Helen Hancock, Rebecca Maier, Ian Pedley, Rob Jones

“…Findings to be disseminated through patient and professional organisations that have expressed their support, media outlets and peer-reviewed journal publication.Trial registration number ISRCTN10246848; pre-results…”
Get full text

AI-assisted detection for chest X-rays (AID-CXR): a multi-reader multi-case study protocol by Fergus Gleeson, Alex Novak, Indrajeet Das, Ruchir Shah, Edwin van Beek, Sarim Ather, Howell Fu, Nabeeha Salik, Alan Campbell, Farhaan Khan, Abdala Trinidad Espinosa Morgado, Marusa Kotnik, Louise Wing, John Murchison, Jong Seok Ahn, Sang Hyup Lee, Ambika Seth

“…Advances in machine learning and computer vision technologies have led to the development of several artificial intelligence (AI) tools to detect abnormalities on CXRs, which may expand diagnostic support to a wider field of health professionals. …”
Get full text

Patient-Centered Risk Prediction, Prevention, and Intervention Platform (TIMELY) to Support the Continuum of Care in Coronary Artery Disease Using eHealth and Artificial Intelligen... by Mirela Habibovic, Emma Douma, Hendrik Schäfer, Manuela Sestayo-Fernandez, Tom Roovers, Xin Sun, Henrik Schmidt, Mona Kotewitsch, Jos Widdershoven, David Cantarero-Prieto, Frank Mooren, Carlos Pena-Gil, José Rámon González Juanatey, Martin Schmidt, Hagen Malberg, Vassilis Tsakanikas, Dimitrios Fotiadis, Dimitris Gatsios, Jos Bosch, Willem Johan Kop, Boris Schmitz

“…ObjectiveThe TIMELY project aims to develop and evaluate a personalized, artificial intelligence–driven eHealth platform and app to support sustainable behavior change during phase-3 CR, subsequently reducing cardiac risk scores. …”
Get full text

Impact of Supervised-concurrent Exercise During Pregnancy on Infant Neuromotor Skills: A Post-hoc Analysis Stratified by Maternal BMI by Sandra Sanchez-Parente, Kara Kern, Alex Claiborne, Breanna Wisseman, Dylan Steen, Brittany Roenker, Ashton Lilley, Cody Strom, Edward Newton, James DeVente, Steven Mouro, David Collier, Devon Kuehn, Katrina D. Dubose, George Kelley, Amy Gross McMillan, Jose Castro-Piñero, Virginia A Aparicio, Linda E. May

“…Further studies are needed to understand the influence of concurrent exercise training during pregnancy on infants whose mothers are overweight or obese, and the potential mechanism behind the role of maternal BMI in the development of infant neuromotor skills. Clinical Trial Registration ClinicalTrials.gov Identifier: NCT03838146.…”
Get full text